Aliases for RNF181 Gene
External Ids for RNF181 Gene
Previous GeneCards Identifiers for RNF181 Gene
RNF181 binds the integrin alpha-IIb (ITGA2B; MIM 607759)/beta-3 (ITGB3; MIM 173470) complex and has E3 ubiquitin ligase activity (Brophy et al., 2008 [PubMed 18331836]).[supplied by OMIM, Dec 2008]
GeneCards Summary for RNF181 Gene
RNF181 (Ring Finger Protein 181) is a Protein Coding gene. Diseases associated with RNF181 include Deafness, Autosomal Recessive 88. Among its related pathways are Metabolism of proteins and Protein ubiquitination. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF115.
UniProtKB/Swiss-Prot Summary for RNF181 Gene
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.