Aliases for RNF25 Gene
External Ids for RNF25 Gene
Previous GeneCards Identifiers for RNF25 Gene
The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF25 Gene
RNF25 (Ring Finger Protein 25) is a Protein Coding gene. Diseases associated with RNF25 include Hypomagnesemia 3, Renal. Among its related pathways are Class I MHC mediated antigen processing and presentation and Tryptophan metabolism. Gene Ontology (GO) annotations related to this gene include ligase activity and NF-kappaB binding.
UniProtKB/Swiss-Prot Summary for RNF25 Gene
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.