Aliases for RO60 Gene

Aliases for RO60 Gene

  • Ro60, Y RNA Binding Protein 2 3 5
  • 60 KDa SS-A/Ro Ribonucleoprotein 2 3 4
  • TROVE Domain Family Member 2 2 3 4
  • Sjoegren Syndrome Type A Antigen 3 4
  • 60 KDa Ribonucleoprotein Ro 3 4
  • Ro60 Autoantigen 3 4
  • Ro/SSA 60kDa 2 3
  • TROVE2 3 4
  • SSA2 3 4
  • Sjogren Syndrome Antigen A2 (60kDa, Ribonucleoprotein Autoantigen SS-A/Ro) 2
  • Sjogren Syndrome Antigen A2 (60kD, Ribonucleoprotein Autoantigen SS-A/Ro) 3
  • Gastric Cancer Multi-Drug Resistance Protein 3
  • TROVE Domain Family, Member 2 2
  • Sjoegren Syndrome Antigen A2 4
  • Ro 60 KDa Autoantigen 4
  • 60 KDa Ro Protein 4
  • RORNP 3
  • RoRNP 4
  • Ro60 4
  • SS-A 4

External Ids for RO60 Gene

Previous HGNC Symbols for RO60 Gene

  • SSA2
  • TROVE2

Summaries for RO60 Gene

GeneCards Summary for RO60 Gene

RO60 (Ro60, Y RNA Binding Protein) is a Protein Coding gene. Diseases associated with RO60 include Sjogren Syndrome and Lupus Erythematosus. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

UniProtKB/Swiss-Prot Summary for RO60 Gene

  • RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation (PubMed:18056422). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).
  • May play roles in cilia formation and/or maintenance.

Gene Wiki entry for RO60 Gene

Additional gene information for RO60 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RO60 Gene

Genomics for RO60 Gene

GeneHancer (GH) Regulatory Elements for RO60 Gene

Promoters and enhancers for RO60 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J193057 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 512.6 +0.2 208 5.1 HNRNPK ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 POLR2G SP1 NCOR1 RO60 UCHL5 lnc-GLRX2-2 CDC73 ENSG00000231767 B3GALT2 SCARNA18B
GH01J192580 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.2 -478.8 -478798 0.3 RXRA CTCF EP300 RCOR1 RAD21 TRIM22 POLR2A BCL11A CBFB ZNF384 lnc-UCHL5-5 RGS1 ENSG00000226723 RO60 CDC73 RGS2 LOC105371664 ENSG00000285280
GH01J192986 Enhancer 1 Ensembl 10.6 -73.0 -73021 0.4 NRF1 BCLAF1 PHB2 ZBTB11 AFF1 TARDBP HES1 TOE1 MYC CTBP1 piR-35564-009 RO60 SCARNA18B UCHL5 ENSG00000285280 lnc-TROVE2-3-003
GH01J193007 Enhancer 0.8 ENCODE 10.6 -51.3 -51306 0.3 EP300 FOXK2 TCF12 NCOR1 NONO KDM6A TCF7 FOXA1 SKI TEAD1 UCHL5 SCARNA18B RO60 ZNF101P2
GH01J192805 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.3 -250.5 -250546 5.9 HNRNPK EP300 CTCF TCF12 NRF1 POLR2G SP1 GTF2E2 PHF8 FOS RGS2 lnc-UCHL5-10 CDC73 RGS1 RO60 LOC100130137 ENSG00000285280
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RO60 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RO60

Genomic Locations for RO60 Gene

Genomic Locations for RO60 Gene
chr1:193,059,422-193,091,777
(GRCh38/hg38)
Size:
32,356 bases
Orientation:
Plus strand
chr1:193,028,552-193,060,907
(GRCh37/hg19)
Size:
32,356 bases
Orientation:
Plus strand

Genomic View for RO60 Gene

Genes around RO60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RO60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RO60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RO60 Gene

Proteins for RO60 Gene

  • Protein details for RO60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10155-RO60_HUMAN
    Recommended name:
    60 kDa SS-A/Ro ribonucleoprotein
    Protein Accession:
    P10155
    Secondary Accessions:
    • B2RBB9
    • Q5LJ98
    • Q5LJ99
    • Q5LJA0
    • Q86WL3
    • Q86WL4
    • Q92787
    • Q9H1W6

    Protein attributes for RO60 Gene

    Size:
    538 amino acids
    Molecular mass:
    60671 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.
    Miscellaneous:
    • Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus erythematosus (SLE).

    Alternative splice isoforms for RO60 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RO60 Gene

Post-translational modifications for RO60 Gene

  • Ubiquitination at Lys224, Lys227, Lys342, and Lys359
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RO60 Gene

Domains & Families for RO60 Gene

Gene Families for RO60 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RO60 Gene

Blocks:
  • RNA-binding region RNP-1 (RNA recognition motif)
  • TROVE
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RO60 Gene

GenScript: Design optimal peptide antigens:
  • TROVE domain family, member 2 (Q5LJ97_HUMAN)
  • TROVE domain family member 2 (RO60_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P10155

UniProtKB/Swiss-Prot:

RO60_HUMAN :
  • The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).
  • Belongs to the Ro 60 kDa family.
Domain:
  • The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity).
  • The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.
Family:
  • Belongs to the Ro 60 kDa family.
genes like me logo Genes that share domains with RO60: view

Function for RO60 Gene

Molecular function for RO60 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation (PubMed:18056422). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammaotry cytokine secretion. Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853).
UniProtKB/Swiss-Prot Function:
May play roles in cilia formation and/or maintenance.

Phenotypes From GWAS Catalog for RO60 Gene

Gene Ontology (GO) - Molecular Function for RO60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA,IDA 26382853
GO:0030620 U2 snRNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RO60: view
genes like me logo Genes that share phenotypes with RO60: view

Animal Models for RO60 Gene

MGI Knock Outs for RO60:
  • Ro60 Ro60<tm1Woln>

miRNA for RO60 Gene

miRTarBase miRNAs that target RO60

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RO60 Gene

Localization for RO60 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RO60 Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RO60 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 2
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RO60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:1990904 ribonucleoprotein complex TAS,IDA 17289661
genes like me logo Genes that share ontologies with RO60: view

Pathways & Interactions for RO60 Gene

genes like me logo Genes that share pathways with RO60: view

Pathways by source for RO60 Gene

1 KEGG pathway for RO60 Gene

Gene Ontology (GO) - Biological Process for RO60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002520 immune system development IEA --
GO:0006383 transcription by RNA polymerase III TAS 3200833
GO:0007224 smoothened signaling pathway IEA --
GO:0009411 response to UV IEA --
GO:0010468 regulation of gene expression IDA 26382853
genes like me logo Genes that share ontologies with RO60: view

No data available for SIGNOR curated interactions for RO60 Gene

Drugs & Compounds for RO60 Gene

(1) Drugs for RO60 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for RO60 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RO60: view

Transcripts for RO60 Gene

mRNA/cDNA for RO60 Gene

6 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

  • OriGene