Aliases for RNF182 Gene
External Ids for RNF182 Gene
Previous GeneCards Identifiers for RNF182 Gene
GeneCards Summary for RNF182 Gene
RNF182 (Ring Finger Protein 182) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000288658.
UniProtKB/Swiss-Prot Summary for RNF182 Gene
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514).