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Aliases for RNFT2 Gene

Aliases for RNFT2 Gene

  • Ring Finger Protein, Transmembrane 2 2 3 5
  • Transmembrane Protein 118 2 3 4
  • TMEM118 3 4
  • RING Finger And Transmembrane Domain-Containing Protein 2 3

External Ids for RNFT2 Gene

Previous HGNC Symbols for RNFT2 Gene

  • TMEM118

Previous GeneCards Identifiers for RNFT2 Gene

  • GC12P115660
  • GC12P117176
  • GC12P114185

Summaries for RNFT2 Gene

GeneCards Summary for RNFT2 Gene

RNFT2 (Ring Finger Protein, Transmembrane 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include electron transfer activity and iron-sulfur cluster binding. An important paralog of this gene is RNFT1.

Additional gene information for RNFT2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNFT2 Gene

Genomics for RNFT2 Gene

GeneHancer (GH) Regulatory Elements for RNFT2 Gene

Promoters and enhancers for RNFT2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J116735 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 650.7 -0.9 -864 3 CLOCK MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D GLIS1 RNFT2 C12orf49 FBXW8 MED13L ENSG00000258034 RPL36P15 MAP1LC3B2 PIR60746
GH12J116716 Enhancer 1 Ensembl ENCODE 12.1 -20.7 -20665 1.3 INSM2 FEZF1 ZNF335 GLIS2 ZNF366 ZSCAN5C SCRT2 ZNF680 OVOL3 TSHZ1 RNFT2 C12orf49 PIR42431 GC12M116721 ENSG00000257654
GH12J116713 Enhancer 0.4 ENCODE 12.1 -24.8 -24794 0.1 CTCF SCRT2 ZIC2 C12orf49 RNFT2 GC12M116721 PIR42431 ENSG00000257654
GH12J116839 Enhancer 0.5 FANTOM5 2 +101.6 101578 0.1 ZFHX2 ZNF366 EGR2 NOS1 RNFT2 HRK GC12M116856 ENSG00000275467
GH12J116759 Enhancer 1.1 Ensembl ENCODE 0.3 +22.0 21991 1.6 HDGF ATF1 SMAD1 POLR2B E2F8 ZNF143 ATF7 SNIP1 GMEB1 SMARCA4 FBXW8 MED13L ENSG00000258034 RPL21P105 GC12P116783 RNFT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNFT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNFT2 gene promoter:
  • Msx-1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for RNFT2 Gene

Genomic Locations for RNFT2 Gene
115,454 bases
Plus strand
115,341 bases
Plus strand

Genomic View for RNFT2 Gene

Genes around RNFT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNFT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNFT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNFT2 Gene

Proteins for RNFT2 Gene

  • Protein details for RNFT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger and transmembrane domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • E9PAM7
    • Q96SU5

    Protein attributes for RNFT2 Gene

    444 amino acids
    Molecular mass:
    48965 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH11878.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNFT2 Gene


neXtProt entry for RNFT2 Gene

Post-translational modifications for RNFT2 Gene

  • Ubiquitination at Lys360
  • Modification sites at PhosphoSitePlus

Other Protein References for RNFT2 Gene

No data available for DME Specific Peptides for RNFT2 Gene

Domains & Families for RNFT2 Gene

Gene Families for RNFT2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNFT2 Gene

Suggested Antigen Peptide Sequences for RNFT2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNFT2: view

No data available for UniProtKB/Swiss-Prot for RNFT2 Gene

Function for RNFT2 Gene

Phenotypes From GWAS Catalog for RNFT2 Gene

Gene Ontology (GO) - Molecular Function for RNFT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNFT2: view
genes like me logo Genes that share phenotypes with RNFT2: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNFT2 Gene

Localization for RNFT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNFT2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNFT2 gene
Compartment Confidence
plasma membrane 2
mitochondrion 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNFT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNFT2: view

Pathways & Interactions for RNFT2 Gene

SuperPathways for RNFT2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNFT2 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNFT2 Gene

Drugs & Compounds for RNFT2 Gene

No Compound Related Data Available

Transcripts for RNFT2 Gene

mRNA/cDNA for RNFT2 Gene

Unigene Clusters for RNFT2 Gene

Ring finger protein, transmembrane 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNFT2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15
SP2: -
SP4: - -

Relevant External Links for RNFT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNFT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNFT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNFT2 Gene

This gene is overexpressed in Brain - Cortex (x4.7) and Brain - Frontal Cortex (BA9) (x4.2).

Protein differential expression in normal tissues from HIPED for RNFT2 Gene

This gene is overexpressed in Ovary (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNFT2 Gene

Protein tissue co-expression partners for RNFT2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNFT2 Gene:


SOURCE GeneReport for Unigene cluster for RNFT2 Gene:


Evidence on tissue expression from TISSUES for RNFT2 Gene

  • Muscle(4)
  • Nervous system(3)
genes like me logo Genes that share expression patterns with RNFT2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNFT2 Gene

Orthologs for RNFT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNFT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNFT2 34 33
  • 99.32 (n)
(Bos Taurus)
Mammalia RNFT2 34 33
  • 91.22 (n)
(Canis familiaris)
Mammalia RNFT2 34
  • 90 (a)
(Mus musculus)
Mammalia Rnft2 16 34 33
  • 87.54 (n)
(Rattus norvegicus)
Mammalia Rnft2 33
  • 87.24 (n)
(Monodelphis domestica)
Mammalia RNFT2 34
  • 73 (a)
(Gallus gallus)
Aves RNFT2 34 33
  • 79.02 (n)
(Anolis carolinensis)
Reptilia RNFT2 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnft2 33
  • 66.82 (n)
(Danio rerio)
Actinopterygii rnft2 34 33
  • 67.91 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004640 33
  • 42.61 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13605 34
  • 13 (a)
(Caenorhabditis elegans)
Secernentea ZC13.1 34 33
  • 41.76 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G01960 33
  • 44.01 (n)
(Oryza sativa)
Liliopsida Os01g0168400 33
  • 44.25 (n)
Species where no ortholog for RNFT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNFT2 Gene

Gene Tree for RNFT2 (if available)
Gene Tree for RNFT2 (if available)
Evolutionary constrained regions (ECRs) for RNFT2: view image

Paralogs for RNFT2 Gene

Paralogs for RNFT2 Gene

(1) SIMAP similar genes for RNFT2 Gene using alignment to 5 proteins:

  • F8W6L4_HUMAN
genes like me logo Genes that share paralogs with RNFT2: view

Variants for RNFT2 Gene

Sequence variations from dbSNP and Humsavar for RNFT2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000015444 -- 116,810,773(+) G/A intron_variant
rs1000067131 -- 116,765,014(+) G/A intron_variant
rs1000112560 -- 116,792,078(+) G/C intron_variant
rs1000117920 -- 116,836,069(+) G/C intron_variant
rs1000120352 -- 116,817,082(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNFT2 Gene

Variant ID Type Subtype PubMed ID
nsv898 CNV insertion 18451855
nsv832523 CNV gain+loss 17160897
nsv53492 CNV deletion 16902084
nsv1039046 CNV gain 25217958
esv3630859 CNV loss 21293372
esv3630858 CNV loss 21293372
esv3630857 CNV gain 21293372
esv3630848 CNV gain 21293372
esv3580484 CNV loss 25503493
esv2672682 CNV deletion 23128226
esv2660236 CNV deletion 23128226
esv2658721 CNV deletion 23128226
esv1515587 CNV deletion 17803354

Variation tolerance for RNFT2 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.49; 29.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNFT2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNFT2 Gene

Disorders for RNFT2 Gene

Additional Disease Information for RNFT2

No disorders were found for RNFT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNFT2 Gene

Publications for RNFT2 Gene

  1. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58

Products for RNFT2 Gene

Sources for RNFT2 Gene

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