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Aliases for RNF148 Gene

Aliases for RNF148 Gene

  • Ring Finger Protein 148 2 3 5
  • RING Finger Protein 148 3

External Ids for RNF148 Gene

Previous GeneCards Identifiers for RNF148 Gene

  • GC07U901252
  • GC07M121896
  • GC07M121935
  • GC07M122128
  • GC07M122341
  • GC07M116705

Summaries for RNF148 Gene

GeneCards Summary for RNF148 Gene

RNF148 (Ring Finger Protein 148) is a Protein Coding gene. An important paralog of this gene is RNF133.

Additional gene information for RNF148 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF148 Gene

Genomics for RNF148 Gene

GeneHancer (GH) Regulatory Elements for RNF148 Gene

Promoters and enhancers for RNF148 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J122677 Enhancer 0.9 ENCODE 11.5 +24.0 23980 2.6 CLOCK FOXA2 MLX ARID4B NEUROD1 DMAP1 ATF7 FOS SP5 PPARG RNF133 RNF148 ENSG00000225795 RPS26P31 CADPS2
GH07J122633 Enhancer 0.5 FANTOM5 10.6 +69.4 69410 0.3 IKZF2 SPI1 RNF133 RNF148 CADPS2 ENSG00000225795 LOC105375481
GH07J122736 Enhancer 0.4 ENCODE 11.3 -33.4 -33448 0.2 NANOG IKZF1 ZSCAN5C RNF133 RNF148 LOC100422456 CADPS2
GH07J122652 Enhancer 0.4 ENCODE 10.5 +50.0 49985 0.2 FOXA2 HOMEZ RNF133 RNF148 ENSG00000225795 LOC105375481 CADPS2
GH07J122674 Enhancer 0.2 ENCODE 11.7 +28.3 28275 0.3 ENSG00000225795 RNF133 RNF148 LOC105375481 CADPS2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF148 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RNF148 gene promoter:
  • Nkx2-5
  • Max1
  • c-Myc
  • CUTL1
  • FOXF2
  • Nkx6-1
  • Tal-1beta
  • E47
  • POU3F2
  • POU3F2 (N-Oct-5b)

Genomic Locations for RNF148 Gene

Genomic Locations for RNF148 Gene
1,304 bases
Minus strand
1,304 bases
Minus strand

Genomic View for RNF148 Gene

Genes around RNF148 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF148 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF148 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF148 Gene

Proteins for RNF148 Gene

  • Protein details for RNF148 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RING finger protein 148
    Protein Accession:
    Secondary Accessions:
    • A4D0X4
    • Q8N308

    Protein attributes for RNF148 Gene

    305 amino acids
    Molecular mass:
    34397 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RNF148 Gene

Post-translational modifications for RNF148 Gene

  • Glycosylation at posLast=4343
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF148 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF148 Gene

Domains & Families for RNF148 Gene

Gene Families for RNF148 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for RNF148 Gene

Suggested Antigen Peptide Sequences for RNF148 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with RNF148: view

No data available for UniProtKB/Swiss-Prot for RNF148 Gene

Function for RNF148 Gene

Gene Ontology (GO) - Molecular Function for RNF148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF148: view
genes like me logo Genes that share phenotypes with RNF148: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RNF148

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RNF148 Gene

Localization for RNF148 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF148 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF148 gene
Compartment Confidence
mitochondrion 2
plasma membrane 1
extracellular 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for RNF148 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with RNF148: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RNF148 Gene

Pathways & Interactions for RNF148 Gene

SuperPathways for RNF148 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RNF148 Gene


No data available for Pathways by source and SIGNOR curated interactions for RNF148 Gene

Drugs & Compounds for RNF148 Gene

No Compound Related Data Available

Transcripts for RNF148 Gene

mRNA/cDNA for RNF148 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RNF148 Gene

Ring finger protein 148:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF148 Gene

No ASD Table

Relevant External Links for RNF148 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RNF148 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF148 Gene

mRNA differential expression in normal tissues according to GTEx for RNF148 Gene

This gene is overexpressed in Testis (x44.7).

NURSA nuclear receptor signaling pathways regulating expression of RNF148 Gene:


SOURCE GeneReport for Unigene cluster for RNF148 Gene:


mRNA Expression by UniProt/SwissProt for RNF148 Gene:

Tissue specificity: Abundantly expressed in testis and slightly in pancreas. Mainly present in the interstitial cells of testicular tissues.

Evidence on tissue expression from TISSUES for RNF148 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with RNF148: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF148 Gene

Orthologs for RNF148 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF148 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RNF148 33
  • 99.02 (n)
(Canis familiaris)
Mammalia RNF148 33
  • 88.11 (n)
(Bos Taurus)
Mammalia RNF148 33
  • 85.59 (n)
(Rattus norvegicus)
Mammalia Rnf148 33
  • 83.89 (n)
(Mus musculus)
Mammalia Rnf148 16 34 33
  • 83.11 (n)
(Monodelphis domestica)
Mammalia RNF148 34
  • 70 (a)
(Gallus gallus)
Aves -- 34
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
(Danio rerio)
Actinopterygii rnf128a 34
  • 34 (a)
si:dkeyp-86f7.4 34
  • 33 (a)
(Caenorhabditis elegans)
Secernentea H10E21.5 34
  • 14 (a)
Species where no ortholog for RNF148 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RNF148 Gene

Gene Tree for RNF148 (if available)
Gene Tree for RNF148 (if available)
Evolutionary constrained regions (ECRs) for RNF148: view image

Paralogs for RNF148 Gene

(5) SIMAP similar genes for RNF148 Gene using alignment to 3 proteins:

  • RN148_HUMAN
  • A4D0X4_HUMAN
genes like me logo Genes that share paralogs with RNF148: view

Variants for RNF148 Gene

Sequence variations from dbSNP and Humsavar for RNF148 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000497063 -- 122,704,565(-) T/C upstream_transcript_variant
rs1001465563 -- 122,704,462(-) T/G upstream_transcript_variant
rs1002203681 -- 122,703,589(-) T/C upstream_transcript_variant
rs1002527856 -- 122,702,180(-) T/C coding_sequence_variant, missense_variant
rs1003746635 -- 122,703,796(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RNF148 Gene

Variant ID Type Subtype PubMed ID
esv3891198 CNV gain 25118596

Variation tolerance for RNF148 Gene

Residual Variation Intolerance Score: 49.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.38; 27.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF148 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF148 Gene

Disorders for RNF148 Gene

Additional Disease Information for RNF148

No disorders were found for RNF148 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RNF148 Gene

Publications for RNF148 Gene

  1. Identification of a novel human testicular interstitial gene, RNF148, and its expression regulated by histone deacetylases. (PMID: 24089095) Liu YQ … Zhang SZ (Genetics and molecular research : GMR 2013) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  5. Does this have a familiar RING? (PMID: 8744354) Saurin AJ … Freemont PS (Trends in biochemical sciences 1996) 2 3 58

Products for RNF148 Gene

Sources for RNF148 Gene

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