Aliases for RNF24 Gene
External Ids for RNF24 Gene
- HGNC: 13779
- Entrez Gene: 11237
- Ensembl: ENSG00000101236
- OMIM: 612489
- UniProtKB: Q9Y225
Previous GeneCards Identifiers for RNF24 Gene
- GC20M003901
- GC20M003861
- GC20M003908
- GC20M003860
- GC20M003912
- GC20M003916
Summaries for RNF24 Gene
-
This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
GeneCards Summary for RNF24 Gene
RNF24 (Ring Finger Protein 24) is a Protein Coding gene. An important paralog of this gene is RNF122.
UniProtKB/Swiss-Prot for RNF24 Gene
-
May play a role in TRPCs intracellular trafficking.
Additional gene information for RNF24 Gene
- Monarch Initiative
- Search for RNF24 at DataMed
- Search for RNF24 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF24 Gene
Genomics for RNF24 Gene
GeneHancer (GH) Regulatory Elements for RNF24 Gene
Promoters and enhancers for RNF24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RNF24 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RNF24 gene promoter:
Regulatory Element Products
Genomic Locations for RNF24 Gene
Genomic Locations for RNF24 Gene
- chr20:3,927,309-4,015,582
- (GRCh38/hg38)
- Size:
- 88,274 bases
- Orientation:
- Minus strand
- chr20:3,907,956-3,996,229
- (GRCh37/hg19)
Genomic View for RNF24 Gene
Genes around RNF24 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p13 by Entrez Gene
- 20p13 by HGNC
- 20p13 by Ensembl
RNF24 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNF24 Gene
Proteins for RNF24 Gene
-
Protein details for RNF24 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y225-RNF24_HUMAN
- Recommended name:
- RING finger protein 24
- Protein Accession:
- Q9Y225
- D3DVZ2
- D3DVZ3
- Q9UMH1
Protein attributes for RNF24 Gene
- Size:
- 148 amino acids
- Molecular mass:
- 17210 Da
- Quaternary structure:
-
- Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.
Protein Expression for RNF24 Gene
Post-translational modifications for RNF24 Gene
Other Protein References for RNF24 Gene
Antibody Products
- Novus Biologicals Antibodies for RNF24
- Invitrogen Antibodies for RNF24
- Search GeneTex for Antibodies for RNF24
Protein Products
-
OriGene Purified Proteins for RNF24
- Search Origene for MassSpec and Protein Over-expression Lysates for RNF24
- Origene Custom Protein Services for RNF24
- antibodies-online: Search results for 4 available RNF24 Proteins ranked by validation data
- Compare Top RNF24 Proteins
-
Quality Products:
- Search GeneTex for Proteins for RNF24
Assay Products
No data available for DME Specific Peptides for RNF24 Gene
Domains & Families for RNF24 Gene
Gene Families for RNF24 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for RNF24 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RNF24 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for RNF24 Gene
Function for RNF24 Gene
Molecular function for RNF24 Gene
- UniProtKB/Swiss-Prot Function:
- May play a role in TRPCs intracellular trafficking.
Phenotypes From GWAS Catalog for RNF24 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 25416956 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0061630 | ubiquitin protein ligase activity | IBA | -- |
Phenotypes for RNF24 Gene
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for RNF24
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- Overview of 97 available RNF24 gene related products
- Applied Biological Materials CRISPR for RNF24
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF24
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miRNA for RNF24 Gene
- miRTarBase miRNAs that target RNF24
-
- hsa-mir-26b-5p (MIRT029537)
- hsa-mir-4762-3p (MIRT616208)
- hsa-mir-5585-5p (MIRT616209)
- hsa-mir-548ax (MIRT616210)
- hsa-mir-548ao-5p (MIRT616211)
- hsa-mir-6513-5p (MIRT672561)
- hsa-mir-887-5p (MIRT672562)
- hsa-mir-3913-5p (MIRT672563)
- hsa-mir-3122 (MIRT672564)
- hsa-mir-450a-1-3p (MIRT672565)
- hsa-mir-6780a-5p (MIRT672566)
- hsa-mir-6779-5p (MIRT672567)
- hsa-mir-3689c (MIRT672568)
- hsa-mir-3689b-3p (MIRT672569)
- hsa-mir-3689a-3p (MIRT672570)
- hsa-mir-30b-3p (MIRT672571)
- hsa-mir-1273h-5p (MIRT672572)
- hsa-mir-6788-5p (MIRT672573)
- hsa-mir-30c-2-3p (MIRT672574)
- hsa-mir-30c-1-3p (MIRT672575)
- hsa-mir-7977 (MIRT672576)
- hsa-mir-6799-5p (MIRT672577)
- hsa-mir-6883-5p (MIRT672578)
- hsa-mir-6785-5p (MIRT672579)
- hsa-mir-4728-5p (MIRT672580)
- hsa-mir-149-3p (MIRT672581)
- hsa-mir-7106-5p (MIRT672582)
- hsa-mir-4736 (MIRT672583)
- hsa-mir-3665 (MIRT672584)
- hsa-mir-383-3p (MIRT672585)
- hsa-mir-3922-5p (MIRT672586)
- hsa-mir-940 (MIRT672587)
- hsa-mir-6893-5p (MIRT672588)
- hsa-mir-6808-5p (MIRT672589)
- hsa-mir-3714 (MIRT672590)
- hsa-mir-24-3p (MIRT673420)
- hsa-mir-4284 (MIRT673421)
- hsa-mir-5693 (MIRT673422)
- hsa-mir-4683 (MIRT687017)
- hsa-mir-4786-5p (MIRT687018)
- hsa-mir-4738-3p (MIRT687019)
- hsa-mir-664a-5p (MIRT687020)
- hsa-mir-4794 (MIRT687021)
- hsa-mir-8073 (MIRT687022)
- hsa-mir-221-5p (MIRT687023)
- hsa-mir-6827-3p (MIRT687024)
- hsa-mir-340-3p (MIRT687025)
- hsa-mir-4793-5p (MIRT687026)
- hsa-mir-4433a-3p (MIRT687027)
- hsa-mir-4459 (MIRT687028)
- hsa-mir-4768-3p (MIRT687029)
- hsa-mir-6888-5p (MIRT687030)
- hsa-mir-6502-3p (MIRT687031)
- hsa-mir-433-5p (MIRT687032)
- hsa-mir-1199-5p (MIRT761222)
- hsa-mir-340-5p (MIRT765745)
- hsa-mir-3936 (MIRT767845)
- hsa-mir-4303 (MIRT768505)
- hsa-mir-4444 (MIRT769166)
- hsa-mir-615-5p (MIRT775988)
- hsa-mir-6751-3p (MIRT778347)
- hsa-mir-6807-5p (MIRT779607)
miRNA Products
Inhibitory RNA Products
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- Overview of 97 available RNF24 gene related products
Clone Products
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF24
- Applied Biological Materials Clones for RNF24
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RNF24
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF24 Gene
Localization for RNF24 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNF24 Gene
- Golgi apparatus membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| golgi apparatus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
- Golgi apparatus (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IEA | -- |
| GO:0005794 | Golgi apparatus | IDA,IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for RNF24 Gene
No Data Available
Interacting Proteins for RNF24 Gene
Selected Interacting proteins:
Q9Y225-RNF24_HUMAN
ENSP00000388550
for RNF24 Gene via
IID
UniProtKB
STRING
GPS-Prot Interaction Network for RNF24
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000209 | protein polyubiquitination | IBA | -- |
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for RNF24 Gene
Transcripts for RNF24 Gene
mRNA/cDNA for RNF24 Gene
- (120) Selected AceView cDNA sequences:
- (6) Additional mRNA sequences :
- (10) REFSEQ mRNAs :
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000336095 7453 bps (uc002wkh.4)
- ENST00000358395 3242 bps (uc002wkj.4)
- ENST00000432261 3149 bps (uc061veo.1)
- ENST00000545616 1128 bps (uc002wki.4)
Unigene Clusters for RNF24 Gene
- Ring finger protein 24:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RNF24
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF24
- genomics-online: gRNA clones - Search results for 97 available RNF24 gene related products
- Overview of 97 available RNF24 gene related products
- Applied Biological Materials CRISPR for RNF24
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF24
- GenScript: Design CRISPR guide RNA sequences for RNF24
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF24
- Browse OriGene Inhibitory RNA Products For RNF24
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF24
- genomics-online: shRNA clones - Search results for 97 available RNF24 gene related products
- Overview of 97 available RNF24 gene related products
Clone Products
-
OriGene ORF clones in human for RNF24
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- VectorBuilder custom plasmid, inducible vectors for RNF24
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNF24
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF24
- Applied Biological Materials Clones for RNF24
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - |
Expression for RNF24 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Kidney (Urinary System)
mRNA differential expression in normal tissues according to GTEx for RNF24 Gene
This gene is overexpressed in Whole Blood (x13.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF24 Gene
NURSA nuclear receptor signaling pathways regulating expression of RNF24 Gene:
RNF24SOURCE GeneReport for Unigene cluster for RNF24 Gene:
Hs.589884Evidence on tissue expression from TISSUES for RNF24 Gene
- Kidney(4.1)
- Blood(4)
- Nervous system(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for RNF24
-
OriGene qPCR primer pairs for RNF24
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF24 Gene
Orthologs for RNF24 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RNF24 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | RNF24 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RNF24 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RNF24 34 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RNF24 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rnf24 16 34 33 |
|
||
| chicken (Gallus gallus) |
Aves | RNF24 34 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100485988 33 |
|
||
| Str.3540 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.15788 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rnf24 34 33 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for RNF24 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for RNF24 Gene
- ENSEMBL:
- Gene Tree for RNF24 (if available)
- TreeFam:
- Gene Tree for RNF24 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RNF24: view image
Paralogs for RNF24 Gene
Variants for RNF24 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000013313 | -- | 3,997,118(-) | C/A/T | intron_variant | |
| rs1000026891 | -- | 3,945,959(-) | T/A | intron_variant | |
| rs1000072371 | -- | 3,989,566(-) | T/C | intron_variant | |
| rs1000083616 | -- | 4,001,985(-) | G/T | intron_variant | |
| rs1000102545 | -- | 3,942,088(-) | A/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3645053 | CNV | loss | 21293372 |
| esv3645054 | CNV | gain | 21293372 |
| esv3645064 | CNV | loss | 21293372 |
| esv3645065 | CNV | loss | 21293372 |
| nsv1073040 | CNV | deletion | 25765185 |
| nsv1116844 | CNV | deletion | 24896259 |
| nsv1133291 | CNV | tandem duplication | 24896259 |
| nsv472501 | CNV | novel sequence insertion | 20440878 |
| nsv527924 | CNV | gain | 19592680 |
| nsv585308 | CNV | loss | 21841781 |
| nsv828673 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.24;
5.27% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RNF24 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RNF24
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF24 Gene
Disorders for RNF24 Gene
Additional Disease Information for RNF24
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for RNF24 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF24 Gene
Publications for RNF24 Gene
- RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PMID: 17850865) Lussier MP … Boulay G (Cell calcium 2008) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
- A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for RNF24 Gene
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- VectorBuilder custom plasmid, inducible vectors for RNF24
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 24 available RNF24 Antibodies ranked by validation data
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- antibodies-online: Search results for 4 available RNF24 Proteins ranked by validation data
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- Quality Products:
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- genomics-online: cdna clones - Search results for 97 available RNF24 gene related products
- Overview of 97 available RNF24 gene related products
- orf clones - Search results for 97 available RNF24 gene related products
- Overview of 97 available RNF24 gene related products
- genomics-online: gRNA clones - Search results for 97 available RNF24 gene related products
- Overview of 97 available RNF24 gene related products
- genomics-online: primer clones - Search results for 97 available RNF24 gene related products
- Overview of 97 available RNF24 gene related products
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- Overview of 97 available RNF24 gene related products
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Sources for RNF24 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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