Aliases for RNMT Gene

Aliases for RNMT Gene

  • RNA Guanine-7 Methyltransferase 2 3 5
  • MRNA Cap Guanine-N7 Methyltransferase 2 3 4
  • MRNA (Guanine-N(7)-)-Methyltransferase 3 4
  • RNA (Guanine-7-) Methyltransferase 2 3
  • MRNA Cap Methyltransferase 3 4
  • EC 2.1.1.56 4 52
  • RG7MT1 3 4
  • HCMT1 3 4
  • Hcm1p 3 4
  • HMet 3 4
  • MRNA (Guanine-7-)Methyltransferase 3
  • KIAA0398 4
  • CMT1c 3
  • CMT1 3
  • Cm1p 3
  • MET 3
  • Met 3

External Ids for RNMT Gene

Previous GeneCards Identifiers for RNMT Gene

  • GC18M013747
  • GC18P013812

Summaries for RNMT Gene

GeneCards Summary for RNMT Gene

RNMT (RNA Guanine-7 Methyltransferase) is a Protein Coding gene. Diseases associated with RNMT include Bowen-Conradi Syndrome and Dubowitz Syndrome. Among its related pathways are Formation of HIV-1 elongation complex containing HIV-1 Tat and HIV Life Cycle. Gene Ontology (GO) annotations related to this gene include RNA binding and mRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot Summary for RNMT Gene

  • Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884).

Gene Wiki entry for RNMT Gene

Additional gene information for RNMT Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNMT Gene

Genomics for RNMT Gene

GeneHancer (GH) Regulatory Elements for RNMT Gene

Promoters and enhancers for RNMT Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNMT on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNMT

Top Transcription factor binding sites by QIAGEN in the RNMT gene promoter:
  • aMEF-2
  • AREB6
  • Cdc5
  • MEF-2A
  • Pax-4a
  • POU2F1
  • POU2F1a
  • POU2F1b
  • POU2F1c
  • STAT5A

Genomic Locations for RNMT Gene

Genomic Locations for RNMT Gene
chr18:13,726,647-13,764,558
(GRCh38/hg38)
Size:
37,912 bases
Orientation:
Plus strand
chr18:13,726,659-13,764,557
(GRCh37/hg19)
Size:
37,899 bases
Orientation:
Plus strand

Genomic View for RNMT Gene

Genes around RNMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNMT Gene

Proteins for RNMT Gene

  • Protein details for RNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43148-MCES_HUMAN
    Recommended name:
    mRNA cap guanine-N7 methyltransferase
    Protein Accession:
    O43148
    Secondary Accessions:
    • B0YJ90
    • D3DUJ5
    • O94996
    • Q9UIJ9

    Protein attributes for RNMT Gene

    Size:
    476 amino acids
    Molecular mass:
    54844 Da
    Quaternary structure:
    • Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity (PubMed:11114884). Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates (PubMed:11114884). Interacts with elongating form of polymerase II and RNGTT (PubMed:9705270). Interacts with RAMAC, this interaction significantly enhances RNA-binding and cap methyltransferase activity (PubMed:22099306, Ref.14).

    Three dimensional structures from OCA and Proteopedia for RNMT Gene

    Alternative splice isoforms for RNMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNMT Gene

Selected DME Specific Peptides for RNMT Gene

O43148:
  • EQADMMLRNAC
  • RSQSRIF
  • CGKGGDL
  • EMAKKYNM
  • FDICSCQF
  • YPLFGCKYDF

Post-translational modifications for RNMT Gene

  • Ubiquitination at Lys163 and Lys208
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for RNMT

Domains & Families for RNMT Gene

Gene Families for RNMT Gene

Protein Domains for RNMT Gene

Suggested Antigen Peptide Sequences for RNMT Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61036, highly similar to Homo sapiens RNA (guanine-7-) methyltransferase (RNMT), mRNA (B7Z8S9_HUMAN)
  • mRNA cap methyltransferase (MCES_HUMAN)
  • mRNA cap guanine-N7 methyltransferase (Q05D80_HUMAN)
  • RNMT protein (Q05DQ2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O43148

UniProtKB/Swiss-Prot:

MCES_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
genes like me logo Genes that share domains with RNMT: view

Function for RNMT Gene

Molecular function for RNMT Gene

UniProtKB/Swiss-Prot Function:
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAMAC complex that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5'-terminal GpppC (PubMed:11114884).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60856, Rhea:RHEA-COMP:15681, Rhea:RHEA-COMP:15683, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:143971, ChEBI:CHEBI:143975; EC=2.1.1.56; Evidence={ECO:0000255 PROSITE-ProRule:PRU00895, ECO:0000269 PubMed:10347220, ECO:0000269 PubMed:27422871, ECO:0000269 PubMed:9705270, ECO:0000269 PubMed:9790902};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:60852, Rhea:RHEA-COMP:15680, Rhea:RHEA-COMP:15682, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:143973, ChEBI:CHEBI:143974; EC=2.1.1.56; Evidence={ECO:0000255 PROSITE-ProRule:PRU00895, ECO:0000269 PubMed:10347220, ECO:0000269 PubMed:27422871, ECO:0000269 PubMed:9705270, ECO:0000269 PubMed:9790902};.
UniProtKB/Swiss-Prot EnzymeRegulation:
Methyltransferase activity is activated by RAMAC (PubMed:27422871).
GENATLAS Biochemistry:
messenger RNA (guanine-7) cap methyltransferase

Enzyme Numbers (IUBMB) for RNMT Gene

Phenotypes From GWAS Catalog for RNMT Gene

Gene Ontology (GO) - Molecular Function for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IMP 9790902
GO:0004482 mRNA (guanine-N7-)-methyltransferase activity TAS --
GO:0005515 protein binding IPI 22099306
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with RNMT: view
genes like me logo Genes that share phenotypes with RNMT: view

Animal Models for RNMT Gene

MGI Knock Outs for RNMT:
  • Rnmt Rnmt<tm1b(KOMP)Mbp>

Animal Model Products

  • Taconic Biosciences Mouse Models for RNMT

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNMT

Clone Products

  • Addgene plasmids for RNMT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNMT Gene

Localization for RNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNMT Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNMT gene
Compartment Confidence
nucleus 5
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IDA,TAS 9790902
GO:0005654 nucleoplasm TAS --
GO:0005845 mRNA cap binding complex IDA,IBA 22099306
GO:0031533 mRNA cap methyltransferase complex IDA 27422871
genes like me logo Genes that share ontologies with RNMT: view

Pathways & Interactions for RNMT Gene

genes like me logo Genes that share pathways with RNMT: view

Pathways by source for RNMT Gene

1 BioSystems pathway for RNMT Gene
1 KEGG pathway for RNMT Gene

Gene Ontology (GO) - Biological Process for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006370 7-methylguanosine mRNA capping IBA,TAS --
GO:0006397 mRNA processing IEA --
GO:0032259 methylation IEA --
GO:0106005 RNA 5'-cap (guanine-N7)-methylation IEA --
genes like me logo Genes that share ontologies with RNMT: view

No data available for SIGNOR curated interactions for RNMT Gene

Drugs & Compounds for RNMT Gene

(1) Drugs for RNMT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(2) Additional Compounds for RNMT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium
  • Acylcarnitine
  • AdoMet
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine
485-80-3
genes like me logo Genes that share compounds with RNMT: view

Transcripts for RNMT Gene

mRNA/cDNA for RNMT Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNMT

Clone Products

  • Addgene plasmids for RNMT

Alternative Splicing Database (ASD) splice patterns (SP) for RNMT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for RNMT Gene

GeneLoc Exon Structure for
RNMT

Expression for RNMT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNMT Gene

This gene is overexpressed in Breast (21.2) and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNMT Gene



Protein tissue co-expression partners for RNMT Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNMT

SOURCE GeneReport for Unigene cluster for RNMT Gene:

Hs.592347

mRNA Expression by UniProt/SwissProt for RNMT Gene:

O43148-MCES_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for RNMT Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RNMT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNMT Gene

Orthologs for RNMT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNMT 31 30
  • 99.51 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNMT 30
  • 91.53 (n)
-- 31
  • 90 (a)
OneToMany
-- 31
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RNMT 31 30
  • 89.68 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnmt 30
  • 82.34 (n)
mouse
(Mus musculus)
Mammalia Rnmt 17 31 30
  • 81.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 81 (a)
OneToMany
-- 31
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RNMT 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNMT 31 30
  • 74.15 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNMT 31
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnmt 30
  • 71.24 (n)
Str.2305 30
African clawed frog
(Xenopus laevis)
Amphibia xCMT1 30
zebrafish
(Danio rerio)
Actinopterygii rnmt 31 30
  • 62.91 (n)
OneToOne
wufi09c12 30
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Bd 31 32 30
  • 53.92 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003460 30
  • 49.58 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-72 31 30
  • 51.51 (n)
OneToOne
C25A1.3 32
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABD1 33 31
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6979 31
  • 46 (a)
OneToOne
Species where no ortholog for RNMT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNMT Gene

ENSEMBL:
Gene Tree for RNMT (if available)
TreeFam:
Gene Tree for RNMT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNMT: view image

Paralogs for RNMT Gene

(1) SIMAP similar genes for RNMT Gene using alignment to 7 proteins:

  • MCES_HUMAN
  • F5H2D9_HUMAN
  • K7EP06_HUMAN
  • K7EPP5_HUMAN
  • K7ERH6_HUMAN
  • Q05D80_HUMAN
  • Q05DQ2_HUMAN
genes like me logo Genes that share paralogs with RNMT: view

No data available for Paralogs for RNMT Gene

Variants for RNMT Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNMT Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
757966 Likely Benign: not provided 13,754,134(+) A/G SYNONYMOUS_VARIANT
758114 Benign: not provided 13,734,511(+) A/G SYNONYMOUS_VARIANT
773596 Benign: not provided 13,746,277(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for RNMT Gene

Structural Variations from Database of Genomic Variants (DGV) for RNMT Gene

Variant ID Type Subtype PubMed ID
esv8144 CNV gain 19470904
nsv576529 CNV gain 21841781

Variation tolerance for RNMT Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNMT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNMT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNMT Gene

Disorders for RNMT Gene

MalaCards: The human disease database

(2) MalaCards diseases for RNMT Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bowen-conradi syndrome
  • bwcns
dubowitz syndrome
  • dubowitz's syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RNMT in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RNMT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RNMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNMT Gene

Publications for RNMT Gene

  1. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. (PMID: 9705270) Pillutla RC … Shatkin AJ (The Journal of biological chemistry 1998) 2 3 4 54
  2. Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM. (PMID: 27422871) Varshney D … Cowling VH (Nucleic acids research 2016) 3 4 54
  3. RAM/Fam103a1 is required for mRNA cap methylation. (PMID: 22099306) Gonatopoulos-Pournatzis T … Cowling VH (Molecular cell 2011) 3 4 54
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  5. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B … Blom HJ (Birth defects research. Part A, Clinical and molecular teratology 2009) 3 41 54

Products for RNMT Gene

Sources for RNMT Gene