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Aliases for RNF157 Gene
Aliases for RNF157 Gene
External Ids for RNF157 Gene
- HGNC: 29402
- Entrez Gene: 114804
- Ensembl: ENSG00000141576
- UniProtKB: Q96PX1
Previous GeneCards Identifiers for RNF157 Gene
- GC17M074738
- GC17M071651
- GC17M074138
- GC17M069567
Summaries for RNF157 Gene
GeneCards Summary for RNF157 Gene
RNF157 (Ring Finger Protein 157) is a Protein Coding gene. An important paralog of this gene is MGRN1.
UniProtKB/Swiss-Prot Summary for RNF157 Gene
-
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).
Additional gene information for RNF157 Gene
- HGNC(29402)
- Entrez Gene(114804)
- Ensembl(ENSG00000141576)
- UniProtKB(Q96PX1)
- Open Targets Platform(ENSG00000141576)
- Search for RNF157 at DataMed
- Search for RNF157 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF157 Gene
Genomics for RNF157 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RNF157 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RNF157 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF157
- Top Transcription factor binding sites by QIAGEN in the RNF157 gene promoter:
-
- Bach1
- COUP
- COUP-TF
- COUP-TF1
- Evi-1
- GATA-1
- HNF-4alpha1
- HNF-4alpha2
- JunD
- NF-kappaB1
Genomic Locations for RNF157 Gene
Genomic Locations for RNF157 Gene
- chr17:76,142,456-76,240,493
- (GRCh38/hg38)
- Size:
- 98,038 bases
- Orientation:
- Minus strand
- chr17:74,138,534-74,236,454
- (GRCh37/hg19)
- Size:
- 97,921 bases
- Orientation:
- Minus strand
Genomic View for RNF157 Gene
Genes around RNF157 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
RNF157 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNF157 Gene
Proteins for RNF157 Gene
-
Protein details for RNF157 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96PX1-RN157_HUMAN
- Recommended name:
- E3 ubiquitin ligase RNF157
- Protein Accession:
- Q96PX1
- Q8NB72
- Q96N56
Protein attributes for RNF157 Gene
- Size:
- 679 amino acids
- Molecular mass:
- 73579 Da
- Quaternary structure:
-
- Interacts with APBB1 (PubMed:25342469). Interacts with CHD1; CHD1-binding controls RNF157 stability (PubMed:28655764). Interacts with ATRN, MEGF8, TECR, MSI2, PLRG1, BYSL, MTERF3, PSMA1, MRPS18B, PRPF4, FASTKD2, SLC25A1, SMU1, CNOT9, MRPS2, MAGT1, FXR2, EMD, PSMD8, HDAC1, RAN, HSD17B12, TXNDC5 AND MRPL19 (PubMed:28655764).
- SequenceCaution:
-
- Sequence=BAB67810.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71053.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03669.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for RNF157 Gene
Post-translational modifications for RNF157 Gene
- Phosphorylation at Ser-660, Ser-661, Ser-662 and Ser-663 downstream of the PI3K and MAPK pathways influences the E3 ligase activity and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner (PubMed:28655764).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for RNF157 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for RNF157
- Invitrogen Antibodies for RNF157 (AFLGC-RNF157)
- antibodies-online: Show 8 available RNF157 Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for RNF157
- Search Origene for MassSpec and Protein Over-expression Lysates for RNF157
- Origene Custom Protein Services for RNF157
- Novus Biologicals proteins for RNF157
-
Abcam proteins for RNF157
No data available for DME Specific Peptides for RNF157 Gene
Domains & Families for RNF157 Gene
Gene Families for RNF157 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for RNF157 Gene
- InterPro:
- Blocks:
-
- Zn-finger, RING
- ProtoNet:
Suggested Antigen Peptide Sequences for RNF157 Gene
- GenScript: Design optimal peptide antigens:
-
- RNF157 protein (Q9BTC5_HUMAN)
- RING finger protein 157 (RN157_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96PX1UniProtKB/Swiss-Prot:
RN157_HUMAN :- The D-box motifs play a key role in RNF157 stabilization (PubMed:28655764).
- Domain:
-
- The D-box motifs play a key role in RNF157 stabilization (PubMed:28655764).
Function for RNF157 Gene
Molecular function for RNF157 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence={ECO:0000269|PubMed:25342469};.
- UniProtKB/Swiss-Prot Induction:
- Expression is cell cycle-specific with higher levels in cells arrested in G1/S and G2/M (PubMed:28655764).
Enzyme Numbers (IUBMB) for RNF157 Gene
Phenotypes From GWAS Catalog for RNF157 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
| GO:0061630 | ubiquitin protein ligase activity | IBA,ISS | -- |
Phenotypes for RNF157 Gene
- MGI mutant phenotypes for RNF157:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RNF157:
Animal Models for RNF157 Gene
- MGI Knock Outs for RNF157:
-
- Rnf157 Rnf157<tm1b(EUCOMM)Wtsi>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNF157 - Select products 50% OFF >
- * RNF157 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RNF157
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF157
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF157
miRNA for RNF157 Gene
- miRTarBase miRNAs that target RNF157
-
- mmu-miR-30e-5p (MIRT013409)
- hsa-miR-335-5p (MIRT017355)
- hsa-miR-18a-5p (MIRT050735)
- hsa-miR-6880-5p (MIRT460671)
- hsa-miR-6870-5p (MIRT460672)
- hsa-miR-7111-5p (MIRT460673)
- hsa-miR-5698 (MIRT460674)
- hsa-miR-4723-5p (MIRT460675)
- hsa-miR-6825-5p (MIRT460676)
- hsa-miR-6883-5p (MIRT460677)
- hsa-miR-6785-5p (MIRT460678)
- hsa-miR-4728-5p (MIRT460679)
- hsa-miR-149-3p (MIRT460680)
- hsa-miR-7106-5p (MIRT460681)
- hsa-miR-4763-3p (MIRT460682)
- hsa-miR-1207-5p (MIRT460683)
- hsa-miR-6797-5p (MIRT460684)
- hsa-miR-1249-5p (MIRT460685)
- hsa-miR-766-5p (MIRT460686)
- hsa-miR-6077 (MIRT460687)
- hsa-miR-6722-3p (MIRT460688)
- hsa-miR-1909-3p (MIRT460689)
- hsa-miR-6133 (MIRT460690)
- hsa-miR-6130 (MIRT460691)
- hsa-miR-6129 (MIRT460692)
- hsa-miR-6127 (MIRT460693)
- hsa-miR-4510 (MIRT460694)
- hsa-miR-4419a (MIRT460695)
- hsa-miR-4784 (MIRT460696)
- hsa-miR-3150b-3p (MIRT460697)
- hsa-miR-605-3p (MIRT460698)
- hsa-miR-6798-5p (MIRT460699)
- hsa-miR-6794-5p (MIRT460700)
- hsa-miR-4716-3p (MIRT460701)
- hsa-miR-4756-5p (MIRT460702)
- hsa-miR-4739 (MIRT460703)
- hsa-miR-1321 (MIRT460704)
- hsa-miR-6893-5p (MIRT460705)
- hsa-miR-940 (MIRT460706)
- hsa-miR-6808-5p (MIRT460707)
- hsa-miR-3714 (MIRT460708)
- hsa-miR-2355-3p (MIRT551942)
- hsa-miR-3674 (MIRT551943)
- hsa-miR-676-3p (MIRT551944)
- hsa-miR-6772-3p (MIRT551945)
- hsa-miR-580-3p (MIRT551946)
- hsa-miR-7975 (MIRT551947)
- hsa-miR-4473 (MIRT551948)
- hsa-miR-636 (MIRT551949)
- hsa-miR-4732-5p (MIRT551950)
- hsa-miR-6832-5p (MIRT551951)
- hsa-miR-3907 (MIRT551952)
- hsa-miR-4448 (MIRT551953)
- hsa-miR-4268 (MIRT551954)
- hsa-miR-539-5p (MIRT551955)
- hsa-miR-6730-5p (MIRT551956)
- hsa-miR-6080 (MIRT551957)
- hsa-miR-520f-3p (MIRT551958)
- hsa-miR-302c-3p (MIRT551959)
- hsa-miR-512-3p (MIRT551960)
- hsa-miR-5584-5p (MIRT551961)
- hsa-miR-6873-5p (MIRT551962)
- hsa-miR-4735-3p (MIRT551963)
- hsa-miR-18b-5p (MIRT551964)
- mmu-miR-466o-3p (MIRT596399)
- mmu-miR-466m-3p (MIRT596400)
- mmu-miR-466f-3p (MIRT596401)
- mmu-miR-466i-3p (MIRT596402)
- mmu-miR-362-3p (MIRT596403)
- mmu-miR-329-3p (MIRT596404)
- mmu-miR-3097-5p (MIRT596405)
- mmu-miR-743b-5p (MIRT596406)
- mmu-miR-466h-3p (MIRT604731)
- hsa-miR-6809-3p (MIRT615926)
- hsa-miR-6833-3p (MIRT615927)
- hsa-miR-4768-5p (MIRT615928)
- hsa-miR-3191-5p (MIRT615929)
- hsa-miR-1248 (MIRT615930)
- hsa-miR-498 (MIRT634349)
- hsa-miR-4279 (MIRT634350)
- hsa-miR-1200 (MIRT634351)
- hsa-miR-6778-3p (MIRT634352)
- hsa-miR-4682 (MIRT634353)
- hsa-miR-1976 (MIRT634354)
- hsa-miR-3653-5p (MIRT634355)
- hsa-miR-6747-3p (MIRT634356)
- hsa-miR-6727-3p (MIRT634357)
- hsa-miR-4722-3p (MIRT634358)
- hsa-miR-544b (MIRT634359)
- hsa-miR-4324 (MIRT634360)
- hsa-miR-660-3p (MIRT634361)
- hsa-miR-33b-5p (MIRT636263)
- hsa-miR-33a-5p (MIRT636264)
- hsa-miR-4430 (MIRT636265)
- hsa-miR-3652 (MIRT636266)
- hsa-miR-4634 (MIRT636267)
- hsa-miR-122-5p (MIRT636268)
- hsa-miR-504-3p (MIRT636269)
- hsa-miR-3135b (MIRT636270)
- hsa-miR-6868-3p (MIRT638313)
- hsa-miR-1237-3p (MIRT638314)
- hsa-miR-150-5p (MIRT666531)
- hsa-miR-4532 (MIRT666532)
- hsa-miR-1247-3p (MIRT666533)
- hsa-miR-6814-5p (MIRT666534)
- hsa-miR-4650-5p (MIRT666535)
- hsa-miR-1972 (MIRT666536)
- hsa-miR-15a-3p (MIRT666537)
- hsa-miR-4740-3p (MIRT678693)
- hsa-miR-1306-5p (MIRT678694)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF157
- Browse OriGene Inhibitory RNA Products For RNF157
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF157
Clone Products
- Applied Biological Materials (abm): Clones for RNF157 - Select products 50% OFF >
- * RNF157 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RNF157
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF157
Cell Line Products
-
Horizon Cell Lines for RNF157
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF157 Gene
Localization for RNF157 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNF157 Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| golgi apparatus | 2 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| extracellular | 0 |
- Golgi apparatus (2)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005737 | cytoplasm | IBA,ISS | -- |
| GO:0005769 | early endosome | IBA | 21873635 |
| GO:0005886 | plasma membrane | IBA | 21873635 |
| GO:0044297 | cell body | ISS | -- |
Pathways & Interactions for RNF157 Gene
Interacting Proteins for RNF157 Gene
GPS-Prot Interaction Network for RNF157
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008333 | endosome to lysosome transport | IBA | 21873635 |
| GO:0016567 | protein ubiquitination | IBA,ISS | -- |
| GO:0043066 | negative regulation of apoptotic process | ISS | -- |
| GO:0043951 | negative regulation of cAMP-mediated signaling | IBA | 21873635 |
| GO:0045744 | negative regulation of G protein-coupled receptor signaling pathway | IBA | 21873635 |
No data available for Pathways by source and SIGNOR curated interactions for RNF157 Gene
Transcripts for RNF157 Gene
mRNA/cDNA for RNF157 Gene
- 2 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000269391 5054 nts (view in UCSC)
- ENST00000319945 2937 nts (view in UCSC)
- ENST00000589317 568 nts (view in UCSC)
- ENST00000589912 286 nts (view in UCSC)
- ENST00000591355 559 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RNF157 - Select products 50% OFF >
- * RNF157 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RNF157
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF157
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF157
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF157
- Browse OriGene Inhibitory RNA Products For RNF157
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF157
Clone Products
- Applied Biological Materials (abm): Clones for RNF157 - Select products 50% OFF >
- * RNF157 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RNF157
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF157
Relevant External Links for RNF157 Gene
- GeneLoc Exon Structure for
- RNF157
Expression for RNF157 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
-
Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for RNF157 Gene
This gene is overexpressed in Brain - Cortex (x5.3), Brain - Frontal Cortex (BA9) (x4.8), Muscle - Skeletal (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.2).
This gene is overexpressed in Frontal cortex (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF157 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF157
SOURCE GeneReport for Unigene cluster for RNF157 Gene:
Hs.500643Evidence on tissue expression from TISSUES for RNF157 Gene
- Nervous system(4.8)
- Eye(2.2)
- Muscle(2.1)
Primer Products
-
OriGene qPCR primer pairs for RNF157
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF157 Gene
Orthologs for RNF157 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RNF157 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RNF157 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RNF157 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rnf157 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RNF157 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rnf157 30 |
|
||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RNF157 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RNF157 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RNF157 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rnf157 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-49c17.3 30 |
|
||
| RNF157 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG9941 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | C11H1.3 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for RNF157 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RNF157 Gene
- ENSEMBL:
- Gene Tree for RNF157 (if available)
- TreeFam:
- Gene Tree for RNF157 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RNF157: view image
Paralogs for RNF157 Gene
Variants for RNF157 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF157 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 728893 | Benign: not provided | 76,155,315(-) | C/A | SYNONYMOUS_VARIANT,INTRON_VARIANT | |
| 790187 | Benign: not provided | 76,152,455(-) | C/A | SYNONYMOUS_VARIANT | |
| 791204 | Benign: not provided | 76,167,779(-) | C/T | SYNONYMOUS_VARIANT | |
| 791506 | Benign: not provided | 76,158,415(-) | G/A | MISSENSE_VARIANT | |
| rs11539879 | - | p.Gly208Arg |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv26992 | CNV | loss | 19812545 |
| esv3358456 | CNV | insertion | 20981092 |
| esv3641276 | CNV | loss | 21293372 |
| esv3641277 | CNV | loss | 21293372 |
| esv3641278 | OTHER | inversion | 21293372 |
| nsv2144 | CNV | insertion | 18451855 |
| nsv828104 | CNV | loss | 20364138 |
| nsv833546 | CNV | loss | 17160897 |
| nsv833547 | CNV | loss | 17160897 |
| nsv978462 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.55;
55.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RNF157 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RNF157
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF157 Gene
Disorders for RNF157 Gene
Additional Disease Information for RNF157
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for RNF157 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF157 Gene
Publications for RNF157 Gene
- Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4
- Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle. (PMID: 28655764) Dogan T … Hatzivassiliou G (The Journal of biological chemistry 2017) 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41
ExternalLinks
Products for RNF157 Gene
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Sources for RNF157 Gene
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