Aliases for ROR2 Gene
External Ids for ROR2 Gene
Previous HGNC Symbols for ROR2 Gene
Previous GeneCards Identifiers for ROR2 Gene
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]
GeneCards Summary for ROR2 Gene
ROR2 (Receptor Tyrosine Kinase Like Orphan Receptor 2) is a Protein Coding gene. Diseases associated with ROR2 include Robinow Syndrome, Autosomal Recessive 1 and Brachydactyly, Type B1. Among its related pathways are ERK Signaling and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ROR1.
UniProtKB/Swiss-Prot Summary for ROR2 Gene
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443).