Aliases for ROBO1 Gene
External Ids for ROBO1 Gene
Previous GeneCards Identifiers for ROBO1 Gene
Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
GeneCards Summary for ROBO1 Gene
ROBO1 (Roundabout Guidance Receptor 1) is a Protein Coding gene. Diseases associated with ROBO1 include Pituitary Stalk Interruption Syndrome and Dyslexia. Among its related pathways are Development Slit-Robo signaling and Guidance Cues and Growth Cone Motility. Gene Ontology (GO) annotations related to this gene include identical protein binding and LRR domain binding. An important paralog of this gene is ROBO2.
UniProtKB/Swiss-Prot Summary for ROBO1 Gene
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity).