Aliases for RNF6 Gene
External Ids for RNF6 Gene
Previous GeneCards Identifiers for RNF6 Gene
The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF6 Gene
RNF6 (Ring Finger Protein 6) is a Protein Coding gene. Diseases associated with RNF6 include Esophageal Cancer and Squamous Cell Carcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and androgen receptor binding. An important paralog of this gene is RLIM.
UniProtKB/Swiss-Prot for RNF6 Gene
E3 ubiquitin-protein ligase mediating Lys-48-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates Lys-6 and Lys-27-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.