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Aliases for RNU2-1 Gene

Subcategory (RNA class) for RNU2-1 Gene

non-coding RNA

Quality Score for this RNA gene is


Aliases for RNU2-1 Gene

  • RNA, U2 Small Nuclear 1 2 3 5
  • RNU2 3
  • U2 3

External Ids for RNU2-1 Gene

Previous GeneCards Identifiers for RNU2-1 Gene

  • GC17M8A0032
  • GC11M062609
  • GC01P053219
  • GC01P051335
  • GC07P116543
  • GC17U901855

Summaries for RNU2-1 Gene

Entrez Gene Summary for RNU2-1 Gene

  • The spliceosome is a multicomponent ribonucleoprotein complex that catalyzes the removal of introns from nuclear mRNA precursors. The spliceosome is composed of four small ribonucleoprotein particles (the U1, U2, and U4/U6 snRNPs) and numerous additional proteins. The U2 small nuclear RNA (snRNA) is a RNA component of the U2 snRNP that interacts with the 3' region of the intron at the branch site. Several sites in the human genome express U2 snRNAs. This locus represents an array of U2 snRNA genes located at 17q21-22 that undergoes concerted evolution to homogenize repeat units within the array. Each repeat in this array is approximately 6.1 kb long and contains a single copy of the U2 snRNA. Arrays of six to more than 30 repeats have been reported. [provided by RefSeq, Mar 2009]

GeneCards Summary for RNU2-1 Gene

RNU2-1 (RNA, U2 Small Nuclear 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Among its related pathways are mRNA Splicing - Major Pathway.

Gene Wiki entry for RNU2-1 Gene

Additional gene information for RNU2-1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNU2-1 Gene

Genomics for RNU2-1 Gene

GeneHancer (GH) Regulatory Elements for RNU2-1 Gene

Promoters and enhancers for RNU2-1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J043233 Promoter 0.5 Ensembl 650.7 +0.1 76 1.4 RNU2-1 TMEM106A LINC00854
GH17J043210 Promoter/Enhancer 1.4 Ensembl ENCODE 0.3 +21.4 21379 4.4 HDGF ELF3 PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 TMEM106A NBR2 RND2 VAT1 NBR1 PTGES3L PSMC3IP RNU2-1
GH17J043215 Enhancer 0.9 ENCODE 0.4 +16.5 16545 3.9 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 SLC30A9 NFKBIZ PAF1 NBR2 DHX8 ENSG00000267758 STAT5A TMUB2 HMGN1P29 ASB16-AS1 VAT1 RND2 LINC00910
GH17J043231 Promoter 0.5 Ensembl 0.7 +2.5 2476 0.2 RNU2-1 TMEM106A LINC00854
GH17J043239 Promoter 0.5 Ensembl 0.4 -5.5 -5524 0.2 ENSG00000275616 ENSG00000273709 RNU2-1 LINC00854
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNU2-1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNU2-1 gene promoter:
  • HNF-3beta
  • POU2F1
  • POU2F1a
  • STAT5B
  • Olf-1

Genomic Locations for RNU2-1 Gene

Genomic Locations for RNU2-1 Gene
191 bases
Minus strand

Genomic View for RNU2-1 Gene

Genes around RNU2-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNU2-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNU2-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNU2-1 Gene

Proteins for RNU2-1 Gene

Post-translational modifications for RNU2-1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for RNU2-1 Gene

Domains & Families for RNU2-1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNU2-1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for RNU2-1 Gene

Function for RNU2-1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU2-1 Gene

Localization for RNU2-1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RNU2-1 Gene

Pathways & Interactions for RNU2-1 Gene

SuperPathways for RNU2-1 Gene

SuperPathway Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with RNU2-1: view

Pathways by source for RNU2-1 Gene

1 BioSystems pathway for RNU2-1 Gene

Interacting Proteins for RNU2-1 Gene

Gene Ontology (GO) - Biological Process for RNU2-1 Gene


No data available for SIGNOR curated interactions for RNU2-1 Gene

Drugs & Compounds for RNU2-1 Gene

No Compound Related Data Available

Transcripts for RNU2-1 Gene

mRNA/cDNA for RNU2-1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(2) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for RNU2-1 Gene

No ASD Table

Relevant External Links for RNU2-1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNU2-1 Gene

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNU2-1 Gene

Orthologs for RNU2-1 Gene

Evolution for RNU2-1 Gene

Gene Tree for RNU2-1 (if available)
Gene Tree for RNU2-1 (if available)

No data available for Orthologs for RNU2-1 Gene

Paralogs for RNU2-1 Gene

No data available for Paralogs for RNU2-1 Gene

Variants for RNU2-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNU2-1 Gene

Variant ID Type Subtype PubMed ID
dgv1466n106 OTHER inversion 24896259
esv2672913 CNV deletion 23128226
esv33998 OTHER inversion 15654335
esv6011 OTHER inversion 19470904
nsv1079031 OTHER inversion 25765185
nsv1146669 OTHER inversion 26484159
nsv1160487 CNV duplication 26073780
nsv510712 CNV deletion 20534489
nsv962328 CNV duplication 23825009

Additional Variant Information for RNU2-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for RNU2-1 Gene

Disorders for RNU2-1 Gene

Additional Disease Information for RNU2-1

No disorders were found for RNU2-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNU2-1 Gene

Publications for RNU2-1 Gene

  1. Nuclease S1-sensitive sites in multigene families: human U2 small nuclear RNA genes. (PMID: 2411549) Htun H … Dahlberg JE (The EMBO journal 1985) 2 3 58
  2. Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for primary central nervous system lymphoma. (PMID: 26250566) Baraniskin A … Schroers R (Neuro-oncology 2016) 3 58
  3. Binding affinity and cooperativity control U2B″/snRNA/U2A' RNP formation. (PMID: 24866816) Williams SG … Hall KB (Biochemistry 2014) 3 58
  4. Analysis of U2 small nuclear RNA fragments in the bile differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders. (PMID: 24482036) Baraniskin A … Hahn SA (Digestive diseases and sciences 2014) 3 58
  5. Alternative processing of the U2 small nuclear RNA produces a 19-22nt fragment with relevance for the detection of non-small cell lung cancer in human serum. (PMID: 23527303) Mazières J … Michot B (PloS one 2013) 3 58

Products for RNU2-1 Gene

Sources for RNU2-1 Gene

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