Aliases for RNF169 Gene
External Ids for RNF169 Gene
Previous GeneCards Identifiers for RNF169 Gene
GeneCards Summary for RNF169 Gene
RNF169 (Ring Finger Protein 169) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and nucleosome binding. An important paralog of this gene is RNF168.
UniProtKB/Swiss-Prot Summary for RNF169 Gene
Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair.