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Aliases for RNF224 Gene

Aliases for RNF224 Gene

  • Ring Finger Protein 224 2 3 5
  • RING Finger Protein 224 3

External Ids for RNF224 Gene

Previous GeneCards Identifiers for RNF224 Gene

  • GC09P140122

Summaries for RNF224 Gene

GeneCards Summary for RNF224 Gene

RNF224 (Ring Finger Protein 224) is a Protein Coding gene.

Additional gene information for RNF224 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF224 Gene

Genomics for RNF224 Gene

GeneHancer (GH) Regulatory Elements for RNF224 Gene

Promoters and enhancers for RNF224 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J137221 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 656.6 -0.2 -176 11.2 HDGF PKNOX1 CLOCK ZFP64 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B RNF224 EHMT1 LOC100418938 ENTR1 ANAPC2 SNHG7 RNF208 CYSRT1 NDOR1 SLC34A3
GH09J137233 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.8 +11.0 11035 9.9 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 TUBB4B EHMT1 ENTR1 ANAPC2 NDOR1 DPH7 INPP5E LOC100418938 MAN1B1 SNHG7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF224 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RNF224 Gene

Genomic Locations for RNF224 Gene
chr9:137,227,271-137,229,640
(GRCh38/hg38)
Size:
2,370 bases
Orientation:
Plus strand
chr9:140,122,018-140,124,090
(GRCh37/hg19)
Size:
2,073 bases
Orientation:
Plus strand

Genomic View for RNF224 Gene

Genes around RNF224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF224 Gene

Proteins for RNF224 Gene

  • Protein details for RNF224 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DH78-RN224_HUMAN
    Recommended name:
    RING finger protein 224
    Protein Accession:
    P0DH78

    Protein attributes for RNF224 Gene

    Size:
    156 amino acids
    Molecular mass:
    16549 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF224 Gene

Post-translational modifications for RNF224 Gene

No Post-translational modifications

Other Protein References for RNF224 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF224 Gene

Domains & Families for RNF224 Gene

Gene Families for RNF224 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF224 Gene

Suggested Antigen Peptide Sequences for RNF224 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF224: view

No data available for UniProtKB/Swiss-Prot for RNF224 Gene

Function for RNF224 Gene

Gene Ontology (GO) - Molecular Function for RNF224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF224: view

Phenotypes for RNF224 Gene

genes like me logo Genes that share phenotypes with RNF224: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF224 Gene

Localization for RNF224 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF224 gene
Compartment Confidence
nucleus 3
extracellular 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for RNF224 Gene

Pathways & Interactions for RNF224 Gene

SuperPathways for RNF224 Gene

No Data Available

Interacting Proteins for RNF224 Gene

Gene Ontology (GO) - Biological Process for RNF224 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNF224 Gene

Drugs & Compounds for RNF224 Gene

No Compound Related Data Available

Transcripts for RNF224 Gene

mRNA/cDNA for RNF224 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF224 Gene

Ring finger protein 224:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF224 Gene

No ASD Table

Relevant External Links for RNF224 Gene

GeneLoc Exon Structure for
RNF224
ECgene alternative splicing isoforms for
RNF224

Expression for RNF224 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF224 Gene

mRNA differential expression in normal tissues according to GTEx for RNF224 Gene

This gene is overexpressed in Pituitary (x9.5) and Esophagus - Mucosa (x6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF224 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNF224 Gene:

RNF224

SOURCE GeneReport for Unigene cluster for RNF224 Gene:

Hs.730186
genes like me logo Genes that share expression patterns with RNF224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF224 Gene

Orthologs for RNF224 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF224 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF224 34 33
  • 99.15 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNF224 34 33
  • 79.32 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Gm757 34 33
  • 77.62 (n)
OneToOne
Rnf224 16
rat
(Rattus norvegicus)
Mammalia Rnf224 33
  • 77.37 (n)
dog
(Canis familiaris)
Mammalia RNF224 34 33
  • 77.07 (n)
OneToOne
chicken
(Gallus gallus)
Aves RNF224 33
  • 67.72 (n)
lizard
(Anolis carolinensis)
Reptilia RNF224 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497669 33
  • 70.43 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100334516 33
  • 60.98 (n)
RNF224 34
  • 36 (a)
OneToOne
Species where no ortholog for RNF224 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF224 Gene

ENSEMBL:
Gene Tree for RNF224 (if available)
TreeFam:
Gene Tree for RNF224 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF224: view image

Paralogs for RNF224 Gene

No data available for Paralogs for RNF224 Gene

Variants for RNF224 Gene

Sequence variations from dbSNP and Humsavar for RNF224 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000973210 -- 137,227,844(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001318627 -- 137,228,131(+) G/A/C 5_prime_UTR_variant, intron_variant
rs1001645598 -- 137,226,022(+) G/A upstream_transcript_variant
rs1001752150 -- 137,229,795(+) C/T downstream_transcript_variant
rs1002605376 -- 137,226,829(+) G/A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF224 Gene

Variant ID Type Subtype PubMed ID
nsv951207 CNV deletion 24416366
nsv616007 CNV loss 21841781
nsv524322 CNV loss 19592680
nsv1161918 CNV duplication 26073780
esv2422220 CNV deletion 17116639
dgv13011n54 CNV loss 21841781
dgv13010n54 CNV loss 21841781
dgv13009n54 CNV loss 21841781

Variation tolerance for RNF224 Gene

Gene Damage Index Score: 5.72; 73.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF224 Gene

Disorders for RNF224 Gene

Additional Disease Information for RNF224

No disorders were found for RNF224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF224 Gene

Publications for RNF224 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 4 58

Products for RNF224 Gene

Sources for RNF224 Gene

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