Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease ... See more...

Aliases for RNH1 Gene

Aliases for RNH1 Gene

  • Ribonuclease/Angiogenin Inhibitor 1 2 3 4 5
  • Placental Ribonuclease Inhibitor 3 4
  • Placental RNase Inhibitor 3 4
  • Ribonuclease Inhibitor 3 4
  • RNH 3 4
  • RAI 3 4
  • Ribonuclease/Angiogenin Inhibitor 2
  • Testicular Tissue Protein Li 164 3
  • PRI 4

External Ids for RNH1 Gene

Previous HGNC Symbols for RNH1 Gene

  • RNH

Previous GeneCards Identifiers for RNH1 Gene

  • GC11M000485
  • GC11M000310

Summaries for RNH1 Gene

Entrez Gene Summary for RNH1 Gene

  • Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

GeneCards Summary for RNH1 Gene

RNH1 (Ribonuclease/Angiogenin Inhibitor 1) is a Protein Coding gene. Diseases associated with RNH1 include Simple Partial Epilepsy and Pulmonary Valve Insufficiency. Gene Ontology (GO) annotations related to this gene include ribonuclease inhibitor activity. An important paralog of this gene is CARMIL2.

UniProtKB/Swiss-Prot Summary for RNH1 Gene

  • Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Gene Wiki entry for RNH1 Gene

Additional gene information for RNH1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNH1 Gene

Genomics for RNH1 Gene

GeneHancer (GH) Regulatory Elements for RNH1 Gene

Promoters and enhancers for RNH1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNH1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNH1

Top Transcription factor binding sites by QIAGEN in the RNH1 gene promoter:
  • AML1a
  • E47
  • GATA-1
  • GR

Genomic Locations for RNH1 Gene

Genomic Locations for RNH1 Gene
chr11:494,512-507,300
(GRCh38/hg38)
Size:
12,789 bases
Orientation:
Minus strand
chr11:494,512-507,300
(GRCh37/hg19)
Size:
12,789 bases
Orientation:
Minus strand

Genomic View for RNH1 Gene

Genes around RNH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNH1 Gene

Proteins for RNH1 Gene

  • Protein details for RNH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13489-RINI_HUMAN
    Recommended name:
    Ribonuclease inhibitor
    Protein Accession:
    P13489
    Secondary Accessions:
    • Q8IZK8
    • Q96FD7
    • Q9BQ80
    • Q9UDK6

    Protein attributes for RNH1 Gene

    Size:
    461 amino acids
    Molecular mass:
    49973 Da
    Quaternary structure:
    • Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.

    Three dimensional structures from OCA and Proteopedia for RNH1 Gene

neXtProt entry for RNH1 Gene

Post-translational modifications for RNH1 Gene

  • The N-terminus is blocked.
  • At least 30 of the 32 cysteine residues are in the reduced form.
  • Ubiquitination at Lys89, Lys238, Lys321, Lys452, and Lys454
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNH1 Gene

Domains & Families for RNH1 Gene

Gene Families for RNH1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RNH1 Gene

Blocks:
  • Leucine-rich repeat, ribonuclease inhibitor subtype
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNH1 Gene

GenScript: Design optimal peptide antigens:
  • Ribonuclease/angiogenin inhibitor 1 (RINI_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13489

UniProtKB/Swiss-Prot:

RINI_HUMAN :
  • The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.
Domain:
  • The LRR domain forms a horseshoe-shaped structure that interacts tightly with target RNases via a large protein interaction surface on its interior side.
genes like me logo Genes that share domains with RNH1: view

Function for RNH1 Gene

Molecular function for RNH1 Gene

UniProtKB/Swiss-Prot Function:
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.

Phenotypes From GWAS Catalog for RNH1 Gene

Gene Ontology (GO) - Molecular Function for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 2742853
GO:0008428 ribonuclease inhibitor activity IDA 3470787
genes like me logo Genes that share ontologies with RNH1: view
genes like me logo Genes that share phenotypes with RNH1: view

Animal Models for RNH1 Gene

MGI Knock Outs for RNH1:
  • Rnh1 Rnh1<tm1Rall>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNH1

Clone Products

  • Addgene plasmids for RNH1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNH1 Gene

Localization for RNH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNH1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNH1 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0032311 angiogenin-PRI complex IPI 3470787
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with RNH1: view

Pathways & Interactions for RNH1 Gene

PathCards logo

SuperPathways for RNH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006402 mRNA catabolic process NAS 2081593
GO:0043086 negative regulation of catalytic activity IEA --
GO:0045765 regulation of angiogenesis IDA 3470787
genes like me logo Genes that share ontologies with RNH1: view

No data available for Pathways by source and SIGNOR curated interactions for RNH1 Gene

Drugs & Compounds for RNH1 Gene

No Compound Related Data Available

Transcripts for RNH1 Gene

mRNA/cDNA for RNH1 Gene

8 REFSEQ mRNAs :
31 NCBI additional mRNA sequence :
24 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNH1

Clone Products

  • Addgene plasmids for RNH1

Alternative Splicing Database (ASD) splice patterns (SP) for RNH1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a ·
SP1: - - - - - - -
SP2: - - - - - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - -
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - -
SP10: - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - -
SP13: - -
SP14: - -
SP15: - - - - - - - - - - - - - - - - - -
SP16: - - - - - - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - - - -
SP19: - - - - - -
SP20: - - - - -
SP21: - -
SP22: - - - - - - - - - - - -
SP23: - - - - - - - - - - - - - - - -
SP24: - - - - - - - - - - - - - - - - - -
SP25: - - - - -
SP26: - - - - - - - -
SP27: - - - - -
SP28: - - -
SP29:
SP30: - -
SP31: - -
SP32: - -

ExUns: 10b · 10c · 10d · 10e ^ 11a · 11b · 11c · 11d · 11e · 11f · 11g ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b · 14c ^ 15a · 15b · 15c · 15d · 15e ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5:
SP6: - - - - -
SP7: - - - - -
SP8: - - - - - - -
SP9: - - - - -
SP10:
SP11: - - - - -
SP12: - - - - -
SP13: - - - - -
SP14: - - - - - - -
SP15: - -
SP16: - - - - -
SP17: - - - - -
SP18:
SP19: - - - - - - -
SP20: - - - - -
SP21: - - - - - - - - -
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29: - -
SP30: - - - - - - -
SP31:
SP32: - -

ExUns: 15f · 15g · 15h ^ 16 ^ 17 ^ 18a · 18b ^ 19
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:
SP28:
SP29: - - - - - -
SP30:
SP31:
SP32:

Relevant External Links for RNH1 Gene

GeneLoc Exon Structure for
RNH1

Expression for RNH1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNH1 Gene

Protein differential expression in normal tissues from HIPED for RNH1 Gene

This gene is overexpressed in Bone marrow stromal cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNH1 Gene



Protein tissue co-expression partners for RNH1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNH1

SOURCE GeneReport for Unigene cluster for RNH1 Gene:

Hs.530687

Evidence on tissue expression from TISSUES for RNH1 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Intestine(4.5)
  • Skin(4.2)
  • Lung(3)
  • Blood(2.9)
  • Eye(2.7)
  • Heart(2.5)
  • Pancreas(2.3)
  • Kidney(2.1)
  • Muscle(2.1)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with RNH1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNH1 Gene

Orthologs for RNH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNH1 31 30
  • 99.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNH1 31 30
  • 81.57 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rnh1 17 31 30
  • 78.97 (n)
rat
(Rattus norvegicus)
Mammalia Rnh1 30
  • 78.68 (n)
dog
(Canis familiaris)
Mammalia RNH1 31 30
  • 78.1 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNH1 31
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNH1 31
  • 27 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNH1 31 30
  • 59.62 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNH1 31
  • 46 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii RNH1 (23 of 23) 31
  • 40 (a)
OneToMany
RNH1 (22 of 23) 31
  • 37 (a)
OneToMany
RNH1 (21 of 23) 31
  • 37 (a)
OneToMany
RNH1 (7 of 23) 31
  • 35 (a)
OneToMany
RNH1 (13 of 23) 31
  • 30 (a)
OneToMany
RNH1 (10 of 23) 31
  • 25 (a)
OneToMany
RNH1 (5 of 23) 31
  • 15 (a)
OneToMany
RNH1 (20 of 23) 31
  • 14 (a)
OneToMany
RNH1 (18 of 23) 31
  • 12 (a)
OneToMany
RNH1 (9 of 23) 31
  • 11 (a)
OneToMany
RNH1 (15 of 23) 31
  • 11 (a)
OneToMany
RNH1 (6 of 23) 31
  • 10 (a)
OneToMany
RNH1 (4 of 23) 31
  • 10 (a)
OneToMany
RNH1 (2 of 23) 31
  • 10 (a)
OneToMany
RNH1 (17 of 23) 31
  • 10 (a)
OneToMany
RNH1 (11 of 23) 31
  • 10 (a)
OneToMany
RNH1 (16 of 23) 31
  • 10 (a)
OneToMany
RNH1 (3 of 23) 31
  • 10 (a)
OneToMany
RNH1 (1 of 23) 31
  • 10 (a)
OneToMany
RNH1 (19 of 23) 31
  • 10 (a)
OneToMany
RNH1 (14 of 23) 31
  • 10 (a)
OneToMany
RNH1 (8 of 23) 31
  • 9 (a)
OneToMany
RNH1 (12 of 23) 31
  • 8 (a)
OneToMany
Species where no ortholog for RNH1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNH1 Gene

ENSEMBL:
Gene Tree for RNH1 (if available)
TreeFam:
Gene Tree for RNH1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNH1: view image

Paralogs for RNH1 Gene

Paralogs for RNH1 Gene

(12) SIMAP similar genes for RNH1 Gene using alignment to 10 proteins:

  • RINI_HUMAN
  • E9PIK5_HUMAN
  • E9PIM9_HUMAN
  • E9PLZ3_HUMAN
  • E9PMA9_HUMAN
  • E9PMI1_HUMAN
  • E9PMJ3_HUMAN
  • E9PMN0_HUMAN
  • E9PR82_HUMAN
  • H0YCR7_HUMAN
genes like me logo Genes that share paralogs with RNH1: view

Variants for RNH1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNH1 Gene