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Aliases for RNF44 Gene

Aliases for RNF44 Gene

  • Ring Finger Protein 44 2 3 5
  • RING Finger Protein 44 3
  • KIAA1100 4

External Ids for RNF44 Gene

Previous GeneCards Identifiers for RNF44 Gene

  • GC00U991271
  • GC05M175889
  • GC05M175934
  • GC05M175886
  • GC05M170877

Summaries for RNF44 Gene

Entrez Gene Summary for RNF44 Gene

  • The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF44 Gene

RNF44 (Ring Finger Protein 44) is a Protein Coding gene. An important paralog of this gene is RNF38.

Additional gene information for RNF44 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF44 Gene

Genomics for RNF44 Gene

GeneHancer (GH) Regulatory Elements for RNF44 Gene

Promoters and enhancers for RNF44 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J176529 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 663.5 +9.1 9114 10.3 MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A ZNF610 RNF44 GC05P176534 ENSG00000250909 NSD1 ENSG00000251414 FAF2 RPL21P60 ZNF346-IT1 UIMC1 CDHR2
GH05J177021 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.2 -479.1 -479128 2.7 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF346 UIMC1 FAF2 NSD1 ENSG00000247679 ENSG00000251414 ENSG00000250909 FAM193B LOC202181 FGFR4
GH05J176539 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.9 -2.4 -2372 11.8 HDGF FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 CDHR2 RN7SL684P FAF2 NSD1 ENSG00000250909 ENSG00000251414 ZNF346-IT1 ZNF346 RNF44 UIMC1
GH05J175852 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.1 +689.7 689673 1.5 FOXA2 SIN3A THRB HSF1 CREM MIXL1 CEBPB ZHX2 MIER2 TGIF2 FAF2 RNF44 SIMC1 PIR44146 LOC105377744 CPLX2 GC05P175702
GH05J176502 Enhancer 0.4 FANTOM5 ENCODE 4.9 +39.9 39866 1.3 RNF44 CLTB PIR40188 GC05P176517 FAF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF44 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF44 gene promoter:

Genomic Locations for RNF44 Gene

Genomic Locations for RNF44 Gene
chr5:176,526,697-176,543,413
(GRCh38/hg38)
Size:
16,717 bases
Orientation:
Minus strand
chr5:175,953,698-175,965,026
(GRCh37/hg19)

Genomic View for RNF44 Gene

Genes around RNF44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF44 Gene

Proteins for RNF44 Gene

  • Protein details for RNF44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L0R7-RNF44_HUMAN
    Recommended name:
    RING finger protein 44
    Protein Accession:
    Q7L0R7
    Secondary Accessions:
    • B4DYE0
    • Q8ND05
    • Q9UPQ2

    Protein attributes for RNF44 Gene

    Size:
    432 amino acids
    Molecular mass:
    47728 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA83052.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF44 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF44 Gene

Post-translational modifications for RNF44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF44 Gene

Domains & Families for RNF44 Gene

Gene Families for RNF44 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF44 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF44 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF44: view

No data available for UniProtKB/Swiss-Prot for RNF44 Gene

Function for RNF44 Gene

Phenotypes From GWAS Catalog for RNF44 Gene

Gene Ontology (GO) - Molecular Function for RNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF44: view
genes like me logo Genes that share phenotypes with RNF44: view

Animal Model Products

miRNA for RNF44 Gene

miRTarBase miRNAs that target RNF44

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF44 Gene

Localization for RNF44 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF44 gene
Compartment Confidence
nucleus 3
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IBA --
genes like me logo Genes that share ontologies with RNF44: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF44 Gene

Pathways & Interactions for RNF44 Gene

SuperPathways for RNF44 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF44: view

No data available for Pathways by source and SIGNOR curated interactions for RNF44 Gene

Drugs & Compounds for RNF44 Gene

No Compound Related Data Available

Transcripts for RNF44 Gene

Unigene Clusters for RNF44 Gene

Ring finger protein 44:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF44 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: -
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7: -

Relevant External Links for RNF44 Gene

GeneLoc Exon Structure for
RNF44
ECgene alternative splicing isoforms for
RNF44

Expression for RNF44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF44 Gene

Protein differential expression in normal tissues from HIPED for RNF44 Gene

This gene is overexpressed in Platelet (39.3) and Pancreas (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF44 Gene



Protein tissue co-expression partners for RNF44 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF44 Gene:

RNF44

SOURCE GeneReport for Unigene cluster for RNF44 Gene:

Hs.434888

Evidence on tissue expression from TISSUES for RNF44 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RNF44: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF44 Gene

Orthologs for RNF44 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF44 34 33
  • 99.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNF44 34 33
  • 92.65 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNF44 34 33
  • 91.28 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf44 33
  • 89.52 (n)
mouse
(Mus musculus)
Mammalia Rnf44 16 34 33
  • 89.33 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF44 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF44 34 33
  • 79.81 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF44 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf44 33
  • 72.51 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf44 34 33
  • 69.39 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mura 34
  • 13 (a)
OneToMany
Species where no ortholog for RNF44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF44 Gene

ENSEMBL:
Gene Tree for RNF44 (if available)
TreeFam:
Gene Tree for RNF44 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF44: view image

Paralogs for RNF44 Gene

Paralogs for RNF44 Gene

(1) SIMAP similar genes for RNF44 Gene using alignment to 5 proteins:

  • RNF44_HUMAN
  • B4DYE0_HUMAN
  • D6RAW5_HUMAN
  • D6RHW8_HUMAN
  • H0Y9W0_HUMAN
genes like me logo Genes that share paralogs with RNF44: view

Variants for RNF44 Gene

Sequence variations from dbSNP and Humsavar for RNF44 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000124392 -- 176,533,143(-) A/C intron_variant
rs1000407384 -- 176,533,377(-) T/C intron_variant
rs1000653990 -- 176,536,778(-) GGGGGGGG/GGGGGGG 5_prime_UTR_variant, intron_variant
rs1000654022 -- 176,528,718(-) C/T 3_prime_UTR_variant, non_coding_transcript_variant
rs1000885739 -- 176,540,623(-) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF44 Gene

Variant ID Type Subtype PubMed ID
esv2731169 CNV deletion 23290073
esv2731170 CNV deletion 23290073
esv2731171 CNV deletion 23290073
nsv1112430 CNV deletion 24896259
nsv1148759 CNV deletion 26484159
nsv471056 CNV loss 18288195
nsv516244 CNV loss 19592680
nsv600344 CNV loss 21841781
nsv600345 CNV loss 21841781
nsv823350 CNV gain 20364138
nsv950722 CNV deletion 24416366

Variation tolerance for RNF44 Gene

Residual Variation Intolerance Score: 70.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.21; 39.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF44

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF44 Gene

Disorders for RNF44 Gene

Additional Disease Information for RNF44

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNF44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF44 Gene

Publications for RNF44 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  2. Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. (PMID: 22267201) Stolk L … Lunetta KL (Nature genetics 2012) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 58

Products for RNF44 Gene

Sources for RNF44 Gene

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