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RNF146 (Ring Finger Protein 146) is a Protein Coding gene. Diseases associated with RNF146 include Cherubism and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Signaling by GPCR and Signaling by Wnt. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004842 | ubiquitin-protein transferase activity | IBA,IDA | 21478859 |
GO:0005515 | protein binding | IPI | 21478859 |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0016740 | transferase activity | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Deubiquitination |
.74
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|
2 | Metabolism of proteins | ||
3 | Signaling by Wnt |
.71
|
|
4 | Regulation of activated PAK-2p34 by proteasome mediated degradation | ||
5 | Signaling by GPCR |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006511 | ubiquitin-dependent protein catabolic process | IBA,IMP | 21478859 |
GO:0016055 | Wnt signaling pathway | IEA | -- |
GO:0016567 | protein ubiquitination | IEA | -- |
GO:0051865 | protein autoubiquitination | IDA | 21478859 |
GO:0070936 | protein K48-linked ubiquitination | IMP | 21478859 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||
SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||
SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||
SP9: | - | ||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | ||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
SP12: | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RNF146 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RNF146 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RNF146A 31 |
|
OneToMany | |
RNF146B 30 31 |
|
OneToMany | |||
Mouse (Mus musculus) |
Mammalia | Rnf146 30 17 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RNF146 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rnf146 30 |
|
||
Platypus (Ornithorhynchus anatinus) |
Mammalia | RNF146 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RNF146 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RNF146 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rnf146 30 |
|
||
Str.11229 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.14626 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rnf146 30 31 |
|
OneToOne | |
wufi29e08 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG8786 31 |
|
OneToOne | |
Worm (Caenorhabditis elegans) |
Secernentea | C55A6.1 31 |
|
OneToMany | |
Y105E8A.14 31 |
|
OneToMany | |||
C26B9.6 31 |
|
OneToMany | |||
C02B8.6 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
734128 | Benign: not provided | 127,287,583(+) | G/A | MISSENSE_VARIANT | |
rs10081141 | - | p.Cys25Arg |
Disorder | Aliases | PubMed IDs |
---|---|---|
cherubism |
|
|
arthrogryposis, renal dysfunction, and cholestasis 1 |
|
|
breast cancer |
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alzheimer disease |
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