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Aliases for RNF182 Gene

Aliases for RNF182 Gene

  • Ring Finger Protein 182 2 3 5
  • RING-Type E3 Ubiquitin Transferase RNF182 3 4
  • E3 Ubiquitin-Protein Ligase RNF182 3
  • RING Finger Protein 182 4
  • EC 4

External Ids for RNF182 Gene

Previous GeneCards Identifiers for RNF182 Gene

  • GC06P014034

Summaries for RNF182 Gene

GeneCards Summary for RNF182 Gene

RNF182 (Ring Finger Protein 182) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF182 Gene

  • E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.

Additional gene information for RNF182 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF182 Gene

Genomics for RNF182 Gene

GeneHancer (GH) Regulatory Elements for RNF182 Gene

Promoters and enhancers for RNF182 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J013923 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 676.6 +0.3 283 2.6 HDGF ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF143 FOS ZNF263 SP3 RNF182 MRPL35P1
GH06J013916 Enhancer 0.7 ENCODE 39.4 -7.9 -7856 1.1 MEIS2 TAL1 EBF1 CTBP1 ZNF316 GATA2 POLR2A SCRT2 SMARCE1 ZBTB2 RNF182 PIR49028
GH06J013926 Enhancer 0.8 ENCODE 29.6 +2.9 2899 1.1 HDAC1 ATF1 RAD21 CHAMP1 CBX5 ZSCAN5C CREM REST ZEB2 ZNF592 RNF182 CD83 RNU7-133P MRPL35P1
GH06J014073 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +150.5 150535 2.2 HDGF PKNOX1 ZSCAN4 FEZF1 YY1 ZNF335 IKZF2 SMARCA5 RXRA SP1 CD83 RNU7-133P RNF182 RANBP9 LOC105374939 ENSG00000233981
GH06J013985 Enhancer 0.7 ENCODE 19.3 +61.4 61353 0.7 HDAC1 MAX ZNF644 CHAMP1 POLR2B ZNF316 MTA3 POLR2A ZFP91 TRIM24 GC06P013986 RNF182 RNU7-133P GC06P013975 PIR47048
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF182 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF182 gene promoter:
  • NF-AT4
  • NF-AT3
  • NF-AT2
  • NF-AT1
  • NF-AT
  • AP-1
  • c-Fos
  • c-Jun
  • Olf-1
  • CUTL1

Genomic Locations for RNF182 Gene

Genomic Locations for RNF182 Gene
55,857 bases
Plus strand
55,857 bases
Plus strand

Genomic View for RNF182 Gene

Genes around RNF182 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF182 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF182 Gene

Proteins for RNF182 Gene

  • Protein details for RNF182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF182
    Protein Accession:
    Secondary Accessions:
    • B2RDG2
    • Q8NBG3

    Protein attributes for RNF182 Gene

    247 amino acids
    Molecular mass:
    27402 Da
    Quaternary structure:
    • Interacts with ATP6V0C.

neXtProt entry for RNF182 Gene

Post-translational modifications for RNF182 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF182 Gene

Domains & Families for RNF182 Gene

Gene Families for RNF182 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RNF182 Gene

Suggested Antigen Peptide Sequences for RNF182 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain is required for E3 ligase activity.
  • The RING-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with RNF182: view

Function for RNF182 Gene

Molecular function for RNF182 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for RNF182 Gene

Phenotypes From GWAS Catalog for RNF182 Gene

Gene Ontology (GO) - Molecular Function for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18298843
GO:0005515 protein binding IPI 18298843
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF182: view
genes like me logo Genes that share phenotypes with RNF182: view

Animal Model Products

miRNA for RNF182 Gene

miRTarBase miRNAs that target RNF182

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF182 Gene

Localization for RNF182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF182 Gene

Membrane; Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF182 gene
Compartment Confidence
nucleus 3
plasma membrane 1
peroxisome 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 18298843
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF182: view

Pathways & Interactions for RNF182 Gene

genes like me logo Genes that share pathways with RNF182: view

UniProtKB/Swiss-Prot Q8N6D2-RN182_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF182: view

No data available for SIGNOR curated interactions for RNF182 Gene

Drugs & Compounds for RNF182 Gene

No Compound Related Data Available

Transcripts for RNF182 Gene

Unigene Clusters for RNF182 Gene

Ring finger protein 182:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF182 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for RNF182 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF182 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF182 Gene

mRNA differential expression in normal tissues according to GTEx for RNF182 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.8), Brain - Cerebellum (x5.5), Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Frontal Cortex (BA9) (x4.8), Brain - Hippocampus (x4.7), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for RNF182 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF182 Gene

Protein tissue co-expression partners for RNF182 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF182 Gene:


SOURCE GeneReport for Unigene cluster for RNF182 Gene:


mRNA Expression by UniProt/SwissProt for RNF182 Gene:

Tissue specificity: Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains.

Evidence on tissue expression from TISSUES for RNF182 Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with RNF182: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF182 Gene

Orthologs for RNF182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF182 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF182 34 33
  • 99.6 (n)
(Monodelphis domestica)
Mammalia RNF182 34
  • 94 (a)
(Canis familiaris)
Mammalia RNF182 34 33
  • 91.5 (n)
(Mus musculus)
Mammalia Rnf182 16 34 33
  • 88.53 (n)
(Rattus norvegicus)
Mammalia Rnf182 33
  • 87.99 (n)
(Ornithorhynchus anatinus)
Mammalia RNF182 34
  • 86 (a)
(Bos Taurus)
Mammalia RNF182 34 33
  • 83.81 (n)
(Gallus gallus)
Aves RNF182 34 33
  • 82.1 (n)
(Anolis carolinensis)
Reptilia RNF182 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf182 33
  • 76.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17893 33
(Danio rerio)
Actinopterygii rnf182 34 33
  • 57.84 (n)
Species where no ortholog for RNF182 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF182 Gene

Gene Tree for RNF182 (if available)
Gene Tree for RNF182 (if available)
Evolutionary constrained regions (ECRs) for RNF182: view image

Paralogs for RNF182 Gene

(1) SIMAP similar genes for RNF182 Gene using alignment to 5 proteins:

  • RN182_HUMAN
  • C9IZ30_HUMAN
  • C9JVS8_HUMAN Pseudogenes for RNF182 Gene

genes like me logo Genes that share paralogs with RNF182: view

No data available for Paralogs for RNF182 Gene

Variants for RNF182 Gene

Sequence variations from dbSNP and Humsavar for RNF182 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
VAR_035959 A colorectal cancer sample p.Val43Ala
VAR_035960 A colorectal cancer sample p.Pro58Leu
rs1000004207 -- 13,932,037(+) C/G intron_variant
rs1000012516 -- 13,973,423(+) G/A/T intron_variant
rs1000107970 -- 13,967,329(+) TTT/TT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF182 Gene

Variant ID Type Subtype PubMed ID
dgv10302n54 CNV loss 21841781
nsv475212 CNV novel sequence insertion 20440878
nsv478535 CNV novel sequence insertion 20440878

Variation tolerance for RNF182 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF182 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF182 Gene

Disorders for RNF182 Gene

Additional Disease Information for RNF182

No disorders were found for RNF182 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF182 Gene

Publications for RNF182 Gene

  1. A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation. (PMID: 18298843) Liu QY … Liu R (Molecular neurodegeneration 2008) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. (PMID: 25260751) Charlaftis N … Gallagher E (The EMBO journal 2014) 3 58

Products for RNF182 Gene

Sources for RNF182 Gene

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