Aliases for RNF152 Gene
External Ids for RNF152 Gene
Previous GeneCards Identifiers for RNF152 Gene
GeneCards Summary for RNF152 Gene
RNF152 (Ring Finger Protein 152) is a Protein Coding gene. Diseases associated with RNF152 include Galloway-Mowat Syndrome 5. Among its related pathways are Metabolism of proteins and mTOR signaling pathway (KEGG). Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is SPRYD4.
UniProtKB/Swiss-Prot Summary for RNF152 Gene
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).