Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RNF165 Gene

Aliases for RNF165 Gene

  • Ring Finger Protein 165 2 3
  • RING Finger Protein 165 4 5
  • E3 Ubiquitin-Protein Ligase RNF165 3
  • EC 2.3.2.27 4
  • RNF111L2 3
  • ARKL2 3

External Ids for RNF165 Gene

Previous GeneCards Identifiers for RNF165 Gene

  • GC18U900221
  • GC18P042169
  • GC18P043914
  • GC18P040771

Summaries for RNF165 Gene

Entrez Gene Summary for RNF165 Gene

  • Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF165 Gene

RNF165 (Ring Finger Protein 165) is a Protein Coding gene. An important paralog of this gene is RNF111.

UniProtKB/Swiss-Prot for RNF165 Gene

  • E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.

Additional gene information for RNF165 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF165 Gene

Genomics for RNF165 Gene

GeneHancer (GH) Regulatory Elements for RNF165 Gene

Promoters and enhancers for RNF165 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I046333 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.4 +9.7 9743 5.5 PKNOX1 ZSCAN4 SIN3A ZNF2 RAD21 YY1 ETS1 ZNF335 GLIS2 RCOR1 RNF165 GC18P046376
GH18I046418 Enhancer 0.9 Ensembl ENCODE 17.2 +92.7 92700 1.2 SRF RXRA NR2F1 MAFG EBF1 REST RAD21 NR2F2 JUND ATF3 RNF165 LOC105372095 GC18P046450
GH18I046410 Enhancer 1 FANTOM5 Ensembl ENCODE 12.6 +85.3 85338 4.2 KLF1 RFX1 RXRA L3MBTL2 FEZF1 ZIC2 NR2F2 POLR2A GLIS1 PRDM10 RNF165 LOC105372095 GC18P046450
GH18I046414 Enhancer 0.7 Ensembl ENCODE 17.9 +88.0 88014 0.8 SP1 PKNOX1 L3MBTL2 IKZF1 RCOR1 MNT CHD2 RNF165 LOC105372095 GC18P046450
GH18I046259 Enhancer 0.9 Ensembl ENCODE 11.2 -64.1 -64119 6.6 PKNOX1 ZSCAN4 CEBPG ZBTB40 PRDM10 TRIM24 ATF7 RFX1 CEBPB EP300 RNF165 ATP5F1A C18orf25 GC18P046277
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RNF165 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF165 gene promoter:

Genomic Locations for RNF165 Gene

Genomic Locations for RNF165 Gene
chr18:46,326,809-46,463,140
(GRCh38/hg38)
Size:
136,332 bases
Orientation:
Plus strand
chr18:43,906,772-44,043,103
(GRCh37/hg19)

Genomic View for RNF165 Gene

Genes around RNF165 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF165 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF165 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF165 Gene

Proteins for RNF165 Gene

  • Protein details for RNF165 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZSG1-RN165_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF165
    Protein Accession:
    Q6ZSG1
    Secondary Accessions:
    • B3KVD1

    Protein attributes for RNF165 Gene

    Size:
    346 amino acids
    Molecular mass:
    39526 Da
    Quaternary structure:
    • Monomer; binding to the ubiquitin-conjugating enzyme E2 does not trigger homodimerization (PubMed:26656854).

    Three dimensional structures from OCA and Proteopedia for RNF165 Gene

    Alternative splice isoforms for RNF165 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF165 Gene

Post-translational modifications for RNF165 Gene

No data available for DME Specific Peptides for RNF165 Gene

Domains & Families for RNF165 Gene

Gene Families for RNF165 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for RNF165 Gene

Suggested Antigen Peptide Sequences for RNF165 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZSG1

UniProtKB/Swiss-Prot:

RN165_HUMAN :
  • The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin (PubMed:26656854). Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the closed conformation and stimulates ubiquitin transfer (PubMed:26656854).
  • Belongs to the Arkadia family.
Domain:
  • The RING-type zinc finger mediates the E3 ubiquitin-protein ligase activity and binds directly to free ubiquitin (PubMed:26656854). Non-covalent ubiquitin-binding stabilizes the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the closed conformation and stimulates ubiquitin transfer (PubMed:26656854).
Family:
  • Belongs to the Arkadia family.
genes like me logo Genes that share domains with RNF165: view

Function for RNF165 Gene

Molecular function for RNF165 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
Binds free ubiquitin non-covalently via its RING-type zinc finger. Ubiquitin-binding leads to enhance the E3 ubiquitin-protein ligase activity by stabilizing the ubiquitin-conjugating enzyme E2 (donor ubiquitin) in the closed conformation and activating ubiquitin transfer (PubMed:26656854).
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.

Enzyme Numbers (IUBMB) for RNF165 Gene

Phenotypes From GWAS Catalog for RNF165 Gene

Gene Ontology (GO) - Molecular Function for RNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23610558
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF165: view
genes like me logo Genes that share phenotypes with RNF165: view

Animal Model Products

CRISPR Products

miRNA for RNF165 Gene

miRTarBase miRNAs that target RNF165

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF165 Gene

Localization for RNF165 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF165 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF165 gene
Compartment Confidence
nucleus 4
plasma membrane 3
mitochondrion 3
cytosol 3
endoplasmic reticulum 2
extracellular 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with RNF165: view

Pathways & Interactions for RNF165 Gene

SuperPathways for RNF165 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF165 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0007409 axonogenesis IEA --
GO:0008045 motor neuron axon guidance IBA --
GO:0010259 multicellular organism aging IEA --
GO:0030163 protein catabolic process IEA --
genes like me logo Genes that share ontologies with RNF165: view

No data available for Pathways by source and SIGNOR curated interactions for RNF165 Gene

Drugs & Compounds for RNF165 Gene

No Compound Related Data Available

Transcripts for RNF165 Gene

mRNA/cDNA for RNF165 Gene

(4) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF165 Gene

Ring finger protein 165:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF165 Gene

No ASD Table

Relevant External Links for RNF165 Gene

GeneLoc Exon Structure for
RNF165
ECgene alternative splicing isoforms for
RNF165

Expression for RNF165 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF165 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF165 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.9) and Brain - Cerebellum (x5.1).

Protein differential expression in normal tissues from HIPED for RNF165 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RNF165 Gene



Protein tissue co-expression partners for RNF165 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF165 Gene:

RNF165

SOURCE GeneReport for Unigene cluster for RNF165 Gene:

Hs.501114

Evidence on tissue expression from TISSUES for RNF165 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with RNF165: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF165 Gene

Orthologs for RNF165 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF165 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF165 33 34
  • 99.81 (n)
cow
(Bos Taurus)
Mammalia LOC537072 33
  • 95.18 (n)
RNF165 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RNF165 33 34
  • 94.61 (n)
rat
(Rattus norvegicus)
Mammalia Rnf165 33
  • 94.22 (n)
mouse
(Mus musculus)
Mammalia Rnf165 33 16 34
  • 94.03 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF165 34
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 91 (a)
OneToMany
-- 34
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves RNF165 33 34
  • 82.46 (n)
lizard
(Anolis carolinensis)
Reptilia RNF165 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf165 33
  • 79.51 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf165b 33 34
  • 69.89 (n)
rnf165a 34
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG6923 34
  • 5 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea toe-4 34
  • 12 (a)
OneToMany
Species where no ortholog for RNF165 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF165 Gene

ENSEMBL:
Gene Tree for RNF165 (if available)
TreeFam:
Gene Tree for RNF165 (if available)

Paralogs for RNF165 Gene

Paralogs for RNF165 Gene

(1) SIMAP similar genes for RNF165 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with RNF165: view

Variants for RNF165 Gene

Sequence variations from dbSNP and Humsavar for RNF165 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000004578 -- 46,377,235(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000018115 -- 46,437,917(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000018122 -- 46,347,170(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000039152 -- 46,389,646(+) G/C genic_downstream_transcript_variant, intron_variant
rs1000062341 -- 46,421,013(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF165 Gene

Variant ID Type Subtype PubMed ID
dgv596e199 CNV deletion 23128226
esv22561 CNV loss 19812545
esv24686 CNV loss 19812545
esv2677564 CNV deletion 23128226
esv3326438 CNV duplication 20981092
esv3419380 CNV duplication 20981092
esv3642432 CNV loss 21293372
esv3642433 CNV loss 21293372
nsv1072797 CNV deletion 25765185
nsv1144832 CNV deletion 24896259
nsv2279 CNV insertion 18451855
nsv471938 CNV novel sequence insertion 20440878
nsv576811 CNV loss 21841781
nsv576812 CNV loss 21841781
nsv828224 CNV gain 20364138

Variation tolerance for RNF165 Gene

Residual Variation Intolerance Score: 27.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF165 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF165

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF165 Gene

Disorders for RNF165 Gene

Additional Disease Information for RNF165

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNF165 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF165 Gene

Publications for RNF165 Gene

  1. Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity. (PMID: 26656854) Wright JD … Day CL (Nature structural & molecular biology 2016) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. (PMID: 23610558) Kelly CE … Episkopou V (PLoS biology 2013) 3 58
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk SJ … Timmers HT (Molecular systems biology 2009) 3 58

Products for RNF165 Gene

Sources for RNF165 Gene

Content
Loading form....