Aliases for RNF212 Gene
External Ids for RNF212 Gene
Previous HGNC Symbols for RNF212 Gene
This gene encodes a RING finger protein that may function as a ubiquitin ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
GeneCards Summary for RNF212 Gene
RNF212 (Ring Finger Protein 212) is a Protein Coding gene. Diseases associated with RNF212 include Recombination Rate Quantitative Trait Locus 1. Gene Ontology (GO) annotations related to this gene include ligase activity. An important paralog of this gene is RNF212B.
UniProtKB/Swiss-Prot for RNF212 Gene
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).