Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF208 Gene

Aliases for RNF208 Gene

  • Ring Finger Protein 208 2 3 5
  • RING Finger Protein 208 3

External Ids for RNF208 Gene

Previous GeneCards Identifiers for RNF208 Gene

  • GC09P9S0001
  • GC09M139237
  • GC09M140114
  • GC09M109574

Summaries for RNF208 Gene

GeneCards Summary for RNF208 Gene

RNF208 (Ring Finger Protein 208) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity.

Additional gene information for RNF208 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF208 Gene

Genomics for RNF208 Gene

GeneHancer (GH) Regulatory Elements for RNF208 Gene

Promoters and enhancers for RNF208 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J137221 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 7.2 -5.5 -5514 11.2 HDGF PKNOX1 CLOCK ZFP64 ARID4B NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B RNF224 EHMT1 LOC100418938 ENTR1 ANAPC2 SNHG7 RNF208 CYSRT1 NDOR1 SLC34A3
GH09J137216 Enhancer 1.4 Ensembl ENCODE dbSUPER 7.5 +3.3 3301 3.7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 SLC30A9 POLR2B FOS ENSG00000284976 NDOR1 RNF208 CYSRT1 NPDC1
GH09J137204 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 4.7 +15.9 15869 3.3 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 ZNF207 ZNF143 SP3 NDOR1 TMEM203 PIR53478 TPRN EHMT1 ENTR1 CYSRT1 SLC34A3 RNF208 ENSG00000284976
GH09J137233 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.8 -16.7 -16725 9.9 CLOCK MLX FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 SP3 TUBB4B EHMT1 ENTR1 ANAPC2 NDOR1 DPH7 INPP5E LOC100418938 MAN1B1 SNHG7
GH09J137516 Enhancer 0.7 FANTOM5 4.8 -295.6 -295574 0.4 HDAC1 BCL11B ZKSCAN1 MTA3 CTBP1 ZNF366 ZNF169 ZNF444 GATAD2A ZBTB2 SNHG7 EHMT1 DPH7 EXD3 ANAPC2 GRIN1 RNF208 SAPCD2 ABCA2 PNPLA7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF208 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF208 gene promoter:
  • Roaz
  • Pbx1a
  • RP58
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c
  • Pax-4a
  • E47
  • HOXA5
  • AhR

Genomic Locations for RNF208 Gene

Genomic Locations for RNF208 Gene
1,335 bases
Minus strand
1,335 bases
Minus strand

Genomic View for RNF208 Gene

Genes around RNF208 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF208 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF208 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF208 Gene

Proteins for RNF208 Gene

  • Protein details for RNF208 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 208
    Protein Accession:
    Secondary Accessions:
    • A2BFA0

    Protein attributes for RNF208 Gene

    261 amino acids
    Molecular mass:
    27964 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH16958.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH16958.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=AAL16809.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB66475.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for RNF208 Gene

Post-translational modifications for RNF208 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF208 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF208 Gene

Domains & Families for RNF208 Gene

Gene Families for RNF208 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF208 Gene

Suggested Antigen Peptide Sequences for RNF208 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF208: view

No data available for UniProtKB/Swiss-Prot for RNF208 Gene

Function for RNF208 Gene

Phenotypes From GWAS Catalog for RNF208 Gene

Gene Ontology (GO) - Molecular Function for RNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 24105792
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF208: view
genes like me logo Genes that share phenotypes with RNF208: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF208 Gene

Localization for RNF208 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF208 gene
Compartment Confidence
nucleus 5
cytosol 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RNF208: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF208 Gene

Pathways & Interactions for RNF208 Gene

SuperPathways for RNF208 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF208 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051865 protein autoubiquitination IDA 24105792
genes like me logo Genes that share ontologies with RNF208: view

No data available for Pathways by source and SIGNOR curated interactions for RNF208 Gene

Drugs & Compounds for RNF208 Gene

No Compound Related Data Available

Transcripts for RNF208 Gene

mRNA/cDNA for RNF208 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF208 Gene

Ring finger protein 208:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF208 Gene

No ASD Table

Relevant External Links for RNF208 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF208 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF208 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF208 Gene

This gene is overexpressed in Brain - Cortex (x5.3) and Brain - Frontal Cortex (BA9) (x4.2).

NURSA nuclear receptor signaling pathways regulating expression of RNF208 Gene:


SOURCE GeneReport for Unigene cluster for RNF208 Gene:


Evidence on tissue expression from TISSUES for RNF208 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RNF208: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF208 Gene

Orthologs for RNF208 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF208 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF208 33
  • 99.27 (n)
(Monodelphis domestica)
Mammalia RNF208 34
  • 91 (a)
(Bos Taurus)
Mammalia RNF208 34 33
  • 88.89 (n)
(Canis familiaris)
Mammalia RNF208 34 33
  • 88.51 (n)
(Mus musculus)
Mammalia Rnf208 16 34 33
  • 87.61 (n)
(Rattus norvegicus)
Mammalia Rnf208 33
  • 87.36 (n)
(Gallus gallus)
Aves RNF208 34 33
  • 73.69 (n)
(Danio rerio)
Actinopterygii si:dkey-106l3.6 33
  • 62.25 (n)
RNF208 34
  • 58 (a)
Species where no ortholog for RNF208 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF208 Gene

Gene Tree for RNF208 (if available)
Gene Tree for RNF208 (if available)
Evolutionary constrained regions (ECRs) for RNF208: view image

Paralogs for RNF208 Gene

No data available for Paralogs for RNF208 Gene

Variants for RNF208 Gene

Sequence variations from dbSNP and Humsavar for RNF208 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1001341160 -- 137,220,823(-) C/G/T coding_sequence_variant, synonymous_variant
rs1001551269 -- 137,220,033(-) C/T downstream_transcript_variant
rs1002346914 -- 137,222,719(-) G/A upstream_transcript_variant
rs1002441843 -- 137,222,922(-) C/T upstream_transcript_variant
rs1004228476 -- 137,222,189(-) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF208 Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
dgv13010n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
nsv1126931 CNV deletion 24896259
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv616007 CNV loss 21841781
nsv616012 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for RNF208 Gene

Residual Variation Intolerance Score: 68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF208 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF208 Gene

Disorders for RNF208 Gene

Additional Disease Information for RNF208

No disorders were found for RNF208 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF208 Gene

Publications for RNF208 Gene

  1. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  2. Protein microarray characterization of the S-nitrosoproteome. (PMID: 24105792) Lee YI … Dawson TM (Molecular & cellular proteomics : MCP 2014) 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J … Sanderson CM (Molecular & cellular proteomics : MCP 2012) 3 58
  5. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V … Han DK (Science signaling 2009) 4 58

Products for RNF208 Gene

Sources for RNF208 Gene

Loading form....