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Aliases for RNF222 Gene

Aliases for RNF222 Gene

  • Ring Finger Protein 222 2 3 5
  • RING Finger Protein LOC643904 3
  • RING Finger Protein 222 3

External Ids for RNF222 Gene

Previous GeneCards Identifiers for RNF222 Gene

  • GC17M008235
  • GC17M008295
  • GC17M008188
  • GC17M008395
  • GC17M008400
  • GC17M008432
  • GC17M008469
  • GC17M008508

Summaries for RNF222 Gene

GeneCards Summary for RNF222 Gene

RNF222 (Ring Finger Protein 222) is a Protein Coding gene.

Additional gene information for RNF222 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF222 Gene

Genomics for RNF222 Gene

GeneHancer (GH) Regulatory Elements for RNF222 Gene

Promoters and enhancers for RNF222 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J008375 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.9 +21.3 21332 2.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 POLR2B E2F8 KRBA2 PIR59981 ODF4 ENSG00000265749 RNF222 ENSG00000212206 WRAP53 CNTROB RPL26 ENSG00000263809
GH17J008435 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.8 -38.7 -38674 2.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 NDEL1 RPL26 KRBA2 RNF222 RNU7-43P ENSG00000212206 MYH10 GC17P008467
GH17J008419 Enhancer 1.5 FANTOM5 Ensembl ENCODE 12.2 -22.9 -22883 2 HDGF PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 YY1 PIK3R5 RNF222 SPDYE4 RNU7-43P MYH10 NDEL1 PER1 VAMP2 BORCS6 GC17P008467
GH17J008417 Enhancer 1.4 FANTOM5 Ensembl ENCODE 12.2 -20.3 -20316 2.2 ELF3 FOXA2 ARNT RAD21 RARA ZNF366 ATF7 CREM THAP11 SP5 RNF222 SPDYE4 RNU7-43P MYH10 NDEL1 PIK3R5 PER1 CTC1 VAMP2 BORCS6
GH17J008680 Enhancer 1.4 VISTA Ensembl ENCODE dbSUPER 9.9 -283.3 -283339 2.3 MZF1 FEZF1 ZNF2 YY1 ZNF335 ZNF213 ZSCAN5C RCOR1 ZNF202 YY2 PFAS CNTROB WRAP53 ENSG00000265749 CTC1 MYH10 SPDYE4 RNF222 LOC105371525 LOC105371526
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF222 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF222 gene promoter:
  • HFH-3
  • FOXI1
  • AP-2gamma
  • AP-2beta
  • AP-2alphaA
  • AP-2alpha
  • FOXF2
  • FOXO4
  • S8
  • SEF-1 (1)

Genomic Locations for RNF222 Gene

Genomic Locations for RNF222 Gene
7,130 bases
Minus strand
7,123 bases
Minus strand

Genomic View for RNF222 Gene

Genes around RNF222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF222 Gene

Proteins for RNF222 Gene

  • Protein details for RNF222 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 222
    Protein Accession:

    Protein attributes for RNF222 Gene

    220 amino acids
    Molecular mass:
    23767 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF222 Gene

Post-translational modifications for RNF222 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF222 Gene

No data available for DME Specific Peptides for RNF222 Gene

Domains & Families for RNF222 Gene

Gene Families for RNF222 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for RNF222 Gene

Suggested Antigen Peptide Sequences for RNF222 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF222: view

No data available for UniProtKB/Swiss-Prot for RNF222 Gene

Function for RNF222 Gene

Gene Ontology (GO) - Molecular Function for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IBA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF222: view

Phenotypes for RNF222 Gene

genes like me logo Genes that share phenotypes with RNF222: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF222

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF222 Gene

Localization for RNF222 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF222 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF222 gene
Compartment Confidence
nucleus 5
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0016021 integral component of membrane IEA --
GO:0033768 SUMO-targeted ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with RNF222: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF222 Gene

Pathways & Interactions for RNF222 Gene

SuperPathways for RNF222 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
GO:0033234 negative regulation of protein sumoylation IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with RNF222: view

No data available for Pathways by source and SIGNOR curated interactions for RNF222 Gene

Drugs & Compounds for RNF222 Gene

No Compound Related Data Available

Transcripts for RNF222 Gene

mRNA/cDNA for RNF222 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF222 Gene

Ring finger protein 222:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF222

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF222 Gene

No ASD Table

Relevant External Links for RNF222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF222 Gene

mRNA differential expression in normal tissues according to GTEx for RNF222 Gene

This gene is overexpressed in Esophagus - Mucosa (x22.0), Skin - Not Sun Exposed (Suprapubic) (x8.4), Skin - Sun Exposed (Lower leg) (x7.8), Vagina (x6.0), and Cervix - Ectocervix (x4.6).

Protein differential expression in normal tissues from HIPED for RNF222 Gene

This gene is overexpressed in Bone marrow stromal cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF222 Gene

Protein tissue co-expression partners for RNF222 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF222 Gene:


SOURCE GeneReport for Unigene cluster for RNF222 Gene:

genes like me logo Genes that share expression patterns with RNF222: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF222 Gene

Orthologs for RNF222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF222 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF222 34 33
  • 99.09 (n)
(Canis familiaris)
Mammalia RNF222 34 33
  • 88.23 (n)
(Bos Taurus)
Mammalia RNF222 34 33
  • 87.68 (n)
(Rattus norvegicus)
Mammalia Rnf222 33
  • 85.62 (n)
(Mus musculus)
Mammalia Rnf222 16 34 33
  • 85.47 (n)
(Monodelphis domestica)
Mammalia RNF222 34
  • 76 (a)
(Gallus gallus)
Aves LOC101749003 33
  • 64.32 (n)
RNF222 34
  • 48 (a)
(Anolis carolinensis)
Reptilia RNF222 34
  • 37 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732514 33
  • 55.22 (n)
(Danio rerio)
Actinopterygii LOC101886437 33
  • 49.38 (n)
RNF222 34
  • 38 (a)
Species where no ortholog for RNF222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF222 Gene

Gene Tree for RNF222 (if available)
Gene Tree for RNF222 (if available)
Evolutionary constrained regions (ECRs) for RNF222: view image

Paralogs for RNF222 Gene

No data available for Paralogs for RNF222 Gene

Variants for RNF222 Gene

Sequence variations from dbSNP and Humsavar for RNF222 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000030344 -- 8,391,824(-) C/T 3_prime_UTR_variant
rs1000144632 -- 8,391,662(-) T/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant
rs1000344784 -- 8,397,706(-) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant
rs1000884238 -- 8,394,405(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001824361 -- 8,391,955(-) T/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF222 Gene

Variant ID Type Subtype PubMed ID
nsv509651 CNV insertion 20534489
nsv1968 CNV insertion 18451855

Variation tolerance for RNF222 Gene

Gene Damage Index Score: 3.55; 55.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF222 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF222 Gene

Disorders for RNF222 Gene

Additional Disease Information for RNF222

No disorders were found for RNF222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF222 Gene

Publications for RNF222 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 58
  2. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q … Chinnaiyan AM (Nature communications 2014) 3 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 58

Products for RNF222 Gene

Sources for RNF222 Gene

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