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Aliases for ROPN1 Gene

Aliases for ROPN1 Gene

  • Rhophilin Associated Tail Protein 1 2 3 5
  • Cancer/Testis Antigen 91 2 3 4
  • Ropporin, Rhophilin Associated Protein 1 2 3
  • Rhophilin-Associated Protein 1A 3 4
  • ROPN1A 3 4
  • CT91 3 4
  • Testis Secretory Sperm-Binding Protein Li 239w 3
  • Outer Dense Fiber Of Sperm Tails 6 3
  • Ropporin-1A 3
  • Ropporin 3
  • RHPNAP1 3
  • ODF6 3

External Ids for ROPN1 Gene

Previous GeneCards Identifiers for ROPN1 Gene

  • GC03M123636
  • GC03M124969
  • GC03M125008
  • GC03M125170
  • GC03M121061

Summaries for ROPN1 Gene

Entrez Gene Summary for ROPN1 Gene

  • The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for ROPN1 Gene

ROPN1 (Rhophilin Associated Tail Protein 1) is a Protein Coding gene. Among its related pathways are RHO GTPases Activate Rhotekin and Rhophilins and Signaling by Rho GTPases. An important paralog of this gene is ROPN1B.

UniProtKB/Swiss-Prot for ROPN1 Gene

  • Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.

Additional gene information for ROPN1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROPN1 Gene

Genomics for ROPN1 Gene

GeneHancer (GH) Regulatory Elements for ROPN1 Gene

Promoters and enhancers for ROPN1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I123992 Promoter 0.5 Ensembl 550.8 0.0 -23 0.4 ROPN1 GC03P124016
GH03I123990 Promoter 0.5 EPDnew 550.8 +2.0 2018 0.1 ROPN1 CCDC14
GH03I123960 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 16.7 +31.1 31137 1.9 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 GTF3C2 POLR2B GLIS2 CCDC14 ROPN1 MYLK
GH03I123652 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 8.8 +338.6 338649 2.3 ELF3 PKNOX1 ZSCAN4 ARID4B DMAP1 ZNF48 RAD21 YY1 HSF1 ZNF143 MYLK MYLK-AS2 HACD2 MYLK-AS1 ROPN1 PIR59914
GH03I124032 Enhancer 1.1 Ensembl ENCODE 10.9 -41.4 -41374 2.9 PKNOX1 ZNF493 ZNF133 SIN3A GLI4 ZNF2 GLIS2 ZNF143 SP3 REST KALRN SEC22A ROPN1 UMPS MIR5002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ROPN1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ROPN1 gene promoter:

Genomic Locations for ROPN1 Gene

Genomic Locations for ROPN1 Gene
chr3:123,968,521-123,992,178
(GRCh38/hg38)
Size:
23,658 bases
Orientation:
Minus strand
chr3:123,687,368-123,711,025
(GRCh37/hg19)

Genomic View for ROPN1 Gene

Genes around ROPN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROPN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROPN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROPN1 Gene

Proteins for ROPN1 Gene

  • Protein details for ROPN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HAT0-ROP1A_HUMAN
    Recommended name:
    Ropporin-1A
    Protein Accession:
    Q9HAT0
    Secondary Accessions:
    • D3DN99
    • Q9UF38

    Protein attributes for ROPN1 Gene

    Size:
    212 amino acids
    Molecular mass:
    23893 Da
    Quaternary structure:
    • Homodimer. Interacts with AKAP3 and RHPN1 (By similarity). May interact with SPA17 (PubMed:17551920). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity).
    Miscellaneous:
    • Ropporin comes from the Japanese word oppo which means tail.

    Alternative splice isoforms for ROPN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ROPN1 Gene

Post-translational modifications for ROPN1 Gene

  • Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.

No data available for DME Specific Peptides for ROPN1 Gene

Domains & Families for ROPN1 Gene

Gene Families for ROPN1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ROPN1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ROPN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HAT0

UniProtKB/Swiss-Prot:

ROP1A_HUMAN :
  • The RIIa domain mediates interaction with AKAP3.
  • Belongs to the ropporin family.
Domain:
  • The RIIa domain mediates interaction with AKAP3.
Family:
  • Belongs to the ropporin family.
genes like me logo Genes that share domains with ROPN1: view

Function for ROPN1 Gene

Molecular function for ROPN1 Gene

UniProtKB/Swiss-Prot Function:
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.

Gene Ontology (GO) - Molecular Function for ROPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17551920
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with ROPN1: view
genes like me logo Genes that share phenotypes with ROPN1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ROPN1 Gene

Localization for ROPN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROPN1 Gene

Cell projection, cilium, flagellum. Note=In the sperm tail, found in the principal piece and in the cytoplasmic droplet located at the distal end of the midpiece. Inner surface of the fibrous sheath. {ECO:0000250 UniProtKB:Q9ESG2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ROPN1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ROPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,HDA 21630459
GO:0005737 cytoplasm IDA 18421703
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ROPN1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ROPN1 Gene

Pathways & Interactions for ROPN1 Gene

genes like me logo Genes that share pathways with ROPN1: view

Pathways by source for ROPN1 Gene

Gene Ontology (GO) - Biological Process for ROPN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation ISS --
GO:0030317 flagellated sperm motility ISS --
GO:0044782 cilium organization ISS --
GO:0048240 sperm capacitation ISS --
GO:0061512 protein localization to cilium ISS --
genes like me logo Genes that share ontologies with ROPN1: view

No data available for SIGNOR curated interactions for ROPN1 Gene

Drugs & Compounds for ROPN1 Gene

No Compound Related Data Available

Transcripts for ROPN1 Gene

Unigene Clusters for ROPN1 Gene

Rhophilin associated tail protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ROPN1 Gene

No ASD Table

Relevant External Links for ROPN1 Gene

GeneLoc Exon Structure for
ROPN1
ECgene alternative splicing isoforms for
ROPN1

Expression for ROPN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ROPN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ROPN1 Gene

This gene is overexpressed in Testis (x48.2).

Protein differential expression in normal tissues from HIPED for ROPN1 Gene

This gene is overexpressed in Ovary (35.8) and Testis (33.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ROPN1 Gene



Protein tissue co-expression partners for ROPN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ROPN1 Gene:

ROPN1

SOURCE GeneReport for Unigene cluster for ROPN1 Gene:

Hs.733553

mRNA Expression by UniProt/SwissProt for ROPN1 Gene:

Q9HAT0-ROP1A_HUMAN
Tissue specificity: Testis specific in adult. Overexpressed in hematologic tumor cells.
genes like me logo Genes that share expression patterns with ROPN1: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ROPN1 Gene

Orthologs for ROPN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ROPN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ROPN1 33 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia LOC488013 33
  • 88.05 (n)
-- 34
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ROPN1 33 34
  • 86.95 (n)
mouse
(Mus musculus)
Mammalia Ropn1 33 16 34
  • 85.53 (n)
rat
(Rattus norvegicus)
Mammalia Ropn1 33
  • 85.22 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 85 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 77 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4161 34
  • 38 (a)
OneToMany
Species where no ortholog for ROPN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ROPN1 Gene

ENSEMBL:
Gene Tree for ROPN1 (if available)
TreeFam:
Gene Tree for ROPN1 (if available)

Paralogs for ROPN1 Gene

Paralogs for ROPN1 Gene

(2) SIMAP similar genes for ROPN1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ROPN1: view

Variants for ROPN1 Gene

Sequence variations from dbSNP and Humsavar for ROPN1 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000096992 -- 123,972,805(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000147937 -- 123,973,067(-) C/T genic_downstream_transcript_variant, intron_variant
rs1000732115 -- 123,985,356(-) C/T intron_variant
rs1000791034 -- 123,990,417(-) G/A intron_variant
rs1001103238 -- 123,986,206(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ROPN1 Gene

Variant ID Type Subtype PubMed ID
esv3568995 CNV loss 25503493
esv3597635 CNV gain 21293372
nsv460837 CNV gain 19166990
nsv591428 CNV gain 21841781
nsv965206 CNV duplication 23825009
nsv979871 CNV duplication 23825009

Variation tolerance for ROPN1 Gene

Residual Variation Intolerance Score: 65.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.62; 45.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ROPN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ROPN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROPN1 Gene

Disorders for ROPN1 Gene

Additional Disease Information for ROPN1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ROPN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ROPN1 Gene

Publications for ROPN1 Gene

  1. Kalirin: a novel genetic risk factor for ischemic stroke. (PMID: 20107840) Krug T … Oliveira SA (Human genetics 2010) 3 22 44 58
  2. A yeast two-hybrid system using Sp17 identified Ropporin as a novel cancer-testis antigen in hematologic malignancies. (PMID: 17551920) Li Z … Lim SH (International journal of cancer 2007) 3 4 22 58
  3. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. (PMID: 11278869) Carr DW … Narumiya S (The Journal of biological chemistry 2001) 3 22 58
  4. Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella. (PMID: 10591629) Fujita A … Narumiya S (Journal of cell science 2000) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ROPN1 Gene

Sources for ROPN1 Gene

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