Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcell... See more...
Aliases for RNF43 Gene
Aliases for RNF43 Gene
External Ids for RNF43 Gene
- HGNC: 18505
- Entrez Gene: 54894
- Ensembl: ENSG00000108375
- OMIM: 612482
- UniProtKB: Q68DV7
Previous GeneCards Identifiers for RNF43 Gene
- GC17U990330
- GC17M053787
- GC17M056429
- GC17M051791
Summaries for RNF43 Gene
-
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
GeneCards Summary for RNF43 Gene
RNF43 (Ring Finger Protein 43) is a Protein Coding gene. Diseases associated with RNF43 include Sessile Serrated Polyposis Cancer Syndrome and Hyperplastic Polyposis Syndrome. Among its related pathways are Signaling by GPCR and S45 mutants of beta-catenin arent phosphorylated. Gene Ontology (GO) annotations related to this gene include ligase activity and obsolete signal transducer activity. An important paralog of this gene is ENSG00000285897.
UniProtKB/Swiss-Prot Summary for RNF43 Gene
-
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity).
Additional gene information for RNF43 Gene
- HGNC(18505)
- Entrez Gene(54894)
- Ensembl(ENSG00000108375)
- OMIM(612482)
- UniProtKB(Q68DV7)
- Open Targets Platform(ENSG00000108375)
- Monarch Initiative
- Search for RNF43 at DataMed
- Search for RNF43 at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF43 Gene
Genomics for RNF43 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RNF43 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RNF43 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF43
- Top Transcription factor binding sites by QIAGEN in the RNF43 gene promoter:
-
- AhR
- AP-1
- Arnt
- c-Fos
- c-Jun
- FOXL1
- FOXO4
- PPAR-gamma1
- PPAR-gamma2
- SREBP-1a
Genomic Locations for RNF43 Gene
Genomic Locations for RNF43 Gene
- chr17:58,352,500-58,418,894
- (GRCh38/hg38)
- Size:
- 66,395 bases
- Orientation:
- Minus strand
- chr17:56,429,861-56,494,956
- (GRCh37/hg19)
- Size:
- 65,096 bases
- Orientation:
- Minus strand
Genomic View for RNF43 Gene
Genes around RNF43 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q22 by HGNC
- 17q22 by Entrez Gene
- 17q22 by Ensembl
RNF43 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNF43 Gene
Proteins for RNF43 Gene
-
Protein details for RNF43 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q68DV7-RNF43_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase RNF43
- Protein Accession:
- Q68DV7
- A8K4R2
- B7Z443
- B7Z5D5
- B7Z5J5
- Q65ZA4
- Q6AI04
- Q9NXD0
Protein attributes for RNF43 Gene
- Size:
- 783 amino acids
- Molecular mass:
- 85722 Da
- Quaternary structure:
-
- Interacts with AKAP8L, NONO and SFPQ (PubMed:18313049, PubMed:18655028). Interacts with FZD5 (PubMed:22895187). Identified in a complex composed of RNF43, LGR5 and RSPO1 (PubMed:23756651). Interacts with RSPO2 (PubMed:29769720). Interacts with LMBR1L (By similarity).
- SequenceCaution:
-
- Sequence=BAH12871.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
- Miscellaneous:
-
- Acts as a cytotoxic T-lymphocyte tumor antigen, suggesting that it may be used as a target for cancer immunotherapy.
Post-translational modifications for RNF43 Gene
- Autoubiquitinated.
-
Glycosylation at Asn62 and Asn92
- NX_Q68DV7 (NX_Q68DV7-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RNF43 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences RNF43 Antibody
- NSJ Bioreagents RNF43 Antibody
- GeneTex Anti-RNF43 antibody, Internal and Anti-RNF43 antibody
- Novus Biologicals Antibodies for RNF43
-
Abcam antibodies for RNF43
- Invitrogen Antibodies for RNF43 (AFLGC-RNF43)
-
Biorbyt antibodies for RNF43
-
Boster Bio Antibodies for RNF43
- Sino Biological Antibodies for RNF43
Protein Products
-
OriGene Purified Proteins for RNF43
- Search Origene for MassSpec and Protein Over-expression Lysates for RNF43
- Origene Custom Protein Services for RNF43
- Sino Biological Recombinant Proteins for RNF43
- Sino Biological Cell Lysates for RNF43
- antibodies-online: Show 8 available RNF43 Proteins ranked by validation data
- Compare Top RNF43 Proteins
-
Quality Products:
No data available for DME Specific Peptides for RNF43 Gene
Domains & Families for RNF43 Gene
Gene Families for RNF43 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted membrane proteins
Protein Domains for RNF43 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- ProtoNet:
Suggested Antigen Peptide Sequences for RNF43 Gene
- GenScript: Design optimal peptide antigens:
-
- RING finger protein 43 (RNF43_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q68DV7- Family:
-
- Belongs to the ZNRF3 family.
Function for RNF43 Gene
Molecular function for RNF43 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway (PubMed:18313049, PubMed:22575959, PubMed:22895187). Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.
Enzyme Numbers (IUBMB) for RNF43 Gene
Phenotypes From GWAS Catalog for RNF43 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 22575959 |
| GO:0005109 | frizzled binding | IPI | 22895187 |
| GO:0005515 | protein binding | IPI | 18313049 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for RNF43 Gene
- MGI mutant phenotypes for RNF43:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for RNF43:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNF43 - Select products 50% OFF >
- * RNF43 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RNF43
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF43
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF43
miRNA for RNF43 Gene
- miRTarBase miRNAs that target RNF43
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF43
- Browse OriGene Inhibitory RNA Products For RNF43
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF43
Clone Products
- Applied Biological Materials (abm): Clones for RNF43 - Select products 50% OFF >
- * RNF43 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RNF43
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF43
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RNF43 Gene
Localization for RNF43 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNF43 Gene
- Cell membrane. Single-pass type I membrane protein. Endoplasmic reticulum membrane. Single-pass type I membrane protein. Nucleus envelope. Note=According to a report, may be secreted. {ECO:0000269 PubMed:15492824}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| endoplasmic reticulum | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| cytosol | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005635 | nuclear envelope | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005789 | endoplasmic reticulum membrane | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF43 Gene
Pathways & Interactions for RNF43 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | HIV Life Cycle |
.45
|
|
| 2 | Regulation of FZD by ubiquitination | ||
| 3 | Signaling by Wnt |
.71
|
|
| 4 | Wnt signaling pathway | ||
| 5 | Signaling by GPCR | ||
Pathways by source for RNF43 Gene
8 Reactome pathways for RNF43 Gene
1 KEGG pathway for RNF43 Gene
UniProtKB/Swiss-Prot Q68DV7-RNF43_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for RNF43 Gene
Selected Interacting proteins:
Q68DV7-RNF43_HUMAN
ENSP00000463069
for RNF43 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RNF43
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process | IBA,IDA | 22895187 |
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0030178 | negative regulation of Wnt signaling pathway | IMP | 22575959 |
Transcripts for RNF43 Gene
mRNA/cDNA for RNF43 Gene
- 3 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000407977 5516 nts (view in UCSC)
- ENST00000577625 2198 nts (view in UCSC)
- ENST00000577716 4367 nts (view in UCSC)
- ENST00000580014 497 nts (view in UCSC)
- ENST00000581868 2610 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNF43 - Select products 50% OFF >
- * RNF43 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RNF43
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF43
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF43
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF43
- Browse OriGene Inhibitory RNA Products For RNF43
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF43
Clone Products
- Applied Biological Materials (abm): Clones for RNF43 - Select products 50% OFF >
- * RNF43 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RNF43
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF43
Relevant External Links for RNF43 Gene
- GeneLoc Exon Structure for
- RNF43
Expression for RNF43 Gene
mRNA differential expression in normal tissues according to GTEx for RNF43 Gene
This gene is overexpressed in Colon - Transverse (x4.3).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF43
SOURCE GeneReport for Unigene cluster for RNF43 Gene:
Hs.584916mRNA Expression by UniProt/SwissProt for RNF43 Gene:
Q68DV7-RNF43_HUMAN
Tissue specificity:
Expressed in fetal kidney, fetal lung, in colon cancer tissues, hepatocellular carcinomas and lung adenocarcinomas. Overexpressed in colorectal cancer cell lines.
Evidence on tissue expression from TISSUES for RNF43 Gene
- Intestine(3.8)
- Pancreas(2.7)
- Skin(2.6)
- Liver(2.4)
- Stomach(2.4)
- Kidney(2.3)
- Lymph node(2.2)
- Nervous system(2.2)
- Lung(2.1)
Primer Products
-
OriGene qPCR primer pairs for RNF43
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF43 Gene
Orthologs for RNF43 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RNF43 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RNF43 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RNF43 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rnf43 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rnf43 30 17 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RNF43 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RNF43 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RNF43 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RNF43 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | Y47D3B.11 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8714 31 |
|
OneToMany |
- Species where no ortholog for RNF43 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Zebrafish (Danio rerio)
Evolution for RNF43 Gene
- ENSEMBL:
- Gene Tree for RNF43 (if available)
- TreeFam:
- Gene Tree for RNF43 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RNF43: view image
Paralogs for RNF43 Gene
Variants for RNF43 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF43 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 742295 | Likely Benign: not provided | 58,358,806(-) | G/T | MISSENSE_VARIANT | |
| 834367 | Uncertain Significance: not provided | 58,358,101(-) | T/G | MISSENSE_VARIANT | |
| 834383 | Uncertain Significance: not provided | 58,358,212(-) | T/G | MISSENSE_VARIANT | |
| 835283 | Uncertain Significance: not provided | 58,358,371(-) | C/T | MISSENSE_VARIANT | |
| 842205 | Uncertain Significance: not provided | 58,358,327(-) | C/T | SYNONYMOUS_VARIANT |
Residual Variation Intolerance Score:
84.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
20.27;
99.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RNF43 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF43 Gene
Disorders for RNF43 Gene
(10) MalaCards diseases for RNF43 Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| sessile serrated polyposis cancer syndrome |
|
|
| hyperplastic polyposis syndrome |
|
|
| colorectal cancer |
|
|
| malignant epithelial mesothelioma |
|
|
| lynch syndrome |
|
|
Search RNF43 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RNF43_HUMAN- Sessile serrated polyposis cancer syndrome (SSPCS) [MIM:617108]: A rare disease characterized by multiple and/or large serrated polyps developing in the colon, and an increased personal and familial risk of colorectal cancer. A patient is diagnosed with SSPCS if at least one of the following criteria is met: the presence of at least five sessile serrated polyps proximal to the sigmoid colon, two of which are greater than 10 mm in diameter; the presence of any number of serrated polyps occurring proximal to the sigmoid colon in an individual who has a first-degree relative with serrated polyposis; the presence of more than 20 serrated polyps of any size distributed throughout the colon. Sessile serrated polyps are also known as sessile serrated adenomas (SSA) and are estimated to be responsible for 20 to 35% of all colon cancers. Individuals with SSPCS may have a strong personal or family history of extracolonic cancers. {ECO:0000269 PubMed:24512911, ECO:0000269 PubMed:27081527}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Additional Disease Information for RNF43
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for RNF43 Gene
Publications for RNF43 Gene
- A novel oncoprotein RNF43 functions in an autocrine manner in colorectal cancer. (PMID: 15492824) Yagyu R … Nakamura Y (International journal of oncology 2004) 3 4 23
- Ring finger protein 43 as a new target for cancer immunotherapy. (PMID: 15623641) Uchida N … Tahara H (Clinical cancer research : an official journal of the American Association for Cancer Research 2004) 3 4 23
- RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. (PMID: 29769720) Szenker-Ravi E … Reversade B (Nature 2018) 3 4
- The structural basis of R-spondin recognition by LGR5 and RNF43. (PMID: 23756651) Chen PH … He X (Genes & development 2013) 3 4
- ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. (PMID: 22575959) Hao HX … Cong F (Nature 2012) 3 4
ExternalLinks
Products for RNF43 Gene
- View all 10 R&D Systems RNF43 (RNF43) Products
- View all R&D Systems RNF43 (RNF43) Proteins and Enzymes
- View all 8 R&D Systems RNF43 (RNF43) Primary Antibodies
- View all R&D Systems RNF43 (RNF43) cDNA Clones
- Learn more about R&D Systems custom RNF43 antibody, protein, and immunoassay development services
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RNF43
- Search Origene for MassSpec and Protein Over-expression Lysates for RNF43
- Origene Custom Protein Services for RNF43
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF43
- Browse OriGene Inhibitory RNA Products For RNF43
- OriGene qPCR primer pairs for RNF43
- OriGene CRISPR knockouts for RNF43
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RNF43
- Sino Biological Human cDNA Clone for RNF43
- Sino Biological Recombinant Proteins for RNF43
- Sino Biological Cell Lysates for RNF43
- Sino Biological Antibodies for RNF43
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RNF43
- Novus Biologicals proteins and lysates for RNF43
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RNF43
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for RNF43 (AFLGC-RNF43)
- VectorBuilder Custom and pre-made DNA vectors for RNF43 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RNF43 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RNF43 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RNF43 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RNF43
- antibodies-online: Show 3 available RNF43 Antibodies ranked by validation data
- Compare Top RNF43 Antibodies
- antibodies-online: Search results for available RNF43 related products ranked by validation data
- antibodies-online: Show 8 available RNF43 Proteins ranked by validation data
- Compare Top RNF43 Proteins
- Quality Products:
- Horizon Cell Lines for RNF43
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF43
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF43
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RNF43
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF43
- Boster Bio Antibodies for RNF43
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for RNF43
Sources for RNF43 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB