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Aliases for RNF183 Gene

Aliases for RNF183 Gene

  • Ring Finger Protein 183 2 3 5
  • EC 2.3.2.27 4

External Ids for RNF183 Gene

Previous GeneCards Identifiers for RNF183 Gene

  • GC09M113139
  • GC09M115099
  • GC09M116059
  • GC09M085666

Summaries for RNF183 Gene

GeneCards Summary for RNF183 Gene

RNF183 (Ring Finger Protein 183) is a Protein Coding gene. An important paralog of this gene is RNF223.

UniProtKB/Swiss-Prot for RNF183 Gene

  • May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).

Additional gene information for RNF183 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF183 Gene

Genomics for RNF183 Gene

GeneHancer (GH) Regulatory Elements for RNF183 Gene

Promoters and enhancers for RNF183 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I113302 Enhancer 0.7 ENCODE 550.8 +0.2 161 0.9 SOX13 MXI1 FOXA2 SAP130 ARID4B ZMYM3 EGR1 POLR2A NR2F6 THAP11 RNF183 CDC26 PRPF4 WDR31 ALAD C9orf43 POLE3
GH09I113372 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.4 -74.6 -74624 11.9 HDGF PKNOX1 CLOCK FOXA2 ARNT MLX ARID4B SIN3A DMAP1 YBX1 HDHD3 PRPF4 POLE3 C9orf43 RNF183 ALAD CDC26 BSPRY
GH09I113339 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.4 -36.8 -36782 1.7 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 WDR31 PRPF4 CDC26 BSPRY RNF183 RPL32P22 ALAD C9orf43 POLE3 HDHD3
GH09I113463 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 10.6 -160.7 -160678 1.9 ARID4B SIN3A DMAP1 ZNF2 ZNF48 GLIS2 SP3 NFYC REST ZNF610 RGS3 C9orf43 PRPF4 CDC26 POLE3 FKBP15 ALAD RNF183 GC09P114125
GH09I113500 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.6 -200.1 -200098 6.3 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 TCF12 SLC30A9 RXRA RGS3 C9orf43 ALAD RNF183 GC09P114125
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF183 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF183 gene promoter:

Genomic Locations for RNF183 Gene

Genomic Locations for RNF183 Gene
chr9:113,297,093-113,303,376
(GRCh38/hg38)
Size:
6,284 bases
Orientation:
Minus strand
chr9:116,059,373-116,065,656
(GRCh37/hg19)

Genomic View for RNF183 Gene

Genes around RNF183 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF183 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF183 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF183 Gene

Proteins for RNF183 Gene

  • Protein details for RNF183 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96D59-RN183_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase RNF183
    Protein Accession:
    Q96D59

    Protein attributes for RNF183 Gene

    Size:
    192 amino acids
    Molecular mass:
    21617 Da
    Quaternary structure:
    • Interacts with FATE1.

neXtProt entry for RNF183 Gene

Post-translational modifications for RNF183 Gene

No data available for DME Specific Peptides for RNF183 Gene

Domains & Families for RNF183 Gene

Gene Families for RNF183 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Protein Domains for RNF183 Gene

Suggested Antigen Peptide Sequences for RNF183 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF183: view

No data available for UniProtKB/Swiss-Prot for RNF183 Gene

Function for RNF183 Gene

Molecular function for RNF183 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
May act as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).

Enzyme Numbers (IUBMB) for RNF183 Gene

Phenotypes From GWAS Catalog for RNF183 Gene

Gene Ontology (GO) - Molecular Function for RNF183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IDA 26567849
genes like me logo Genes that share ontologies with RNF183: view
genes like me logo Genes that share phenotypes with RNF183: view

Animal Models for RNF183 Gene

MGI Knock Outs for RNF183:

miRNA for RNF183 Gene

miRTarBase miRNAs that target RNF183

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF183 Gene

Localization for RNF183 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF183 Gene

Membrane; Single-pass membrane protein. Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF183 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 3

Gene Ontology (GO) - Cellular Components for RNF183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 26567849
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF183: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF183 Gene

Pathways & Interactions for RNF183 Gene

SuperPathways for RNF183 Gene

No Data Available

UniProtKB/Swiss-Prot Q96D59-RN183_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF183 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 26567849
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF183: view

No data available for Pathways by source and SIGNOR curated interactions for RNF183 Gene

Drugs & Compounds for RNF183 Gene

No Compound Related Data Available

Transcripts for RNF183 Gene

Unigene Clusters for RNF183 Gene

Ring finger protein 183:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF183 Gene

No ASD Table

Relevant External Links for RNF183 Gene

GeneLoc Exon Structure for
RNF183
ECgene alternative splicing isoforms for
RNF183

Expression for RNF183 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF183 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF183 Gene

This gene is overexpressed in Kidney - Cortex (x8.6), Minor Salivary Gland (x7.6), Testis (x5.8), and Esophagus - Mucosa (x5.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF183 Gene



NURSA nuclear receptor signaling pathways regulating expression of RNF183 Gene:

RNF183

SOURCE GeneReport for Unigene cluster for RNF183 Gene:

Hs.729641

Evidence on tissue expression from TISSUES for RNF183 Gene

  • Lung(4)
genes like me logo Genes that share expression patterns with RNF183: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF183 Gene

Orthologs for RNF183 Gene

This gene was present in the common ancestor of mammals.

Orthologs for RNF183 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF183 33 34
  • 98.96 (n)
dog
(Canis familiaris)
Mammalia RNF183 33
  • 89.12 (n)
mouse
(Mus musculus)
Mammalia Rnf183 33 16 34
  • 85.79 (n)
cow
(Bos Taurus)
Mammalia RNF183 33 34
  • 85.64 (n)
rat
(Rattus norvegicus)
Mammalia Rnf183 33
  • 84.39 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF183 34
  • 75 (a)
OneToOne
Species where no ortholog for RNF183 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RNF183 Gene

ENSEMBL:
Gene Tree for RNF183 (if available)
TreeFam:
Gene Tree for RNF183 (if available)

Paralogs for RNF183 Gene

Paralogs for RNF183 Gene

genes like me logo Genes that share paralogs with RNF183: view

Variants for RNF183 Gene

Sequence variations from dbSNP and Humsavar for RNF183 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000225968 -- 113,304,003(-) C/T upstream_transcript_variant
rs1000528155 -- 113,304,899(-) T/G upstream_transcript_variant
rs1000564960 -- 113,302,527(-) A/T genic_upstream_transcript_variant, intron_variant
rs1000778934 -- 113,302,190(-) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1001305469 -- 113,299,625(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF183 Gene

Variant ID Type Subtype PubMed ID
esv3621540 CNV gain 21293372

Variation tolerance for RNF183 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.26; 97.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF183 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF183

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF183 Gene

Disorders for RNF183 Gene

Additional Disease Information for RNF183

No disorders were found for RNF183 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF183 Gene

Publications for RNF183 Gene

  1. Comprehensive functional characterization of cancer-testis antigens defines obligate participation in multiple hallmarks of cancer. (PMID: 26567849) Maxfield KE … Whitehurst AW (Nature communications 2015) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory Bowel Disease. (PMID: 26818663) Yu Q … Chen M (Journal of Crohn's & colitis 2016) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for RNF183 Gene

Sources for RNF183 Gene

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