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Aliases for ROCK2 Gene

Aliases for ROCK2 Gene

  • Rho Associated Coiled-Coil Containing Protein Kinase 2 2 3 5
  • Rho-Associated, Coiled-Coil-Containing Protein Kinase II 3 4
  • P164 ROCK-2 3 4
  • ROCK-II 3 4
  • Rho-Associated, Coiled-Coil-Containing Protein Kinase 2 4
  • Rho-Associated Protein Kinase 2 3
  • Rho Kinase 2 4
  • EC 2.7.11.1 4
  • KIAA0619 4

External Ids for ROCK2 Gene

Previous GeneCards Identifiers for ROCK2 Gene

  • GC02M011106
  • GC02M011371
  • GC02M011343
  • GC02M011272
  • GC02M011319

Summaries for ROCK2 Gene

Entrez Gene Summary for ROCK2 Gene

  • The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008]

GeneCards Summary for ROCK2 Gene

ROCK2 (Rho Associated Coiled-Coil Containing Protein Kinase 2) is a Protein Coding gene. Diseases associated with ROCK2 include Corticobasal Degeneration and Sexual Disorder. Among its related pathways are mTOR Pathway and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is ROCK1.

UniProtKB/Swiss-Prot for ROCK2 Gene

  • Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

Tocris Summary for ROCK2 Gene

  • Rho-kinases (aka Rho-associated coiled-coil kinases or ROCKs) are serine/threonine kinases activated by RhoA GTPases. They are modulators of processes involving cytoskeletal rearrangement such as focal adhesion formation, cell motility and tumor cell invasion.

Additional gene information for ROCK2 Gene

No data available for CIViC summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROCK2 Gene

Genomics for ROCK2 Gene

GeneHancer (GH) Regulatory Elements for ROCK2 Gene

Promoters and enhancers for ROCK2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J011340 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 657.4 +4.6 4613 5.7 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 ZNF213 ROCK2 PQLC3 LOC646050 GC02M011344
GH02J011348 Enhancer 0.8 ENCODE 650.7 -0.2 -185 0.7 ELF3 FOXA2 RAD21 YY1 ZNF614 EGR1 SCRT2 THAP11 KLF11 RXRA ROCK2 PPIAP60 GC02M011344
GH02J011227 Promoter 0.6 EPDnew 650.1 +121.0 120989 0.1 CBFA2T3 ROCK2 GC02P011234 PQLC3
GH02J011373 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 17.9 -26.5 -26524 3.6 ELF3 FOXA2 ARID4B SIN3A ZNF48 RAD21 RARA ZNF366 SCRT2 RCOR1 ROCK2 PQLC3 KCNF1 ENSG00000230952 ENSG00000231403 GC02M011344
GH02J011369 Enhancer 1.4 Ensembl ENCODE dbSUPER 18 -22.7 -22662 2.6 CLOCK FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 ROCK2 PQLC3 ENSG00000230952 ENSG00000231403 GC02M011344
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ROCK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ROCK2 gene promoter:
  • MyoD
  • IRF-7A
  • HSF2
  • FAC1
  • ZIC2
  • AML1a

Genomic Locations for ROCK2 Gene

Genomic Locations for ROCK2 Gene
chr2:11,179,761-11,348,330
(GRCh38/hg38)
Size:
168,570 bases
Orientation:
Minus strand
chr2:11,319,887-11,488,456
(GRCh37/hg19)
Size:
168,570 bases
Orientation:
Minus strand

Genomic View for ROCK2 Gene

Genes around ROCK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ROCK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ROCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ROCK2 Gene

Proteins for ROCK2 Gene

  • Protein details for ROCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75116-ROCK2_HUMAN
    Recommended name:
    Rho-associated protein kinase 2
    Protein Accession:
    O75116
    Secondary Accessions:
    • Q53QZ0
    • Q53SJ7
    • Q9UQN5

    Protein attributes for ROCK2 Gene

    Size:
    1388 amino acids
    Molecular mass:
    160900 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer. Interacts with IRS1, RHOB and RHOC (By similarity). Interacts with RHOA (activated by GTP), PPP1R12A, CHORDC1, SORL1, EP300 and BRCA2. Interacts with NPM1 and this interaction enhances its activity. Interacts with RAF1 (By similarity).
    SequenceCaution:
    • Sequence=AAX93049.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA31594.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ROCK2 Gene

neXtProt entry for ROCK2 Gene

Post-translational modifications for ROCK2 Gene

  • Phosphorylation at Tyr-722 reduces its binding to RHOA and is crucial for focal adhesion dynamics. Dephosphorylation by PTPN11 stimulates its RHOA binding activity.
  • Cleaved by granzyme B during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ROCK2 Gene

Domains & Families for ROCK2 Gene

Suggested Antigen Peptide Sequences for ROCK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75116

UniProtKB/Swiss-Prot:

ROCK2_HUMAN :
  • An interaction between Thr-414 and Asp-48 is essential for kinase activity and dimerization.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Domain:
  • An interaction between Thr-414 and Asp-48 is essential for kinase activity and dimerization.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
genes like me logo Genes that share domains with ROCK2: view

Function for ROCK2 Gene

Molecular function for ROCK2 Gene

UniProtKB/Swiss-Prot Function:
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by RHOA binding. Inhibited by Y-27632 (By similarity).
GENATLAS Biochemistry:
serine/threonine kinase ROCK2/rho kinase,isozyme of ROCK1,one the targets for the small GTPase Rho,putative mediator of the Rho-dependent signaling pathway

Enzyme Numbers (IUBMB) for ROCK2 Gene

Phenotypes From GWAS Catalog for ROCK2 Gene

Gene Ontology (GO) - Molecular Function for ROCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity NAS,IEA 27853422
GO:0005198 structural molecule activity NAS 9933571
GO:0005515 protein binding IPI 17015463
genes like me logo Genes that share ontologies with ROCK2: view
genes like me logo Genes that share phenotypes with ROCK2: view

Animal Models for ROCK2 Gene

MGI Knock Outs for ROCK2:

Animal Model Products

Clone Products

  • Addgene plasmids for ROCK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ROCK2 Gene

Localization for ROCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ROCK2 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic, and associated with actin microfilaments and the plasma membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ROCK2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ROCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IDA 17015463
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with ROCK2: view

Pathways & Interactions for ROCK2 Gene

genes like me logo Genes that share pathways with ROCK2: view

Pathways by source for ROCK2 Gene

SIGNOR curated interactions for ROCK2 Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for ROCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IMP 24065547
GO:0006468 protein phosphorylation IDA,IEA 18559669
GO:0006939 smooth muscle contraction TAS,IEA 12778124
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IMP 25816133
genes like me logo Genes that share ontologies with ROCK2: view

Drugs & Compounds for ROCK2 Gene

(35) Drugs for ROCK2 Gene - From: DrugBank, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Netarsudil Approved Pharma Target, inhibitor 0
Ripasudil Approved Pharma Target, inhibitor 0
(R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE Experimental Pharma Target 0
Hydroxyfasudil Experimental Pharma Rho-kinase inhibitor and vasodilator 0

(8) Additional Compounds for ROCK2 Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
Diglycerides Group A
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group B
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group C
  • (2R)-2-Hydroxy-3-(pentadecanoyloxy)propyl (11Z,14Z)-icosa-11,14-dienoic acid
  • DAG(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2w6)
  • Diacylglycerol(15:0/0:0/20:2)
  • DAG(15:0/0:0/20:2n6)
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)

(5) Tocris Compounds for ROCK2 Gene

Compound Action Cas Number
Fasudil hydrochloride Inhibitor of cyclic nucleotide dependent- and Rho-kinases 105628-07-7
Glycyl-H 1152 dihydrochloride Selective Rho-kinase (ROCK) inhibitor. More selective analog of H 1152 dihydrochloride (Cat. No. 2414) 913844-45-8
H 1152 dihydrochloride Selective Rho-kinase (ROCK) inhibitor 871543-07-6
HA 1100 hydrochloride Cell-permeable, selective Rho-kinase inhibitor 155558-32-0
Y-27632 dihydrochloride Selective p160ROCK inhibitor 129830-38-2
genes like me logo Genes that share compounds with ROCK2: view

Transcripts for ROCK2 Gene

Unigene Clusters for ROCK2 Gene

Rho-associated, coiled-coil containing protein kinase 2:
Representative Sequences:

Clone Products

  • Addgene plasmids for ROCK2

Alternative Splicing Database (ASD) splice patterns (SP) for ROCK2 Gene

No ASD Table

Relevant External Links for ROCK2 Gene

GeneLoc Exon Structure for
ROCK2
ECgene alternative splicing isoforms for
ROCK2

Expression for ROCK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ROCK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ROCK2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.4), Platelet (8.6), and Heart (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ROCK2 Gene



Protein tissue co-expression partners for ROCK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ROCK2 Gene:

ROCK2

SOURCE GeneReport for Unigene cluster for ROCK2 Gene:

Hs.681743

Evidence on tissue expression from TISSUES for ROCK2 Gene

  • Nervous system(4.7)
  • Liver(4.5)
  • Muscle(3.2)
  • Blood(2.9)
  • Heart(2.9)
  • Eye(2.6)
  • Lung(2.6)
  • Intestine(2)
  • Kidney(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with ROCK2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ROCK2 Gene

Orthologs for ROCK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ROCK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ROCK2 34 33
  • 99.83 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ROCK2 34 33
  • 93.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ROCK2 34 33
  • 92.17 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rock2 16 34 33
  • 91.04 (n)
rat
(Rattus norvegicus)
Mammalia Rock2 33
  • 90.73 (n)
oppossum
(Monodelphis domestica)
Mammalia ROCK2 34
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ROCK2 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ROCK2 34 33
  • 83.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ROCK2 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rock2 33
  • 75.39 (n)
Str.15799 33
African clawed frog
(Xenopus laevis)
Amphibia rocka-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii ROCK2 (6 of 10) 34
  • 81 (a)
OneToMany
ROCK2 (9 of 10) 34
  • 80 (a)
OneToMany
ROCK2 (4 of 10) 34
  • 79 (a)
OneToMany
ROCK2 (7 of 10) 34
  • 79 (a)
OneToMany
ROCK2 (3 of 10) 34
  • 78 (a)
OneToMany
ROCK2 (5 of 10) 34
  • 78 (a)
OneToMany
ROCK2 (8 of 10) 34
  • 73 (a)
OneToMany
rock2a 34 33
  • 69.69 (n)
OneToMany
rock2b 34 34
  • 65 (a)
OneToMany
rock2 33
fruit fly
(Drosophila melanogaster)
Insecta rok 34 35 33
  • 49.79 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000406 33
  • 48.97 (n)
worm
(Caenorhabditis elegans)
Secernentea let-502 34 35 33
  • 52.17 (n)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CBK1 34
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
OneToOne
Species where no ortholog for ROCK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ROCK2 Gene

ENSEMBL:
Gene Tree for ROCK2 (if available)
TreeFam:
Gene Tree for ROCK2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ROCK2: view image

Paralogs for ROCK2 Gene

Paralogs for ROCK2 Gene

genes like me logo Genes that share paralogs with ROCK2: view

Variants for ROCK2 Gene

Sequence variations from dbSNP and Humsavar for ROCK2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
VAR_041064 A metastatic melanoma sample p.Ser1194Pro
rs869312716 uncertain-significance, not specified 11,211,744(-) G/A coding_sequence_variant, stop_gained
rs2230774 benign, not specified 11,218,994(-) G/C/T coding_sequence_variant, missense_variant
rs2271621 benign, not specified 11,193,868(-) T/G intron_variant
rs1000008515 -- 11,263,560(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ROCK2 Gene

Variant ID Type Subtype PubMed ID
esv1339412 CNV insertion 17803354
esv2453181 CNV insertion 19546169
esv2543558 CNV insertion 19546169
esv25473 CNV loss 19812545
esv2592438 CNV insertion 19546169
esv2658593 CNV deletion 23128226
esv2662875 CNV deletion 23128226
esv3303269 CNV mobile element insertion 20981092
esv3308103 CNV mobile element insertion 20981092
esv3403571 CNV insertion 20981092
esv3552611 CNV deletion 23714750
esv3589814 CNV loss 21293372
nsv1012083 CNV gain 25217958
nsv1013570 CNV loss 25217958
nsv1071975 CNV deletion 25765185
nsv1072923 CNV deletion 25765185
nsv2607 CNV deletion 18451855
nsv436304 CNV deletion 17901297
nsv498912 CNV loss 21111241
nsv514052 CNV loss 21397061
nsv526038 CNV loss 19592680
nsv930472 CNV insertion 23359205
nsv953448 CNV duplication 24416366
nsv961381 CNV duplication 23825009

Variation tolerance for ROCK2 Gene

Residual Variation Intolerance Score: 17.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.61; 89.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ROCK2 Gene

Human Gene Mutation Database (HGMD)
ROCK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ROCK2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROCK2 Gene

Disorders for ROCK2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ROCK2 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
corticobasal degeneration
  • cbgd
sexual disorder
  • sexual dysfunction
- elite association - COSMIC cancer census association via MalaCards
Search ROCK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ROCK2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ROCK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ROCK2 Gene

Publications for ROCK2 Gene

  1. ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells. (PMID: 19131646) Wang Y … Surks HK (Circulation research 2009) 3 4 22 58
  2. ROCK2 allelic variants are not associated with pre-eclampsia susceptibility in the Finnish population. (PMID: 19435756) Peterson H … Kivinen K (Molecular human reproduction 2009) 3 22 44 58
  3. A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study. (PMID: 18971541) Rankinen T … Bouchard C (Hypertension research : official journal of the Japanese Society of Hypertension 2008) 3 22 44 58
  4. Nuclear Rho kinase, ROCK2, targets p300 acetyltransferase. (PMID: 16574662) Tanaka T … Hamamori Y (The Journal of biological chemistry 2006) 3 4 22 58
  5. Localization of the gene coding for ROCK II/Rho kinase on human chromosome 2p24. (PMID: 9933571) Takahashi N … Kaibuchi K (Genomics 1999) 2 3 4 58

Products for ROCK2 Gene