Aliases for RNH1 Gene
External Ids for RNH1 Gene
Previous HGNC Symbols for RNH1 Gene
Previous GeneCards Identifiers for RNH1 Gene
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
GeneCards Summary for RNH1 Gene
RNH1 (Ribonuclease/Angiogenin Inhibitor 1) is a Protein Coding gene. Diseases associated with RNH1 include Dermatitis, Atopic, 9 and Simple Partial Epilepsy. Gene Ontology (GO) annotations related to this gene include ribonuclease inhibitor activity. An important paralog of this gene is CARMIL2.
UniProtKB/Swiss-Prot Summary for RNH1 Gene
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.