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Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart ... See more...
Aliases for RNF2 Gene
Aliases for RNF2 Gene
External Ids for RNF2 Gene
- HGNC: 10061
- NCBI Entrez Gene: 6045
- Ensembl: ENSG00000121481
- OMIM®: 608985
- UniProtKB/Swiss-Prot: Q99496
Previous GeneCards Identifiers for RNF2 Gene
- GC01P182540
- GC01P180442
- GC01P181534
- GC01P182253
- GC01P181746
- GC01P183281
- GC01P185014
- GC01P156249
Summaries for RNF2 Gene
-
Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF2 Gene
RNF2 (Ring Finger Protein 2) is a Protein Coding gene. Diseases associated with RNF2 include Angelman Syndrome and Microphthalmia, Syndromic 2. Among its related pathways are SUMOylation and Cellular Senescence (REACTOME). Gene Ontology (GO) annotations related to this gene include chromatin binding and ubiquitin-protein transferase activity. An important paralog of this gene is RING1.
UniProtKB/Swiss-Prot Summary for RNF2 Gene
-
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity).
Additional gene information for RNF2 Gene
- HGNC (10061)
- NCBI Entrez Gene (6045)
- Ensembl (ENSG00000121481)
- OMIM® (608985)
- UniProtKB/Swiss-Prot (Q99496)
- Open Targets Platform(ENSG00000121481)
- Alliance of Genome Resources
- Search for RNF2 at DataMed
- Search for RNF2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF2 Gene
Genomics for RNF2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RNF2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RNF2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF2
- Top Transcription factor binding sites by QIAGEN in the RNF2 gene promoter:
-
- CREB
- deltaCREB
- Nkx2-5
- Sp1
Genomic Locations for RNF2 Gene
Latest Assembly
- chr1:185,045,430-185,102,603
- (GRCh38/hg38)
- Size:
- 57,174 bases
- Orientation:
- Plus strand
Previous Assembly
- chr1:185,014,690-185,071,735
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 57,046 bases
- Orientation:
- Plus strand
Genomic View for RNF2 Gene
Genes around RNF2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q25.3 by HGNC
- 1q25.3 by Entrez Gene
- 1q25.3 by Ensembl
RNF2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNF2 Gene
Proteins for RNF2 Gene
-
Protein details for RNF2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q99496-RING2_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase RING2
- Protein Accession:
- Q99496
- B2RBS7
- B3KRH1
- Q5TEN1
- Q5TEN2
Protein attributes for RNF2 Gene
- Size:
- 336 amino acids
- Molecular mass:
- 37655 Da
- Quaternary structure:
-
- Component of chromatin-associated Polycomb (PcG) complexes. Component of a number of PRC1-like complexes; these complexes contain either the polycomb group ring finger protein PCGF1, or PCGF2, or PCGF3, or PCGF4, or PCGF5, or PCGF6 (PubMed:12167701, PubMed:15386022, PubMed:19636380, PubMed:21282530, PubMed:26687479, PubMed:26151332). Part of a complex that contains RNF2, UB2D3 and BMI1; within that complex RNF2 and BMI1 form a tight heterodimer, where UB2D3 interacts only with RNF2 (PubMed:21772249, PubMed:25355358). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249). Part of a complex that contains PCGF5, RNF2 and UBE2D3 (PubMed:26151332). Part of a complex that contains AUTS2, PCGF5, RNF2, CSNK2B AND RYBP (PubMed:25519132). Interacts with RYBP, PCGF2, CBX4, CBX6, CBX7 and CBX8 (PubMed:19636380, PubMed:21282530, PubMed:19791798, PubMed:20696397). Interacts with RNF1/RING1, BMI1 and PHC2 (PubMed:15386022, PubMed:16714294). Interaction with RYBP and CBX7 is mutually exclusive; both compete for the same binding site on RNF2 (By similarity). Component of repressive BCOR complex containing a Polycomb group subcomplex at least composed of RYBP, PCGF1, BCOR and RING1 (PubMed:16943429). Interacts with CBX2 and PHC1. Interacts with CHTOP. Interacts with AURKB (By similarity). Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RNF1/RING1, RNF2/RING2, MBLR, L3MBTL2 and YAF2 (PubMed:12004135). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Interacts with RYBP, HIP2 and TFCP2 (PubMed:11513855, PubMed:11865070, PubMed:20696397). Interacts with NUPR1 (PubMed:28720707).
- Miscellaneous:
-
- The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes.
Three dimensional structures from OCA and Proteopedia for RNF2 Gene
Protein Expression for RNF2 Gene
Selected DME Specific Peptides for RNF2 Gene
- Q99496:
-
- VSPRSLHSELMCPICLDMLKNTMTTKECLHRFC
- KHNNQQALSHSIEEGLKIQAMNRLQRGKK
- KRTKTSDDSGL
- NATVDHLSKYLA
- QIENGSGAEDNGDSSHCSNAS
- EIELVFR
- WKVNKPME
- KTWELSLYEL
- TALRSGNKECPTCRKKLVSKRSLRPDPNFDALIS
- ELYYAPTKE
- HSNQEAGPS
- SEKQYTIYI
- LISKIYPSR
Post-translational modifications for RNF2 Gene
- Polyubiquitinated in the presence of UBE2D3 (in vitro).
- Monoubiquitinated, by auto-ubiquitination.
-
Ubiquitination at Lys112, Lys149, Lys249, Lys261, and Lys323
- NX_Q99496 (NX_Q99496-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RNF2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences RNF2 / RING2 / RING1B Antibody (LS-B417) and RNF2 / RING2 / RING1B Antibody (LS-B12347)
- G Biosciences Immunotag™ RNF2 Antibody
- Novus Biologicals Antibodies for RNF2
-
Abcam antibodies for RNF2
- Invitrogen Antibodies for RNF2 (AFLGC-RNF2)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RNF2
- Sino Biological Antibodies for RNF2
Protein products for research
- Search Origene for MassSpec and Protein Over-expression Lysates for RNF2
- Origene Custom Protein Services for RNF2
- antibodies-online: Show 7 available RNF2 Proteins ranked by validation data
- Compare Top RNF2 Proteins
-
Quality Products:
-
Abcam proteins for RNF2
Assay products for research
- antibodies-online: Show 2 available RNF2 Elisa Kits ranked by validation data
- Compare Top RNF2 Elisa Kits
-
Quality Products:
Domains & Families for RNF2 Gene
Gene Families for RNF2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for RNF2 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
Suggested Antigen Peptide Sequences for RNF2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ34255 fis, clone FCBBF5000353, highly similar to Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (B3KRH1_HUMAN)
- RING finger protein BAP-1 (RING2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for RNF2 Gene
Function for RNF2 Gene
Molecular function for RNF2 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:26151332};.
Enzyme Numbers (IUBMB) for RNF2 Gene
Phenotypes From GWAS Catalog for RNF2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003682 | chromatin binding | IDA | 25519132 |
| GO:0004842 | contributes_to ubiquitin-protein transferase activity | IDA | 16714294 |
| GO:0005515 | protein binding | IPI | 10369680 |
| GO:0008270 | zinc ion binding | IDA | 16714294 |
| GO:0016740 | transferase activity | IEA | -- |
Phenotypes for RNF2 Gene
- MGI mutant phenotypes for RNF2:
-
inferred from 6 alleles
- nervous system phenotype
- growth/size/body region phenotype
- cellular phenotype
- behavior/neurological phenotype
- immune system phenotype
- mortality/aging
- liver/biliary system phenotype
- hematopoietic system phenotype
- neoplasm
- reproductive system phenotype
- skeleton phenotype
- embryo phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for RNF2:
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RNF2 - Starting at $85 >
- * RNF2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RNF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF2
miRNA for RNF2 Gene
- miRTarBase miRNAs that target RNF2
-
- hsa-miR-200b-3p (MIRT006163)
- hsa-miR-200c-3p (MIRT006164)
- hsa-miR-181a-5p (MIRT006166)
- hsa-miR-181b-5p (MIRT006167)
- mmu-miR-9-5p (MIRT015241)
- hsa-miR-155-5p (MIRT021040)
- hsa-miR-186-5p (MIRT021180)
- hsa-miR-26b-5p (MIRT030193)
- hsa-miR-24-3p (MIRT030624)
- hsa-miR-92a-3p (MIRT049365)
- hsa-miR-149-5p (MIRT268871)
- hsa-miR-6504-5p (MIRT554687)
- hsa-miR-4284 (MIRT554688)
- hsa-miR-3064-5p (MIRT554689)
- hsa-miR-664a-5p (MIRT554690)
- hsa-miR-4794 (MIRT554691)
- hsa-miR-7844-5p (MIRT554692)
- hsa-miR-3607-3p (MIRT619337)
- hsa-miR-10b-5p (MIRT619338)
- hsa-miR-10a-5p (MIRT619339)
- hsa-miR-6732-3p (MIRT619340)
- hsa-miR-548as-3p (MIRT619341)
- hsa-miR-548x-3p (MIRT625957)
- hsa-miR-548j-3p (MIRT625958)
- hsa-miR-548aq-3p (MIRT625959)
- hsa-miR-548am-3p (MIRT625960)
- hsa-miR-548aj-3p (MIRT625961)
- hsa-miR-548ah-3p (MIRT625962)
- hsa-miR-548ae-3p (MIRT625963)
- hsa-miR-548z (MIRT625964)
- hsa-miR-548h-3p (MIRT625965)
- hsa-miR-548d-3p (MIRT625966)
- hsa-miR-548bb-3p (MIRT625967)
- hsa-miR-548ac (MIRT625968)
- hsa-miR-524-5p (MIRT639417)
- hsa-miR-520d-5p (MIRT639418)
- hsa-miR-3613-3p (MIRT639419)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF2
- Browse OriGene Inhibitory RNA Products For RNF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF2
Clone products for research
- Applied Biological Materials (abm): Clones for RNF2 - Starting at $45 >
- * RNF2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RNF2
- Addgene plasmids for RNF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF2
Cell Lines for research
-
Horizon Cell Lines for RNF2
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF2 Gene
Localization for RNF2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNF2 Gene
- Nucleus. Chromosome. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells. {ECO:0000250 UniProtKB:Q9CQJ4}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytoskeleton | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
- Nuclear bodies (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000151 | ubiquitin ligase complex | IEA,IDA | 16714294 |
| GO:0000791 | euchromatin | IEA | -- |
| GO:0000792 | heterochromatin | IEA | -- |
| GO:0001739 | sex chromatin | IEA | -- |
| GO:0005634 | nucleus | IEA,IDA | 18629613 |
Pathways & Interactions for RNF2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cellular Senescence (REACTOME) | ||
| 2 | SUMOylation |
.95
|
|
| 3 | Metabolism of proteins | ||
| 4 | Chromatin Regulation / Acetylation | ||
| 5 | DNA Damage | ||
Pathways by source for RNF2 Gene
9 Reactome pathways for RNF2 Gene
2 Cell Signaling Technology pathways for RNF2 Gene
UniProtKB/Swiss-Prot Q99496-RING2_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for RNF2 Gene
Selected Interacting proteins:
Q99496-RING2_HUMAN
ENSP00000356480
for RNF2 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RNF2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | ISS | -- |
| GO:0000278 | mitotic cell cycle | IEA | -- |
| GO:0001702 | gastrulation with mouth forming second | IEA | -- |
| GO:0007281 | germ cell development | IEA | -- |
| GO:0009948 | anterior/posterior axis specification | IEA | -- |
Drugs & Compounds for RNF2 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
Transcripts for RNF2 Gene
mRNA/cDNA for RNF2 Gene
- 1 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000367509 1677 nts (view in UCSC)
- ENST00000367510 3407 nts (view in UCSC)
- ENST00000453650 939 nts (view in UCSC)
- ENST00000498201 631 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RNF2 - Starting at $85 >
- * RNF2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RNF2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF2
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF2
- Browse OriGene Inhibitory RNA Products For RNF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF2
Clone products for research
- Applied Biological Materials (abm): Clones for RNF2 - Starting at $45 >
- * RNF2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for RNF2
- Addgene plasmids for RNF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF2
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||
| SP8: | - |
Relevant External Links for RNF2 Gene
- GeneLoc Exon Structure for
- RNF2
Expression for RNF2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
- Neural Tube (Nervous System)
This gene is overexpressed in Peripheral blood mononuclear cells (24.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF2
SOURCE GeneReport for Unigene cluster for RNF2 Gene:
Hs.591490Evidence on tissue expression from TISSUES for RNF2 Gene
- Nervous system(4.6)
- Liver(2.2)
- Blood(2.1)
- Skin(2.1)
- Kidney(2.1)
Primer products for research
-
OriGene qPCR primer pairs for RNF2
-
OriGene qPCR primer pairs and template standards for RNF2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF2 Gene
Orthologs for RNF2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RNF2 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RNF2 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RNF2 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RNF2 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RNF2 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rnf2 29 16 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rnf2 29 |
|
||
| Chicken (Gallus gallus) |
Aves | RNF2 29 30 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RNF2 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rnf2 29 |
|
||
| Str.682 29 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC398559 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rnf2 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Ring 31 |
|
|
|
| Sce 29 30 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002073 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | spat-3 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9967 30 |
|
OneToMany | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4640 29 |
|
- Species where no ortholog for RNF2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RNF2 Gene
- ENSEMBL:
- Gene Tree for RNF2 (if available)
- TreeFam:
- Gene Tree for RNF2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RNF2: view image
- Alliance of Genome Resources:
- Additional Orthologs for RNF2
Paralogs for RNF2 Gene
(1) SIMAP similar genes for RNF2 Gene using alignment to 2 proteins:
- RING2_HUMAN
- B3KRH1_HUMAN
Pseudogenes.org Pseudogenes for RNF2 Gene
Variants for RNF2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF2 Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 988094 | Uncertain Significance: RNF2-associated neurodevelopmental condition | 185,091,700(+) |
G/A NM_007212.4(RNF2):c.209G>A (p.Arg70His) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
Residual Variation Intolerance Score:
50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.49;
10.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RNF2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF2 Gene
Disorders for RNF2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| angelman syndrome |
|
|
| microphthalmia, syndromic 2 |
|
|
Search RNF2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RNF2
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RNF2 Gene
Publications for RNF2 Gene
- E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. (PMID: 11513855) Lee SJ … Kang S (FEBS letters 2001) 2 3 4 22
- Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. (PMID: 16714294) Li Z … Xu RM (The Journal of biological chemistry 2006) 3 4 22
- Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B. (PMID: 28720707) Santofimia-Castaño P … Neira JL (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 4
- BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. (PMID: 26151332) Taherbhoy AM … Cochran AG (Nature communications 2015) 3 4
- The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G … Cagney G (Scientific reports 2015) 3 4
ExternalLinks
Products for RNF2 Gene
- Custom Antibody Services
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- Origene Custom Protein Services for RNF2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF2
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- OriGene qPCR primer pairs for RNF2
- OriGene qPCR primer pairs and template standards for RNF2
- OriGene CRISPR knockouts for RNF2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RNF2
- Sino Biological Human cDNA Clone for RNF2
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- Novus Biologicals proteins and lysates for RNF2
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- Invitrogen Antibodies for RNF2 (AFLGC-RNF2)
- VectorBuilder Custom and pre-made DNA vectors for RNF2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RNF2 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for RNF2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RNF2
- Addgene plasmids for RNF2
- antibodies-online: Show 23 available RNF2 Antibodies ranked by validation data
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- antibodies-online: Show 2 available RNF2 Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 7 available RNF2 Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for RNF2
- Search Santa Cruz Biotechnology (SCBT) for RNF2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RNF2
- Horizon Cell Lines for RNF2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RNF2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF2
Sources for RNF2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Apr-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) ASD
- (27) SAGE
- (28) SOURCE
- (29) HomoloGene
- (30) PanEnsembl
- (31) euGenes
- (32) SGD
- (33) FlyBase
- (34) WormBase
- (35) Pseudogene
- (36) DGV
- (37) dbSNP
- (38) GenAtlas
- (39) HGMD
- (40) GAD
- (41) BGMUT
- (42) HuGE
- (43) Atlas
- (44) GenBank
- (45) HORDE
- (46) HUGE
- (47) IMGT
- (48) Leiden
- (49) miRBase
- (50) DME
- (51) OriGene
- (52) PubMed
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- (54) Tocris
- (55) Abcam
- (56) Novus Biologicals
- (57) ProSpec
- (58) Sino Biological
- (59) GenScript
- (60) Qiagen
- (61) OCA
- (62) Proteopedia
- (63) MOPED
- (64) neXtProt
- (65) Reactome
- (66) GeneGo (Thomson Reuters)
- (67) DISEASES
- (68) SIMAP
- (69) GenomeRNAi
- (70) LifeMap
- (71) miRTarBase
- (72) MalaCards
- (73) Invitrogen
- (74) BitterDB
- (75) ESI-BIO
- (76) RefSeq
- (77) BioSystems
- (78) MaxQB
- (79) IUPHAR
- (80) BioGPS
- (81) Illumina
- (82) COMPARTMENTS
- (83) HOMER
- (84) PaxDb
- (85) ApexBio
- (86) Addgene
- (87) antibodies-online
- (88) CYP
- (89) NONCODE
- (90) TreeFam
- (91) PathCards
- (92) GeneReviews
- (93) GeneTex
- (94) Taconic Biosciences
- (95) GTEx
- (96) ProteomicsDB
- (97) SCBT
- (98) DGIdb
- (99) ClinicalTrials
- (100) RVIS
- (101) SIGNOR
- (102) diseasecard
- (103) NIH Rare Diseases
- (104) Orphanet
- (105) UMLS
- (106) GTR
- (107) Disease Ontology
- (108) MedlinePlus Genetics
- (109) MeSH
- (110) MedlinePlus
- (111) CDC
- (112) NINDS
- (113) NCBI Bookshelf
- (114) ClinVar
- (115) Gene Damage Index
- (116) HPO
- (117) UDN
- (118) VISTA
- (119) FANTOM5
- (120) ENCODE
- (121) ProSci
- (122) Horizon
- (123) The Signaling Pathways Project (SPP)
- (124) IID
- (125) VectorBuilder
- (126) SNPedia
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- (128) CIViC
- (129) ProteoGenix
- (130) dbSUPER
- (131) TISSUES
- (132) Gene ORGANizer
- (133) abm
- (134) Human Protein Atlas
- (135) GWAS Catalog
- (136) Monarch Initiative
- (137) DataMed
- (138) HumanCyc
- (139) UCNEbase
- (140) EPDnew
- (141) Applied Biosystems
- (142) GlyConnect
- (143) Aminode
- (144) GeneCopoeia
- (145) GPS-Prot
- (146) RNAcentral
- (147) LncRNADisease
- (148) LOVD
- (149) miR2Disease
- (150) DiseaseEnhancer
- (151) Boster Bio
- (152) Biorbyt
- (153) Biocompare
- (154) Mastermind
- (155) CTD^2 Dashboard
- (156) CraniofacialAtlas
- (157) GeneImprint
- (158) Synthego
- (159) ENA
- (160) GtRNAdb
- (161) LncBase
- (162) LncBook
- (163) LNCipedia
- (164) Modomics
- (165) PDBe
- (166) Rfam
- (167) SILVA
- (168) snOPY
- (169) SRPDB
- (170) GENCODE
- (171) TarBase
- (172) Open Targets Platform
- (173) 5SRRNADB
- (174) snoDB
- (175) MirGeneDB
- (176) Alliance of Genome Resources