Aliases for RNF165 Gene
External Ids for RNF165 Gene
Previous GeneCards Identifiers for RNF165 Gene
Encoded in regions involved in pericentric inversions in patients with bipolar affective disorder. [provided by RefSeq, Jul 2008]
GeneCards Summary for RNF165 Gene
RNF165 (Ring Finger Protein 165) is a Protein Coding gene. An important paralog of this gene is RNF111.
UniProtKB/Swiss-Prot for RNF165 Gene
E3 ubiquitin-protein ligase that acts as a regulator of motor axon elongation. Required for efficient motor axon extension in the dorsal forelimb by enhancing the transcriptional responses of the SMAD1/SMAD5/SMAD8 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD6, SMAD7, SKI and SNON isoform of SKIL.