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Aliases for RNF168 Gene

Aliases for RNF168 Gene

  • Ring Finger Protein 168 2 3
  • Ring Finger Protein 168, E3 Ubiquitin Protein Ligase 2 3
  • RING-Type E3 Ubiquitin Transferase RNF168 3 4
  • RING Finger Protein 168 4 5
  • HRNF168 3 4
  • E3 Ubiquitin-Protein Ligase RNF168 3
  • EC 2.3.2.27 4
  • EC 6.3.2 56

External Ids for RNF168 Gene

Previous GeneCards Identifiers for RNF168 Gene

  • GC03M197687
  • GC03M196195
  • GC03M193493

Summaries for RNF168 Gene

Entrez Gene Summary for RNF168 Gene

  • This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome. [provided by RefSeq, Sep 2011]

GeneCards Summary for RNF168 Gene

RNF168 (Ring Finger Protein 168) is a Protein Coding gene. Diseases associated with RNF168 include Riddle Syndrome and Embryonal Testis Carcinoma. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include chromatin binding and ubiquitin-protein transferase activity.

UniProtKB/Swiss-Prot for RNF168 Gene

  • E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of Lys-63-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of Lys-63-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate Lys-63-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of Lys-13 and Lys-15 of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Additional gene information for RNF168 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF168 Gene

Genomics for RNF168 Gene

GeneHancer (GH) Regulatory Elements for RNF168 Gene

Promoters and enhancers for RNF168 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I196498 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 557.5 +1.9 1907 5.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 RNF168 LOC105374306 SDHAP1 SDHAP2 ENSG00000271662 LINC00969 ENSG00000231443 TM4SF19 RNU6ATAC24P UBXN7
GH03I196316 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29.7 +185.7 185687 2.8 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B POLR2B E2F8 ZNF143 ZNF207 TCTEX1D2 ENSG00000272741 TM4SF19-AS1 SDHAP1 SDHAP2 UBXN7 LINC00969 RNU6ATAC24P RNF168 ENSG00000271662
GH03I196567 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.9 -65.0 -65021 2.6 HDGF SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B CBX5 FBXO45 WDR53 SDHAP2 SDHAP1 RNF168 LINC00969 MIR570 CEP19 LINC01063 NCBP2
GH03I196285 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.3 +216.5 216499 3.2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B PCYT1A TM4SF19 WDR53 RNF168 ACAP2 ENSG00000260261 NCBP2 SLC51A ENSG00000231443 ENSG00000228028
GH03I196710 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 14.3 -208.5 -208458 3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZNF766 ZNF207 ZNF143 CEP19 PIGX WDR53 SDHAP1 RNF168 UBXN7 ENSG00000249626 RNU6-646P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF168 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF168 gene promoter:

Genomic Locations for RNF168 Gene

Genomic Locations for RNF168 Gene
chr3:196,468,783-196,503,768
(GRCh38/hg38)
Size:
34,986 bases
Orientation:
Minus strand
chr3:196,195,654-196,230,639
(GRCh37/hg19)

Genomic View for RNF168 Gene

Genes around RNF168 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF168 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF168 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF168 Gene

Proteins for RNF168 Gene

  • Protein details for RNF168 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYW5-RN168_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF168
    Protein Accession:
    Q8IYW5
    Secondary Accessions:
    • Q8NA67
    • Q96NS4

    Protein attributes for RNF168 Gene

    Size:
    571 amino acids
    Molecular mass:
    65020 Da
    Quaternary structure:
    • Monomer. Interacts with UBE2N/UBC13.
    SequenceCaution:
    • Sequence=BAC04060.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RNF168 Gene

neXtProt entry for RNF168 Gene

Selected DME Specific Peptides for RNF168 Gene

Q8IYW5:
  • QDRLLALQLQ
  • PCFSAKRRK
  • RQKGSPD
  • EPVTLPC
  • PGELRREYEEEIS

Post-translational modifications for RNF168 Gene

  • Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).
  • Ubiquitinated.
  • Ubiquitination at isoforms=158, Lys227, isoforms=232, isoforms=334, Lys341, isoforms=389, isoforms=399, Lys406, isoforms=441, isoforms=455, isoforms=468, isoforms=485, Lys524, isoforms=528, isoforms=548, and Lys560
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF168 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for RNF168
  • Santa Cruz Biotechnology (SCBT) Antibodies for RNF168

Domains & Families for RNF168 Gene

Gene Families for RNF168 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for RNF168 Gene

Suggested Antigen Peptide Sequences for RNF168 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IYW5

UniProtKB/Swiss-Prot:

RN168_HUMAN :
  • The MIU motif (motif interacting with ubiquitin) mediates the interaction with both Lys-48- and Lys-63-linked ubiquitin chains (PubMed:19500350). The UMI motif mediates interaction with ubiquitin with a preference for Lys-63-linked ubiquitin (PubMed:21041483). The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs) (PubMed:22742833).
  • Belongs to the RNF168 family.
Domain:
  • The MIU motif (motif interacting with ubiquitin) mediates the interaction with both Lys-48- and Lys-63-linked ubiquitin chains (PubMed:19500350). The UMI motif mediates interaction with ubiquitin with a preference for Lys-63-linked ubiquitin (PubMed:21041483). The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs) (PubMed:22742833).
Family:
  • Belongs to the RNF168 family.
genes like me logo Genes that share domains with RNF168: view

Function for RNF168 Gene

Molecular function for RNF168 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of Lys-63-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of Lys-63-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20/C1orf86 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate Lys-63-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of Lys-13 and Lys-15 of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).

Enzyme Numbers (IUBMB) for RNF168 Gene

Phenotypes From GWAS Catalog for RNF168 Gene

Gene Ontology (GO) - Molecular Function for RNF168 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 19203578
GO:0004842 ubiquitin-protein transferase activity IMP 23760478
GO:0005515 protein binding IPI 19203578
GO:0016740 transferase activity IEA --
GO:0031491 nucleosome binding IDA 22742833
genes like me logo Genes that share ontologies with RNF168: view
genes like me logo Genes that share phenotypes with RNF168: view

Human Phenotype Ontology for RNF168 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Clone Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for RNF168 Gene

Localization for RNF168 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF168 Gene

Nucleus. Note=Localizes to double-strand breaks (DSBs) sites of DNA damage. {ECO:0000255 HAMAP-Rule:MF_03066}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF168 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF168 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 19203578
GO:0005634 nucleus IEA,IDA 19203578
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol IDA --
GO:0035861 site of double-strand break IDA 19500350
genes like me logo Genes that share ontologies with RNF168: view

Pathways & Interactions for RNF168 Gene

genes like me logo Genes that share pathways with RNF168: view

Pathways by source for RNF168 Gene

UniProtKB/Swiss-Prot Q8IYW5-RN168_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for RNF168 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RNF168 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006302 double-strand break repair IDA 19203578
GO:0006303 double-strand break repair via nonhomologous end joining TAS --
GO:0006511 ubiquitin-dependent protein catabolic process IDA 22373579
GO:0006974 cellular response to DNA damage stimulus IEA,IDA 19500350
genes like me logo Genes that share ontologies with RNF168: view

Drugs & Compounds for RNF168 Gene

No Compound Related Data Available

Transcripts for RNF168 Gene

mRNA/cDNA for RNF168 Gene

Unigene Clusters for RNF168 Gene

Ring finger protein 168, E3 ubiquitin protein ligase:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF168 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for RNF168 Gene

GeneLoc Exon Structure for
RNF168
ECgene alternative splicing isoforms for
RNF168

Expression for RNF168 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF168 Gene

Protein differential expression in normal tissues from HIPED for RNF168 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (56.1) and Blymphocyte (12.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF168 Gene



Protein tissue co-expression partners for RNF168 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF168 Gene:

RNF168

SOURCE GeneReport for Unigene cluster for RNF168 Gene:

Hs.250648

Evidence on tissue expression from TISSUES for RNF168 Gene

  • Nervous system(4.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF168 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • immune
  • integumentary
  • lymphatic
  • nervous
  • skeleton
Regions:
Head and neck:
  • brain
  • face
  • head
  • skull
General:
  • blood
  • bone marrow
  • skin
  • white blood cell
genes like me logo Genes that share expression patterns with RNF168: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RNF168 Gene

Orthologs for RNF168 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF168 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF168 33 34
  • 99.36 (n)
dog
(Canis familiaris)
Mammalia RNF168 33 34
  • 83.48 (n)
cow
(Bos Taurus)
Mammalia RNF168 33 34
  • 82.16 (n)
-- 34
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rnf168 33 16 34
  • 75.07 (n)
rat
(Rattus norvegicus)
Mammalia Rnf168 33
  • 74.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 69 (a)
OneToMany
-- 34
  • 42 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
chicken
(Gallus gallus)
Aves RNF168 33 34
  • 55.56 (n)
lizard
(Anolis carolinensis)
Reptilia RNF168 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf168 33
  • 51.9 (n)
Str.18706 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6274 33
zebrafish
(Danio rerio)
Actinopterygii rnf168 34
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3447 34
  • 30 (a)
OneToOne
Species where no ortholog for RNF168 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF168 Gene

ENSEMBL:
Gene Tree for RNF168 (if available)
TreeFam:
Gene Tree for RNF168 (if available)

Paralogs for RNF168 Gene

(3) SIMAP similar genes for RNF168 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for RNF168 Gene

genes like me logo Genes that share paralogs with RNF168: view

No data available for Paralogs for RNF168 Gene

Variants for RNF168 Gene

Sequence variations from dbSNP and Humsavar for RNF168 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs201915239 pathogenic, Riddle syndrome 196,487,566(-) G/A coding_sequence_variant, stop_gained
rs143373143 likely-benign, not specified 196,487,574(-) G/A coding_sequence_variant, missense_variant
rs114025031 benign, not specified 196,487,449(-) C/T coding_sequence_variant, missense_variant
rs3796129 benign, not specified 196,472,333(-) G/C/T coding_sequence_variant, missense_variant
rs6790173 benign, not specified 196,472,298(-) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF168 Gene

Variant ID Type Subtype PubMed ID
esv2677146 CNV deletion 23128226
esv3599286 CNV loss 21293372
nsv1003066 CNV gain 25217958
nsv10389 CNV loss 18304495
nsv469831 CNV gain 16826518
nsv822416 CNV loss 20364138
nsv997797 CNV gain 25217958

Variation tolerance for RNF168 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.27; 81.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF168 Gene

Human Gene Mutation Database (HGMD)
RNF168
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF168

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF168 Gene

Disorders for RNF168 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RNF168 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
riddle syndrome
  • radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties
embryonal testis carcinoma
  • embryonal carcinoma of testis
chromosome 3q29 deletion syndrome
  • microdeletion 3q29 syndrome
diamond-blackfan anemia
  • blackfan - diamond syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RN168_HUMAN
  • Riddle syndrome (RIDDLES) [MIM:611943]: Characterized by increased radiosensitivity, immunodeficiency, mild motor control and learning difficulties, facial dysmorphism, and short stature. Defects are probably due to impaired localization of TP53BP1 and BRCA1 at DNA lesions. {ECO:0000269 PubMed:19203578}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for RNF168

genes like me logo Genes that share disorders with RNF168: view

No data available for Genatlas for RNF168 Gene

Publications for RNF168 Gene

  1. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. (PMID: 23760478) Fradet-Turcotte A … Durocher D (Nature 2013) 3 4 58
  2. RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. (PMID: 22373579) Mallette FA … Richard S (The EMBO journal 2012) 3 4 58
  3. DNA damage-inducible SUMOylation of HERC2 promotes RNF8 binding via a novel SUMO-binding Zinc finger. (PMID: 22508508) Danielsen JR … Mailand N (The Journal of cell biology 2012) 3 4 58
  4. Molecular insights into the function of RING finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation. (PMID: 22589545) Campbell SJ … Glover JN (The Journal of biological chemistry 2012) 3 4 58
  5. A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network. (PMID: 22705371) Yan Z … Wang W (Molecular cell 2012) 3 4 58

Products for RNF168 Gene

Sources for RNF168 Gene

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