The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008] See more...

Aliases for RNF44 Gene

Aliases for RNF44 Gene

  • Ring Finger Protein 44 2 3 5
  • RING Finger Protein 44 3 4
  • KIAA1100 2 4
  • RNF44 5

External Ids for RNF44 Gene

Previous GeneCards Identifiers for RNF44 Gene

  • GC00U991271
  • GC05M175889
  • GC05M175934
  • GC05M175886
  • GC05M170877

Summaries for RNF44 Gene

Entrez Gene Summary for RNF44 Gene

  • The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF44 Gene

RNF44 (Ring Finger Protein 44) is a Protein Coding gene. An important paralog of this gene is RNF38.

Additional gene information for RNF44 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF44 Gene

Genomics for RNF44 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNF44 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF44 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF44

Top Transcription factor binding sites by QIAGEN in the RNF44 gene promoter:
  • AML1a
  • c-Ets-1
  • COMP1
  • MIF-1
  • Sox9
  • Spz1
  • SRF
  • SRF (504 AA)

Genomic Locations for RNF44 Gene

Genomic Locations for RNF44 Gene
17,503 bases
Minus strand
11,329 bases
Minus strand

Genomic View for RNF44 Gene

Genes around RNF44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF44 Gene

Proteins for RNF44 Gene

  • Protein details for RNF44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 44
    Protein Accession:
    Secondary Accessions:
    • B4DYE0
    • Q8ND05
    • Q9UPQ2

    Protein attributes for RNF44 Gene

    432 amino acids
    Molecular mass:
    47728 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA83052.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF44 Gene


neXtProt entry for RNF44 Gene

Post-translational modifications for RNF44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF44 Gene

Domains & Families for RNF44 Gene

Gene Families for RNF44 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF44 Gene

  • Zn-finger, RING

Suggested Antigen Peptide Sequences for RNF44 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ61466, highly similar to Homo sapiens ring finger protein 44 (RNF44), mRNA (B4DYE0_HUMAN)
  • RING finger protein 44 (RNF44_HUMAN)
genes like me logo Genes that share domains with RNF44: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNF44 Gene

Function for RNF44 Gene

Phenotypes From GWAS Catalog for RNF44 Gene

Gene Ontology (GO) - Molecular Function for RNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF44: view
genes like me logo Genes that share phenotypes with RNF44: view

Animal Model Products

CRISPR Products

miRNA for RNF44 Gene

miRTarBase miRNAs that target RNF44

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF44

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF44 Gene

Localization for RNF44 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF44 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF44 Gene

Pathways & Interactions for RNF44 Gene

PathCards logo

SuperPathways for RNF44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF44 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF44 Gene

Drugs & Compounds for RNF44 Gene

No Compound Related Data Available

Transcripts for RNF44 Gene

mRNA/cDNA for RNF44 Gene

8 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF44

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF44 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP3: -
SP4: -
SP7: -

Relevant External Links for RNF44 Gene

GeneLoc Exon Structure for

Expression for RNF44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF44 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Spleen (Hematopoietic System)

Protein differential expression in normal tissues from HIPED for RNF44 Gene

This gene is overexpressed in Platelet (39.3) and Pancreas (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF44 Gene

Protein tissue co-expression partners for RNF44 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF44

SOURCE GeneReport for Unigene cluster for RNF44 Gene:


Evidence on tissue expression from TISSUES for RNF44 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RNF44: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF44 Gene

Orthologs for RNF44 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF44 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF44 30 31
  • 99.84 (n)
(Canis familiaris)
Mammalia RNF44 30 31
  • 92.65 (n)
(Bos Taurus)
Mammalia RNF44 30 31
  • 91.28 (n)
(Rattus norvegicus)
Mammalia Rnf44 30
  • 89.52 (n)
(Mus musculus)
Mammalia Rnf44 30 17 31
  • 89.33 (n)
(Monodelphis domestica)
Mammalia RNF44 31
  • 87 (a)
(Gallus gallus)
Aves RNF44 30 31
  • 79.81 (n)
(Anolis carolinensis)
Reptilia RNF44 31
  • 77 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rnf44 30
  • 72.51 (n)
(Danio rerio)
Actinopterygii rnf44 30 31
  • 69.39 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta mura 31
  • 13 (a)
Species where no ortholog for RNF44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RNF44 Gene

Gene Tree for RNF44 (if available)
Gene Tree for RNF44 (if available)
Evolutionary constrained regions (ECRs) for RNF44: view image

Paralogs for RNF44 Gene

Paralogs for RNF44 Gene

(1) SIMAP similar genes for RNF44 Gene using alignment to 5 proteins:

  • H0Y9W0_HUMAN
genes like me logo Genes that share paralogs with RNF44: view

Variants for RNF44 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF44 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
719431 Benign: not provided 176,529,534(-) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for RNF44 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNF44 Gene

Variant ID Type Subtype PubMed ID
esv2731169 CNV deletion 23290073
esv2731170 CNV deletion 23290073
esv2731171 CNV deletion 23290073
nsv1112430 CNV deletion 24896259
nsv1148759 CNV deletion 26484159
nsv471056 CNV loss 18288195
nsv516244 CNV loss 19592680
nsv600344 CNV loss 21841781
nsv600345 CNV loss 21841781
nsv823350 CNV gain 20364138
nsv950722 CNV deletion 24416366

Variation tolerance for RNF44 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF44 Gene

Disorders for RNF44 Gene

Additional Disease Information for RNF44

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for RNF44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF44 Gene

Publications for RNF44 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4
  2. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 41
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. The ubiquitin ligase STUB1 regulates stability and activity of RUNX1 and RUNX1-RUNX1T1. (PMID: 28536267) Yonezawa T … Goyama S (The Journal of biological chemistry 2017) 3

Products for RNF44 Gene

Sources for RNF44 Gene