Aliases for RNF215 Gene

Aliases for RNF215 Gene

  • Ring Finger Protein 215 2 3 5
  • RING Finger Protein 215 3 4
  • RNF215 5

External Ids for RNF215 Gene

Previous GeneCards Identifiers for RNF215 Gene

  • GC22M029104
  • GC22M030773
  • GC22M013736

Summaries for RNF215 Gene

GeneCards Summary for RNF215 Gene

RNF215 (Ring Finger Protein 215) is a Protein Coding gene. An important paralog of this gene is RNF128.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF215 Gene

Genomics for RNF215 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNF215 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF215 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF215

Top Transcription factor binding sites by QIAGEN in the RNF215 gene promoter:
  • AP-2alpha
  • AP-2alpha isoform 2
  • AP-2alpha isoform 3
  • AP-2alphaA

Genomic Locations for RNF215 Gene

Latest Assembly
52,961 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
8,591 bases
Minus strand

(GRCh37/hg19 by Ensembl)
43,926 bases
Minus strand

Genomic View for RNF215 Gene

Genes around RNF215 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF215 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF215 Gene

Proteins for RNF215 Gene

  • Protein details for RNF215 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 215
    Protein Accession:
    Secondary Accessions:
    • A6NEL1

    Protein attributes for RNF215 Gene

    377 amino acids
    Molecular mass:
    41101 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD43187.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RNF215 Gene

Post-translational modifications for RNF215 Gene

  • Glycosylation at Asn186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF215 Gene

Domains & Families for RNF215 Gene

Gene Families for RNF215 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RNF215 Gene


Suggested Antigen Peptide Sequences for RNF215 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 215 (RN215_HUMAN)
genes like me logo Genes that share domains with RNF215: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNF215 Gene

Function for RNF215 Gene

Phenotypes From GWAS Catalog for RNF215 Gene

Gene Ontology (GO) - Molecular Function for RNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with RNF215: view
genes like me logo Genes that share phenotypes with RNF215: view

miRNA for RNF215 Gene

miRTarBase miRNAs that target RNF215

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF215

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF215 Gene

Localization for RNF215 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF215 Gene

Membrane. Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF215 gene
Compartment Confidence
endosome 3
golgi apparatus 3
plasma membrane 2
extracellular 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA 21873635
GO:0005802 trans-Golgi network IBA 21873635
GO:0016020 membrane IBA 21873635
GO:0016021 integral component of membrane IEA --
GO:0017119 Golgi transport complex IBA 21873635
genes like me logo Genes that share ontologies with RNF215: view

Pathways & Interactions for RNF215 Gene

PathCards logo

SuperPathways for RNF215 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
GO:0006623 protein targeting to vacuole IBA 21873635
GO:0006896 Golgi to vacuole transport IBA 21873635
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF215: view

No data available for Pathways by source and SIGNOR curated interactions for RNF215 Gene

Drugs & Compounds for RNF215 Gene

No Compound Related Data Available

Transcripts for RNF215 Gene

mRNA/cDNA for RNF215 Gene

4 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF215

Alternative Splicing Database (ASD) splice patterns (SP) for RNF215 Gene

No ASD Table

Relevant External Links for RNF215 Gene

GeneLoc Exon Structure for

Expression for RNF215 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF215 Gene

Protein differential expression in normal tissues from HIPED for RNF215 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF215 Gene

Protein tissue co-expression partners for RNF215 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF215

SOURCE GeneReport for Unigene cluster for RNF215 Gene:

genes like me logo Genes that share expression patterns with RNF215: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF215 Gene

Orthologs for RNF215 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF215 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF215 30 31
  • 99.29 (n)
(Canis familiaris)
Mammalia RNF215 30 31
  • 91.3 (n)
(Bos Taurus)
Mammalia RNF215 30 31
  • 89.83 (n)
(Mus musculus)
Mammalia Rnf215 30 17 31
  • 86.33 (n)
(Rattus norvegicus)
Mammalia Rnf215 30
  • 86.23 (n)
(Ornithorhynchus anatinus)
Mammalia RNF215 31
  • 60 (a)
(Monodelphis domestica)
Mammalia RNF215 31
  • 48 (a)
(Gallus gallus)
Aves RNF215 30 31
  • 67.64 (n)
(Anolis carolinensis)
Reptilia RNF215 31
  • 40 (a)
(Danio rerio)
Actinopterygii si:ch211-188g24.2 30
  • 58.49 (n)
RNF215 31
  • 37 (a)
(Caenorhabditis elegans)
Secernentea Y47D3B.11 31
  • 14 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 34 (a)
Species where no ortholog for RNF215 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RNF215 Gene

Gene Tree for RNF215 (if available)
Gene Tree for RNF215 (if available)
Evolutionary constrained regions (ECRs) for RNF215: view image

Paralogs for RNF215 Gene

Paralogs for RNF215 Gene

(3) SIMAP similar genes for RNF215 Gene using alignment to 4 proteins:

  • RN215_HUMAN
  • H0Y2L4_HUMAN
  • H7C0R1_HUMAN
genes like me logo Genes that share paralogs with RNF215: view

Variants for RNF215 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF215 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
rs5749088 - p.Ala322Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RNF215 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RNF215 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv1136354 CNV deletion 24896259
nsv829171 CNV loss 20364138
nsv953067 CNV deletion 24416366

Variation tolerance for RNF215 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF215 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF215 Gene

Disorders for RNF215 Gene

Additional Disease Information for RNF215

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for RNF215 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF215 Gene

Publications for RNF215 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  3. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4
  4. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3

Products for RNF215 Gene

Sources for RNF215 Gene