Aliases for RNF182 Gene

Aliases for RNF182 Gene

  • Ring Finger Protein 182 2 3 5
  • RING-Type E3 Ubiquitin Transferase RNF182 3 4
  • E3 Ubiquitin-Protein Ligase RNF182 3 4
  • RING Finger Protein 182 4
  • EC 2.3.2.27 4
  • MGC33993 2
  • RNF182 5

External Ids for RNF182 Gene

Previous GeneCards Identifiers for RNF182 Gene

  • GC06P014034

Summaries for RNF182 Gene

GeneCards Summary for RNF182 Gene

RNF182 (Ring Finger Protein 182) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is ENSG00000288658.

UniProtKB/Swiss-Prot Summary for RNF182 Gene

  • E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514).

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF182 Gene

Genomics for RNF182 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RNF182 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J013923 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 279.5 +1.2 1224 4.4 NCOR1 MYC IKZF1 ZNF600 JUND ZNF592 ZNF223 ZSCAN16 ZIC2 ZBTB10 RNF182 HSALNG0048199 CD83 RNU7-133P ENSG00000272209 piR-46381-067 RF00017-4796
GH06J013913 Enhancer 1.1 Ensembl ENCODE 39.5 -9.2 -9245 4.8 MYC IKZF1 NCOR1 ZNF592 NFIC ZIC2 NONO REST HES1 FEZF1 RNF182 lnc-MCUR1-9 HSALNG0048196-001 HSALNG0048196-002 MCUR1 RF00017-4796
GH06J013908 Enhancer 1 Ensembl ENCODE 18.4 -15.2 -15248 0.8 ZNF654 IKZF1 REST TRIM22 TBP CTCF ZNF217 ARNT PRDM1 NBN RNF182 CD83 RNU7-133P lnc-MCUR1-9 HSALNG0048196-001 HSALNG0048196-002 MCUR1 RF00017-4796
GH06J013985 Enhancer 0.9 Ensembl ENCODE 19.3 +61.4 61353 0.7 MYC ZNF592 NFIC SMAD5 TBP ZNF316 NFE2 ZFP91 PRDM10 SUPT5H RNF182 RNU7-133P lnc-RNF182-2 piR-53049 CD83
GH06J013984 Enhancer 0.6 Ensembl 21.9 +60.5 60454 1 IKZF1 CEBPB EP300 RFX5 HLTF IRF9 ZBTB33 MLLT1 ATF3 TRIM24 RNF182 RNU7-133P lnc-RNF182-2 piR-53049 CD83
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF182 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF182

Top Transcription factor binding sites by QIAGEN in the RNF182 gene promoter:
  • AP-1
  • c-Fos
  • c-Jun
  • CUTL1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Olf-1

Genomic Locations for RNF182 Gene

Latest Assembly
chr6:13,924,446-13,980,310
(GRCh38/hg38)
Size:
55,865 bases
Orientation:
Plus strand

Previous Assembly
chr6:13,924,677-13,980,541
(GRCh37/hg19 by Entrez Gene)
Size:
55,865 bases
Orientation:
Plus strand

chr6:13,924,677-13,980,533
(GRCh37/hg19 by Ensembl)
Size:
55,857 bases
Orientation:
Plus strand

Genomic View for RNF182 Gene

Genes around RNF182 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF182 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF182 Gene

Proteins for RNF182 Gene

  • Protein details for RNF182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6D2-RN182_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF182
    Protein Accession:
    Q8N6D2
    Secondary Accessions:
    • B2RDG2
    • Q8NBG3

    Protein attributes for RNF182 Gene

    Size:
    247 amino acids
    Molecular mass:
    27402 Da
    Quaternary structure:
    • Interacts with ATP6V0C.

neXtProt entry for RNF182 Gene

Post-translational modifications for RNF182 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF182 Gene

Domains & Families for RNF182 Gene

Gene Families for RNF182 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RNF182 Gene

InterPro:
Blocks:
  • Zn-finger, RING

Suggested Antigen Peptide Sequences for RNF182 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 182 (RN182_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N6D2

UniProtKB/Swiss-Prot:

RN182_HUMAN :
  • The RING-type zinc finger domain is required for E3 ligase activity.
Domain:
  • The RING-type zinc finger domain is required for E3 ligase activity.
genes like me logo Genes that share domains with RNF182: view

Function for RNF182 Gene

Molecular function for RNF182 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:18298843};.

Enzyme Numbers (IUBMB) for RNF182 Gene

Phenotypes From GWAS Catalog for RNF182 Gene

Gene Ontology (GO) - Molecular Function for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18298843
GO:0005515 protein binding IPI 18298843
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF182: view
genes like me logo Genes that share phenotypes with RNF182: view

miRNA for RNF182 Gene

miRTarBase miRNAs that target RNF182

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF182

Clone products for research

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF182 Gene

Localization for RNF182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF182 Gene

Membrane. Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF182 gene
Compartment Confidence
nucleus 3
extracellular 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1
plasma membrane 0
peroxisome 0
cytosol 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 18298843
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF182: view

Pathways & Interactions for RNF182 Gene

genes like me logo Genes that share pathways with RNF182: view

UniProtKB/Swiss-Prot Q8N6D2-RN182_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RNF182: view

No data available for SIGNOR curated interactions for RNF182 Gene

Drugs & Compounds for RNF182 Gene

No Compound Related Data Available

Transcripts for RNF182 Gene

mRNA/cDNA for RNF182 Gene

4 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF182

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for RNF182 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for RNF182 Gene

GeneLoc Exon Structure for
RNF182

Expression for RNF182 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF182 Gene

mRNA differential expression in normal tissues according to GTEx for RNF182 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.8), Brain - Cerebellum (x5.5), Brain - Anterior cingulate cortex (BA24) (x4.8), Brain - Frontal Cortex (BA9) (x4.8), Brain - Hippocampus (x4.7), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for RNF182 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF182 Gene



Protein tissue co-expression partners for RNF182 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF182

SOURCE GeneReport for Unigene cluster for RNF182 Gene:

Hs.111164

mRNA Expression by UniProt/SwissProt for RNF182 Gene:

Q8N6D2-RN182_HUMAN
Tissue specificity: Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains (PubMed:18298843). Highly expressed in innate immune organs such as lymph nodes and spleen and in immune cells such as macrophages and dendritic cells (PubMed:31432514).

Evidence on tissue expression from TISSUES for RNF182 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with RNF182: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF182 Gene

Orthologs for RNF182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF182 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RNF182 29 30
  • 99.6 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RNF182 30
  • 94 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RNF182 29 30
  • 91.5 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rnf182 29 16 30
  • 88.53 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rnf182 29
  • 87.99 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia RNF182 30
  • 86 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RNF182 29 30
  • 83.81 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RNF182 29 30
  • 82.1 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RNF182 30
  • 90 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rnf182 29
  • 76.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17893 29
Zebrafish
(Danio rerio)
Actinopterygii rnf182 29 30
  • 57.84 (n)
OneToOne
Species where no ortholog for RNF182 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RNF182 Gene

ENSEMBL:
Gene Tree for RNF182 (if available)
TreeFam:
Gene Tree for RNF182 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF182: view image
Alliance of Genome Resources:
Additional Orthologs for RNF182

Paralogs for RNF182 Gene

Paralogs for RNF182 Gene

(1) SIMAP similar genes for RNF182 Gene using alignment to 5 proteins:

  • RN182_HUMAN
  • C9IZ30_HUMAN
  • C9JAJ3_HUMAN
  • C9JAK6_HUMAN
  • C9JVS8_HUMAN

Pseudogenes.org Pseudogenes for RNF182 Gene

genes like me logo Genes that share paralogs with RNF182: view

Variants for RNF182 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF182 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
VAR_035959 A colorectal cancer sample p.Val43Ala
VAR_035960 A colorectal cancer sample p.Pro58Leu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RNF182 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RNF182 Gene

Variant ID Type Subtype PubMed ID
dgv10302n54 CNV loss 21841781
nsv475212 CNV novel sequence insertion 20440878
nsv478535 CNV novel sequence insertion 20440878

Variation tolerance for RNF182 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.79; 16.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF182 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF182
Leiden Open Variation Database (LOVD)
RNF182

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF182 Gene

Disorders for RNF182 Gene

Additional Disease Information for RNF182

No disorders were found for RNF182 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF182 Gene

Publications for RNF182 Gene

  1. A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation. (PMID: 18298843) Liu QY … Liu R (Molecular neurodegeneration 2008) 2 3 4
  2. The E3 ubiquitin ligase RNF182 inhibits TLR-triggered cytokine production through promoting p65 ubiquitination and degradation. (PMID: 31432514) Cao Y … Yang S (FEBS letters 2019) 3 4
  3. Activation of the mammalian target of rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial ischemia-reperfusion injury. (PMID: 30450663) Wang JH … Sun JH (Journal of cellular biochemistry 2018) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for RNF182 Gene

Sources for RNF182 Gene