Aliases for RNF183 Gene
External Ids for RNF183 Gene
Previous GeneCards Identifiers for RNF183 Gene
GeneCards Summary for RNF183 Gene
RNF183 (Ring Finger Protein 183) is a Protein Coding gene. An important paralog of this gene is RNF223.
UniProtKB/Swiss-Prot Summary for RNF183 Gene
Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849).