Aliases for ROBO2 Gene
Aliases for ROBO2 Gene
External Ids for ROBO2 Gene
- HGNC: 10250
- Entrez Gene: 6092
- Ensembl: ENSG00000185008
- OMIM: 602431
- UniProtKB: Q9HCK4
Previous GeneCards Identifiers for ROBO2 Gene
- GC03P075389
- GC03P077181
- GC03P076895
- GC03P077010
- GC03P077009
- GC03P077172
- GC03P077608
- GC03P076069
Summaries for ROBO2 Gene
-
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for ROBO2 Gene
ROBO2 (Roundabout Guidance Receptor 2) is a Protein Coding gene. Diseases associated with ROBO2 include Vesicoureteral Reflux 2 and Familial Vesicoureteral Reflux. Among its related pathways are Developmental Biology and Signaling by Robo receptor. Gene Ontology (GO) annotations related to this gene include identical protein binding and axon guidance receptor activity. An important paralog of this gene is ROBO1.
UniProtKB/Swiss-Prot for ROBO2 Gene
-
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
Additional gene information for ROBO2 Gene
- Monarch Initiative
- Search for ROBO2 at DataMed
- Search for ROBO2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ROBO2 Gene
Genomics for ROBO2 Gene
GeneHancer (GH) Regulatory Elements for ROBO2 Gene
Promoters and enhancers for ROBO2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH03I075906 | Promoter/Enhancer | 1 | EPDnew ENCODE | 550.8 | -0.1 | -67 | 0.9 | CTCF L3MBTL2 POLR2A EZH2 | ROBO2 ZNF717 | |
| GH03I076684 | Enhancer | 0.2 | FANTOM5 | 4.5 | +777.7 | 777688 | 0.2 | ROBO2 LOC102724949 GC03P076507 | ||
| GH03I076556 | Enhancer | 0.2 | FANTOM5 | 2.4 | +649.7 | 649696 | 0.4 | ROBO2 GC03P076507 LOC102724949 | ||
| GH03I076042 | Enhancer | 0.7 | ENCODE dbSUPER | 0.1 | +137.3 | 137262 | 2.2 | CTCF HLF POU5F1 ZNF24 ETS1 | HNRNPA3P6 GC03M076048 GC03P076036 ROBO2 | |
| GH03I076046 | Enhancer | 0.6 | ENCODE dbSUPER | 0.1 | +138.5 | 138470 | 0.2 | CTCF ZNF143 RAD21 | GC03M076048 GC03P076036 ROBO2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around ROBO2 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for ROBO2 Gene
Genomic Locations for ROBO2 Gene
- chr3:75,906,675-77,649,964
- (GRCh38/hg38)
- Size:
- 1,743,290 bases
- Orientation:
- Plus strand
- chr3:75,955,845-77,699,115
- (GRCh37/hg19)
Genomic View for ROBO2 Gene
Genes around ROBO2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p12.3 by Ensembl
- 3p12.3 by Entrez Gene
- 3p12.3 by HGNC
ROBO2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ROBO2 Gene
Proteins for ROBO2 Gene
-
Protein details for ROBO2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9HCK4-ROBO2_HUMAN
- Recommended name:
- Roundabout homolog 2
- Protein Accession:
- Q9HCK4
- O43608
- Q19AB4
- Q19AB5
Protein attributes for ROBO2 Gene
- Size:
- 1378 amino acids
- Molecular mass:
- 151200 Da
- Quaternary structure:
-
- Interacts with SLIT2.
- SequenceCaution:
-
- Sequence=AAC39576.1; Type=Frameshift; Positions=601; Evidence={ECO:0000305}; Sequence=BAB13394.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ROBO2 Gene
Protein Expression for ROBO2 Gene
Post-translational modifications for ROBO2 Gene
- Glycosylation at Asn123, Asn426, Asn752, Asn782, isoforms=2, 3789, and isoforms=2, 3845
Other Protein References for ROBO2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001122401.1
- NP_001276968.1
- NP_001276969.1
- NP_001276994.1
- NP_002933.1
- XP_011532283.1
- XP_011532284.1
- XP_011532285.1
- XP_011532286.1
- XP_011532287.1
- XP_016862475.1
- XP_016862476.1
- XP_016862477.1
- XP_016862478.1
- XP_016862479.1
- XP_016862480.1
- XP_016862481.1
- XP_016862482.1
- XP_016862483.1
- XP_016862484.1
- XP_016862485.1
- XP_016862486.1
- XP_016862487.1
- XP_016862488.1
- XP_016862489.1
- XP_016862490.1
- XP_016862491.1
- XP_016862492.1
- XP_016862493.1
- XP_016862494.1
- XP_016862495.1
Antibody Products
- R&D Systems Antibodies for ROBO2 (ROBO2)
-
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-
Abcam antibodies for ROBO2
- Invitrogen Antibodies for ROBO2
- antibodies-online: Search results for 79 available ROBO2 Antibodies ranked by validation data
- Compare Top ROBO2 Antibodies
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Recommended
- 27 WB Antibodies (anti-human)
- 16 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 14 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- Search GeneTex for Antibodies for ROBO2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ROBO2
Protein Products
- R&D Systems Proteins and Enzymes for ROBO2
-
OriGene Purified Proteins for ROBO2
- Search Origene for MassSpec and Protein Over-expression Lysates for ROBO2
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- Sino Biological Cell Lysates for ROBO2
- Search GeneTex for Proteins for ROBO2
-
Abcam proteins for ROBO2
Assay Products
- antibodies-online: Search results for 1 available ROBO2 Elisa Kits ranked by validation data
- Compare Top ROBO2 Elisa Kits
-
Recommended
No data available for DME Specific Peptides for ROBO2 Gene
Domains & Families for ROBO2 Gene
Gene Families for ROBO2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for ROBO2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ROBO2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9HCK4- Family:
-
- Belongs to the immunoglobulin superfamily. ROBO family.
Function for ROBO2 Gene
Molecular function for ROBO2 Gene
- UniProtKB/Swiss-Prot Function:
- Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
Phenotypes From GWAS Catalog for ROBO2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 12504588 |
| GO:0008046 | axon guidance receptor activity | NAS | 9458045 |
| GO:0042802 | identical protein binding | IDA | 12504588 |
Phenotypes for ROBO2 Gene
- MGI mutant phenotypes for ROBO2:
-
inferred from 3 alleles
- nervous system phenotype
- normal phenotype
- homeostasis/metabolism phenotype
- respiratory system phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- digestive/alimentary phenotype
- reproductive system phenotype
- renal/urinary system phenotype
- GenomeRNAi human phenotypes for ROBO2:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ROBO2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ROBO2 gene
- Search ViGene Biosciences for ROBO2
CRISPR Products
-
OriGene CRISPR knockouts for ROBO2
- genomics-online: gRNA clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
- Applied Biological Materials CRISPR for ROBO2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ROBO2
- GenScript: Design CRISPR guide RNA sequences for ROBO2
miRNA for ROBO2 Gene
- miRTarBase miRNAs that target ROBO2
miRNA Products
- Search ViGene Biosciences for ROBO2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ROBO2
- Browse OriGene Inhibitory RNA Products For ROBO2
- genomics-online: shRNA clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ROBO2 gene
Clone Products
- Sino Biological Human cDNA Clone for ROBO2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ROBO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ROBO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ROBO2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ROBO2
Cell Line Products
-
Horizon Cell Lines for ROBO2
-
ViGene Biosciences adenoviral particle packaged cDNA for ROBO2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ROBO2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ROBO2 gene
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ROBO2 Gene
Localization for ROBO2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ROBO2 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 5 |
| cytoskeleton | 2 |
| nucleus | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
- Microtubule organizing center (2)
- Nucleus (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0009986 | cell surface | IDA | 12504588 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030673 | axolemma | ISS,IEA | -- |
Pathways & Interactions for ROBO2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Developmental Biology |
.51
|
|
| 2 | Signaling by Robo receptor | ||
| 3 | Axon guidance | ||
| 4 | Development Slit-Robo signaling | ||
Pathways by source for ROBO2 Gene
4 Reactome pathways for ROBO2 Gene
1 KEGG pathway for ROBO2 Gene
1 GeneGo (Thomson Reuters) pathway for ROBO2 Gene
Interacting Proteins for ROBO2 Gene
Selected Interacting proteins:
ENSP00000417335
Q9HCK4-ROBO2_HUMAN
for ROBO2 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001656 | metanephros development | ISS | -- |
| GO:0001657 | ureteric bud development | IMP | 17357069 |
| GO:0001822 | kidney development | IEA | -- |
| GO:0006935 | chemotaxis | IEA | -- |
| GO:0007155 | cell adhesion | IEA | -- |
No data available for SIGNOR curated interactions for ROBO2 Gene
Transcripts for ROBO2 Gene
mRNA/cDNA for ROBO2 Gene
- (31) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (90) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ROBO2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for ROBO2
- genomics-online: gRNA clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
- Applied Biological Materials CRISPR for ROBO2
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ROBO2
- GenScript: Design CRISPR guide RNA sequences for ROBO2
miRNA Products
- Search ViGene Biosciences for ROBO2
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for ROBO2
- Browse OriGene Inhibitory RNA Products For ROBO2
- genomics-online: shRNA clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for ROBO2 gene
Clone Products
- Sino Biological Human cDNA Clone for ROBO2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ROBO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ROBO2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for ROBO2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for ROBO2
Expression for ROBO2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Heart (Cardiovascular System)
- Atrioventricular Node Cells Atrioventricular Node
- Atrioventricular Canal Cells Atrioventricular Canal
-
Tooth (Integumentary System)
- Dental Papilla Cells Dental Papilla
- Odontoblasts Dentin
-
Testis (Reproductive System)
- Testicular Interstitial Cells Testis Interstitium
-
Brain (Nervous System)
- Fetal Dopaminergic Neurons Substantia Nigra pars Compacta
-
Neurons
- Fetal Dopaminergic Neurons Substantia Nigra pars Compacta
mRNA differential expression in normal tissues according to GTEx for ROBO2 Gene
This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x5.7), Brain - Putamen (basal ganglia) (x5.1), Brain - Caudate (basal ganglia) (x5.0), and Brain - Frontal Cortex (BA9) (x4.1).
This gene is overexpressed in Fetal Brain (24.9), Heart (18.0), and Breast (18.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ROBO2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ROBO2 Gene:
ROBO2SOURCE GeneReport for Unigene cluster for ROBO2 Gene:
Hs.13305Evidence on tissue expression from TISSUES for ROBO2 Gene
- Nervous system(4.8)
- Kidney(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ROBO2 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- immune
- reproductive
- skeleton
- urinary
Regions:
Abdomen:
- kidney
Pelvis:
- placenta
- ureter
- urethra
- urinary bladder
- uterus
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for ROBO2
- genomics-online: primer clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
No data available for mRNA Expression by UniProt/SwissProt for ROBO2 Gene
Orthologs for ROBO2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ROBO2 33 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
| dog (Canis familiaris) |
Mammalia | LOC487691 33 |
|
||
| ROBO2 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | LOC534842 33 |
|
||
| ROBO2 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Robo2 33 16 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Robo2 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ROBO2 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ROBO2 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ROBO2 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | robo2 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | robo2 33 34 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | robo 33 34 |
|
||
| robo3 34 |
|
ManyToMany | |||
| lea 34 |
|
ManyToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010969 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | sax-3 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for ROBO2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ROBO2 Gene
(11) SIMAP similar genes for ROBO2 Gene using alignment to 9 proteins:
Pseudogenes.org Pseudogenes for ROBO2 Gene
Variants for ROBO2 Gene
| SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1031377 | benign, Vesicoureteral reflux | 77,647,271(+) | C/T | 3_prime_UTR_variant | |
| rs1036593490 | uncertain-significance, Vesicoureteral reflux | 77,574,534(+) | A/C | coding_sequence_variant, synonymous_variant | |
| rs10865561 | benign, Vesicoureteral reflux | 77,649,978(+) | C/T | downstream_transcript_variant | |
| rs11127602 | benign, Vesicoureteral reflux | 77,647,169(+) | G/A | 3_prime_UTR_variant | |
| rs113680429 | likely-benign, Vesicoureteral reflux | 77,481,096(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
5.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.82;
58.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ROBO2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ROBO2 Gene
Disorders for ROBO2 Gene
(5) MalaCards diseases for ROBO2 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| vesicoureteral reflux 2 |
|
|
| familial vesicoureteral reflux |
|
|
| renal hypoplasia |
|
|
| ureteral disease |
|
|
| vesicoureteral reflux 1 |
|
|
Search ROBO2 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ROBO2_HUMAN- Note=A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT-ROBO signaling in vitro.
- Vesicoureteral reflux 2 (VUR2) [MIM:610878]: A disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease. {ECO:0000269 PubMed:17357069}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ROBO2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ROBO2 Gene
Publications for ROBO2 Gene
- Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors. (PMID: 9458045) Kidd T … Tear G (Cell 1998) 2 3 4 58
- Human variation in alcohol response is influenced by variation in neuronal signaling genes. (PMID: 20201926) Joslyn G … White RL (Alcoholism, clinical and experimental research 2010) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Whole-genome linkage and association scan in primary, nonsyndromic vesicoureteric reflux. (PMID: 19959718) Cordell HJ … UK VUR Study Group (Journal of the American Society of Nephrology : JASN 2010) 3 44 58
- In search of genes associated with risk for psychopathic tendencies in children: a two-stage genome-wide association study of pooled DNA. (PMID: 20345837) Viding E … Plomin R (Journal of child psychology and psychiatry, and allied disciplines 2010) 3 44 58
Products for ROBO2 Gene
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- OriGene ORF clones in human for ROBO2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ROBO2
- GenScript: Next-day shipping of latest version cDNA ORF clones for ROBO2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ROBO2
- GenScript Custom Assay Services for ROBO2
- GenScript Custom overexpressing Cell Line Services for ROBO2
- GenScript: Design CRISPR guide RNA sequences for ROBO2
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ROBO2
- Sino Biological Human cDNA Clone for ROBO2
- Sino Biological Cell Lysates for ROBO2
- Sino Biological Recombinant Proteins for ROBO2
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for ROBO2
- Novus Biologicals lysates and proteins for ROBO2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for ROBO2
- Abcam proteins for ROBO2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Browse Antibodies at Cloud-Clone Corp.
- Browse Proteins at Cloud-Clone Corp.
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for ROBO2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for ROBO2
- VectorBuilder custom plasmid, inducible vectors for ROBO2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ROBO2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 79 available ROBO2 Antibodies ranked by validation data
- Compare Top ROBO2 Antibodies
- Recommended
- 27 WB Antibodies (anti-human)
- 16 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IHC Antibody (anti-human)
- 14 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 1 IHC Antibody (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 14 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- antibodies-online: Search results for 1 available ROBO2 Elisa Kits ranked by validation data
- Compare Top ROBO2 Elisa Kits
- Recommended
- antibodies-online: Search results for 9 available ROBO2 Proteins ranked by validation data
- Compare Top ROBO2 Proteins
- Search GeneTex for Antibodies for ROBO2
- Search GeneTex for Proteins for ROBO2
- ViGene Biosciences adenoviral particle packaged cDNA for ROBO2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ROBO2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ROBO2 gene
- Search ViGene Biosciences for ROBO2
- Santa Cruz Biotechnology (SCBT) Antibodies for ROBO2
- Search Santa Cruz Biotechnology (SCBT) for ROBO2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ROBO2
- Horizon Cell Lines for ROBO2
- genomics-online: cdna clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
- orf clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
- genomics-online: gRNA clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
- genomics-online: primer clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
- genomics-online: shRNA clones - Search results for 100 available ROBO2 gene related products
- Overview of 100 available ROBO2 gene related products
Sources for ROBO2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew