This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is hi... See more...

Aliases for ROR1 Gene

Aliases for ROR1 Gene

  • Receptor Tyrosine Kinase Like Orphan Receptor 1 2 3 5
  • Inactive Tyrosine-Protein Kinase Transmembrane Receptor ROR1 3 4
  • Neurotrophic Tyrosine Kinase, Receptor-Related 1 3 4
  • NTRKR1 3 4
  • EC 2.7.10.1 52
  • DJ537F10.1 3

External Ids for ROR1 Gene

Previous HGNC Symbols for ROR1 Gene

  • NTRKR1

Previous GeneCards Identifiers for ROR1 Gene

  • GC01P064171
  • GC01P063159
  • GC01P063597
  • GC01P063609
  • GC01P063951
  • GC01P062347
  • GC01P064239

Summaries for ROR1 Gene

Entrez Gene Summary for ROR1 Gene

  • This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for ROR1 Gene

ROR1 (Receptor Tyrosine Kinase Like Orphan Receptor 1) is a Protein Coding gene. Diseases associated with ROR1 include Deafness, Autosomal Recessive 108 and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are ERK Signaling and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ROR2.

UniProtKB/Swiss-Prot Summary for ROR1 Gene

  • Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).

Gene Wiki entry for ROR1 Gene

Additional gene information for ROR1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ROR1 Gene

Genomics for ROR1 Gene

GeneHancer (GH) Regulatory Elements for ROR1 Gene

Promoters and enhancers for ROR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J063773 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 500.7 +1.2 1169 3.6 HNRNPK CTCF TCF12 ZNF639 ZIC2 ZBTB10 ZNF423 ZBTB26 KLF7 TGIF2 ROR1 ENSG00000177452 lnc-ITGB3BP-7
GH01J063771 Enhancer 0.5 ENCODE 500.7 -1.7 -1659 1.6 USF1 REST PRDM4 MAX PKNOX1 ZBTB6 ZNF121 ZNF101 KDM1A ZNF580 ROR1 HSALNG0004130
GH01J063522 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 18.3 -250.7 -250689 3.1 EP300 FOXK2 ZBTB40 ZNF217 ZSCAN5C SIN3A NRF1 MYC TCF12 USF1 ITGB3BP EFCAB7 ALG6 DLEU2L ROR1 FOXD3-AS1 FOXD3 ENSG00000235545 ATG4C DOCK7
GH01J063902 Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 26.6 +139.2 139184 21.6 CTCF TCF12 USF1 JUND ZIC2 REST ZNF623 RAD21 EP300 ATF2 ROR1 piR-61532-003 lnc-ITGB3BP-8
GH01J063826 Enhancer 1 Ensembl ENCODE 17 +58.4 58384 12.4 ZSCAN5C ZNF639 ZNF10 ZIC2 MEF2C ATF2 OSR2 BCL11A WT1 ZBTB17 ROR1 CFL1P3 RF01045-005
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ROR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ROR1

Top Transcription factor binding sites by QIAGEN in the ROR1 gene promoter:
  • Egr-4
  • FAC1
  • FOXO3
  • FOXO3a
  • FOXO3b
  • LCR-F1
  • MyoD
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for ROR1 Gene

Genomic Locations for ROR1 Gene
chr1:63,774,017-64,181,498
(GRCh38/hg38)
Size:
407,482 bases
Orientation:
Plus strand
chr1:64,239,690-64,647,181
(GRCh37/hg19)
Size:
407,492 bases
Orientation:
Plus strand

Genomic View for ROR1 Gene

Genes around ROR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROR1 Gene

Proteins for ROR1 Gene

  • Protein details for ROR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01973-ROR1_HUMAN
    Recommended name:
    Inactive tyrosine-protein kinase transmembrane receptor ROR1
    Protein Accession:
    Q01973
    Secondary Accessions:
    • Q5VVX6
    • Q66K77
    • Q92776

    Protein attributes for ROR1 Gene

    Size:
    937 amino acids
    Molecular mass:
    104283 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ROR1 Gene

    Alternative splice isoforms for ROR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROR1 Gene

Selected DME Specific Peptides for ROR1 Gene

Q01973:
  • GVVLWEI
  • GLQPYYG

Post-translational modifications for ROR1 Gene

  • Glycosylation at Asn47, Asn66, Asn184, and Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for ROR1 Gene

Antibody Products

  • Abcam antibodies for ROR1
  • Santa Cruz Biotechnology (SCBT) Antibodies for ROR1

Domains & Families for ROR1 Gene

Gene Families for ROR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ROR1 Gene

GenScript: Design optimal peptide antigens:
  • ROR1 protein (A2VCQ3_HUMAN)
  • Neurotrophic tyrosine kinase, receptor-related 1 (ROR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q01973

UniProtKB/Swiss-Prot:

ROR1_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.
genes like me logo Genes that share domains with ROR1: view

Function for ROR1 Gene

Molecular function for ROR1 Gene

UniProtKB/Swiss-Prot Function:
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).
GENATLAS Biochemistry:
receptor tyrosine kinase-like orphan receptor 1,with strong homology to the tyrosine kinase domain of growth factor-receptors (TRK),RTK superfamily

Enzyme Numbers (IUBMB) for ROR1 Gene

Phenotypes From GWAS Catalog for ROR1 Gene

Gene Ontology (GO) - Molecular Function for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004714 NOT transmembrane receptor protein tyrosine kinase activity IBA,TAS 21873635
GO:0005515 protein binding IPI,IEA 22439932
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with ROR1: view
genes like me logo Genes that share phenotypes with ROR1: view

Human Phenotype Ontology for ROR1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ROR1 Gene

MGI Knock Outs for ROR1:
  • Ror1 Ror1<tm1.2Meg>

Clone Products

  • Addgene plasmids for ROR1

No data available for Transcription Factor Targets and HOMER Transcription for ROR1 Gene

Localization for ROR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROR1 Gene

Membrane; Single-pass type I membrane protein. Cell projection, axon.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ROR1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2
nucleus 1
endoplasmic reticulum 1
endosome 1
cytosol 1
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IDA,TAS 27162350
GO:0005887 integral component of plasma membrane IBA,TAS 21873635
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with ROR1: view

Pathways & Interactions for ROR1 Gene

PathCards logo

SuperPathways for ROR1 Gene

SuperPathway Contained pathways
1 GPCR Pathway
.73
.73
.62
.59
.58
.58
.55
.38
2 ERK Signaling
.61
.61
.58
.51
.49
3 Nanog in Mammalian ESC Pluripotency
.61
.61
.59
.48
4 Actin Nucleation by ARP-WASP Complex
.66
.66
.41
5 CDK-mediated phosphorylation and removal of Cdc6
genes like me logo Genes that share pathways with ROR1: view

Pathways by source for ROR1 Gene

28 Qiagen pathways for ROR1 Gene
  • 14-3-3 Induced Intracellular Signaling
  • Actin Nucleation and Branching
  • Actin Nucleation by ARP-WASP Complex
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
1 Cell Signaling Technology pathway for ROR1 Gene

SIGNOR curated interactions for ROR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for ROR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007169 NOT transmembrane receptor protein tyrosine kinase signaling pathway IBA,IEA 21873635
GO:0007399 nervous system development IBA 21873635
GO:0007605 sensory perception of sound IMP 27162350
GO:0010976 positive regulation of neuron projection development IBA 21873635
genes like me logo Genes that share ontologies with ROR1: view

Drugs & Compounds for ROR1 Gene

(1) Drugs for ROR1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for ROR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with ROR1: view

Transcripts for ROR1 Gene

mRNA/cDNA for ROR1 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for ROR1

Alternative Splicing Database (ASD) splice patterns (SP) for ROR1 Gene

No ASD Table

Relevant External Links for ROR1 Gene

GeneLoc Exon Structure for
ROR1

Expression for ROR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ROR1 Gene

mRNA differential expression in normal tissues according to GTEx for ROR1 Gene

This gene is overexpressed in Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for ROR1 Gene

This gene is overexpressed in Serum (34.5) and Synovial fluid (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ROR1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ROR1

SOURCE GeneReport for Unigene cluster for ROR1 Gene:

Hs.128753

mRNA Expression by UniProt/SwissProt for ROR1 Gene:

Q01973-ROR1_HUMAN
Tissue specificity: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Evidence on tissue expression from TISSUES for ROR1 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ROR1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ROR1 Gene

Orthologs for ROR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ROR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ROR1 31 30
  • 99.52 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ROR1 31
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ROR1 31 30
  • 93.06 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ROR1 31 30
  • 91.56 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ror1 17 31 30
  • 89.1 (n)
rat
(Rattus norvegicus)
Mammalia Ror1 30
  • 88.36 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ROR1 31
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ROR1 31 30
  • 81.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ROR1 31
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ror1 30
  • 77.45 (n)
zebrafish
(Danio rerio)
Actinopterygii ror1 31 30
  • 70.28 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006219 30
  • 53.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ror 31 32 30
  • 51.53 (n)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cam-1 31
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 39 (a)
ManyToMany
-- 31
  • 39 (a)
ManyToMany
Cin.13123 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13123 30
Species where no ortholog for ROR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ROR1 Gene

ENSEMBL:
Gene Tree for ROR1 (if available)
TreeFam:
Gene Tree for ROR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ROR1: view image

Paralogs for ROR1 Gene

Variants for ROR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ROR1 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
709548 Benign: not provided 64,177,595(+) G/A SYNONYMOUS_VARIANT
752807 Likely Benign: not provided 64,178,465(+) G/A SYNONYMOUS_VARIANT
761148 Likely Benign: not provided 64,178,708(+) A/G SYNONYMOUS_VARIANT
788763 Benign: not provided 64,142,631(+) G/A SYNONYMOUS_VARIANT
805275 Benign: not provided 64,178,111(+) C/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ROR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for ROR1 Gene

Variant ID Type Subtype PubMed ID
esv2664106 CNV deletion 23128226
esv2676273 CNV deletion 23128226
esv2749085 CNV deletion 23290073
esv3305358 CNV mobile element insertion 20981092
esv3309693 CNV mobile element insertion 20981092
esv3376683 CNV insertion 20981092
esv3411421 CNV insertion 20981092
esv3431289 CNV insertion 20981092
esv3586248 CNV gain 21293372
esv3586249 CNV loss 21293372
esv3586250 CNV loss 21293372
esv3586252 CNV loss 21293372
esv8740 CNV gain 19470904
esv993189 CNV deletion 20482838
nsv1154 CNV deletion 18451855
nsv823087 CNV loss 20364138
nsv830037 CNV gain 17160897
nsv945976 CNV duplication 23825009
nsv945977 CNV duplication 23825009

Variation tolerance for ROR1 Gene

Residual Variation Intolerance Score: 9.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ROR1 Gene

Human Gene Mutation Database (HGMD)
ROR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ROR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROR1 Gene

Disorders for ROR1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ROR1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 108
  • dfnb108
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
adenocarcinoma
  • adenocarcinomas
her2-receptor positive breast cancer
mantle cell lymphoma
  • mcl
- elite association - COSMIC cancer census association via MalaCards
Search ROR1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ROR1_HUMAN
  • Deafness, autosomal recessive, 108 (DFNB108) [MIM:617654]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:27162350}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ROR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ROR1: view

No data available for Genatlas for ROR1 Gene

Publications for ROR1 Gene

  1. Human neural tissues express a truncated Ror1 receptor tyrosine kinase, lacking both extracellular and transmembrane domains. (PMID: 8875995) Reddy UR … Pleasure D (Oncogene 1996) 2 3 4 23 54
  2. A novel family of cell surface receptors with tyrosine kinase-like domain. (PMID: 1334494) Masiakowski P … Carroll RD (The Journal of biological chemistry 1992) 2 3 4 54
  3. ROR1 is essential for proper innervation of auditory hair cells and hearing in humans and mice. (PMID: 27162350) Diaz-Horta O … Tekin M (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 4 54
  4. Evolutionary divergence in the catalytic activity of the CAM-1, ROR1 and ROR2 kinase domains. (PMID: 25029443) Bainbridge TW … Ernst JA (PloS one 2014) 3 4 54
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54

Products for ROR1 Gene

  • Addgene plasmids for ROR1

Sources for ROR1 Gene