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Aliases for RNF180 Gene

Aliases for RNF180 Gene

  • Ring Finger Protein 180 2 3 5
  • RING-Type E3 Ubiquitin Transferase RNF180 3 4
  • E3 Ubiquitin-Protein Ligase RNF180 3
  • RING Finger Protein 180 4
  • EC 4
  • RINES 3

External Ids for RNF180 Gene

Previous GeneCards Identifiers for RNF180 Gene

  • GC05P063498
  • GC05P060416

Summaries for RNF180 Gene

GeneCards Summary for RNF180 Gene

RNF180 (Ring Finger Protein 180) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin conjugating enzyme binding.

UniProtKB/Swiss-Prot for RNF180 Gene

  • E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.

Additional gene information for RNF180 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF180 Gene

Genomics for RNF180 Gene

GeneHancer (GH) Regulatory Elements for RNF180 Gene

Promoters and enhancers for RNF180 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J064165 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 659.4 +0.8 789 1.4 MXI1 BACH1 SIN3A ZNF335 EGR1 POLR2A EZH2 SMARCE1 ZNF687 NR2F1 RNF180 PIR52951
GH05J064166 Promoter 0.7 EPDnew 650.7 +0.0 21 0.1 CBX8 MLLT1 EZH2 RNF180 PIR52951
GH05J064210 Enhancer 0.6 Ensembl ENCODE 11.6 +45.8 45825 1.4 JUND JUN RNF180 PIR52951
GH05J064299 Enhancer 0.3 ENCODE 9.9 +134.5 134474 1.4 MAFK RNF180 PIR52951
GH05J063959 Enhancer 0.4 ENCODE 5.5 -205.6 -205578 1.2 CTCF POLR2A SIN3A RNF180 HTR1A ENSG00000248285 LOC105378999
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF180 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF180 gene promoter:
  • Evi-1

Genomic Locations for RNF180 Gene

Genomic Locations for RNF180 Gene
209,065 bases
Plus strand
207,026 bases
Plus strand

Genomic View for RNF180 Gene

Genes around RNF180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF180 Gene

Proteins for RNF180 Gene

  • Protein details for RNF180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase RNF180
    Protein Accession:
    Secondary Accessions:
    • Q0JSU3
    • Q495A8
    • Q8NBD1

    Protein attributes for RNF180 Gene

    592 amino acids
    Molecular mass:
    68254 Da
    Quaternary structure:
    • Interacts with ZIC2.
    • Sequence=CAD89939.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF180 Gene


neXtProt entry for RNF180 Gene

Post-translational modifications for RNF180 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF180 Gene

Domains & Families for RNF180 Gene

Gene Families for RNF180 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RNF180 Gene

Suggested Antigen Peptide Sequences for RNF180 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain mediates polyubiquitination of the interacting protein.
  • The RING-type zinc finger domain mediates polyubiquitination of the interacting protein.
genes like me logo Genes that share domains with RNF180: view

Function for RNF180 Gene

Molecular function for RNF180 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for RNF180 Gene

Phenotypes From GWAS Catalog for RNF180 Gene

Gene Ontology (GO) - Molecular Function for RNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0031624 ubiquitin conjugating enzyme binding IEA,IBA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA,IBA --
genes like me logo Genes that share ontologies with RNF180: view
genes like me logo Genes that share phenotypes with RNF180: view

Animal Models for RNF180 Gene

MGI Knock Outs for RNF180:

Animal Model Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RNF180 Gene

Localization for RNF180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF180 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus envelope.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF180 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with RNF180: view

Pathways & Interactions for RNF180 Gene

SuperPathways for RNF180 Gene

No Data Available

UniProtKB/Swiss-Prot Q86T96-RN180_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for RNF180 Gene

Gene Ontology (GO) - Biological Process for RNF180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0016567 protein ubiquitination IEA --
GO:0030534 adult behavior IBA,IEA --
GO:0031398 positive regulation of protein ubiquitination IEA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA,IBA --
genes like me logo Genes that share ontologies with RNF180: view

No data available for Pathways by source and SIGNOR curated interactions for RNF180 Gene

Drugs & Compounds for RNF180 Gene

No Compound Related Data Available

Transcripts for RNF180 Gene

Unigene Clusters for RNF180 Gene

Ring finger protein 180:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF180 Gene

No ASD Table

Relevant External Links for RNF180 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF180 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF180 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF180 Gene

This gene is overexpressed in Artery - Tibial (x4.0).

Protein differential expression in normal tissues from HIPED for RNF180 Gene

This gene is overexpressed in Breast (34.9) and Stomach (34.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF180 Gene

Protein tissue co-expression partners for RNF180 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF180 Gene:


SOURCE GeneReport for Unigene cluster for RNF180 Gene:


Evidence on tissue expression from TISSUES for RNF180 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with RNF180: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF180 Gene

Orthologs for RNF180 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF180 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF180 34
  • 99 (a)
(Canis familiaris)
Mammalia RNF180 34 33
  • 91.67 (n)
(Bos Taurus)
Mammalia RNF180 34 33
  • 90.99 (n)
(Rattus norvegicus)
Mammalia Rnf180 33
  • 85.02 (n)
(Mus musculus)
Mammalia Rnf180 16 34 33
  • 83.65 (n)
(Monodelphis domestica)
Mammalia RNF180 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia RNF180 34
  • 36 (a)
(Gallus gallus)
Aves RNF180 34 33
  • 65.18 (n)
(Anolis carolinensis)
Reptilia RNF180 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf180 33
  • 58.3 (n)
(Danio rerio)
Actinopterygii rnf180 34 33
  • 54.79 (n)
RNF180 (2 of 2) 34
  • 50 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7166 34
  • 33 (a)
Species where no ortholog for RNF180 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF180 Gene

Gene Tree for RNF180 (if available)
Gene Tree for RNF180 (if available)
Evolutionary constrained regions (ECRs) for RNF180: view image

Paralogs for RNF180 Gene

No data available for Paralogs for RNF180 Gene

Variants for RNF180 Gene

Sequence variations from dbSNP and Humsavar for RNF180 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000016006 -- 64,252,000(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000019959 -- 64,190,521(+) G/A intron_variant
rs1000022150 -- 64,233,948(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000026587 -- 64,200,437(+) A/C/G intron_variant
rs1000042652 -- 64,325,580(+) T/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF180 Gene

Variant ID Type Subtype PubMed ID
nsv968183 CNV duplication 23825009
nsv830322 CNV gain 17160897
nsv598351 CNV gain 21841781
nsv476583 CNV novel sequence insertion 20440878
esv2730269 CNV deletion 23290073
esv2638843 CNV deletion 19546169
esv2514773 CNV deletion 19546169

Variation tolerance for RNF180 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF180 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF180 Gene

Disorders for RNF180 Gene

Additional Disease Information for RNF180

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNF180 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF180 Gene

Publications for RNF180 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Mediation of the malignant biological characteristics of gastric cancer cells by the methylated CpG islands in RNF180 DNA promoter. (PMID: 27223257) Deng J … Liang H (Oncotarget 2016) 3 58
  5. Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis. (PMID: 27050149) Han F … Yuan Y (Oncotarget 2016) 3 58

Products for RNF180 Gene

Sources for RNF180 Gene

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