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RNU2-58P Gene(Pseudogene)

RNA, U2 Small Nuclear 58, Pseudogene

GCID:
GC17M059129
GIFtS:
11
Genes Participants
UDN Logo

Aliases for RNU2-58P Gene

Subcategory (RNA class) for RNU2-58P Gene

snRNA

Aliases for RNU2-58P Gene

  • RNA, U2 Small Nuclear 58, Pseudogene 2 3 5

External Ids for RNU2-58P Gene

ORGUL Members for RNU2-58P Gene

Previous GeneCards Identifiers for RNU2-58P Gene

  • GC17M057208
  • GC00U935845

Summaries for RNU2-58P Gene

GeneCards Summary for RNU2-58P Gene

RNU2-58P (RNA, U2 Small Nuclear 58, Pseudogene) is a Pseudogene, and is affiliated with the snRNA class.

fRNAdb sequence ontologies for RNU2-58P Gene - the ORGUL cluster for this gene includes several descriptions:

  • U2_snRNA: U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.

  • U2 spliceosomal RNA: U2 is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre-mRNA splicing). Complementary binding between U2 snRNA (in an area lying towards the 5' end but 3' to hairpin I) and the branchpoint sequence (BPS) of the intron results in the bulging out of an unpaired adenosine, on the BPS, which initiates a nucleophilic attack at the intronic 5' splice site, thus starting the first of two transesterification reactions that mediate splicing.

Additional gene information for RNU2-58P Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNU2-58P Gene

Genomics for RNU2-58P Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for RNU2-58P Gene

Promoters and enhancers for RNU2-58P Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17I059151 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE 11.3 -26.8 -26832 9.6 CLOCK ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 SP3 NFYC GC17M059154 PRR11 SKA2 MKS1 NDUFB8P2 TUBD1 TRIM37 RPS6KB1 SMG8 RNFT1
GH17I059123 Enhancer 0.4 FANTOM5 0.4 +6.3 6256 0.1 ZNF121 ZNF362 GC17M059121 MIR301A SKA2 PRR11 SMG8 GDPD1 RNU2-58P
GH17I059126 Enhancer 0.2 FANTOM5 0.8 +3.0 3032 0.1 GC17M059121 RNU2-58P SKA2
GH17I059121 Enhancer 0.3 dbSUPER 0.4 +7.3 7315 0.6 ZNF362 GC17M059121 MIR301A SKA2 PRR11 SMG8 RNU2-58P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNU2-58P on UCSC Golden Path with GeneCards custom track

Genomic Locations for RNU2-58P Gene

Genomic Locations for RNU2-58P Gene
chr17:59,129,276-59,129,458
(GRCh38/hg38)
Size:
183 bases
Orientation:
Minus strand

Genomic View for RNU2-58P Gene

Genes around RNU2-58P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNU2-58P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNU2-58P Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

ORGUL Member Location for RNU2-58P Gene

ORGUL Member Location for RNU2-58P gene

No data available for RefSeq DNA sequence for RNU2-58P Gene

Proteins for RNU2-58P Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for RNU2-58P Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU2-58P Gene

Domains & Families for RNU2-58P Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU2-58P Gene

Function for RNU2-58P Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for RNU2-58P Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU2-58P Gene

Localization for RNU2-58P Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RNU2-58P Gene

Pathways & Interactions for RNU2-58P Gene

SuperPathways for RNU2-58P Gene

PathCards logo More details on SuperPathways for RNU2-58P
No Data Available

Interacting Proteins for RNU2-58P Gene

Gene Ontology (GO) - Biological Process for RNU2-58P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNU2-58P Gene

Drugs & Compounds for RNU2-58P Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for RNU2-58P Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RNU2-58P Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNU2-58P Gene

No ASD Table

Relevant External Links for RNU2-58P Gene

GeneLoc Exon Structure for
RNU2-58P
ECgene alternative splicing isoforms for
RNU2-58P

Expression for RNU2-58P Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNU2-58P Gene

mRNA expression in normal human tissues for RNU2-58P Gene
mRNA expression by GTEx for RNU2-58P Gene
genes like me logo Genes that share expression patterns with RNU2-58P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNU2-58P Gene

Orthologs for RNU2-58P Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNU2-58P Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia U2 34
  • 60 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia U2 34
  • 48 (a)
 ManyToMany
dog
(Canis familiaris)
 Mammalia U2 34
  • 45 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia U2 34
  • 39 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii U2 34
  • 45 (a)
 ManyToMany
Species where no ortholog for RNU2-58P was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNU2-58P Gene

ENSEMBL:
Gene Tree for RNU2-58P (if available)
TreeFam:
Gene Tree for RNU2-58P (if available)

Paralogs for RNU2-58P Gene

No data available for Paralogs for RNU2-58P Gene

Variants for RNU2-58P Gene

Additional Variant Information for RNU2-58P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNU2-58P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for RNU2-58P Gene

Disorders for RNU2-58P Gene

No disorders were found for RNU2-58P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot , Genatlas and External Links for RNU2-58P Gene

Publications for RNU2-58P Gene

  1. Crystal structure of a model branchpoint-U2 snRNA duplex containing bulged adenosines. (PMID: 11350032) Berglund JA … Schultz SC (RNA (New York, N.Y.) 2001) 1
  2. A conserved pseudouridine modification in eukaryotic U2 snRNA induces a change in branch-site architecture. (PMID: 11424937) Newby MI … Greenbaum NL (RNA (New York, N.Y.) 2001) 1
  3. The uRNA database. (PMID: 9016512) Zwieb C (Nucleic acids research 1997) 1
  4. The spliceosomal snRNAs of Caenorhabditis elegans. (PMID: 2339054) Thomas J … Blumenthal T (Nucleic acids research 1990) 1

Products for RNU2-58P Gene

Sources for RNU2-58P Gene

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