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Aliases for RNF157 Gene

Aliases for RNF157 Gene

  • Ring Finger Protein 157 2 3 5
  • RING-Type E3 Ubiquitin Transferase RNF157 3 4
  • E3 Ubiquitin Ligase RNF157 3
  • RING Finger Protein 157 4
  • EC 2.3.2.27 4
  • KIAA1917 4

External Ids for RNF157 Gene

Previous GeneCards Identifiers for RNF157 Gene

  • GC17M074738
  • GC17M071651
  • GC17M074138
  • GC17M069567

Summaries for RNF157 Gene

GeneCards Summary for RNF157 Gene

RNF157 (Ring Finger Protein 157) is a Protein Coding gene. An important paralog of this gene is MGRN1.

UniProtKB/Swiss-Prot for RNF157 Gene

  • E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).

Additional gene information for RNF157 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF157 Gene

Genomics for RNF157 Gene

GeneHancer (GH) Regulatory Elements for RNF157 Gene

Promoters and enhancers for RNF157 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J076238 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 669.2 -0.3 -301 3.6 ATF1 ARNT SIN3A ZNF2 ZNF48 YY1 POLR2B GLIS2 FOS ATF7 RNF157 UBALD2 FOXJ1 QRICH2 AANAT UBE2O LOC105371896
GH17J076239 Enhancer 0.6 ENCODE dbSUPER 650.7 +1.9 1902 0 SLC30A9 ATF4 KLF9 RNF157 ATF4P3
GH17J076258 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 29.6 -27.6 -27602 19.6 CLOCK DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZC3H11A UBALD2 UNK ENSG00000267342 SRSF2 TRIM65 ENSG00000266980 ENSG00000267546 METTL23 MFSD11 EXOC7
GH17J076250 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 14.6 -11.8 -11811 3.1 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 YY1 RNF157 FOXJ1 JMJD6 UNC13D UBALD2 H3F3B RHBDF2 ACOX1 WBP2 ST6GALNAC2
GH17J076240 Enhancer 1.1 ENCODE dbSUPER 19.4 +2.2 2188 0.3 FOXA2 MLX ARID4B SIN3A YY1 SLC30A9 RXRA SP5 MXD4 PPARG RNF157 ATF4P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF157 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF157 gene promoter:
  • NF-kappaB1
  • HNF-4alpha2
  • HNF-4alpha1
  • COUP-TF1
  • COUP-TF
  • COUP
  • GATA-1
  • Bach1
  • Evi-1
  • JunD

Genomic Locations for RNF157 Gene

Genomic Locations for RNF157 Gene
chr17:76,142,453-76,240,373
(GRCh38/hg38)
Size:
97,921 bases
Orientation:
Minus strand
chr17:74,138,534-74,236,454
(GRCh37/hg19)
Size:
97,921 bases
Orientation:
Minus strand

Genomic View for RNF157 Gene

Genes around RNF157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF157 Gene

Proteins for RNF157 Gene

  • Protein details for RNF157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PX1-RN157_HUMAN
    Recommended name:
    E3 ubiquitin ligase RNF157
    Protein Accession:
    Q96PX1
    Secondary Accessions:
    • Q8NB72
    • Q96N56

    Protein attributes for RNF157 Gene

    Size:
    679 amino acids
    Molecular mass:
    73579 Da
    Quaternary structure:
    • Interacts with APBB1 (PubMed:25342469). Interact with CHD1; CHD1-binding controls RNF157 stability (PubMed:28655764). Interacts with ATRN, MEGF8, TECR, MSI2, PLRG1, BYSL, MTERF3, PSMA1, MRPS18B, PRPF4, FASTKD2, SLC25A1, SMU1, CNOT9, MRPS2, MAGT1, FXR2, EMD, PSMD8, HDAC1, RAN, HSD17B12, TXNDC5 AND MRPL19 (PubMed:28655764).
    SequenceCaution:
    • Sequence=BAB67810.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71053.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC03669.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RNF157 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF157 Gene

Post-translational modifications for RNF157 Gene

  • Phosphorylation at Ser-660, Ser-661, Ser-662 and Ser-663 downstream of the PI3K and MAPK pathways influences the E3 ligase activity and stability of RNF157 during the cell cycle in an anaphase-promoting complex/cyclosome-CDH1-dependent manner (PubMed:28655764).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RNF157 Gene

Domains & Families for RNF157 Gene

Gene Families for RNF157 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RNF157 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF157 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PX1

UniProtKB/Swiss-Prot:

RN157_HUMAN :
  • The D-box motifs play a key role in RNF157 stabilization (PubMed:28655764).
Domain:
  • The D-box motifs play a key role in RNF157 stabilization (PubMed:28655764).
genes like me logo Genes that share domains with RNF157: view

Function for RNF157 Gene

Molecular function for RNF157 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons (PubMed:25342469). Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical (PubMed:25342469). May act as a scaffold molecule to regulate this process (PubMed:25342469). Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle (PubMed:28655764).
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Induction:
Expression is cell cycle-specific with higher levels in cells arrested in G1/S and G2/M (PubMed:28655764).

Enzyme Numbers (IUBMB) for RNF157 Gene

Gene Ontology (GO) - Molecular Function for RNF157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF157: view
genes like me logo Genes that share phenotypes with RNF157: view

Animal Models for RNF157 Gene

MGI Knock Outs for RNF157:
  • Rnf157 Rnf157<tm1b(EUCOMM)Wtsi>

Animal Model Products

miRNA for RNF157 Gene

miRTarBase miRNAs that target RNF157

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF157 Gene

Localization for RNF157 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF157 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF157 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with RNF157: view

Pathways & Interactions for RNF157 Gene

SuperPathways for RNF157 Gene

No Data Available

Interacting Proteins for RNF157 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000269391%0d%0a9606.ENSP00000357051%0d%0a9606.ENSP00000053867%0d%0a
Selected Interacting proteins: Q96PX1-RN157_HUMAN ENSP00000269391 for RNF157 Gene via IID STRING

Gene Ontology (GO) - Biological Process for RNF157 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RNF157 Gene

Drugs & Compounds for RNF157 Gene

No Compound Related Data Available

Transcripts for RNF157 Gene

Unigene Clusters for RNF157 Gene

Ring finger protein 157:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF157 Gene

No ASD Table

Relevant External Links for RNF157 Gene

GeneLoc Exon Structure for
RNF157
ECgene alternative splicing isoforms for
RNF157

Expression for RNF157 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF157 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF157 Gene

This gene is overexpressed in Brain - Cortex (x5.3), Brain - Frontal Cortex (BA9) (x4.8), Muscle - Skeletal (x4.4), and Brain - Anterior cingulate cortex (BA24) (x4.2).

Protein differential expression in normal tissues from HIPED for RNF157 Gene

This gene is overexpressed in Frontal cortex (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF157 Gene



Protein tissue co-expression partners for RNF157 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RNF157 Gene:

RNF157

SOURCE GeneReport for Unigene cluster for RNF157 Gene:

Hs.500643

Evidence on tissue expression from TISSUES for RNF157 Gene

  • Nervous system(4.7)
  • Eye(2.2)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with RNF157: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF157 Gene

Orthologs for RNF157 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF157 34 33
  • 98.55 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNF157 34 33
  • 89.21 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RNF157 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf157 16 34 33
  • 87.86 (n)
cow
(Bos Taurus)
Mammalia RNF157 34 33
  • 87.24 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rnf157 33
  • 85.03 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RNF157 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF157 34 33
  • 78.72 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF157 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf157 33
  • 72.4 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-49c17.3 33
  • 70.97 (n)
RNF157 34
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9941 34
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C11H1.3 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
Species where no ortholog for RNF157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF157 Gene

ENSEMBL:
Gene Tree for RNF157 (if available)
TreeFam:
Gene Tree for RNF157 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF157: view image

Paralogs for RNF157 Gene

Paralogs for RNF157 Gene

(1) SIMAP similar genes for RNF157 Gene using alignment to 5 proteins:

  • RN157_HUMAN
  • K7EKB4_HUMAN
  • K7ENU4_HUMAN
  • K7ER42_HUMAN
  • Q9BTC5_HUMAN
genes like me logo Genes that share paralogs with RNF157: view

Variants for RNF157 Gene

Sequence variations from dbSNP and Humsavar for RNF157 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000050774 -- 76,144,509(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000063858 -- 76,217,754(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000083361 -- 76,195,684(-) G/A intron_variant
rs1000108575 -- 76,178,752(-) C/A intron_variant
rs1000109133 -- 76,188,417(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF157 Gene

Variant ID Type Subtype PubMed ID
esv26992 CNV loss 19812545
esv3358456 CNV insertion 20981092
esv3641276 CNV loss 21293372
esv3641277 CNV loss 21293372
esv3641278 OTHER inversion 21293372
nsv2144 CNV insertion 18451855
nsv828104 CNV loss 20364138
nsv833546 CNV loss 17160897
nsv833547 CNV loss 17160897
nsv978462 CNV duplication 23825009

Variation tolerance for RNF157 Gene

Residual Variation Intolerance Score: 63.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.55; 55.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF157 Gene

Disorders for RNF157 Gene

Additional Disease Information for RNF157

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNF157 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF157 Gene

Publications for RNF157 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 58
  2. Role of the E3 ubiquitin ligase RNF157 as a novel downstream effector linking PI3K and MAPK signaling pathways to the cell cycle. (PMID: 28655764) Dogan T … Hatzivassiliou G (The Journal of biological chemistry 2017) 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58

Products for RNF157 Gene

Sources for RNF157 Gene

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