Aliases for ROS1 Gene
Aliases for ROS1 Gene
- ROS Proto-Oncogene 1, Receptor Tyrosine Kinase 2 3 5
- V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1 2 3
- C-Ros Oncogene 1 , Receptor Tyrosine Kinase 2 3
- Proto-Oncogene C-Ros-1 3 4
- MCF3 3 4
- ROS 3 4
- V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian) 2
- ROS Proto-Oncogene 1 , Receptor Tyrosine Kinase 3
External Ids for ROS1 Gene
- HGNC: 10261
- Entrez Gene: 6098
- Ensembl: ENSG00000047936
- OMIM: 165020
- UniProtKB: P08922
Previous GeneCards Identifiers for ROS1 Gene
- GC06M117444
- GC06M117632
- GC06M117655
- GC06M117716
- GC06M117609
- GC06M115190
Summaries for ROS1 Gene
-
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]
-
ROS1 is a receptor tyrosine kinase that is frequently involved in genetic rearrangement in a variety of human cancers (e.g. NSCLC, gastric cancer, ovarian cancer, cholangiocarcinoma, colorectal cancer, angiosarcoma...). The resulting fusion protein harbors the constitutively active ROS1 kinase domain and drives cellular proliferation (Davies et. al.). In NSCLC about 1% harbor a ROS1 rearrangement. These patients are predominantely female and have a lower T-stage (Warth et. al.). Treatment with crizotinib leads to a reported objective response rate of appr. 70% and a median duration of response of 18 months (Shaw et. al.). Resistance mechanisms to crizotinib have been described and involve mutations in the kinase domain. More selective inhibitors of ROS1 might overcome this resistance (Davare et. al.).
GeneCards Summary for ROS1 Gene
ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ROS1 include Lung Large Cell Carcinoma and Cholangiocarcinoma. Among its related pathways are ERK Signaling and Actin Nucleation by ARP-WASP Complex. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is IGF1R.
UniProtKB/Swiss-Prot for ROS1 Gene
-
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Additional gene information for ROS1 Gene
- Monarch Initiative
- Search for ROS1 at DataMed
- Search for ROS1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROS1 Gene
Genomics for ROS1 Gene
GeneHancer (GH) Regulatory Elements for ROS1 Gene
Promoters and enhancers for ROS1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ROS1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ROS1 Gene
Genomic Locations for ROS1 Gene
- chr6:117,287,918-117,425,922
- (GRCh38/hg38)
- Size:
- 138,005 bases
- Orientation:
- Minus strand
- chr6:117,609,463-117,747,018
- (GRCh37/hg19)
Genomic View for ROS1 Gene
Genes around ROS1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.1 by Ensembl
- 6q22.1 by Entrez Gene
- 6q22.1 by HGNC
ROS1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ROS1 Gene
Proteins for ROS1 Gene
-
Protein details for ROS1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P08922-ROS1_HUMAN
- Recommended name:
- Proto-oncogene tyrosine-protein kinase ROS
- Protein Accession:
- P08922
- Q15368
- Q5TDB5
Protein attributes for ROS1 Gene
- Size:
- 2347 amino acids
- Molecular mass:
- 263915 Da
- Quaternary structure:
-
- Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity). Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation.
Protein Expression for ROS1 Gene
Post-translational modifications for ROS1 Gene
- Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation (By similarity). Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity). Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11.
- Glycosylation at Asn52, Asn114, isoforms=123, isoforms=324, isoforms=352, Asn396, Asn471, isoforms=607, Asn628, isoforms=706, Asn714, isoforms=732, isoforms=939, isoforms=961, isoforms=1015, Asn1087, isoforms=1090, Asn1095, isoforms=1211, isoforms=1272, isoforms=1330, isoforms=1458, Asn1461, Asn1474, Asn1499, isoforms=1565, isoforms=1669, Asn1715, Asn1738, and isoforms=1808
- Modification sites at PhosphoSitePlus
Other Protein References for ROS1 Gene
Antibody Products
- Novus Biologicals Antibodies for ROS1
-
Abcam antibodies for ROS1
-
Cloud-Clone Corp. Antibodies for ROS1
- Invitrogen Antibodies for ROS1
- GeneTex ROS1 antibody for ROS1
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ROS1
- Origene Custom Protein Services for ROS1
- Novus Biologicals proteins for ROS1
-
Cloud-Clone Corp. Proteins for ROS1
- Search GeneTex for Proteins for ROS1
-
Abcam proteins for ROS1
Assay Products
-
Cloud-Clone Corp. Assay Kits for ROS1
No data available for DME Specific Peptides for ROS1 Gene
Domains & Families for ROS1 Gene
Gene Families for ROS1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ROS1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ROS1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P08922UniProtKB/Swiss-Prot:
ROS1_HUMAN :- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
- Family:
-
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Function for ROS1 Gene
Molecular function for ROS1 Gene
- GENATLAS Biochemistry:
- avian UR2 sarcoma virus oncogene (v-ros) homolog
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by dephosphorylation by PTPN6.
- UniProtKB/Swiss-Prot Function:
- Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
Enzyme Numbers (IUBMB) for ROS1 Gene
Phenotypes From GWAS Catalog for ROS1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004713 | protein tyrosine kinase activity | IEA,IDA | 16885344 |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 17416557 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for ROS1 Gene
- MGI mutant phenotypes for ROS1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for ROS1:
-
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Resistant to vaccinia virus (VACV-A4L) infection
- Increased transferrin (TF) endocytosis
- FOXO1 nuclear localization
- Decreased viability
- Decreased substrate adherent cell growth
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased viability with TRAIL
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Condensed cis-Golgi
- Increased simian virus 40 (SV40) infection
- Increased colony dispersion (increased number of colonies and decreased number of cells per colony)
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ROS1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ROS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ROS1 gene
- Search ViGene Biosciences for ROS1
CRISPR Products
-
OriGene CRISPR knockouts for ROS1
- genomics-online: gRNA clones - Search results for 62 available ROS1 gene related products
- Overview of 62 available ROS1 gene related products
- Applied Biological Materials CRISPR for ROS1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ROS1
- GenScript: Design CRISPR guide RNA sequences for ROS1
miRNA for ROS1 Gene
- miRTarBase miRNAs that target ROS1
miRNA Products
- Search ViGene Biosciences for ROS1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ROS1
- Browse OriGene Inhibitory RNA Products For ROS1
- genomics-online: shRNA clones - Search results for 62 available ROS1 gene related products
- Overview of 62 available ROS1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ROS1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ROS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ROS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ROS1
- Applied Biological Materials Clones for ROS1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for ROS1
-
ViGene Biosciences adenoviral particle packaged cDNA for ROS1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ROS1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ROS1 gene
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ROS1 Gene
Localization for ROS1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ROS1 Gene
- Cell membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| lysosome | 1 |
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0009986 | cell surface | IEA | -- |
| GO:0016020 | membrane | TAS,IEA | 3785223 |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0048471 | perinuclear region of cytoplasm | IEA | -- |
Pathways & Interactions for ROS1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | GPCR Pathway |
.73
.62
|
.55
|
| 2 | ERK Signaling |
.61
.58
|
.49
|
| 3 | Nanog in Mammalian ESC Pluripotency |
.61
|
.48
|
| 4 | Actin Nucleation by ARP-WASP Complex |
.41
|
|
| 5 | Activation of cAMP-Dependent PKA | ||
Pathways by source for ROS1 Gene
2 BioSystems pathways for ROS1 Gene
1 Cell Signaling Technology pathway for ROS1 Gene
Interacting Proteins for ROS1 Gene
Selected Interacting proteins:
P08922-ROS1_HUMAN
ENSP00000357494
for ROS1 Gene via
IID
MINT
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001558 | regulation of cell growth | IDA | 16885344 |
| GO:0002066 | columnar/cuboidal epithelial cell development | ISS,IEA | -- |
| GO:0006468 | protein phosphorylation | IEA,IDA | 16885344 |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IEA | -- |
| GO:0007283 | spermatogenesis | ISS,IEA | -- |
Drugs & Compounds for ROS1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Crizotinib | Approved | Pharma | Inhibition, Biomarker, inhibitor | C-MET/ALK inhibitor,potent and ATP-competitve, Potent c-MET/ALK inhibitor, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor | 107 | |
| cabozantinib | Approved, Investigational | Pharma | Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors | 0 | ||
| Ceritinib | Approved | Pharma | 38 | |||
| ATP | Investigational | Nutra | Agonist | 0 | ||
| tyrosine | Nutra | 761 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Full agonist, Agonist | 58-64-0 |
|
(1) ApexBio Compounds for ROS1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Dovitinib (TKI-258, CHIR-258) | Multitargeted RTK inhibitor | 405169-16-6 |
Transcripts for ROS1 Gene
mRNA/cDNA for ROS1 Gene
- (14) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (245) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ROS1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ROS1
- genomics-online: gRNA clones - Search results for 62 available ROS1 gene related products
- Overview of 62 available ROS1 gene related products
- Applied Biological Materials CRISPR for ROS1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ROS1
- GenScript: Design CRISPR guide RNA sequences for ROS1
miRNA Products
- Search ViGene Biosciences for ROS1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ROS1
- Browse OriGene Inhibitory RNA Products For ROS1
- genomics-online: shRNA clones - Search results for 62 available ROS1 gene related products
- Overview of 62 available ROS1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ROS1 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for ROS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ROS1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ROS1
- Applied Biological Materials Clones for ROS1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for ROS1 Gene
mRNA differential expression in normal tissues according to GTEx for ROS1 Gene
This gene is overexpressed in Lung (x37.5).
This gene is overexpressed in Amniocyte (42.0) and Tlymphocyte (16.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ROS1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ROS1 Gene:
ROS1SOURCE GeneReport for Unigene cluster for ROS1 Gene:
Hs.1041mRNA Expression by UniProt/SwissProt for ROS1 Gene:
P08922-ROS1_HUMAN
Tissue specificity:
Expressed in brain. Expression is increased in primary gliomas.
Evidence on tissue expression from TISSUES for ROS1 Gene
- Lung(3.2)
Primer Products
-
OriGene qPCR primer pairs for ROS1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ROS1 Gene
Orthologs for ROS1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ROS1 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ROS1 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | ROS1 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ros1 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ros1 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ROS1 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ROS1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ROS1 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
ManyToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ros1 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ros1 33 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | sev 35 33 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000015 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | R151.4 35 |
|
|
|
| T21G5.1 35 |
|
|
|||
| ZK593.9 35 |
|
|
|||
| ddr-1 34 |
|
ManyToMany |
- Species where no ortholog for ROS1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ROS1 Gene
Paralogs for ROS1 Gene
(35) SIMAP similar genes for ROS1 Gene using alignment to 3 proteins:
- SLC34A2/ROS fusion
- SDC4-ROS1_S2
- R32
- EZR-ROS1
- CD74/ROS fusion
- TPM3-ROS1
- SDC4-ROS1_S4
- R34
- LRIG3(NM_153377)-ROS1
- LRIG3(NM_001136051)-ROS1
- CD74-ROS1_C6
- R32
- SLC34A2/ROS1 fusion
- SLC34A2-ROS1
- SDC4-ROS1_S4
- R32
- FGR
- SRC
- DKFZp434L0319
- ABL1
- tec
- FYN
- FNDC3B
- FRK
- KIT
- EPHA2
- urf-ret
- RYK
- FNDC3A
- PTK6
- FGFR3
- DKFZp686M05208
- TIE1
- TYRO3
- TTN
Variants for ROS1 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519788 | likely-pathogenic, Adenocarcinoma of lung | 117,317,184(-) | C/T | coding_sequence_variant, genic_downstream_transcript_variant, missense_variant | |
| rs61743088 | likely-pathogenic, Abnormality of brain morphology | 117,394,232(-) | C/G/T | coding_sequence_variant, missense_variant | |
| VAR_041447 | A gastric adenocarcinoma sample | p.Tyr419His | |||
| VAR_041450 | A lung large cell carcinoma sample | p.Gln865His | |||
| VAR_041456 | A colorectal adenocarcinoma sample | p.Lys2003Arg |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv6141n100 | CNV | gain | 25217958 |
| esv2635247 | CNV | deletion | 19546169 |
| esv2759465 | CNV | loss | 17122850 |
| esv2763593 | CNV | gain | 21179565 |
| esv3303146 | CNV | mobile element insertion | 20981092 |
| esv3383830 | CNV | insertion | 20981092 |
| esv3610491 | CNV | loss | 21293372 |
| nsv478464 | CNV | novel sequence insertion | 20440878 |
| nsv510048 | OTHER | sequence alteration | 20534489 |
| nsv526934 | CNV | loss | 19592680 |
| nsv830785 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
17.08;
98.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ROS1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROS1 Gene
Disorders for ROS1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung large cell carcinoma |
|
|
| cholangiocarcinoma |
|
|
| gastric adenocarcinoma |
|
|
| adenocarcinoma |
|
|
| large cell carcinoma |
|
|
Search ROS1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ROS1_HUMAN- Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells. {ECO:0000269 PubMed:12661006}.
Additional Disease Information for ROS1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ROS1 Gene
Publications for ROS1 Gene
- Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). (PMID: 12661006) Charest A … Housman D (Genes, chromosomes & cancer 2003) 3 4 22 58
- Characterization of ROS1 cDNA from a human glioblastoma cell line. (PMID: 2352949) Birchmeier C … Wigler M (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 22 58
- Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PMID: 19709766) Koch W … Kastrati A (International journal of cardiology 2011) 3 44 58
- Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for ROS1 Gene
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- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ROS1
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ROS1
- Novus Biologicals proteins for ROS1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ROS1
- Abcam proteins for ROS1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for ROS1
- Cloud-Clone Corp. Proteins for ROS1
- Cloud-Clone Corp. Assay Kits for ROS1
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- ApexBio compounds for ROS1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ROS1
- VectorBuilder custom plasmid, inducible vectors for ROS1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ROS1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for ROS1
- antibodies-online: Search results for 187 available ROS1 Antibodies ranked by validation data
- Compare Top ROS1 Antibodies
- antibodies-online: Search results for 7 available ROS1 Elisa Kits ranked by validation data
- Compare Top ROS1 Elisa Kits
- Recommended
- antibodies-online: Search results for 10 available ROS1 Proteins ranked by validation data
- Compare Top ROS1 Proteins
- GeneTex ROS1 antibody for ROS1
- Search GeneTex for Proteins for ROS1
- ViGene Biosciences adenoviral particle packaged cDNA for ROS1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ROS1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ROS1 gene
- Search ViGene Biosciences for ROS1
- Horizon Cell Lines for ROS1
- genomics-online: cdna clones - Search results for 62 available ROS1 gene related products
- Overview of 62 available ROS1 gene related products
- orf clones - Search results for 62 available ROS1 gene related products
- Overview of 62 available ROS1 gene related products
- genomics-online: gRNA clones - Search results for 62 available ROS1 gene related products
- Overview of 62 available ROS1 gene related products
- genomics-online: primer clones - Search results for 62 available ROS1 gene related products
- Overview of 62 available ROS1 gene related products
- genomics-online: shRNA clones - Search results for 62 available ROS1 gene related products
- Overview of 62 available ROS1 gene related products
Sources for ROS1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems