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Aliases for RNF166 Gene

Aliases for RNF166 Gene

  • Ring Finger Protein 166 2 3 5
  • RING Finger Protein 166 3

External Ids for RNF166 Gene

Previous GeneCards Identifiers for RNF166 Gene

  • GC16M088508
  • GC16M087290
  • GC16M088762
  • GC16M074457

Summaries for RNF166 Gene

GeneCards Summary for RNF166 Gene

RNF166 (Ring Finger Protein 166) is a Protein Coding gene. An important paralog of this gene is RNF114.

Additional gene information for RNF166 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF166 Gene

Genomics for RNF166 Gene

GeneHancer (GH) Regulatory Elements for RNF166 Gene

Promoters and enhancers for RNF166 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J088698 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 687.5 +3.6 3590 9.4 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B SIN3A DMAP1 YY1 CBX5 RNF166 CTU2 ZC3H18 ANKRD11 ENSG00000268218 LINC00304 SNAI3-AS1 ENSG00000259877 BANP SNAI3
GH16J088452 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 16.1 +251.5 251485 6 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZFPM1 RNF166 ZCCHC14 ENSG00000260121 ZC3H18 SNAI3 MIR5189
GH16J088685 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.5 +19.5 19466 3.6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 CBX5 FOS KLF13 PIR40856 SNAI3 SNORD68 ACSF3 RPL13 ANKRD11 BANP SNAI3-AS1 RNF166 MVD
GH16J088779 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.4 -76.3 -76336 6.7 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 PIEZO1 ANKRD11 ZC3H18 APRT ENSG00000259877 LINC00304 BANP ENSG00000268218 SNORD68 CDT1
GH16J088649 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 8.7 +54.8 54824 4.7 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 IRF4 CYBA ANKRD11 BANP LOC101927863 ZC3H18 ENSG00000268218 SNAI3-AS1 ACSF3 RPL13 SNORD68
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF166 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF166 gene promoter:
  • Olf-1
  • GR-alpha
  • GR
  • Pax-5
  • Tal-1beta
  • E47
  • ITF-2
  • CREB
  • deltaCREB

Genomic Locations for RNF166 Gene

Genomic Locations for RNF166 Gene
9,927 bases
Minus strand
9,927 bases
Minus strand

Genomic View for RNF166 Gene

Genes around RNF166 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF166 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF166 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF166 Gene

Proteins for RNF166 Gene

  • Protein details for RNF166 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 166
    Protein Accession:
    Secondary Accessions:
    • B3KQ03
    • D3DX75
    • H3BTU8
    • Q96DM0

    Protein attributes for RNF166 Gene

    237 amino acids
    Molecular mass:
    26122 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for RNF166 Gene


neXtProt entry for RNF166 Gene

Post-translational modifications for RNF166 Gene

  • Ubiquitination at Lys167 and posLast=129129
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RNF166 Gene

Domains & Families for RNF166 Gene

Gene Families for RNF166 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RNF166 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF166: view

No data available for UniProtKB/Swiss-Prot for RNF166 Gene

Function for RNF166 Gene

Phenotypes From GWAS Catalog for RNF166 Gene

Gene Ontology (GO) - Molecular Function for RNF166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031624 ubiquitin conjugating enzyme binding IBA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with RNF166: view
genes like me logo Genes that share phenotypes with RNF166: view

Animal Model Products

miRNA for RNF166 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF166 Gene

Localization for RNF166 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF166 gene
Compartment Confidence
nucleus 4
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
genes like me logo Genes that share ontologies with RNF166: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF166 Gene

Pathways & Interactions for RNF166 Gene

SuperPathways for RNF166 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with RNF166: view

No data available for Pathways by source and SIGNOR curated interactions for RNF166 Gene

Drugs & Compounds for RNF166 Gene

No Compound Related Data Available

Transcripts for RNF166 Gene

Unigene Clusters for RNF166 Gene

Ring finger protein 166:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF166 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - -
SP7: - -

Relevant External Links for RNF166 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF166 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF166 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF166 Gene

This gene is overexpressed in Whole Blood (x12.9).

Protein differential expression in normal tissues from HIPED for RNF166 Gene

This gene is overexpressed in Neutrophil (46.1), Peripheral blood mononuclear cells (12.3), and Blymphocyte (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF166 Gene

Protein tissue co-expression partners for RNF166 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF166 Gene:


SOURCE GeneReport for Unigene cluster for RNF166 Gene:


Evidence on tissue expression from TISSUES for RNF166 Gene

  • Intestine(4.3)
  • Nervous system(4.3)
  • Blood(4.2)
  • Eye(4)
genes like me logo Genes that share expression patterns with RNF166: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF166 Gene

Orthologs for RNF166 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF166 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF166 34 33
  • 99.72 (n)
(Bos Taurus)
Mammalia RNF166 34 33
  • 91.28 (n)
(Mus musculus)
Mammalia Rnf166 16 34 33
  • 91.14 (n)
(Rattus norvegicus)
Mammalia Rnf166 33
  • 90.15 (n)
(Canis familiaris)
Mammalia RNF166 34 33
  • 90.01 (n)
(Monodelphis domestica)
Mammalia RNF166 34
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia RNF166 34
  • 86 (a)
(Gallus gallus)
Aves RNF166 34 33
  • 83.69 (n)
(Anolis carolinensis)
Reptilia RNF166 34
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf166 33
  • 77.12 (n)
(Danio rerio)
Actinopterygii RNF166 (1 of 2) 34
  • 89 (a)
RNF166 (2 of 2) 34
  • 82 (a)
LOC100334524 33
  • 75.81 (n)
Species where no ortholog for RNF166 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF166 Gene

Gene Tree for RNF166 (if available)
Gene Tree for RNF166 (if available)
Evolutionary constrained regions (ECRs) for RNF166: view image

Paralogs for RNF166 Gene

Paralogs for RNF166 Gene

(7) SIMAP similar genes for RNF166 Gene using alignment to 4 proteins:

  • RN166_HUMAN
  • H3BQ58_HUMAN
genes like me logo Genes that share paralogs with RNF166: view

Variants for RNF166 Gene

Sequence variations from dbSNP and Humsavar for RNF166 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000040633 -- 88,706,261(-) C/T coding_sequence_variant, genic_upstream_transcript_variant, missense_variant
rs1000079824 -- 88,703,274(-) A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000143981 -- 88,708,407(-) G/A/T upstream_transcript_variant
rs1000384739 -- 88,703,797(-) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000433889 -- 88,701,800(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF166 Gene

Variant ID Type Subtype PubMed ID
nsv952070 CNV deletion 24416366
nsv833327 CNV loss 17160897
nsv833325 CNV loss 17160897
nsv827833 CNV gain 20364138
nsv482951 CNV loss 15286789
nsv471114 CNV gain 18288195
nsv471113 CNV loss 18288195
nsv1121921 CNV deletion 24896259
nsv1065973 CNV loss 25217958
dgv3064n100 CNV gain 25217958

Variation tolerance for RNF166 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF166 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF166 Gene

Disorders for RNF166 Gene

Additional Disease Information for RNF166

No disorders were found for RNF166 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF166 Gene

Publications for RNF166 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy. (PMID: 27880896) Heath RJ … Xavier RJ (Cell reports 2016) 3 58

Products for RNF166 Gene

Sources for RNF166 Gene

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