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Aliases for RNF167 Gene

Aliases for RNF167 Gene

  • Ring Finger Protein 167 2 3 5
  • RING-Type E3 Ubiquitin Transferase RNF167 3 4
  • RING105 3 4
  • E3 Ubiquitin-Protein Ligase RNF167 3
  • RING Finger Protein 167 4
  • 5730408C10Rik 3
  • EC 2.3.2.27 4
  • LP2254 3

External Ids for RNF167 Gene

Previous GeneCards Identifiers for RNF167 Gene

  • GC17P004784
  • GC17P004845

Summaries for RNF167 Gene

Entrez Gene Summary for RNF167 Gene

  • RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

GeneCards Summary for RNF167 Gene

RNF167 (Ring Finger Protein 167) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF13.

UniProtKB/Swiss-Prot for RNF167 Gene

  • May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.

Additional gene information for RNF167 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF167 Gene

Genomics for RNF167 Gene

GeneHancer (GH) Regulatory Elements for RNF167 Gene

Promoters and enhancers for RNF167 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J004937 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 656.3 +5.0 5009 14.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC ENO3 RNF167 SLC25A11 PFN1 ZNF232 SPAG7 CHRNE LOC100130950 CAMTA2 RPAIN
GH17J004965 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.3 +28.6 28608 5.4 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 SP3 SPAG7 PIR49988 MIR6865 MIR6864 ENSG00000262429 ZNF232 NUP88 MIS12 INCA1 CHRNE
GH17J004996 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.8 +58.8 58839 4.2 HDGF MLX ARID4B SIN3A DMAP1 YBX1 YY1 ZNF766 ZNF207 ZNF143 INCA1 KIF1C NUP88 CHRNE ZNF232 MIS12 ZZEF1 CAMTA2 DERL2 ENSG00000234203
GH17J004852 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -86.4 -86373 3.3 NFIB ZIC2 ZFHX2 POLR2A EED ZNF547 PRDM10 FOSL2 RUNX3 ZBTB20 CHRNE MINK1 PLD2 ZMYND15 CXCL16 RNF167 SLC25A11 SPAG7 ENO3 PFN1
GH17J004856 Enhancer 1.2 Ensembl ENCODE dbSUPER 10.8 -81.2 -81232 5.3 ELF3 FOXA2 ZBTB40 RAD21 EGR1 PRPF4 FOS THAP11 MIXL1 EGR2 ATP6V0CP1 CHRNE C17orf107 ZFP3 MINK1 PLD2 ARRB2 LOC101559451 RPS12P29 PELP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF167 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF167 gene promoter:

Genomic Locations for RNF167 Gene

Genomic Locations for RNF167 Gene
chr17:4,940,008-4,945,222
(GRCh38/hg38)
Size:
5,215 bases
Orientation:
Plus strand
chr17:4,843,303-4,848,517
(GRCh37/hg19)

Genomic View for RNF167 Gene

Genes around RNF167 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF167 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF167 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF167 Gene

Proteins for RNF167 Gene

  • Protein details for RNF167 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6Y7-RN167_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF167
    Protein Accession:
    Q9H6Y7
    Secondary Accessions:
    • D3DTK8
    • Q6XYE0
    • Q8NDC1
    • Q9Y3V1

    Protein attributes for RNF167 Gene

    Size:
    350 amino acids
    Molecular mass:
    38299 Da
    Quaternary structure:
    • Interacts with SLC22A18.
    SequenceCaution:
    • Sequence=AAP34453.1; Type=Frameshift; Positions=65; Evidence={ECO:0000305};

neXtProt entry for RNF167 Gene

Post-translational modifications for RNF167 Gene

  • Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.
  • Ubiquitination at Lys272, posLast=223223, posLast=214214, posLast=210210, and Lys97
  • Glycosylation at Asn79
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF167 Gene

Domains & Families for RNF167 Gene

Gene Families for RNF167 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for RNF167 Gene

Suggested Antigen Peptide Sequences for RNF167 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF167: view

No data available for UniProtKB/Swiss-Prot for RNF167 Gene

Function for RNF167 Gene

Molecular function for RNF167 Gene

UniProtKB/Swiss-Prot Function:
May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Enzyme Numbers (IUBMB) for RNF167 Gene

Phenotypes From GWAS Catalog for RNF167 Gene

Gene Ontology (GO) - Molecular Function for RNF167 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 16314844
GO:0005515 protein binding IPI 16314844
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF167: view
genes like me logo Genes that share phenotypes with RNF167: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF167

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF167 Gene

Localization for RNF167 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF167 Gene

Endomembrane system; Single-pass membrane protein. Note=Targeted to cytoplasmic membranes.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF167 gene
Compartment Confidence
plasma membrane 2
cytosol 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RNF167 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16314844
GO:0012505 endomembrane system IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF167: view

Pathways & Interactions for RNF167 Gene

SuperPathways for RNF167 Gene

No Data Available

UniProtKB/Swiss-Prot Q9H6Y7-RN167_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF167 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 16314844
GO:0016567 protein ubiquitination IEA --
GO:0045786 negative regulation of cell cycle IMP 16314844
genes like me logo Genes that share ontologies with RNF167: view

No data available for Pathways by source and SIGNOR curated interactions for RNF167 Gene

Drugs & Compounds for RNF167 Gene

No Compound Related Data Available

Transcripts for RNF167 Gene

Unigene Clusters for RNF167 Gene

Ring finger protein 167:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF167 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^
SP1: - - - - - - - - -
SP2: -
SP3: -
SP4: -
SP5: - - - - -
SP6: - -
SP7: - - -
SP8: - - - - - - -
SP9:
SP10: - - - -
SP11: - - - - -
SP12: - - - -
SP13: -
SP14: - - - - -
SP15: - - -
SP16:
SP17: - -
SP18: - -
SP19: - - - - - -
SP20:

ExUns: 12a · 12b · 12c ^ 13a · 13b · 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for RNF167 Gene

GeneLoc Exon Structure for
RNF167
ECgene alternative splicing isoforms for
RNF167

Expression for RNF167 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF167 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF167 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for RNF167 Gene

This gene is overexpressed in Adrenal (56.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF167 Gene



Protein tissue co-expression partners for RNF167 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF167 Gene:

RNF167

SOURCE GeneReport for Unigene cluster for RNF167 Gene:

Hs.7158

mRNA Expression by UniProt/SwissProt for RNF167 Gene:

Q9H6Y7-RN167_HUMAN
Tissue specificity: Strongly expressed in the kidney and liver (at protein level).

Evidence on tissue expression from TISSUES for RNF167 Gene

  • Nervous system(4.9)
  • Intestine(4.4)
  • Liver(4.4)
  • Lung(2.9)
  • Eye(2.4)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with RNF167: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF167 Gene

Orthologs for RNF167 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RNF167 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF167 34 33
  • 99.62 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RNF167 34 33
  • 92.99 (n)
OneToMany
-- 34
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Rnf167 16 34 33
  • 90.19 (n)
rat
(Rattus norvegicus)
Mammalia Rnf167 33
  • 89.19 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF167 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF167 34
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF167 34
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF167 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf167 33
  • 61.22 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf167 34 33
  • 58.2 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10277 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18B12.4 34 33
  • 44.73 (n)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G22670 33
  • 45.36 (n)
rice
(Oryza sativa)
Liliopsida Os03g0167500 33
  • 45.47 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.598 34
  • 30 (a)
OneToMany
Species where no ortholog for RNF167 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF167 Gene

ENSEMBL:
Gene Tree for RNF167 (if available)
TreeFam:
Gene Tree for RNF167 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF167: view image

Paralogs for RNF167 Gene

(6) SIMAP similar genes for RNF167 Gene using alignment to 8 proteins:

  • RN167_HUMAN
  • I3L0L6_HUMAN
  • I3L0V7_HUMAN
  • I3L1K4_HUMAN
  • I3L2D4_HUMAN
  • I3L2Y3_HUMAN
  • I3L462_HUMAN
  • K7EN24_HUMAN
genes like me logo Genes that share paralogs with RNF167: view

Variants for RNF167 Gene

Sequence variations from dbSNP and Humsavar for RNF167 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1057519428 benign, Renal carnitine transport defect 4,944,793(+) GGGG/GGGGG coding_sequence_variant, frameshift
rs1001333628 -- 4,939,520(+) C/T upstream_transcript_variant
rs1001421365 -- 4,944,804(+) G/A coding_sequence_variant, missense_variant
rs1001935294 -- 4,940,684(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1002258441 -- 4,944,987(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF167 Gene

Variant ID Type Subtype PubMed ID
dgv3088n100 CNV gain 25217958
esv3572365 CNV gain 25503493
nsv574273 CNV gain 21841781
nsv574275 CNV gain 21841781
nsv833347 CNV loss 17160897
nsv833349 CNV loss 17160897
nsv833350 CNV loss 17160897

Variation tolerance for RNF167 Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF167 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF167

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF167 Gene

Disorders for RNF167 Gene

Additional Disease Information for RNF167

No disorders were found for RNF167 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF167 Gene

Publications for RNF167 Gene

  1. Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation. (PMID: 23353890) Yamazaki Y … Palmer RH (The EMBO journal 2013) 2 3 58
  2. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. (PMID: 23129617) Lussier MP … Roche KW (Proceedings of the National Academy of Sciences of the United States of America 2012) 2 3 58
  3. Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. (PMID: 16314844) Yamada HY … Gorbsky GJ (Oncogene 2006) 3 4 58
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for RNF167 Gene

Sources for RNF167 Gene

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