Aliases for RNF181 Gene
External Ids for RNF181 Gene
Previous GeneCards Identifiers for RNF181 Gene
RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]
GeneCards Summary for RNF181 Gene
RNF181 (Ring Finger Protein 181) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein ubiquitination. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is PJA2.
UniProtKB/Swiss-Prot for RNF181 Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.