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RNF149 (Ring Finger Protein 149) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is RNF150.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO:0061630 | ubiquitin protein ligase activity | IEA,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0016020 | membrane | IEA,HDA | 19946888 |
GO:0016021 | integral component of membrane | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006511 | ubiquitin-dependent protein catabolic process | IBA | 21873635 |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0031647 | regulation of protein stability | IEA | -- |
GO:0035690 | cellular response to drug | IEA | -- |
GO:0043409 | negative regulation of MAPK cascade | IEA | -- |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RNF149 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RNF149 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RNF149 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rnf149 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rnf149 30 17 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RNF149 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RNF149 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RNF149 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RNF149 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rnf149 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | H10E21.5 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs763258401 | A breast cancer sample |
p.Glu7Lys |
|||
rs11123868 | - |
p.Ser9Gly |
|||
rs13151 | - |
p.Asp356Glu |
|||
rs17856945 | - |
p.Leu344Phe |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv34123 | CNV | loss | 18971310 |
esv3591764 | CNV | loss | 21293372 |
esv3892993 | CNV | gain | 25118596 |
nsv961845 | CNV | duplication | 23825009 |
No disorders were found for RNF149 Gene.