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Aliases for RNF26 Gene

Aliases for RNF26 Gene

  • Ring Finger Protein 26 2 3
  • RING Finger Protein 26 4 5
  • Ring Finger Protein With Leucine Zipper 2
  • EC 2.3.2.27 4

External Ids for RNF26 Gene

Previous GeneCards Identifiers for RNF26 Gene

  • GC11P121204
  • GC11P120717
  • GC11P119239
  • GC11P118743
  • GC11P118742
  • GC11P118710
  • GC11P115145
  • GC11P119205

Summaries for RNF26 Gene

Entrez Gene Summary for RNF26 Gene

  • The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived from different types of cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF26 Gene

RNF26 (Ring Finger Protein 26) is a Protein Coding gene.

UniProtKB/Swiss-Prot for RNF26 Gene

  • E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of Lys-11-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379).

Additional gene information for RNF26 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF26 Gene

Genomics for RNF26 Gene

GeneHancer (GH) Regulatory Elements for RNF26 Gene

Promoters and enhancers for RNF26 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I119332 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 568.6 -0.4 -413 3.7 HDGF PKNOX1 CLOCK ATF1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 YY1 RNF26 GC11M119332 C1QTNF5
GH11I119336 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 84.8 +4.6 4564 5.3 PKNOX1 ATF1 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ATF7 RUNX3 SP3 ENSG00000245385 C1QTNF5 RNF26 CBL GC11M119337 MFRP
GH11I118906 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.8 -415.7 -415707 24.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 BCL9L DPAGT1 UBE4A ENSG00000254909 RPL23AP64 ARCN1 ENSG00000254428 RNF26 CCDC84 KMT2A
GH11I119090 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 22.3 -240.8 -240828 5.9 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 GC11M119097 H2AFX KMT2A HINFP UBE4A ARCN1 BCL9L RPL5P30 ENSG00000254909 CCDC84
GH11I119314 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 21.8 -15.7 -15691 8.2 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 POLR2B ZNF766 MCAM RNF26 CBL IFT46 RPS25 ENSG00000271751 GC11M119321 MIR6756
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF26 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF26 gene promoter:

Genomic Locations for RNF26 Gene

Genomic Locations for RNF26 Gene
chr11:119,334,500-119,337,314
(GRCh38/hg38)
Size:
2,815 bases
Orientation:
Plus strand
chr11:119,205,237-119,208,023
(GRCh37/hg19)

Genomic View for RNF26 Gene

Genes around RNF26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF26 Gene

Proteins for RNF26 Gene

  • Protein details for RNF26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY78-RNF26_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF26
    Protein Accession:
    Q9BY78
    Secondary Accessions:
    • Q542Y8

    Protein attributes for RNF26 Gene

    Size:
    433 amino acids
    Molecular mass:
    47737 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF26 Gene

Post-translational modifications for RNF26 Gene

No Post-translational modifications

Other Protein References for RNF26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF26 Gene

Domains & Families for RNF26 Gene

Gene Families for RNF26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF26 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF26: view

No data available for UniProtKB/Swiss-Prot for RNF26 Gene

Function for RNF26 Gene

Molecular function for RNF26 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102). Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 (PubMed:27368102). Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of Lys-11-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379). Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379).

Enzyme Numbers (IUBMB) for RNF26 Gene

Phenotypes From GWAS Catalog for RNF26 Gene

Gene Ontology (GO) - Molecular Function for RNF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27368102
GO:0008270 zinc ion binding NAS 11352657
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IDA 25254379
genes like me logo Genes that share ontologies with RNF26: view
genes like me logo Genes that share phenotypes with RNF26: view

miRNA for RNF26 Gene

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF26 Gene

Localization for RNF26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF26 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF26 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,IDA 25254379
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF26: view

Pathways & Interactions for RNF26 Gene

SuperPathways for RNF26 Gene

No Data Available

UniProtKB/Swiss-Prot Q9BY78-RNF26_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007032 endosome organization IDA 27368102
GO:0016567 protein ubiquitination IEA,IDA 27368102
GO:0032479 regulation of type I interferon production IDA 25254379
GO:0050687 negative regulation of defense response to virus IDA 25254379
GO:0070979 protein K11-linked ubiquitination IDA 25254379
genes like me logo Genes that share ontologies with RNF26: view

No data available for Pathways by source and SIGNOR curated interactions for RNF26 Gene

Drugs & Compounds for RNF26 Gene

No Compound Related Data Available

Transcripts for RNF26 Gene

mRNA/cDNA for RNF26 Gene

(1) REFSEQ mRNAs :
(85) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF26 Gene

No ASD Table

Relevant External Links for RNF26 Gene

GeneLoc Exon Structure for
RNF26
ECgene alternative splicing isoforms for
RNF26

Expression for RNF26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF26 Gene

Protein differential expression in normal tissues from HIPED for RNF26 Gene

This gene is overexpressed in Adrenal (46.7) and Heart (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF26 Gene



Protein tissue co-expression partners for RNF26 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF26 Gene:

RNF26

SOURCE GeneReport for Unigene cluster for RNF26 Gene:

Hs.524084

mRNA Expression by UniProt/SwissProt for RNF26 Gene:

Q9BY78-RNF26_HUMAN
Tissue specificity: Ubiquitous. Up-regulated in several cancer cell lines.

Evidence on tissue expression from TISSUES for RNF26 Gene

  • Nervous system(4.9)
  • Muscle(4.2)
  • Skin(3.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with RNF26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF26 Gene

Orthologs for RNF26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF26 33 34
  • 99.69 (n)
dog
(Canis familiaris)
Mammalia RNF26 33 34
  • 89.22 (n)
cow
(Bos Taurus)
Mammalia RNF26 33 34
  • 88.76 (n)
mouse
(Mus musculus)
Mammalia Gm9008 34
  • 87 (a)
OneToMany
Rnf26 33 16 34
  • 84.43 (n)
rat
(Rattus norvegicus)
Mammalia Rnf26 33
  • 83.73 (n)
chicken
(Gallus gallus)
Aves RNF26 33 34
  • 60.42 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf26 33
  • 49.44 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18835 33
zebrafish
(Danio rerio)
Actinopterygii rnf26 33 34
  • 50.84 (n)
Dr.18731 33
Species where no ortholog for RNF26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF26 Gene

ENSEMBL:
Gene Tree for RNF26 (if available)
TreeFam:
Gene Tree for RNF26 (if available)

Paralogs for RNF26 Gene

No data available for Paralogs for RNF26 Gene

Variants for RNF26 Gene

Sequence variations from dbSNP and Humsavar for RNF26 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000151481 -- 119,335,003(+) G/A 5_prime_UTR_variant
rs1000274665 -- 119,334,651(+) C/T 5_prime_UTR_variant
rs1000889657 -- 119,333,296(+) C/T upstream_transcript_variant
rs1000899962 -- 119,337,353(+) GG/G downstream_transcript_variant
rs1001489294 -- 119,333,647(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF26 Gene

Variant ID Type Subtype PubMed ID
nsv826104 CNV gain 20364138
nsv826103 CNV gain 20364138
nsv522705 CNV loss 19592680

Variation tolerance for RNF26 Gene

Residual Variation Intolerance Score: 47% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF26 Gene

Disorders for RNF26 Gene

Additional Disease Information for RNF26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNF26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF26 Gene

Publications for RNF26 Gene

  1. Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper. (PMID: 11352657) Katoh M (Biochemical and biophysical research communications 2001) 2 3 4 22 58
  2. An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport. (PMID: 27368102) Jongsma ML … Neefjes J (Cell 2016) 3 4 58
  3. RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms. (PMID: 25254379) Qin Y … Shu HB (PLoS pathogens 2014) 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58

Products for RNF26 Gene

Sources for RNF26 Gene

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