Aliases for RNF152 Gene

Aliases for RNF152 Gene

  • Ring Finger Protein 152 2 3 5
  • RING-Type E3 Ubiquitin Transferase RNF152 3 4
  • E3 Ubiquitin-Protein Ligase RNF152 3 4
  • RING Finger Protein 152 4
  • EC 2.3.2.27 4

External Ids for RNF152 Gene

Previous GeneCards Identifiers for RNF152 Gene

  • GC18M057629
  • GC18M057631
  • GC18M059475
  • GC18M056192

Summaries for RNF152 Gene

GeneCards Summary for RNF152 Gene

RNF152 (Ring Finger Protein 152) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Protein ubiquitination. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF135.

UniProtKB/Swiss-Prot Summary for RNF152 Gene

  • E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).

Additional gene information for RNF152 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF152 Gene

Genomics for RNF152 Gene

GeneHancer (GH) Regulatory Elements for RNF152 Gene

Promoters and enhancers for RNF152 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J061890 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas 500.7 +1.3 1317 4.6 EP300 CTCF ZNF10 ZBTB10 POLR2A ZBTB26 EZH2 HDAC2 MXI1 ZNF341 LOC105372159 RNF152 lnc-RNF152-3 lnc-PIGN-6
GH18J061731 Enhancer 1.1 FANTOM5 Ensembl ENCODE 15.1 +160.3 160283 5.6 FOS FOXA2 NR2F2 ZBTB33 JUND RAD21 RXRA MAX SMARCA4 EGR1 RNF152 ENSG00000267038 RELCH lnc-CDH20-6 ENSG00000267175
GH18J061604 Promoter/Enhancer 1.4 Ensembl ENCODE CraniofacialAtlas dbSUPER 10.6 +287.9 287923 3.3 JUND FOS POLR2A GABPA REST FOSL2 JUN FOSL1 ETS1 TAL1 ENSG00000267279 RNF152 ENSG00000267316 lnc-CDH20-3 ENSG00000267175
GH18J061851 Enhancer 0.8 Ensembl ENCODE 16.2 +41.1 41131 4.6 EP300 JUND FOS ATF2 MXI1 CREB1 MAFF MAFK SPI1 CTCF RNF152 lnc-PIGN-6 lnc-RNF152-3
GH18J061764 Enhancer 0.8 Ensembl ENCODE 10.9 +129.3 129342 1.4 EP300 BCL11A CEBPG TAL1 MAFK NR2F1 NFATC3 ATF2 TBX21 MEIS2 RNF152 piR-31199-154 AY882305-002
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF152 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF152

Top Transcription factor binding sites by QIAGEN in the RNF152 gene promoter:
  • Cdc5
  • Gfi-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • Olf-1
  • POU6F1 (c2)
  • ZIC2

Genomic Locations for RNF152 Gene

Genomic Locations for RNF152 Gene
chr18:61,808,067-61,894,432
(GRCh38/hg38)
Size:
86,366 bases
Orientation:
Minus strand
chr18:59,475,296-59,561,480
(GRCh37/hg19)
Size:
86,185 bases
Orientation:
Minus strand

Genomic View for RNF152 Gene

Genes around RNF152 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF152 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF152 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF152 Gene

Proteins for RNF152 Gene

  • Protein details for RNF152 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8N0-RN152_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF152
    Protein Accession:
    Q8N8N0
    Secondary Accessions:
    • B3KV99
    • Q52LA4

    Protein attributes for RNF152 Gene

    Size:
    203 amino acids
    Molecular mass:
    22357 Da
    Quaternary structure:
    • Interacts with RRAGA (inactive GDP-bound form); stimulated by amino acid starvation (PubMed:25936802). Interacts with SEC16A (By similarity).

neXtProt entry for RNF152 Gene

Post-translational modifications for RNF152 Gene

  • Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RNF152 Gene

No data available for DME Specific Peptides for RNF152 Gene

Domains & Families for RNF152 Gene

Gene Families for RNF152 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RNF152 Gene

Blocks:
  • Zn-finger, RING
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RNF152 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 152 (RN152_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8N8N0

UniProtKB/Swiss-Prot:

RN152_HUMAN :
  • Belongs to the RNF152 family.
Family:
  • Belongs to the RNF152 family.
genes like me logo Genes that share domains with RNF152: view

Function for RNF152 Gene

Molecular function for RNF152 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27; Evidence=. ;.

Enzyme Numbers (IUBMB) for RNF152 Gene

Phenotypes From GWAS Catalog for RNF152 Gene

Gene Ontology (GO) - Molecular Function for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 21203937
GO:0016740 transferase activity IEA --
GO:0031267 small GTPase binding IPI 25936802
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IMP,IEA 25936802
genes like me logo Genes that share ontologies with RNF152: view
genes like me logo Genes that share phenotypes with RNF152: view

Animal Model Products

CRISPR Products

miRNA for RNF152 Gene

miRTarBase miRNAs that target RNF152

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF152 Gene

Localization for RNF152 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF152 Gene

Lysosome membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF152 gene
Compartment Confidence
lysosome 5
plasma membrane 2
cytosol 2
extracellular 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
endosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005764 lysosome IDA,IEA 21203937
GO:0005765 lysosomal membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031301 integral component of organelle membrane IMP 25936802
genes like me logo Genes that share ontologies with RNF152: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF152 Gene

Pathways & Interactions for RNF152 Gene

genes like me logo Genes that share pathways with RNF152: view

Pathways by source for RNF152 Gene

UniProtKB/Swiss-Prot Q8N8N0-RN152_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF152 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS,IEA 21203937
GO:0010508 positive regulation of autophagy IEA,IMP 25936802
GO:0016567 protein ubiquitination TAS --
GO:0034198 cellular response to amino acid starvation IEA,IDA 25936802
GO:0070534 protein K63-linked ubiquitination IMP 25936802
genes like me logo Genes that share ontologies with RNF152: view

No data available for SIGNOR curated interactions for RNF152 Gene

Drugs & Compounds for RNF152 Gene

No Compound Related Data Available

Transcripts for RNF152 Gene

mRNA/cDNA for RNF152 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF152 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2:
SP3: -

Relevant External Links for RNF152 Gene

GeneLoc Exon Structure for
RNF152

Expression for RNF152 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF152 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RNF152 Gene

This gene is overexpressed in Kidney - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for RNF152 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RNF152 Gene



Protein tissue co-expression partners for RNF152 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF152

SOURCE GeneReport for Unigene cluster for RNF152 Gene:

Hs.667457

mRNA Expression by UniProt/SwissProt for RNF152 Gene:

Q8N8N0-RN152_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for RNF152 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RNF152: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF152 Gene

Orthologs for RNF152 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RNF152 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF152 31 30
  • 99.18 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RNF152 31
  • 95 (a)
OneToOne
LOC609935 30
  • 90.8 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF152 31
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RNF152 31
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rnf152 17 31 30
  • 88.18 (n)
rat
(Rattus norvegicus)
Mammalia Rnf152 30
  • 88.01 (n)
cow
(Bos Taurus)
Mammalia RNF152 30
  • 83.64 (n)
chicken
(Gallus gallus)
Aves RNF152 31 30
  • 84.73 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RNF152 31
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486837 30
  • 72.58 (n)
zebrafish
(Danio rerio)
Actinopterygii rnf152 31 30
  • 66.16 (n)
OneToOne
Dr.20455 30
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7669 30
Species where no ortholog for RNF152 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RNF152 Gene

ENSEMBL:
Gene Tree for RNF152 (if available)
TreeFam:
Gene Tree for RNF152 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF152: view image

Paralogs for RNF152 Gene

(3) SIMAP similar genes for RNF152 Gene using alignment to 2 proteins:

  • RN152_HUMAN
  • K7EMG3_HUMAN

Pseudogenes.org Pseudogenes for RNF152 Gene

genes like me logo Genes that share paralogs with RNF152: view

Variants for RNF152 Gene

Additional dbSNP identifiers (rs#s) for RNF152 Gene

Structural Variations from Database of Genomic Variants (DGV) for RNF152 Gene

Variant ID Type Subtype PubMed ID
nsv961055 CNV duplication 23825009

Variation tolerance for RNF152 Gene

Residual Variation Intolerance Score: 36.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.11; 38.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF152 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF152

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF152 Gene

Disorders for RNF152 Gene

Additional Disease Information for RNF152

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RNF152 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF152 Gene

Publications for RNF152 Gene

  1. The ubiquitination of rag A GTPase by RNF152 negatively regulates mTORC1 activation. (PMID: 25936802) Deng L … Wang P (Molecular cell 2015) 3 4 54
  2. RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities. (PMID: 21203937) Zhang S … Tang J (Protein & cell 2010) 3 4 54
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 41 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for RNF152 Gene

Sources for RNF152 Gene