ROS1 Gene (Protein Coding)

ROS Proto-Oncogene 1, Receptor Tyrosine Kinase

GC06M117287
GIFtS:
45
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008] See more...

Aliases for ROS1 Gene

Aliases for ROS1 Gene

  • ROS Proto-Oncogene 1, Receptor Tyrosine Kinase 2 3 5
  • MCF3 2 3 4
  • ROS 2 3 4
  • V-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1 2 3
  • C-Ros Oncogene 1 , Receptor Tyrosine Kinase 2 3
  • Proto-Oncogene Tyrosine-Protein Kinase ROS 3 4
  • Proto-Oncogene C-Ros-1 3 4
  • C-Ros-1 2 3
  • V-Ros UR2 Sarcoma Virus Oncogene Homolog 1 (Avian) 2
  • ROS Proto-Oncogene 1 , Receptor Tyrosine Kinase 3
  • Transmembrane Tyrosine-Specific Protein Kinase 3
  • Receptor Tyrosine Kinase C-Ros Oncogene 1 4
  • C-Ros Receptor Tyrosine Kinase 4
  • Proto-Oncogene C-Ros 4
  • EC 2.7.10.1 4
  • ROS1 5

External Ids for ROS1 Gene

Previous GeneCards Identifiers for ROS1 Gene

  • GC06M117444
  • GC06M117632
  • GC06M117655
  • GC06M117716
  • GC06M117609
  • GC06M115190

Summaries for ROS1 Gene

Entrez Gene Summary for ROS1 Gene

  • This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

CIViC Summary for ROS1 Gene

  • ROS1 is a receptor tyrosine kinase that is frequently involved in genetic rearrangement in a variety of human cancers (e.g. NSCLC, gastric cancer, ovarian cancer, cholangiocarcinoma, colorectal cancer, angiosarcoma...). The resulting fusion protein harbors the constitutively active ROS1 kinase domain and drives cellular proliferation (Davies et. al.). In NSCLC about 1% harbor a ROS1 rearrangement. These patients are predominantely female and have a lower T-stage (Warth et. al.). Treatment with crizotinib leads to a reported objective response rate of appr. 70% and a median duration of response of 18 months (Shaw et. al.). Resistance mechanisms to crizotinib have been described and involve mutations in the kinase domain. More selective inhibitors of ROS1 might overcome this resistance (Davare et. al.).

GeneCards Summary for ROS1 Gene

ROS1 (ROS Proto-Oncogene 1, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ROS1 include Lung Cancer Susceptibility 3 and Lung Cancer. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Akt Signaling. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is INSR.

UniProtKB/Swiss-Prot Summary for ROS1 Gene

  • Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Gene Wiki entry for ROS1 Gene

Additional gene information for ROS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ROS1 Gene

Genomics for ROS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ROS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J117439 Promoter/Enhancer 1.4 EPDnew ENCODE dbSUPER 255.4 -15.2 -15238 3 SSRP1 JUND KLF9 CEBPA BRCA1 YY1 MXD4 CEBPB FOXA1 KLF11 ROS1 DCBLD1 NUS1 HSALNG0053056 lnc-DCBLD1-2 ENSG00000282218
GH06J117446 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 250.4 -23.4 -23431 5.8 ZNF654 JUND CEBPA REST CEBPB TRIM22 CTCF MAX EP300 ZNF610 ROS1 DCBLD1 SLC35F1 CALHM6 HSALNG0053056 lnc-DCBLD1-1 ENSG00000226181 ENSG00000282218
GH06J117425 Promoter/Enhancer 0.9 EPDnew Ensembl ENCODE 255.7 +0.7 744 3 HLF ROS1 DCBLD1 ENSG00000226181 HSALNG0053054 ENSG00000282218 VGLL2
GH06J117344 Promoter 0.4 EPDnew 250.2 +82.0 82012 0.1 RFX1 ROS1 HSALNG0053053 piR-57229 HSALNG0053052 VGLL2 ENSG00000282218
GH06J117418 Promoter 0.3 EPDnew 250.4 +7.5 7482 0.1 ROS1 HSALNG0053054 ENSG00000282218 VGLL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ROS1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ROS1

Top Transcription factor binding sites by QIAGEN in the ROS1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • CREB
  • deltaCREB
  • HNF-1
  • HNF-1A
  • MRF-2
  • Nkx2-5
  • p53

Genomic Locations for ROS1 Gene

Latest Assembly
chr6:117,287,353-117,426,065
(GRCh38/hg38)
Size:
138,713 bases
Orientation:
Minus strand

Previous Assembly
chr6:117,608,516-117,747,105
(GRCh37/hg19 by Entrez Gene)
Size:
138,590 bases
Orientation:
Minus strand

chr6:117,609,463-117,747,018
(GRCh37/hg19 by Ensembl)
Size:
137,556 bases
Orientation:
Minus strand

Genomic View for ROS1 Gene

Genes around ROS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROS1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ROS1 Gene

Proteins for ROS1 Gene

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  • Protein details for ROS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08922-ROS1_HUMAN
    Recommended name:
    Proto-oncogene tyrosine-protein kinase ROS
    Protein Accession:
    P08922
    Secondary Accessions:
    • Q15368
    • Q5TDB5

    Protein attributes for ROS1 Gene

    Size:
    2347 amino acids
    Molecular mass:
    263915 Da
    Quaternary structure:
    • Interacts with PTPN6 (via SH2 1 domain); the interaction is direct and promotes ROS1 dephosphorylation (By similarity). Interacts with PTPN11; may activate the PI3 kinase-mTOR signaling pathway. Interacts with VAV3; constitutive interaction mediating VAV3 phosphorylation.

    Three dimensional structures from OCA and Proteopedia for ROS1 Gene

neXtProt entry for ROS1 Gene

Protein Expression for ROS1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ROS1 Gene

  • Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2274 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation (By similarity). Phosphorylation at Tyr-2274 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity). Phosphorylation at Tyr-2274 and/or Tyr-2334 recruits PTPN11.
  • Glycosylation at Asn52, Asn114, Asn123, Asn324, Asn352, Asn396, Asn471, Asn607, Asn628, Asn706, Asn714, Asn732, Asn939, Asn961, Asn1015, Asn1087, Asn1090, Asn1095, Asn1211, Asn1272, Asn1330, Asn1458, Asn1461, Asn1474, Asn1499, Asn1565, Asn1669, Asn1715, Asn1738, and Asn1808
  • Modification sites at PhosphoSitePlus

Other Protein References for ROS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ROS1 Gene

Domains & Families for ROS1 Gene

Gene Families for ROS1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ROS1 Gene

InterPro:
Blocks:
  • Tyrosine protein kinase, active site
  • Receptor tyrosine kinase, class II

Suggested Antigen Peptide Sequences for ROS1 Gene

GenScript: Design optimal peptide antigens:
  • Tyrosine-protein kinase receptor (Q5H8Y1_HUMAN)
  • V-ros UR2 sarcoma virus oncogene homolog 1 (Avian) (Q5H8Y3_HUMAN)
  • Proto-oncogene c-Ros-1 (ROS_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P08922

UniProtKB/Swiss-Prot:

ROS1_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with ROS1: view

Function for ROS1 Gene

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  6. Cell Lines for research

Molecular function for ROS1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10028};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by dephosphorylation by PTPN6.
GENATLAS Biochemistry:
avian UR2 sarcoma virus oncogene (v-ros) homolog

Enzyme Numbers (IUBMB) for ROS1 Gene

Phenotypes From GWAS Catalog for ROS1 Gene

Gene Ontology (GO) - Molecular Function for ROS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA,IDA 16885344
GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA,IBA 21873635
GO:0005515 protein binding IEA,IPI 17416557
genes like me logo Genes that share ontologies with ROS1: view
genes like me logo Genes that share phenotypes with ROS1: view

Animal Models for ROS1 Gene

MGI Knock Outs for ROS1:

Animal Models for research

miRNA for ROS1 Gene

miRTarBase miRNAs that target ROS1

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ROS1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ROS1 Gene

Localization for ROS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROS1 Gene

Cell membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ROS1 gene
Compartment Confidence
plasma membrane 4
extracellular 2
cytoskeleton 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ROS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA 21873635
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA,TAS 3785223
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ROS1: view

Pathways & Interactions for ROS1 Gene

PathCards logo

SuperPathways for ROS1 Gene

SuperPathway Contained pathways
1 GPCR Pathway
Paxillin Interactions
.73
Ras Pathway
.73
GPCR Pathway
.62
Pancreatic Adenocarcinoma
.59
Breast Cancer Regulation by Stathmin1
.58
NFAT in Immune Response
.58
Estrogen Pathway
.55
P2Y Receptor Signaling
.38
2 ERK Signaling
ERK Signaling
.61
Rho Family GTPases
.61
MAPK Signaling
.58
Molecular Mechanisms of Cancer
.51
ILK Signaling
.49
3 Nanog in Mammalian ESC Pluripotency
GSK3 Signaling
.61
Nanog in Mammalian ESC Pluripotency
.61
14-3-3 Induced Intracellular Signaling
.59
eNOS Signaling
.48
4 Actin Nucleation by ARP-WASP Complex
Actin Nucleation and Branching
.66
Actin Nucleation by ARP-WASP Complex
.66
CDC42 Pathway
.41
5 Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA
.77
Activation of PKA through GPCR
.71
genes like me logo Genes that share pathways with ROS1: view

Pathways by source for ROS1 Gene

2 BioSystems pathways for ROS1 Gene
28 Qiagen pathways for ROS1 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for ROS1 Gene

SIGNOR curated interactions for ROS1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ROS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001558 regulation of cell growth IDA 16885344
GO:0002066 columnar/cuboidal epithelial cell development IEA,ISS --
GO:0006468 protein phosphorylation IEA,IDA 16885344
GO:0007165 signal transduction IEA --
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA,IBA 21873635
genes like me logo Genes that share ontologies with ROS1: view

Drugs & Compounds for ROS1 Gene

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(18) Drugs for ROS1 Gene - From: DrugBank, PharmGKB, ClinicalTrials, ApexBio, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Entrectinib Approved, Investigational Pharma Target, inhibitor Orally active inhibitor of ALK kinase 24
Crizotinib Approved Pharma Inhibition, Biomarker, inhibitor C-MET/ALK inhibitor,potent and ATP-competitve, Potent c-MET/ALK inhibitor, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor 146
Tyrosine Approved, Investigational Nutra 1149
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
lorlatinib Approved, Investigational Pharma 0

(1) Additional Compounds for ROS1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
 58-64-0

(1) ApexBio Compounds for ROS1 Gene

Compound Action Cas Number
Dovitinib (TKI-258, CHIR-258) Multitargeted RTK inhibitor 405169-16-6
genes like me logo Genes that share compounds with ROS1: view

Drug products for research

Transcripts for ROS1 Gene

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mRNA/cDNA for ROS1 Gene

3 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ROS1

Alternative Splicing Database (ASD) splice patterns (SP) for ROS1 Gene

No ASD Table

Relevant External Links for ROS1 Gene

GeneLoc Exon Structure for
ROS1

Expression for ROS1 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ROS1 Gene

mRNA expression in normal human tissues for ROS1 Gene
mRNA expression by BioGPS for ROS1 GenemRNA expression by GTEx for ROS1 Gene

mRNA differential expression in normal tissues according to GTEx for ROS1 Gene

This gene is overexpressed in Lung (x37.5).

Protein differential expression in normal tissues from HIPED for ROS1 Gene

This gene is overexpressed in Amniocyte (42.0) and Tlymphocyte (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ROS1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ROS1

SOURCE GeneReport for Unigene cluster for ROS1 Gene:

Hs.1041

mRNA Expression by UniProt/SwissProt for ROS1 Gene:

P08922-ROS1_HUMAN
Tissue specificity: Expressed in brain. Expression is increased in primary gliomas.

Evidence on tissue expression from TISSUES for ROS1 Gene

  • Lung(2.9)
  • Blood(2.4)
  • Nervous system(2.4)
  • Intestine(2.2)
  • Liver(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with ROS1: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ROS1 Gene

Orthologs for ROS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ROS1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ROS1 29 30
  • 99.43 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia ROS1 29 30
  • 87.48 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia ROS1 29 30
  • 87.43 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ros1 29 16 30
  • 83.68 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ros1 29
  • 82.71 (n)
Oppossum
(Monodelphis domestica)
 Mammalia ROS1 30
  • 72 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia ROS1 30
  • 49 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves ROS1 29 30
  • 62.99 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia -- 30
  • 23 (a)
 ManyToMany
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ros1 29
  • 56.83 (n)
Zebrafish
(Danio rerio)
 Actinopterygii ros1 29 30
  • 54.59 (n)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta sev 29 30 31
  • 41.53 (n)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP000015 29
  • 40.66 (n)
Worm
(Caenorhabditis elegans)
 Secernentea T21G5.1 31
  • 37 (a)
R151.4 31
  • 37 (a)
ZK593.9 31
  • 33 (a)
ddr-1 30
  • 16 (a)
 ManyToMany
Species where no ortholog for ROS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ROS1 Gene

ENSEMBL:
Gene Tree for ROS1 (if available)
TreeFam:
Gene Tree for ROS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ROS1: view image
Alliance of Genome Resources:
Additional Orthologs for ROS1

Paralogs for ROS1 Gene

Paralogs for ROS1 Gene

(31) SIMAP similar genes for ROS1 Gene using alignment to 3 proteins:

  • ROS1_HUMAN
  • H0Y3T9_HUMAN
  • Q5H8Y1_HUMAN
genes like me logo Genes that share paralogs with ROS1: view

Variants for ROS1 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ROS1 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs1057519788 Pathogenic/Likely Pathogenic: Lung adenocarcinoma 117,317,184(-) C/T
NM_002944.2(ROS1):c.6094G>A (p.Gly2032Arg) 		MISSENSE
rs112120894 Benign: not provided 117,386,995(-) A/G
NM_002944.2(ROS1):c.2019T>C (p.Ser673=) 		SYNONYMOUS
rs115286894 Benign: not provided 117,362,700(-) T/A
NM_002944.2(ROS1):c.3284A>T (p.Asn1095Ile) 		MISSENSE
rs115534545 Benign: not provided 117,365,730(-) A/G
NM_002944.2(ROS1):c.2824T>C (p.Phe942Leu) 		MISSENSE
rs12664076 Benign: not provided 117,329,369(-) C/Gp.Asp1776His
NM_002944.2(ROS1):c.5326G>C (p.Asp1776His) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ROS1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ROS1 Gene

Variant ID Type Subtype PubMed ID
dgv6141n100 CNV gain 25217958
esv2635247 CNV deletion 19546169
esv2759465 CNV loss 17122850
esv2763593 CNV gain 21179565
esv3303146 CNV mobile element insertion 20981092
esv3383830 CNV insertion 20981092
esv3610491 CNV loss 21293372
nsv478464 CNV novel sequence insertion 20440878
nsv510048 OTHER sequence alteration 20534489
nsv526934 CNV loss 19592680
nsv830785 CNV gain 17160897

Variation tolerance for ROS1 Gene

Residual Variation Intolerance Score: 57.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.08; 98.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ROS1 Gene

Human Gene Mutation Database (HGMD)
ROS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ROS1
Leiden Open Variation Database (LOVD)
ROS1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROS1 Gene

Disorders for ROS1 Gene

MalaCards: The human disease database

(28) MalaCards diseases for ROS1 Gene - From: CVR, COP, and GCD

Disorder Aliases PubMed IDs
lung cancer susceptibility 3
  • lncr3
lung cancer
  • lung cancer, susceptibility to
lung large cell carcinoma
  • large cell carcinoma of lung
adenocarcinoma
  • adenocarcinomas
large cell carcinoma
  • carcinoma large cell
- elite association - COSMIC cancer census association via MalaCards
Search ROS1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ROS1_HUMAN
  • Note=A chromosomal aberration involving ROS1 is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which is localized to the Golgi and has a constitutive receptor tyrosine kinase activity. A SLC34A2-ROS1 chimeric protein produced in non-small cell lung cancer cells also retains a constitutive kinase activity. A third type of chimeric protein CD74-ROS1 was also identified in those cells. {ECO:0000269 PubMed:12661006}.

Additional Disease Information for ROS1

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with ROS1: view

No data available for Genatlas for ROS1 Gene

Publications for ROS1 Gene

  1. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). (PMID: 12661006) Charest A … Housman D (Genes, chromosomes & cancer 2003) 3 4 22
  2. Characterization of ROS1 cDNA from a human glioblastoma cell line. (PMID: 2352949) Birchmeier C … Wigler M (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 22
  3. Variations of specific non-candidate genes and risk of myocardial infarction: a replication study. (PMID: 19709766) Koch W … Kastrati A (International journal of cardiology 2011) 3 40
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  5. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 40

ExternalLinks

View latest publications for ROS1 gene in Mastermind

Products for ROS1 Gene

  • Addgene plasmids for ROS1

Sources for ROS1 Gene