Aliases for RNH1 Gene
External Ids for RNH1 Gene
Previous HGNC Symbols for RNH1 Gene
Previous GeneCards Identifiers for RNH1 Gene
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
GeneCards Summary for RNH1 Gene
RNH1 (Ribonuclease/Angiogenin Inhibitor 1) is a Protein Coding gene. Diseases associated with RNH1 include Simple Partial Epilepsy and Pulmonary Valve Insufficiency. Gene Ontology (GO) annotations related to this gene include ribonuclease inhibitor activity. An important paralog of this gene is CARMIL2.
UniProtKB/Swiss-Prot Summary for RNH1 Gene
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.