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Aliases for RNF219 Gene

Aliases for RNF219 Gene

  • Ring Finger Protein 219 2 3 5
  • C13orf7 3 4
  • Chromosome 13 Open Reading Frame 7 2
  • RING Finger Protein 219 3

External Ids for RNF219 Gene

Previous HGNC Symbols for RNF219 Gene

  • C13orf7

Previous GeneCards Identifiers for RNF219 Gene

  • GC13M078087
  • GC13M079188
  • GC13M059888

Summaries for RNF219 Gene

GeneCards Summary for RNF219 Gene

RNF219 (Ring Finger Protein 219) is a Protein Coding gene.

Additional gene information for RNF219 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF219 Gene

Genomics for RNF219 Gene

GeneHancer (GH) Regulatory Elements for RNF219 Gene

Promoters and enhancers for RNF219 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J078657 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 0.0 -14 3 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF143 RNF219 RBM26 ENSG00000271776 POU4F1 GC13P078744
GH13J079496 Enhancer 0.5 dbSUPER 10.1 -838.4 -838426 1.4 PKNOX1 ZNF362 ZNF585B SCRT2 RBM26 RNF219 NDFIP2 NDFIP2-AS1 LINC01068
GH13J078986 Enhancer 0.4 UCNEbase 5.4 -327.9 -327856 0.2 RNF219 LOC105370273 GC13M078992
GH13J078646 Enhancer 1 Ensembl ENCODE 0.4 +12.0 12020 2 MLX TEAD4 TAL1 ARID4B ERF RARA TEAD3 TCF12 CTBP1 NCOR1 POU4F1 ENSG00000271776 GC13P078650 GC13M078632 RNF219
GH13J078421 Enhancer 0.2 FANTOM5 1.3 +237.1 237057 0.3 RPL31P54 RNF219 GC13M078419 GC13M078356 RNY3P3 RNF219-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF219 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF219 gene promoter:
  • LHX3b
  • Lhx3a
  • Hlf
  • AML1a
  • HOXA3
  • Ik-3
  • E47
  • Pax-2
  • Pax-2b

Genomic Locations for RNF219 Gene

Genomic Locations for RNF219 Gene
44,894 bases
Minus strand
44,894 bases
Minus strand

Genomic View for RNF219 Gene

Genes around RNF219 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF219 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF219 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF219 Gene

Proteins for RNF219 Gene

  • Protein details for RNF219 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 219
    Protein Accession:
    Secondary Accessions:
    • B2RN99
    • Q8TBY2
    • Q9H0T2
    • Q9H8M0

    Protein attributes for RNF219 Gene

    726 amino acids
    Molecular mass:
    81116 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14594.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BC028586; Type=Frameshift; Positions=614; Evidence={ECO:0000305}; Sequence=CAB66586.3; Type=Frameshift; Positions=614; Evidence={ECO:0000305};

neXtProt entry for RNF219 Gene

Post-translational modifications for RNF219 Gene

  • Ubiquitination at posLast=569569 and Lys292
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF219 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RNF219
  • Boster Bio Antibodies for RNF219
  • Santa Cruz Biotechnology (SCBT) Antibodies for RNF219

No data available for DME Specific Peptides for RNF219 Gene

Domains & Families for RNF219 Gene

Gene Families for RNF219 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF219 Gene

Suggested Antigen Peptide Sequences for RNF219 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF219: view

No data available for UniProtKB/Swiss-Prot for RNF219 Gene

Function for RNF219 Gene

Phenotypes From GWAS Catalog for RNF219 Gene

Gene Ontology (GO) - Molecular Function for RNF219 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF219: view
genes like me logo Genes that share phenotypes with RNF219: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF219 Gene

Localization for RNF219 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF219 gene
Compartment Confidence
nucleus 3
cytoskeleton 2
mitochondrion 2
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF219 Gene

Pathways & Interactions for RNF219 Gene

SuperPathways for RNF219 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF219 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF219 Gene

Drugs & Compounds for RNF219 Gene

No Compound Related Data Available

Transcripts for RNF219 Gene

mRNA/cDNA for RNF219 Gene

Unigene Clusters for RNF219 Gene

Ring finger protein 219:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF219 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - - - - - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: - - - - -
SP6: - - - - - -
SP7: -
SP8: - -

Relevant External Links for RNF219 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF219 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF219 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF219 Gene

This gene is overexpressed in Liver, secretome (51.7) and Testis (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF219 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF219 Gene:


SOURCE GeneReport for Unigene cluster for RNF219 Gene:


Evidence on tissue expression from TISSUES for RNF219 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RNF219: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF219 Gene

Orthologs for RNF219 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF219 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF219 34 33
  • 99.68 (n)
(Canis familiaris)
Mammalia RNF219 34 33
  • 92.24 (n)
(Bos Taurus)
Mammalia RNF219 34 33
  • 90.19 (n)
(Mus musculus)
Mammalia Rnf219 16 34 33
  • 83.1 (n)
(Rattus norvegicus)
Mammalia Rnf219 33
  • 81.24 (n)
(Monodelphis domestica)
Mammalia RNF219 34
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia RNF219 34
  • 68 (a)
(Gallus gallus)
Aves RNF219 34 33
  • 68.41 (n)
(Anolis carolinensis)
Reptilia RNF219 34
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf219 33
  • 57.32 (n)
(Danio rerio)
Actinopterygii RNF219 34
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4956 34
  • 36 (a)
Species where no ortholog for RNF219 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF219 Gene

Gene Tree for RNF219 (if available)
Gene Tree for RNF219 (if available)
Evolutionary constrained regions (ECRs) for RNF219: view image

Paralogs for RNF219 Gene

No data available for Paralogs for RNF219 Gene

Variants for RNF219 Gene

Sequence variations from dbSNP and Humsavar for RNF219 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000018810 -- 78,650,121(-) A/C intron_variant
rs1000048383 -- 78,660,248(-) TTTT/TTTTT upstream_transcript_variant
rs1000071132 -- 78,650,362(-) G/T intron_variant
rs1000105031 -- 78,625,880(-) A/T intron_variant
rs1000247224 -- 78,660,515(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF219 Gene

Variant ID Type Subtype PubMed ID
dgv234n27 CNV loss 19166990
dgv3268n54 CNV loss 21841781
dgv339n67 CNV gain 20364138
dgv340n67 CNV loss 20364138
esv2421781 CNV deletion 20811451
esv2667717 CNV deletion 23128226
esv2747700 CNV deletion 23290073
esv3580774 CNV loss 25503493
esv3580775 CNV loss 25503493
esv3632802 CNV loss 21293372
nsv1098 CNV insertion 18451855
nsv1142153 CNV tandem duplication 24896259
nsv1160140 CNV deletion 26073780
nsv442321 CNV loss 18776908
nsv514712 CNV loss 21397061
nsv517259 CNV loss 19592680

Variation tolerance for RNF219 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF219 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF219 Gene

Disorders for RNF219 Gene

Additional Disease Information for RNF219

No disorders were found for RNF219 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF219 Gene

Publications for RNF219 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A … Ross MT (Nature 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RNF219 Gene

Sources for RNF219 Gene

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