Aliases for RNF166 Gene
External Ids for RNF166 Gene
Previous GeneCards Identifiers for RNF166 Gene
GeneCards Summary for RNF166 Gene
RNF166 (Ring Finger Protein 166) is a Protein Coding gene. Diseases associated with RNF166 include Generalized Epilepsy With Febrile Seizures Plus, Type 9 and Myopathy, Congenital, Compton-North. An important paralog of this gene is RNF114.
UniProtKB/Swiss-Prot Summary for RNF166 Gene
E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Plays also a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896).