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Aliases for RNMT Gene

Aliases for RNMT Gene

  • RNA Guanine-7 Methyltransferase 2 3 5
  • MRNA (Guanine-N(7)-)-Methyltransferase 3 4
  • MRNA Cap Guanine-N7 Methyltransferase 2 3
  • RNA (Guanine-7-) Methyltransferase 2 3
  • MRNA Cap Methyltransferase 3 4
  • EC 2.1.1.56 4 56
  • RG7MT1 3 4
  • HCMT1 3 4
  • Hcm1p 3 4
  • HMet 3 4
  • MRNA (Guanine-7-)Methyltransferase 3
  • KIAA0398 4
  • CMT1c 3
  • CMT1 3
  • Cm1p 3
  • MET 3

External Ids for RNMT Gene

Previous GeneCards Identifiers for RNMT Gene

  • GC18M013747
  • GC18P013812

Summaries for RNMT Gene

GeneCards Summary for RNMT Gene

RNMT (RNA Guanine-7 Methyltransferase) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. Gene Ontology (GO) annotations related to this gene include RNA binding and mRNA (guanine-N7-)-methyltransferase activity.

UniProtKB/Swiss-Prot for RNMT Gene

  • Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5-terminal GpppC (PubMed:11114884).

Gene Wiki entry for RNMT Gene

Additional gene information for RNMT Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNMT Gene

Genomics for RNMT Gene

GeneHancer (GH) Regulatory Elements for RNMT Gene

Promoters and enhancers for RNMT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I013725 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 567.1 +0.0 13 3.2 PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 SLC30A9 RNMT FAM210A PTPN2 CEP192
GH18I012946 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.8 -778.9 -778940 3.3 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SEH1L CEP192 PSMG2 PTPN2 RNMT ENSG00000267249 GC18M015028
GH18I012989 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.8 -735.5 -735492 3.7 YBX1 FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 SP3 NFYC CEP192 ENSG00000266969 PSMG2 PTPN2 PRELID3A CEP76 ENSG00000267249 ENSG00000267199 ENSG00000260302 RNMT
GH18I013824 Promoter/Enhancer 1.5 FANTOM5 Ensembl 11 +97.6 97554 0.4 HDGF RB1 ZNF133 ZNF2 KLF5 ZBTB7B ZNF48 RAD21 ZNF335 EGR1 MC5R ZNF519 ENSG00000267756 CEP192 PTPN2 RNMT GC18M015416
GH18I013379 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.6 -344.9 -344910 4 USF1 RXRA ZSCAN4 MAX REST ZNF398 MNT ZIC2 RAD21 NR2F2 LDLRAD4 RNMT PTPN2 CEP192 ENSG00000267393 LDLRAD4-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNMT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNMT gene promoter:

Genomic Locations for RNMT Gene

Genomic Locations for RNMT Gene
chr18:13,726,647-13,764,558
(GRCh38/hg38)
Size:
37,912 bases
Orientation:
Plus strand
chr18:13,726,659-13,764,557
(GRCh37/hg19)

Genomic View for RNMT Gene

Genes around RNMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNMT Gene

Proteins for RNMT Gene

  • Protein details for RNMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43148-MCES_HUMAN
    Recommended name:
    mRNA cap guanine-N7 methyltransferase
    Protein Accession:
    O43148
    Secondary Accessions:
    • B0YJ90
    • D3DUJ5
    • O94996
    • Q9UIJ9

    Protein attributes for RNMT Gene

    Size:
    476 amino acids
    Molecular mass:
    54844 Da
    Quaternary structure:
    • Interacts with importin alpha, leading to stimulate both RNA-binding and methyltransferase activity (PubMed:11114884). Interaction with importin alpha and beta is required for its nuclear localization, importin beta dissociating in response to RanGTP, allowing RNMT-importin alpha to bind RNA substrates (PubMed:11114884). Interacts with elongating form of polymerase II and RNGTT (PubMed:9705270). Interacts with RAM/FAM103A1, this interaction significantly enhances RNA-binding and cap methyltransferase activity (PubMed:22099306, Ref.14).

    Three dimensional structures from OCA and Proteopedia for RNMT Gene

    Alternative splice isoforms for RNMT Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNMT Gene

Selected DME Specific Peptides for RNMT Gene

O43148:
  • EQADMMLRNAC
  • RSQSRIF
  • CGKGGDL
  • EMAKKYNM
  • FDICSCQF
  • YPLFGCKYDF

Post-translational modifications for RNMT Gene

  • Ubiquitination at isoforms=2163 and isoforms=2208
  • Modification sites at PhosphoSitePlus

Domains & Families for RNMT Gene

Gene Families for RNMT Gene

Protein Domains for RNMT Gene

Graphical View of Domain Structure for InterPro Entry

O43148

UniProtKB/Swiss-Prot:

MCES_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.
genes like me logo Genes that share domains with RNMT: view

Function for RNMT Gene

Molecular function for RNMT Gene

GENATLAS Biochemistry:
messenger RNA (guanine-7) cap methyltransferase
UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + G(5)pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5)pppR-RNA.
UniProtKB/Swiss-Prot EnzymeRegulation:
Methyltransferase activity is activated by RAM/FAM103A1 (PubMed:27422871).
UniProtKB/Swiss-Prot Function:
Catalytic subunit of the mRNA-capping methyltransferase RNMT:RAM/FAM103A1 complex that methylates the N7 position of the added guanosine to the 5-cap structure of mRNAs (PubMed:9790902, PubMed:9705270, PubMed:10347220, PubMed:11114884, PubMed:22099306, PubMed:27422871). Binds RNA containing 5-terminal GpppC (PubMed:11114884).

Enzyme Numbers (IUBMB) for RNMT Gene

Phenotypes From GWAS Catalog for RNMT Gene

Gene Ontology (GO) - Molecular Function for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS,IMP 9790902
GO:0004482 mRNA (guanine-N7-)-methyltransferase activity TAS --
GO:0005515 protein binding IPI 22099306
GO:0008168 methyltransferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with RNMT: view
genes like me logo Genes that share phenotypes with RNMT: view

Animal Models for RNMT Gene

MGI Knock Outs for RNMT:
  • Rnmt tm1b(KOMP)Mbp

Animal Model Products

  • Taconic Biosciences Mouse Models for RNMT

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RNMT

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNMT Gene

Localization for RNMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNMT Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNMT gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus TAS,IDA 9790902
GO:0005654 nucleoplasm TAS --
GO:0005845 mRNA cap binding complex IDA 22099306
GO:0031533 mRNA cap methyltransferase complex IDA 27422871
genes like me logo Genes that share ontologies with RNMT: view

Pathways & Interactions for RNMT Gene

genes like me logo Genes that share pathways with RNMT: view

Pathways by source for RNMT Gene

1 BioSystems pathway for RNMT Gene
1 KEGG pathway for RNMT Gene

Gene Ontology (GO) - Biological Process for RNMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006370 7-methylguanosine mRNA capping TAS,IMP --
GO:0006397 mRNA processing IEA --
GO:0032259 methylation IEA --
GO:0106005 RNA 5-cap (guanine-N7)-methylation IEA --
genes like me logo Genes that share ontologies with RNMT: view

No data available for SIGNOR curated interactions for RNMT Gene

Drugs & Compounds for RNMT Gene

(1) Drugs for RNMT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
s-adenosylhomocysteine Experimental Pharma 0

(2) Additional Compounds for RNMT Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
s-adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
  • 2-S-Adenosyl-L-methionine
  • 5'-Deoxyadenosine-5'-L-methionine disulfate ditosylate
  • 5'-Deoxyadenosine-5'-L-methionine disulphate ditosylate
  • Active methionine
29908-03-0
genes like me logo Genes that share compounds with RNMT: view

Transcripts for RNMT Gene

Unigene Clusters for RNMT Gene

RNA (guanine-7-) methyltransferase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for RNMT

Alternative Splicing Database (ASD) splice patterns (SP) for RNMT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for RNMT Gene

GeneLoc Exon Structure for
RNMT
ECgene alternative splicing isoforms for
RNMT

Expression for RNMT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNMT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNMT Gene

This gene is overexpressed in Breast (21.2) and Peripheral blood mononuclear cells (11.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNMT Gene



Protein tissue co-expression partners for RNMT Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNMT Gene:

RNMT

SOURCE GeneReport for Unigene cluster for RNMT Gene:

Hs.592347

mRNA Expression by UniProt/SwissProt for RNMT Gene:

O43148-MCES_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for RNMT Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RNMT: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNMT Gene

Orthologs for RNMT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RNMT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNMT 33 34
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia RNMT 33
  • 91.53 (n)
-- 34
  • 90 (a)
OneToMany
-- 34
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia RNMT 33 34
  • 89.68 (n)
rat
(Rattus norvegicus)
Mammalia Rnmt 33
  • 82.34 (n)
mouse
(Mus musculus)
Mammalia Rnmt 33 16 34
  • 81.77 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 81 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RNMT 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNMT 33 34
  • 74.15 (n)
lizard
(Anolis carolinensis)
Reptilia RNMT 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnmt 33
  • 71.24 (n)
Str.2305 33
African clawed frog
(Xenopus laevis)
Amphibia xCMT1 33
zebrafish
(Danio rerio)
Actinopterygii rnmt 33 34
  • 62.91 (n)
wufi09c12 33
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Bd 33 34 35
  • 53.92 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003460 33
  • 49.58 (n)
worm
(Caenorhabditis elegans)
Secernentea tag-72 33 34
  • 51.51 (n)
C25A1.3 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ABD1 34 36
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6979 34
  • 46 (a)
OneToOne
Species where no ortholog for RNMT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNMT Gene

ENSEMBL:
Gene Tree for RNMT (if available)
TreeFam:
Gene Tree for RNMT (if available)

Paralogs for RNMT Gene

(1) SIMAP similar genes for RNMT Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RNMT: view

No data available for Paralogs for RNMT Gene

Variants for RNMT Gene

Sequence variations from dbSNP and Humsavar for RNMT Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000050802 -- 13,756,044(+) G/A/T intron_variant
rs1000141547 -- 13,754,456(+) G/C intron_variant
rs1000204455 -- 13,762,234(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000250024 -- 13,742,246(+) G/T intron_variant
rs1000280335 -- 13,726,478(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNMT Gene

Variant ID Type Subtype PubMed ID
esv8144 CNV gain 19470904
nsv576529 CNV gain 21841781

Variation tolerance for RNMT Gene

Residual Variation Intolerance Score: 73.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNMT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNMT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNMT Gene

Disorders for RNMT Gene

Additional Disease Information for RNMT

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNMT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNMT Gene

Publications for RNMT Gene

  1. Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. (PMID: 9705270) Pillutla RC … Shatkin AJ (The Journal of biological chemistry 1998) 2 3 4 58
  2. Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM. (PMID: 27422871) Varshney D … Cowling VH (Nucleic acids research 2016) 3 4 58
  3. RAM/Fam103a1 is required for mRNA cap methylation. (PMID: 22099306) Gonatopoulos-Pournatzis T … Cowling VH (Molecular cell 2011) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1). (PMID: 19161160) Franke B … Blom HJ (Birth defects research. Part A, Clinical and molecular teratology 2009) 3 44 58

Products for RNMT Gene

  • Addgene plasmids for RNMT

Sources for RNMT Gene

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