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Aliases for ROPN1B Gene

Aliases for ROPN1B Gene

  • Rhophilin Associated Tail Protein 1B 2 3 5
  • Ropporin, Rhophilin Associated Protein 1B 2 3
  • Rhophilin-Associated Protein 1B 3 4
  • Testis Tissue Sperm-Binding Protein Li 83P 3
  • AKAP-Binding Sperm Protein Ropporin 3
  • Ropporin-1B 3

External Ids for ROPN1B Gene

Previous GeneCards Identifiers for ROPN1B Gene

  • GC03P127171
  • GC03P125688
  • GC03P123068

Summaries for ROPN1B Gene

GeneCards Summary for ROPN1B Gene

ROPN1B (Rhophilin Associated Tail Protein 1B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and receptor signaling complex scaffold activity. An important paralog of this gene is ROPN1.

UniProtKB/Swiss-Prot for ROPN1B Gene

  • Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.

Additional gene information for ROPN1B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROPN1B Gene

Genomics for ROPN1B Gene

GeneHancer (GH) Regulatory Elements for ROPN1B Gene

Promoters and enhancers for ROPN1B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I125968 Promoter/Enhancer 0.7 EPDnew Ensembl 565.9 +0.1 90 0.9 ROPN1B PIR42058
GH03I125989 Enhancer 1.4 FANTOM5 Ensembl ENCODE 15.4 +21.6 21557 1.8 ARID4B SIN3A ZBTB40 RAD21 YY1 ETS1 ZNF335 POLR2B THAP11 SP3 PIR42058 ALG1L FAM86JP ROPN1B SLC41A3 CFAP100 ZXDC ENSG00000248607
GH03I126099 Promoter/Enhancer 1.1 EPDnew ENCODE 8.6 +131.6 131626 1.7 NR2F1 MAX JUNB BATF ZIC2 ATF2 IRF4 BCL11A ATF7 MYC SLC41A3 FAM86JP ALG1L ROPN1B LOC105374085
GH03I125929 Enhancer 0.6 Ensembl 9.5 -39.7 -39743 0.8 CTCF KLF1 ZNF654 RB1 ZNF189 NFIB TRIM22 ZIC2 ZNF2 ZBTB40 FAM86JP ALG1L ROPN1B LOC101927056
GH03I126129 Enhancer 0.6 ENCODE 7.3 +160.5 160549 0.2 E2F1 MTA1 MAX SMC3 CEBPB RCOR1 RAD21 NR2F2 ROPN1B GC03P126153 ALDH1L1-AS1 ALDH1L1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ROPN1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ROPN1B gene promoter:

Genomic Locations for ROPN1B Gene

Genomic Locations for ROPN1B Gene
14,311 bases
Plus strand

Genomic View for ROPN1B Gene

Genes around ROPN1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROPN1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROPN1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROPN1B Gene

Proteins for ROPN1B Gene

  • Protein details for ROPN1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • D3DNA6
    • Q96BM7

    Protein attributes for ROPN1B Gene

    212 amino acids
    Molecular mass:
    23964 Da
    Quaternary structure:
    • Homodimer. Interacts with RHPN1 (By similarity). May interact with SPA17 (By similarity). Interacts with AKAP3 (PubMed:11278869). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity).
    • Ropporin comes from the Japanese word oppo which means tail.

    Alternative splice isoforms for ROPN1B Gene


neXtProt entry for ROPN1B Gene

Post-translational modifications for ROPN1B Gene

  • Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ROPN1B Gene

Domains & Families for ROPN1B Gene

Gene Families for ROPN1B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ROPN1B Gene


Suggested Antigen Peptide Sequences for ROPN1B Gene

Graphical View of Domain Structure for InterPro Entry



  • The RIIa domain mediates interaction with AKAP3.
  • Belongs to the ropporin family.
  • The RIIa domain mediates interaction with AKAP3.
  • Belongs to the ropporin family.
genes like me logo Genes that share domains with ROPN1B: view

Function for ROPN1B Gene

Molecular function for ROPN1B Gene

UniProtKB/Swiss-Prot Function:
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.

Gene Ontology (GO) - Molecular Function for ROPN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11278869
GO:0030159 receptor signaling complex scaffold activity NAS 11278869
GO:0042803 protein homodimerization activity NAS 11278869
GO:0046982 protein heterodimerization activity IPI 11278869
genes like me logo Genes that share ontologies with ROPN1B: view
genes like me logo Genes that share phenotypes with ROPN1B: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ROPN1B Gene

Localization for ROPN1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROPN1B Gene

Cell projection, cilium, flagellum. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. {ECO:0000250 UniProtKB:Q9ESG2}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ROPN1B gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for ROPN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11278869
GO:0031514 motile cilium IDA 11278869
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ROPN1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ROPN1B Gene

Pathways & Interactions for ROPN1B Gene

SuperPathways for ROPN1B Gene

No Data Available

Interacting Proteins for ROPN1B Gene

Gene Ontology (GO) - Biological Process for ROPN1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis NAS 11278869
GO:0001932 regulation of protein phosphorylation ISS --
GO:0007266 Rho protein signal transduction TAS 11278869
GO:0007283 spermatogenesis NAS 11278869
GO:0007340 acrosome reaction NAS 11278869
genes like me logo Genes that share ontologies with ROPN1B: view

No data available for Pathways by source and SIGNOR curated interactions for ROPN1B Gene

Drugs & Compounds for ROPN1B Gene

No Compound Related Data Available

Transcripts for ROPN1B Gene

Unigene Clusters for ROPN1B Gene

Rhophilin associated tail protein 1B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9
SP1: - -
SP4: - - -

Relevant External Links for ROPN1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ROPN1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ROPN1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROPN1B Gene

This gene is overexpressed in Testis (x39.0).

Protein differential expression in normal tissues from HIPED for ROPN1B Gene

This gene is overexpressed in Ovary (57.2) and Testis (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ROPN1B Gene

Protein tissue co-expression partners for ROPN1B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ROPN1B Gene:


SOURCE GeneReport for Unigene cluster for ROPN1B Gene:

genes like me logo Genes that share expression patterns with ROPN1B: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ROPN1B Gene

Orthologs for ROPN1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROPN1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ROPN1B 33 34
  • 98.27 (n)
(Canis familiaris)
Mammalia -- 34
  • 87 (a)
(Bos Taurus)
Mammalia ROPN1 34
  • 86 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 86 (a)
(Mus musculus)
Mammalia Ropn1 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 78 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4161 34
  • 37 (a)
Species where no ortholog for ROPN1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ROPN1B Gene

Gene Tree for ROPN1B (if available)
Gene Tree for ROPN1B (if available)

Paralogs for ROPN1B Gene

Paralogs for ROPN1B Gene

(6) SIMAP similar genes for ROPN1B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ROPN1B: view

Variants for ROPN1B Gene

Sequence variations from dbSNP and Humsavar for ROPN1B Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000888964 -- 125,979,550(+) G/A intron_variant
rs1000948651 -- 125,973,491(+) T/C intron_variant
rs1001085977 -- 125,979,267(+) T/C intron_variant
rs1001206468 -- 125,979,968(+) C/T intron_variant
rs1001279851 -- 125,979,888(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ROPN1B Gene

Variant ID Type Subtype PubMed ID
esv2759174 CNV loss 17122850
nsv1011457 CNV gain 25217958
nsv3984 CNV deletion 18451855
nsv591465 CNV gain 21841781
nsv829716 CNV gain+loss 17160897
nsv967059 CNV duplication 23825009

Variation tolerance for ROPN1B Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.06; 50.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ROPN1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROPN1B Gene

Disorders for ROPN1B Gene

Additional Disease Information for ROPN1B

No disorders were found for ROPN1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ROPN1B Gene

Publications for ROPN1B Gene

  1. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr DW … Narumiya S (The Journal of biological chemistry 2001) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. (PMID: 10591629) Fujita A … Narumiya S (Journal of cell science 2000) 3 58

Products for ROPN1B Gene

Sources for ROPN1B Gene

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