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Aliases for RNF212B Gene

Aliases for RNF212B Gene

  • Ring Finger Protein 212B 2 3 5
  • C14orf164 3 4
  • Chromosome 14 Open Reading Frame 164 2
  • RING Finger Protein C14orf164-Like 3
  • RING Finger Protein 212B 3

External Ids for RNF212B Gene

Previous HGNC Symbols for RNF212B Gene

  • C14orf164

Previous GeneCards Identifiers for RNF212B Gene

  • GC14P023395
  • GC14P023560
  • GC14P023674
  • GC14P023797
  • GC14P023887
  • GC14P023946
  • GC14P024059
  • GC14P024177

Summaries for RNF212B Gene

GeneCards Summary for RNF212B Gene

RNF212B (Ring Finger Protein 212B) is a Protein Coding gene. An important paralog of this gene is RNF212.

Additional gene information for RNF212B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF212B Gene

Genomics for RNF212B Gene

GeneHancer (GH) Regulatory Elements for RNF212B Gene

Promoters and enhancers for RNF212B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J023187 Enhancer 1 Ensembl ENCODE 650.7 +1.9 1855 0.3 CTCF ARNT ERF KDM3A RAD21 CC2D1A ARID2 FOXK2 VEZF1 ZNF143 RNF212B LOC105370406
GH14J023185 Enhancer 0.7 ENCODE 650.7 0.0 -19 0.2 MEIS2 ARNT JUN ZNF384 FOSL1 ZNF316 FOXK2 FOS NFE2 MAFK RNF212B SLC7A8
GH14J023067 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.3 -114.9 -114854 5.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ACIN1 C14orf93 RBM23 LOC102724814 NGDN HAUS4 PRMT5 PSMB11 PSMB5 C14orf119
GH14J023145 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -38.8 -38765 2.8 PKNOX1 SMAD1 ATF1 ARNT YBX1 ZNF2 NCOA2 TCF12 ZNF766 GATA2 ACIN1 C14orf93 ENSG00000259321 RBM23 LOC102724814 NGDN HAUS4 SLC7A8 RNF212B CEBPE
GH14J023140 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 11.6 -43.3 -43260 2.9 MXI1 USF1 NFIB MAX BMI1 RFX5 ZNF507 ZNF121 ZNF335 GATA3 SLC7A8 RNF212B CEBPE ACIN1 SLC22A17 C14orf93 CMTM5 IL25 DHRS4-AS1 RNU6-1138P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF212B on UCSC Golden Path with GeneCards custom track

Genomic Locations for RNF212B Gene

Genomic Locations for RNF212B Gene
88,970 bases
Plus strand
88,162 bases
Plus strand

Genomic View for RNF212B Gene

Genes around RNF212B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF212B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF212B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF212B Gene

Proteins for RNF212B Gene

  • Protein details for RNF212B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 212B
    Protein Accession:

    Protein attributes for RNF212B Gene

    300 amino acids
    Molecular mass:
    33570 Da
    Quaternary structure:
    No Data Available
    • Sequence=EB710205; Type=Frameshift; Positions=40; Evidence={ECO:0000305};

neXtProt entry for RNF212B Gene

Post-translational modifications for RNF212B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF212B Gene

Domains & Families for RNF212B Gene

Gene Families for RNF212B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF212B Gene


Suggested Antigen Peptide Sequences for RNF212B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF212B: view

No data available for UniProtKB/Swiss-Prot for RNF212B Gene

Function for RNF212B Gene

Gene Ontology (GO) - Molecular Function for RNF212B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019789 SUMO transferase activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF212B: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF212B Gene

Localization for RNF212B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF212B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for RNF212B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex IBA --
genes like me logo Genes that share ontologies with RNF212B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for RNF212B Gene

Pathways & Interactions for RNF212B Gene

SuperPathways for RNF212B Gene

No Data Available

Interacting Proteins for RNF212B Gene

Gene Ontology (GO) - Biological Process for RNF212B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007129 synapsis IBA --
GO:0016925 protein sumoylation IBA --
genes like me logo Genes that share ontologies with RNF212B: view

No data available for Pathways by source and SIGNOR curated interactions for RNF212B Gene

Drugs & Compounds for RNF212B Gene

No Compound Related Data Available

Transcripts for RNF212B Gene

mRNA/cDNA for RNF212B Gene

(12) REFSEQ mRNAs :
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF212B Gene

No ASD Table

Relevant External Links for RNF212B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF212B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF212B Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF212B Gene:

genes like me logo Genes that share expression patterns with RNF212B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF212B Gene

Orthologs for RNF212B Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF212B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14H14orf164 33
  • 99.44 (n)
C14orf164 34
  • 99 (a)
(Canis familiaris)
Mammalia C8H14orf164 33
  • 89.52 (n)
C14orf164 34
  • 85 (a)
(Bos Taurus)
Mammalia C10H14orf164 33
  • 88.85 (n)
C14orf164 34
  • 84 (a)
(Rattus norvegicus)
Mammalia LOC102550789 33
  • 85.07 (n)
(Mus musculus)
Mammalia LOC102632837 33
  • 84.85 (n)
Rnf212b 16
(Monodelphis domestica)
Mammalia C14orf164 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia C14orf164 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101735053 33
  • 58.37 (n)
(Danio rerio)
Actinopterygii C2H14orf164 34
  • 36 (a)
(Caenorhabditis elegans)
Secernentea D1081.9 34
  • 22 (a)
zhp-3 34
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.285 34
  • 28 (a)
Species where no ortholog for RNF212B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF212B Gene

Gene Tree for RNF212B (if available)
Gene Tree for RNF212B (if available)
Evolutionary constrained regions (ECRs) for RNF212B: view image

Paralogs for RNF212B Gene

Paralogs for RNF212B Gene

genes like me logo Genes that share paralogs with RNF212B: view

Variants for RNF212B Gene

Sequence variations from dbSNP and Humsavar for RNF212B Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000044977 -- 23,274,675(+) A/C downstream_transcript_variant
rs1000048658 -- 23,231,795(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000055152 -- 23,194,197(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000155947 -- 23,190,976(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000165876 -- 23,190,734(+) G/A/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF212B Gene

Variant ID Type Subtype PubMed ID
nsv977447 CNV duplication 23825009
nsv1112497 CNV deletion 24896259
esv3633775 CNV loss 21293372
esv3633774 CNV loss 21293372
esv2763062 CNV gain 21179565
esv2658154 CNV deletion 23128226

Variation tolerance for RNF212B Gene

Gene Damage Index Score: 1.59; 30.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF212B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF212B Gene

Disorders for RNF212B Gene

Additional Disease Information for RNF212B

No disorders were found for RNF212B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF212B Gene

Publications for RNF212B Gene

  1. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 3 4 58
  2. The sequence of the human genome. (PMID: 11181995) Venter JC … Zhu X (Science (New York, N.Y.) 2001) 3 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for RNF212B Gene

Sources for RNF212B Gene

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