Aliases for RNF214 Gene

Aliases for RNF214 Gene

  • Ring Finger Protein 214 2 3 5
  • RING Finger Protein 214 3 4
  • DKFZp547C195 2
  • RNF214 5

External Ids for RNF214 Gene

Previous GeneCards Identifiers for RNF214 Gene

  • GC11P116609
  • GC11P117104
  • GC11P113036

Summaries for RNF214 Gene

GeneCards Summary for RNF214 Gene

RNF214 (Ring Finger Protein 214) is a Protein Coding gene. Diseases associated with RNF214 include Ehlers-Danlos Syndrome, Musculocontractural Type, 1 and Fetal Akinesia Deformation Sequence 1.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF214 Gene

Genomics for RNF214 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNF214 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF214 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF214

Top Transcription factor binding sites by QIAGEN in the RNF214 gene promoter:
  • AML1a

Genomic Locations for RNF214 Gene

Latest Assembly
53,830 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
53,784 bases
Plus strand

(GRCh37/hg19 by Ensembl)
53,821 bases
Plus strand

Genomic View for RNF214 Gene

Genes around RNF214 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF214 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF214 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF214 Gene

Proteins for RNF214 Gene

  • Protein details for RNF214 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 214
    Protein Accession:
    Secondary Accessions:
    • B2RUW0
    • B4DTD1

    Protein attributes for RNF214 Gene

    703 amino acids
    Molecular mass:
    77667 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF214 Gene


neXtProt entry for RNF214 Gene

Post-translational modifications for RNF214 Gene

  • Ubiquitination at Lys259
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF214 Gene

No data available for DME Specific Peptides for RNF214 Gene

Domains & Families for RNF214 Gene

Gene Families for RNF214 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF214 Gene

  • Zn-finger, RING

Suggested Antigen Peptide Sequences for RNF214 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54868, weakly similar to Ubiquitin ligase protein DZIP3 (EC 6.3.2.-) (B2RUW0_HUMAN)
  • cDNA FLJ58281 (B4DTD1_HUMAN)
  • RING finger protein 214 (RN214_HUMAN)
genes like me logo Genes that share domains with RNF214: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNF214 Gene

Function for RNF214 Gene

Phenotypes From GWAS Catalog for RNF214 Gene

Gene Ontology (GO) - Molecular Function for RNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF214: view
genes like me logo Genes that share phenotypes with RNF214: view

miRNA for RNF214 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF214

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF214 Gene

Localization for RNF214 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF214 gene
Compartment Confidence
cytosol 3
nucleus 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for RNF214 Gene

Pathways & Interactions for RNF214 Gene

PathCards logo

SuperPathways for RNF214 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF214 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF214: view

No data available for Pathways by source and SIGNOR curated interactions for RNF214 Gene

Drugs & Compounds for RNF214 Gene

No Compound Related Data Available

Transcripts for RNF214 Gene

mRNA/cDNA for RNF214 Gene

11 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF214

Alternative Splicing Database (ASD) splice patterns (SP) for RNF214 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP5: -

Relevant External Links for RNF214 Gene

GeneLoc Exon Structure for

Expression for RNF214 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF214 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF214 Gene

This gene is overexpressed in Adrenal (29.8) and Fetal Brain (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF214 Gene

Protein tissue co-expression partners for RNF214 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF214

SOURCE GeneReport for Unigene cluster for RNF214 Gene:


Evidence on tissue expression from TISSUES for RNF214 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RNF214: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF214 Gene

Orthologs for RNF214 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF214 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF214 30 31
  • 99.76 (n)
(Bos Taurus)
Mammalia RNF214 30 31
  • 92.98 (n)
(Canis familiaris)
Mammalia RNF214 30 31
  • 92.92 (n)
(Rattus norvegicus)
Mammalia RGD1307500 30
  • 89.87 (n)
(Mus musculus)
Mammalia Rnf214 30 17 31
  • 89.82 (n)
(Monodelphis domestica)
Mammalia RNF214 31
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RNF214 31
  • 67 (a)
(Gallus gallus)
Aves RNF214 30 31
  • 76.2 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rnf214 30
  • 56.19 (n)
(Danio rerio)
Actinopterygii si:dkey-111e8.1 30
  • 46.78 (n)
RNF214 (1 of 2) 31
  • 31 (a)
RNF214 (2 of 2) 31
  • 17 (a)
Species where no ortholog for RNF214 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RNF214 Gene

Gene Tree for RNF214 (if available)
Gene Tree for RNF214 (if available)
Evolutionary constrained regions (ECRs) for RNF214: view image

Paralogs for RNF214 Gene

No data available for Paralogs for RNF214 Gene

Variants for RNF214 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RNF214 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RNF214 Gene

Variant ID Type Subtype PubMed ID
dgv2186n54 CNV loss 21841781
nsv509443 CNV insertion 20534489
nsv513334 CNV insertion 21212237
nsv516483 CNV gain 19592680

Variation tolerance for RNF214 Gene

Residual Variation Intolerance Score: 8.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.78; 33.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF214 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF214 Gene

Disorders for RNF214 Gene

MalaCards: The human disease database

(2) MalaCards diseases for RNF214 Gene - From: COP

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RNF214

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RNF214: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF214 Gene

Publications for RNF214 Gene

  1. Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study. (PMID: 21779381) Schürks M … Kurth T (PloS one 2011) 3 41
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. (PMID: 32694731) Aregger M … Moffat J (Nature metabolism 2020) 3
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells. (PMID: 30995489) MacLeod G … Angers S (Cell reports 2019) 3

Products for RNF214 Gene

Sources for RNF214 Gene