Aliases for ROBO2 Gene
External Ids for ROBO2 Gene
Previous GeneCards Identifiers for ROBO2 Gene
The protein encoded by this gene belongs to the ROBO family, part of the immunoglobulin superfamily of proteins that are highly conserved from fly to human. The encoded protein is a transmembrane receptor for the slit homolog 2 protein and functions in axon guidance and cell migration. Mutations in this gene are associated with vesicoureteral reflux, characterized by the backward flow of urine from the bladder into the ureters or the kidney. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for ROBO2 Gene
ROBO2 (Roundabout Guidance Receptor 2) is a Protein Coding gene. Diseases associated with ROBO2 include Vesicoureteral Reflux 2 and Familial Vesicoureteral Reflux. Among its related pathways are Development Slit-Robo signaling and Axon guidance. Gene Ontology (GO) annotations related to this gene include identical protein binding and axon guidance receptor activity. An important paralog of this gene is ROBO1.
UniProtKB/Swiss-Prot Summary for ROBO2 Gene
Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.