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Aliases for RNU4-1 Gene
Subcategory (RNA class) for RNU4-1 Gene
snRNA
Number of RNA Genes sources:
3 / 17
Aliases for RNU4-1 Gene
External Ids for RNU4-1 Gene
- HGNC: 10192
- Entrez Gene: 26835
- Ensembl: ENSG00000200795
Previous HGNC Symbols for RNU4-1 Gene
- RNU4B2
- RNU4A
Previous GeneCards Identifiers for RNU4-1 Gene
- GC12U900787
- GC12M119218
- GC12M120730
- GC12M117739
Summaries for RNU4-1 Gene
GeneCards Summary for RNU4-1 Gene
RNU4-1 (RNA, U4 Small Nuclear 1) is an RNA Gene, and is affiliated with the snRNA class. Diseases associated with RNU4-1 include Hemometra and Primary Optic Atrophy. Among its related pathways are mRNA Splicing - Major Pathway and RNA transport.
Rfam classification for RNU4-1 Gene
-
U4 spliceosomal RNA
Additional gene information for RNU4-1 Gene
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNU4-1 Gene
Genomics for RNU4-1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RNU4-1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RNU4-1 on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the RNU4-1 gene promoter:
-
- ATF-2
- c-Jun
- c-Myb
- FOXJ2
- FOXJ2 (long isoform)
- POU3F2
- POU3F2 (N-Oct-5a)
- POU3F2 (N-Oct-5b)
- STAT1
- STAT3
Genomic Locations for RNU4-1 Gene
Genomic Locations for RNU4-1 Gene
- chr12:120,293,094-120,293,237
- (GRCh38/hg38)
- Size:
- 144 bases
- Orientation:
- Minus strand
- chr12:120,730,897-120,731,040
- (GRCh37/hg19)
- Size:
- 144 bases
- Orientation:
- Minus strand
Genomic View for RNU4-1 Gene
Genes around RNU4-1 on UCSC Golden Path with GeneCards custom track
RNU4-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 12q24.31 by HGNC
- 12q24.23 by Entrez Gene
- 12q24.23 by Ensembl
RNU4-1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNU4-1 Gene
Proteins for RNU4-1 Gene
Post-translational modifications for RNU4-1 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNU4-1
- Origene Custom Protein Services for RNU4-1
No data available for DME Specific Peptides for RNU4-1 Gene
Domains & Families for RNU4-1 Gene
Gene Families for RNU4-1 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNU4-1 Gene
Function for RNU4-1 Gene
Phenotypes From GWAS Catalog for RNU4-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0017070 | U6 snRNA binding | IEA | -- |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNU4-1 - Select products 50% OFF >
- * RNU4-1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for RNU4-1
miRNA Products
Inhibitory RNA Products
Clone Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU4-1 Gene
Localization for RNU4-1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005687 | U4 snRNP | IEA | -- |
| GO:0046540 | U4/U6 x U5 tri-snRNP complex | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for RNU4-1 Gene
Pathways & Interactions for RNU4-1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | mRNA Splicing - Major Pathway |
.47
|
Spliceosomal Splicing Cycle
.01
|
| 2 | RNA transport | ||
Pathways by source for RNU4-1 Gene
2 KEGG pathways for RNU4-1 Gene
1 Qiagen pathway for RNU4-1 Gene
- Spliceosomal Splicing Cycle
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000244 | spliceosomal tri-snRNP complex assembly | IEA | -- |
| GO:0000353 | formation of quadruple SL/U4/U5/U6 snRNP | IEA | -- |
No data available for Interacting Proteins and SIGNOR curated interactions for RNU4-1 Gene
Transcripts for RNU4-1 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for RNU4-1 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00003F07BD_9606 | snRNA | 144 | 4 |
HGNC: 10192, RefSeq: NR_003925, PDBe: 6AH0_I, 6AHD_I, ENA: M15956.1:271..414:ncRNA, |
| URS0000629D9A_9606 | snRNA | 141 | 2 |
Ensembl: ENST00000363925 (view in UCSC) , Rfam: RF00015, |
| URS0000200C70_9606 | snRNA | 144 | 2 |
PDBe: 5O9Z_4, ENA: V00592.1:1..145:ncRNA, |
| URS00004D7446_9606 | snRNA | 144 | 1 |
ENA: K00472.1:1..145:ncRNA, |
| URS00008FED2D_9606 | snRNA | 144 | 1 |
PDBe: 3JCR_M, |
RNU4-1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for RNU4-1 Gene
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNU4-1 - Select products 50% OFF >
- * RNU4-1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Browse CRISPR knockouts for RNU4-1
miRNA Products
Inhibitory RNA Products
Clone Products
Relevant External Links for RNU4-1 Gene
- GeneLoc Exon Structure for
- RNU4-1
Expression for RNU4-1 Gene
mRNA differential expression in normal tissues according to GTEx for RNU4-1 Gene
This gene is overexpressed in Testis (x6.2), Whole Blood (x4.8), and Pancreas (x4.1).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNU4-1
Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNU4-1 Gene
Orthologs for RNU4-1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | U4 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Gm24265 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | U4 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | U4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | U4 31 |
|
ManyToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | U4 31 31 31 |
|
ManyToMany |
- Species where no ortholog for RNU4-1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for RNU4-1 Gene
No data available for Paralogs for RNU4-1 Gene
Variants for RNU4-1 Gene
Additional Variant Information for RNU4-1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RNU4-1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for RNU4-1 Gene
Disorders for RNU4-1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hemometra |
|
|
| primary optic atrophy |
|
|
Search RNU4-1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RNU4-1
No data available for UniProtKB/Swiss-Prot and Genatlas for RNU4-1 Gene
Publications for RNU4-1 Gene
- Genes for human U4 small nuclear RNA. (PMID: 3582982) Bark C … Pettersson U (Gene 1986) 2 3
- High-affinity RNA targets of the Survival Motor Neuron protein reveal diverse preferences for sequence and structural motifs. (PMID: 30165668) Ottesen EW … Singh RN (Nucleic acids research 2018) 3
- RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
- NUFIP and the HSP90/R2TP chaperone bind the SMN complex and facilitate assembly of U4-specific proteins. (PMID: 26275778) Bizarro J … Bertrand E (Nucleic acids research 2015) 3
- BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing. (PMID: 25263594) Guo R … Shi Y (Molecular cell 2014) 3
ExternalLinks
Products for RNU4-1 Gene
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- Custom Assay Services
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- Browse OriGene qPCR primer pairs and template standards
- Browse CRISPR knockouts for RNU4-1
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- Browse Sino Biological Recombinant Proteins
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
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- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for RNU4-1
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for RNU4-1
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for RNU4-1
Sources for RNU4-1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
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- (19) KEGG
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- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
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- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
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- (122) ENCODE
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- (124) Horizon
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- (128) SNPedia
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- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
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- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
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- (152) DiseaseEnhancer
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- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (170) snOPY
- (171) SRPDB
- (172) GENCODE
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