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Aliases for RNU12 Gene
Subcategory (RNA class) for RNU12 Gene
snRNA
Number of RNA Genes sources:
2 / 17
Aliases for RNU12 Gene
External Ids for RNU12 Gene
- HGNC: 19380
- Entrez Gene: 267010
- Ensembl: ENSG00000276027
Previous HGNC Symbols for RNU12 Gene
- RNU12P
Previous GeneCards Identifiers for RNU12 Gene
- GC00U990629
- GC0XP045252
- GC0XP045818
- GC0XP046037
- GC0XP046747
- GC0XP046876
- GC22P041340
- GC22P043010
- GC22P025971
- GC22P043013
- GC22P043016
Summaries for RNU12 Gene
GeneCards Summary for RNU12 Gene
RNU12 (RNA, U12 Small Nuclear) is an RNA Gene, and is affiliated with the snRNA class. Diseases associated with RNU12 include Congenital Cerebellar Ataxia Due To Rnu12 Mutation.
Rfam classification for RNU12 Gene
-
U12 minor spliceosomal RNA
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for RNU12 Gene
Genomics for RNU12 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RNU12 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH22J042612 | Promoter/Enhancer | 2.4 | EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER | 600.7 | -0.4 | -430 | 4.3 | BRCA1 ARHGAP35 SP1 HNRNPL GATAD2A CTCF PRDM10 REST ZNF629 TFE3 | POLDIP3 ENSG00000270022 RNU12 lnc-CYB5R3-1 RN7SKP80 XRCC6 RPL5P34 RRP7BP NAGA PHETA2 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RNU12 on the GeneHancer Hub at the UCSC Golden Path
- Top Transcription factor binding sites by QIAGEN in the RNU12 gene promoter:
-
- CREB
- deltaCREB
- Nkx3-1
- Nkx3-1 v1
- Nkx3-1 v2
- Nkx3-1 v3
- Nkx3-1 v4
Genomic Locations for RNU12 Gene
Genomic Locations for RNU12 Gene
- chr22:42,614,914-42,615,643
- (GRCh38/hg38)
- Size:
- 730 bases
- Orientation:
- Plus strand
- chr22:43,011,250-43,011,913
- (GRCh37/hg19)
- Size:
- 664 bases
- Orientation:
- Plus strand
Genomic View for RNU12 Gene
Genes around RNU12 on UCSC Golden Path with GeneCards custom track
RNU12 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
- Cytogenetic band:
-
- 22q13.2 by HGNC
- 22q13.2 by Entrez Gene
- 22q13.2 by Ensembl
RNU12 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNU12 Gene
Proteins for RNU12 Gene
Post-translational modifications for RNU12 Gene
No Post-translational modifications
Antibody Products
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNU12
- Origene Custom Protein Services for RNU12
No data available for DME Specific Peptides for RNU12 Gene
Domains & Families for RNU12 Gene
Gene Families for RNU12 Gene
No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNU12 Gene
Function for RNU12 Gene
Phenotypes From GWAS Catalog for RNU12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045131 | pre-mRNA branch point binding | IEA | -- |
Phenotypes for RNU12 Gene
- GenomeRNAi human phenotypes for RNU12:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNU12 - Select products 50% OFF >
- * RNU12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RNU12
miRNA Products
Inhibitory RNA Products
Clone Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNU12 Gene
Localization for RNU12 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005693 | U12 snRNP | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for RNU12 Gene
Pathways & Interactions for RNU12 Gene
No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for RNU12 Gene
Transcripts for RNU12 Gene
Non-coding RNA (ncRNA) Transcripts from RNAcentral for RNU12 Gene
| RNAcentral Transcript ID | Subcategory | Length (nts) | # of Sources | Source Identifiers and Annotations |
|---|---|---|---|---|
| URS00006ECA78_9606 | snRNA | 150 | 2 |
Ensembl: ENST00000362512 (view in UCSC) , Rfam: RF00007, |
| URS000075EF5D_9606 | snRNA | 149 | 2 |
HGNC: 19380, RefSeq: NR_029422, |
| URS00004069B6_9606 | snRNA | 730 | 1 |
ENA: L43846.1:1..731:ncRNA, |
| URS0000273346_9606 | snRNA | 151 | 1 | |
| URS0000622072_9606 | snRNA | 149 | 1 |
ENA: J04119.1:1..150:ncRNA, |
RNU12 in the GeneCards ncRNA compendium hub on the UCSC Golden Path
Additional transcripts not in RNAcentral for RNU12 Gene
- 1 NCBI additional mRNA sequence :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNU12 - Select products 50% OFF >
- * RNU12 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RNU12
miRNA Products
Inhibitory RNA Products
Clone Products
Relevant External Links for RNU12 Gene
- GeneLoc Exon Structure for
- RNU12
Expression for RNU12 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNU12
SOURCE GeneReport for Unigene cluster for RNU12 Gene:
Hs.574857Primer Products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNU12 Gene
Orthologs for RNU12 Gene
No data available for Orthologs for RNU12 Gene
Paralogs for RNU12 Gene
No data available for Paralogs for RNU12 Gene
Variants for RNU12 Gene
Additional Variant Information for RNU12 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for RNU12 Gene
Disorders for RNU12 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| congenital cerebellar ataxia due to rnu12 mutation |
|
|
Search RNU12 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RNU12
No data available for UniProtKB/Swiss-Prot and Genatlas for RNU12 Gene
Publications for RNU12 Gene
- U12 snRNA in vertebrates: evolutionary conservation of 5' sequences implicated in splicing of pre-mRNAs containing a minor class of introns. (PMID: 7489523) Tarn WY … Steitz JA (RNA (New York, N.Y.) 1995) 2 3
- VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
- RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3
- Mutation in noncoding RNA RNU12 causes early onset cerebellar ataxia. (PMID: 27863452) Elsaid MF … Aleem AA (Annals of neurology 2017) 3
- Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome. (PMID: 25586593) Madan V … Koeffler HP (Nature communications 2015) 3
ExternalLinks
Products for RNU12 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNU12
- Origene Custom Protein Services for RNU12
- Browse OriGene Inhibitory RNA Products For RNU12
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for RNU12
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RNU12
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for knockout CRISPR/Cas9 clones, lentivirus, and/or AAV products for RNU12
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles, and/or promoter clone products for RNU12
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RNU12
- Search GeneCopoeia for shRNA, lentivirus, and/or AAV clone products for RNU12
Sources for RNU12 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB