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Aliases for RNF215 Gene

Aliases for RNF215 Gene

  • Ring Finger Protein 215 2 3 5

External Ids for RNF215 Gene

Previous GeneCards Identifiers for RNF215 Gene

  • GC22M029104
  • GC22M030773
  • GC22M013736

Summaries for RNF215 Gene

GeneCards Summary for RNF215 Gene

RNF215 (Ring Finger Protein 215) is a Protein Coding gene. An important paralog of this gene is ZNRF3.

Additional gene information for RNF215 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF215 Gene

Genomics for RNF215 Gene

GeneHancer (GH) Regulatory Elements for RNF215 Gene

Promoters and enhancers for RNF215 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22I030415 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 576.3 +0.3 332 11.6 MLX FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 RNF215 ENSG00000272689 ENSG00000273350 MTFP1 RNU6-564P TUG1 SF3A1 TBC1D10A SEC14L3 PES1
GH22I030385 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.3 +34.8 34774 2.1 HDGF ARNT INSM2 ARID4B KLF17 ZNF2 RAD21 ZNF335 GLIS2 ARID2 RNF215 CASTOR1 ENSG00000249590 TBC1D10A ENSG00000248751 OSM SF3A1 CCDC157 LIF ENSG00000181123
GH22I030234 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 31.8 +175.0 175041 24.6 PKNOX1 ARID4B SIN3A ZNF2 ZBTB7B ZNF416 ZNF143 FOS ZNF263 SP5 LIF LOC91370 TUG1 SF3A1 EWSR1 MORC2 PES1 RNF215 TBC1D10A ENSG00000272689
GH22I030322 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 30.7 +94.9 94851 8 HDGF PKNOX1 ARID4B SIN3A YY1 GLIS2 ZNF213 ATF7 RUNX3 SP3 TBC1D10A RNF215 CCDC157 CASTOR1 SEC14L3 TUG1 SF3A1 ENSG00000248751 SEC14L2 ENSG00000249590
GH22I030287 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 30.2 +131.6 131613 5 HDGF ARNT ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF213 ZNF207 ZNF143 CASTOR1 RNF215 CCDC157 DUSP18 ENSG00000248751 TBC1D10A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF215 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF215 gene promoter:

Genomic Locations for RNF215 Gene

Genomic Locations for RNF215 Gene
52,961 bases
Minus strand

Genomic View for RNF215 Gene

Genes around RNF215 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF215 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF215 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF215 Gene

Proteins for RNF215 Gene

  • Protein details for RNF215 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 215
    Protein Accession:
    Secondary Accessions:
    • A6NEL1

    Protein attributes for RNF215 Gene

    377 amino acids
    Molecular mass:
    41101 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD43187.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RNF215 Gene

Post-translational modifications for RNF215 Gene

  • Glycosylation at isoforms=186
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF215 Gene

Domains & Families for RNF215 Gene

Gene Families for RNF215 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RNF215 Gene


Suggested Antigen Peptide Sequences for RNF215 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF215: view

No data available for UniProtKB/Swiss-Prot for RNF215 Gene

Function for RNF215 Gene

Phenotypes From GWAS Catalog for RNF215 Gene

Gene Ontology (GO) - Molecular Function for RNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF215: view
genes like me logo Genes that share phenotypes with RNF215: view

Animal Model Products

miRNA for RNF215 Gene

miRTarBase miRNAs that target RNF215

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF215 Gene

Localization for RNF215 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF215 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF215 gene
Compartment Confidence
plasma membrane 2
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF215 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF215: view

Pathways & Interactions for RNF215 Gene

SuperPathways for RNF215 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF215 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF215 Gene

Drugs & Compounds for RNF215 Gene

No Compound Related Data Available

Transcripts for RNF215 Gene

mRNA/cDNA for RNF215 Gene

Unigene Clusters for RNF215 Gene

Ring finger protein 215:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF215 Gene

No ASD Table

Relevant External Links for RNF215 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF215 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF215 Gene

Protein differential expression in normal tissues from HIPED for RNF215 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF215 Gene

Protein tissue co-expression partners for RNF215 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF215 Gene:


SOURCE GeneReport for Unigene cluster for RNF215 Gene:

genes like me logo Genes that share expression patterns with RNF215: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF215 Gene

Orthologs for RNF215 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF215 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF215 33 34
  • 99.29 (n)
(Canis familiaris)
Mammalia RNF215 33 34
  • 91.3 (n)
(Bos Taurus)
Mammalia RNF215 33 34
  • 89.83 (n)
(Mus musculus)
Mammalia Rnf215 33 16 34
  • 86.33 (n)
(Rattus norvegicus)
Mammalia Rnf215 33
  • 86.23 (n)
(Ornithorhynchus anatinus)
Mammalia RNF215 34
  • 60 (a)
(Monodelphis domestica)
Mammalia RNF215 34
  • 48 (a)
(Gallus gallus)
Aves RNF215 33 34
  • 67.64 (n)
(Anolis carolinensis)
Reptilia RNF215 34
  • 40 (a)
(Danio rerio)
Actinopterygii si:ch211-188g24.2 33
  • 58.49 (n)
RNF215 34
  • 37 (a)
(Caenorhabditis elegans)
Secernentea Y47D3B.11 34
  • 14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
Species where no ortholog for RNF215 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF215 Gene

Gene Tree for RNF215 (if available)
Gene Tree for RNF215 (if available)

Paralogs for RNF215 Gene

(3) SIMAP similar genes for RNF215 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with RNF215: view

Variants for RNF215 Gene

Sequence variations from dbSNP and Humsavar for RNF215 Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1001464615 -- 30,383,540(-) C/T intron_variant
rs1001552393 -- 30,384,213(-) G/A intron_variant
rs1001728427 -- 30,378,818(-) A/G 3_prime_UTR_variant
rs1001809165 -- 30,386,277(-) A/G intron_variant
rs1001860195 -- 30,380,713(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF215 Gene

Variant ID Type Subtype PubMed ID
nsv1110864 OTHER inversion 24896259
nsv1136354 CNV deletion 24896259
nsv829171 CNV loss 20364138
nsv953067 CNV deletion 24416366

Variation tolerance for RNF215 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.05; 50.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF215 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF215 Gene

Disorders for RNF215 Gene

Additional Disease Information for RNF215

No disorders were found for RNF215 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF215 Gene

Publications for RNF215 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  2. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 4 58
  3. Toward a complete human genome sequence. (PMID: 9847074) Sanger Center … Genome Sequencing Center (Genome research 1998) 3 58

Products for RNF215 Gene

Sources for RNF215 Gene

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