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Aliases for RNF215 Gene
External Ids for RNF215 Gene
- HGNC: 33434
- Entrez Gene: 200312
- Ensembl: ENSG00000099999
- UniProtKB: Q9Y6U7
Previous GeneCards Identifiers for RNF215 Gene
- GC22M029104
- GC22M030773
- GC22M013736
Summaries for RNF215 Gene
GeneCards Summary for RNF215 Gene
RNF215 (Ring Finger Protein 215) is a Protein Coding gene. An important paralog of this gene is RNF167.
Additional gene information for RNF215 Gene
- HGNC(33434)
- Entrez Gene(200312)
- Ensembl(ENSG00000099999)
- UniProtKB(Q9Y6U7)
- Open Targets Platform(ENSG00000099999)
- Search for RNF215 at DataMed
- Search for RNF215 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF215 Gene
Genomics for RNF215 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RNF215 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RNF215 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF215
- Top Transcription factor binding sites by QIAGEN in the RNF215 gene promoter:
-
- AP-2alpha
- AP-2alpha isoform 2
- AP-2alpha isoform 3
- AP-2alphaA
Genomic Locations for RNF215 Gene
Genomic Locations for RNF215 Gene
- chr22:30,368,811-30,421,771
- (GRCh38/hg38)
- Size:
- 52,961 bases
- Orientation:
- Minus strand
- chr22:30,773,835-30,817,760
- (GRCh37/hg19)
- Size:
- 43,926 bases
- Orientation:
- Minus strand
Genomic View for RNF215 Gene
Genes around RNF215 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.2 by HGNC
- 22q12.2 by Entrez Gene
- 22q12.2 by Ensembl
RNF215 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNF215 Gene
Proteins for RNF215 Gene
-
Protein details for RNF215 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y6U7-RN215_HUMAN
- Recommended name:
- RING finger protein 215
- Protein Accession:
- Q9Y6U7
- A6NEL1
Protein attributes for RNF215 Gene
- Size:
- 377 amino acids
- Molecular mass:
- 41101 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAD43187.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for RNF215 Gene
Post-translational modifications for RNF215 Gene
Other Protein References for RNF215 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RNF215
- Novus Biologicals Antibodies for RNF215
- Invitrogen Antibodies for RNF215 (AFLGC-RNF215)
- antibodies-online: Show 9 available RNF215 Antibodies ranked by validation data
-
Biorbyt antibodies for RNF215
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNF215
- Origene Custom Protein Services for RNF215
No data available for DME Specific Peptides for RNF215 Gene
Domains & Families for RNF215 Gene
Gene Families for RNF215 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for RNF215 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RNF215 Gene
- GenScript: Design optimal peptide antigens:
-
- RING finger protein 215 (RN215_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNF215 Gene
Function for RNF215 Gene
Phenotypes From GWAS Catalog for RNF215 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0061630 | ubiquitin protein ligase activity | IBA | 21873635 |
Phenotypes for RNF215 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNF215 - Select products 50% OFF >
- * RNF215 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RNF215
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF215
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF215
miRNA for RNF215 Gene
- miRTarBase miRNAs that target RNF215
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF215
- Browse OriGene Inhibitory RNA Products For RNF215
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF215
Clone Products
- Applied Biological Materials (abm): Clones for RNF215 - Select products 50% OFF >
- * RNF215 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RNF215
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF215
Cell Line Products
-
Horizon Cell Lines for RNF215
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF215 Gene
Localization for RNF215 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNF215 Gene
- Membrane. Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| endosome | 3 |
| golgi apparatus | 3 |
| plasma membrane | 2 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
- Microtubules (2)
- Nucleoli (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005737 | cytoplasm | IBA | -- |
| GO:0005768 | endosome | IBA | 21873635 |
| GO:0005770 | late endosome | IBA | -- |
| GO:0005794 | Golgi apparatus | IBA | -- |
Pathways & Interactions for RNF215 Gene
Interacting Proteins for RNF215 Gene
GPS-Prot Interaction Network for RNF215
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process | IBA | 21873635 |
| GO:0006623 | protein targeting to vacuole | IBA | 21873635 |
| GO:0006896 | Golgi to vacuole transport | IBA | 21873635 |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0051788 | response to misfolded protein | IBA | -- |
No data available for Pathways by source and SIGNOR curated interactions for RNF215 Gene
Transcripts for RNF215 Gene
mRNA/cDNA for RNF215 Gene
- 1 REFSEQ mRNAs :
- 4 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000215798 1651 nts (view in UCSC)
- ENST00000332468 8141 nts (view in UCSC)
- ENST00000382363 2011 nts (view in UCSC)
- ENST00000421022 361 nts (view in UCSC)
- ENST00000431544 535 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNF215 - Select products 50% OFF >
- * RNF215 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RNF215
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF215
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF215
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF215
- Browse OriGene Inhibitory RNA Products For RNF215
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF215
Clone Products
- Applied Biological Materials (abm): Clones for RNF215 - Select products 50% OFF >
- * RNF215 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RNF215
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF215
Relevant External Links for RNF215 Gene
- GeneLoc Exon Structure for
- RNF215
Expression for RNF215 Gene
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF215 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF215
SOURCE GeneReport for Unigene cluster for RNF215 Gene:
Hs.592194Primer Products
-
OriGene qPCR primer pairs for RNF215
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF215 Gene
Orthologs for RNF215 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RNF215 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RNF215 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RNF215 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rnf215 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rnf215 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RNF215 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RNF215 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RNF215 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RNF215 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-188g24.2 30 |
|
||
| RNF215 31 |
|
OneToOne | |||
| Worm (Caenorhabditis elegans) |
Secernentea | Y47D3B.11 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for RNF215 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
Evolution for RNF215 Gene
- ENSEMBL:
- Gene Tree for RNF215 (if available)
- TreeFam:
- Gene Tree for RNF215 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RNF215: view image
Paralogs for RNF215 Gene
Variants for RNF215 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF215 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs5749088 | - | p.Ala322Thr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1110864 | OTHER | inversion | 24896259 |
| nsv1136354 | CNV | deletion | 24896259 |
| nsv829171 | CNV | loss | 20364138 |
| nsv953067 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.05;
50.49% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RNF215 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RNF215
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF215 Gene
Disorders for RNF215 Gene
Additional Disease Information for RNF215
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for RNF215 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF215 Gene
Publications for RNF215 Gene
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
- Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
- The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4
- Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3
ExternalLinks
Products for RNF215 Gene
- Custom Antibody ServicesOriGene Antibodies for RNF215
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for RNF215
- Origene Custom Protein Services for RNF215
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF215
- Browse OriGene Inhibitory RNA Products For RNF215
- OriGene qPCR primer pairs for RNF215
- OriGene CRISPR knockouts for RNF215
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RNF215
- Sino Biological Human cDNA Clone for RNF215
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RNF215
- Novus Biologicals proteins and lysates for RNF215
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for RNF215 (AFLGC-RNF215)
- VectorBuilder Custom and pre-made DNA vectors for RNF215 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RNF215 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RNF215 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RNF215 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RNF215
- antibodies-online: Show 9 available RNF215 Antibodies ranked by validation data
- antibodies-online: Search results for available RNF215 related products ranked by validation data
- antibodies-online: Search results for available RNF215 related products ranked by validation data
- Horizon Cell Lines for RNF215
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF215
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF215
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RNF215
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF215
- Biorbyt antibodies for RNF215
Sources for RNF215 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB