This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016] See more...

Aliases for RNF24 Gene

Aliases for RNF24 Gene

  • Ring Finger Protein 24 2 3 5
  • RING Finger Protein 24 3 4
  • G1L 2 3
  • RNF24 5

External Ids for RNF24 Gene

Previous GeneCards Identifiers for RNF24 Gene

  • GC20M003901
  • GC20M003861
  • GC20M003908
  • GC20M003860
  • GC20M003912
  • GC20M003916

Summaries for RNF24 Gene

Entrez Gene Summary for RNF24 Gene

  • This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]

GeneCards Summary for RNF24 Gene

RNF24 (Ring Finger Protein 24) is a Protein Coding gene. An important paralog of this gene is RNF122.

UniProtKB/Swiss-Prot Summary for RNF24 Gene

Gene Wiki entry for RNF24 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF24 Gene

Genomics for RNF24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNF24 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J004012 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 624.6 +0.2 161 7.3 GATAD2A HNRNPL PRDM10 ZNF629 TFE3 LEF1 IKZF1 NFKBIZ CTCF ZNF692 RNF24 PANK2-AS1 PANK2 ADAM33 RPL21P2 ENSG00000205300 AP5S1 SMOX HSALNG0128292 piR-57460-391
GH20J004062 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14.1 -51.6 -51587 9.3 IKZF1 ZNF692 JUND ZIC2 PKNOX1 PATZ1 REST ZNF341 SOX13 RBAK RNF24 PANK2-AS1 CENPB C20orf27 AP5S1 ENSG00000205300 RPL21P2 SMOX
GH20J003887 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 8.8 +125.4 125436 5.5 SP1 HNRNPL CREB1 GATAD2A CTCF TEAD4 PRDM10 ZNF629 TFE3 RFX1 PANK2-AS1 PANK2 CDC25B UBOX5 ADAM33 RNF24 PRND MIR103A2
GH20J004038 Enhancer 1.5 FANTOM5 ENCODE CraniofacialAtlas dbSUPER 10.8 -22.8 -22828 1.6 SP1 PRDM10 ZNF692 POLR2A PRDM1 MTA2 ZSCAN4 PKNOX1 MTA1 PATZ1 PANK2-AS1 RNF24 MAVS PANK2 piR-48049-047 RPL21P2 SMOX
GH20J003931 Promoter/Enhancer 1.2 Ensembl ENCODE 10.2 +81.3 81301 4.6 PRDM1 IRF2 SP1 ZNF600 ZNF561 SCRT2 EED ETS1 YY1 SCRT1 piR-54339 piR-44080 PANK2-AS1 PANK2 RNF24 MAVS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF24

Top Transcription factor binding sites by QIAGEN in the RNF24 gene promoter:
  • AREB6
  • Egr-2
  • FOXJ2 (long isoform)
  • HTF

Genomic Locations for RNF24 Gene

Genomic Locations for RNF24 Gene
chr20:3,927,309-4,015,588
(GRCh38/hg38)
Size:
88,280 bases
Orientation:
Minus strand
chr20:3,907,956-3,996,229
(GRCh37/hg19)
Size:
88,274 bases
Orientation:
Minus strand

Genomic View for RNF24 Gene

Genes around RNF24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF24 Gene

Proteins for RNF24 Gene

  • Protein details for RNF24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y225-RNF24_HUMAN
    Recommended name:
    RING finger protein 24
    Protein Accession:
    Q9Y225
    Secondary Accessions:
    • D3DVZ2
    • D3DVZ3
    • Q9UMH1

    Protein attributes for RNF24 Gene

    Size:
    148 amino acids
    Molecular mass:
    17210 Da
    Quaternary structure:
    • Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.

    Three dimensional structures from OCA and Proteopedia for RNF24 Gene

    Alternative splice isoforms for RNF24 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF24 Gene

Post-translational modifications for RNF24 Gene

  • Ubiquitination at Lys61 and Lys107
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF24 Gene

Domains & Families for RNF24 Gene

Gene Families for RNF24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF24 Gene

InterPro:
Blocks:
  • Zn-finger, RING
ProtoNet:

Suggested Antigen Peptide Sequences for RNF24 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 24 (RNF24_HUMAN)
genes like me logo Genes that share domains with RNF24: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNF24 Gene

Function for RNF24 Gene

Molecular function for RNF24 Gene

UniProtKB/Swiss-Prot Function:
May play a role in TRPCs intracellular trafficking.

Phenotypes From GWAS Catalog for RNF24 Gene

Gene Ontology (GO) - Molecular Function for RNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with RNF24: view
genes like me logo Genes that share phenotypes with RNF24: view

Animal Model Products

CRISPR Products

miRNA for RNF24 Gene

miRTarBase miRNAs that target RNF24

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF24

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF24 Gene

Localization for RNF24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF24 Gene

Golgi apparatus membrane. Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF24 gene
Compartment Confidence
golgi apparatus 4
plasma membrane 2
cytosol 2
extracellular 1
cytoskeleton 1
mitochondrion 1
nucleus 1
peroxisome 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IBA,IDA --
GO:0012505 endomembrane system IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF24: view

Pathways & Interactions for RNF24 Gene

PathCards logo

SuperPathways for RNF24 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF24: view

No data available for Pathways by source and SIGNOR curated interactions for RNF24 Gene

Drugs & Compounds for RNF24 Gene

No Compound Related Data Available

Transcripts for RNF24 Gene

mRNA/cDNA for RNF24 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF24

Alternative Splicing Database (ASD) splice patterns (SP) for RNF24 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2: - -
SP3: -

Relevant External Links for RNF24 Gene

GeneLoc Exon Structure for
RNF24

Expression for RNF24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF24 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF24 Gene

This gene is overexpressed in Whole Blood (x13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF24 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF24

SOURCE GeneReport for Unigene cluster for RNF24 Gene:

Hs.589884

Evidence on tissue expression from TISSUES for RNF24 Gene

  • Kidney(4.3)
  • Blood(4.2)
  • Nervous system(2.5)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with RNF24: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF24 Gene

Orthologs for RNF24 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF24 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RNF24 30 31
  • 99.8 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RNF24 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RNF24 30 31
  • 95.72 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RNF24 30 31
  • 95.27 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RNF24 31
  • 95 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Rnf24 30 17 31
  • 92.57 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RNF24 30 31
  • 83.56 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100485988 30
  • 76.83 (n)
Str.3540 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.15788 30
Zebrafish
(Danio rerio)
Actinopterygii rnf24 30 31
  • 75.9 (n)
OneToOne
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 33 (a)
OneToMany
Species where no ortholog for RNF24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RNF24 Gene

ENSEMBL:
Gene Tree for RNF24 (if available)
TreeFam:
Gene Tree for RNF24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF24: view image

Paralogs for RNF24 Gene

Paralogs for RNF24 Gene

(4) SIMAP similar genes for RNF24 Gene using alignment to 2 proteins:

  • RNF24_HUMAN
  • L8E8E3_HUMAN
genes like me logo Genes that share paralogs with RNF24: view

Variants for RNF24 Gene

Additional dbSNP identifiers (rs#s) for RNF24 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNF24 Gene

Variant ID Type Subtype PubMed ID
esv3645053 CNV loss 21293372
esv3645054 CNV gain 21293372
esv3645064 CNV loss 21293372
esv3645065 CNV loss 21293372
nsv1073040 CNV deletion 25765185
nsv1116844 CNV deletion 24896259
nsv1133291 CNV tandem duplication 24896259
nsv472501 CNV novel sequence insertion 20440878
nsv527924 CNV gain 19592680
nsv585308 CNV loss 21841781
nsv828673 CNV gain 20364138

Variation tolerance for RNF24 Gene

Residual Variation Intolerance Score: 50.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.24; 5.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF24 Gene

Disorders for RNF24 Gene

Additional Disease Information for RNF24

No disorders were found for RNF24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF24 Gene

Publications for RNF24 Gene

  1. RNF24, a new TRPC interacting protein, causes the intracellular retention of TRPC. (PMID: 17850865) Lussier MP … Boulay G (Cell calcium 2008) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment. (PMID: 30759391) Kumar S … Einav S (Cell reports 2019) 3

Products for RNF24 Gene

  • Signalway Proteins for RNF24

Sources for RNF24 Gene