Aliases for ROPN1 Gene
External Ids for ROPN1 Gene
Previous GeneCards Identifiers for ROPN1 Gene
The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for ROPN1 Gene
ROPN1 (Rhophilin Associated Tail Protein 1) is a Protein Coding gene. Among its related pathways are RHO GTPases Activate Rhotekin and Rhophilins and Signaling by Rho GTPases. An important paralog of this gene is ROPN1B.
UniProtKB/Swiss-Prot for ROPN1 Gene
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.