RNF146 Gene (Protein Coding)

Ring Finger Protein 146

GC06P127266
GIFtS:
37
See more...

Aliases for RNF146 Gene

Aliases for RNF146 Gene

  • Ring Finger Protein 146 2 3 5
  • Dactylidin 2 3 4
  • RING-Type E3 Ubiquitin Transferase RNF146 3 4
  • E3 Ubiquitin-Protein Ligase RNF146 3 4
  • Iduna 3 4
  • RING Finger Protein 146 4
  • DKFZp434O1427 2
  • EC 2.3.2.27 4
  • DJ351K20.1 2
  • RNF146 5

External Ids for RNF146 Gene

Previous GeneCards Identifiers for RNF146 Gene

  • GC06P127568
  • GC06P127629
  • GC06P125164
  • GC06P127587

Summaries for RNF146 Gene

GeneCards Summary for RNF146 Gene

RNF146 (Ring Finger Protein 146) is a Protein Coding gene. Diseases associated with RNF146 include Cherubism and Arthrogryposis, Renal Dysfunction, And Cholestasis 1. Among its related pathways are Signaling by GPCR and Deubiquitination. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity.

UniProtKB/Swiss-Prot Summary for RNF146 Gene

  • E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.

Gene Wiki entry for RNF146 Gene

Additional gene information for RNF146 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RNF146 Gene

Genomics for RNF146 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for RNF146 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH06J127262 Enhancer 0.3 Ensembl 250.7 -1.0 -1014 0.4 PRDM1 RNF146 C6orf58 piR-39341-346 RSPO3
GH06J127290 Enhancer 0.6 Ensembl 11.6 +28.1 28085 1.8 ZNF592 EBF1 BHLHE40 BATF ATF2 JUNB BACH1 TCF12 ARID3A IKZF1 MN298322 RNF146 KIAA0408 lnc-RNF146-1 lnc-KIAA0408-4 ECHDC1
GH06J127419 Enhancer 1.2 FANTOM5 Ensembl ENCODE 2.4 +157.2 157186 2 BCLAF1 JUND ATF3 CTCF REST TRIM22 HOMEZ FOXA2 MAFF SMAD4 ECHDC1 KIAA0408 RNF146 ENSG00000220522 lnc-KIAA0408-3 piR-42613-083 HSALNG0053371
GH06J127102 Enhancer 1 FANTOM5 Ensembl ENCODE 2.5 -161.2 -161247 3.1 BRCA1 CEBPB CTCF EP300 RAD21 STAT3 TBP TCF7L2 NFE2L2 BHLHE40 RNF146 RF00017-5260 RF00017-5261 RSPO3 lnc-ECHDC1-4 ENSG00000286215 lnc-ECHDC1-1 CENPW
GH06J127115 Enhancer 0.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas 2.3 -147.6 -147600 1.6 RNF146 RSPO3 RF00017-5261 lnc-ECHDC1-4 ENSG00000286215 lnc-ECHDC1-1 CENPW
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RNF146 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RNF146

Top Transcription factor binding sites by QIAGEN in the RNF146 gene promoter:
  • AP-4
  • En-1
  • FOXD1
  • HFH-3
  • N-Myc
  • S8
  • SRY
  • STAT3
  • Zic1
  • Zic3

Genomic Locations for RNF146 Gene

Latest Assembly
chr6:127,263,415-127,289,893
(GRCh38/hg38)
Size:
26,479 bases
Orientation:
Plus strand

Previous Assembly
chr6:127,587,827-127,609,707
(GRCh37/hg19 by Entrez Gene)
Size:
21,881 bases
Orientation:
Plus strand

chr6:127,587,755-127,609,712
(GRCh37/hg19 by Ensembl)
Size:
21,958 bases
Orientation:
Plus strand

Genomic View for RNF146 Gene

Genes around RNF146 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF146 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF146 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RNF146 Gene

Proteins for RNF146 Gene

Products:

  1. Antibodies for research
  2. Protein products for research
  3. Assay products for research

  • Protein details for RNF146 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NTX7-RN146_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF146
    Protein Accession:
    Q9NTX7
    Secondary Accessions:
    • E1P572
    • Q6FIB2
    • Q7L8H4
    • Q96K03
    • Q96T06
    • Q9NTX6

    Protein attributes for RNF146 Gene

    Size:
    359 amino acids
    Molecular mass:
    38950 Da
    Quaternary structure:
    • Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, H1-2, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
    Miscellaneous:
    • Was named dactylidin after the Greek term 'daktylidi' for ring, 'the thing around the finger' (PubMed:15813938). Was named Iduna after the Norse goddess of protection and eternal youth (PubMed:21602803).

    Three dimensional structures from OCA and Proteopedia for RNF146 Gene

    Alternative splice isoforms for RNF146 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RNF146 Gene

Protein Expression for RNF146 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RNF146 Gene

  • Ubiquitinated; autoubiquitinated. Polyubiquitinated in the presence of UBE2D1, UBE2D2 and UBE2D3. Multimonoubiquitinated in the presence of UBE2E1. Not ubiquitinated in the presence of UBE2H, CDC34, UBE2L3, UBE2L6, nor UBE2C. In the absence of PAR, autoubiquitination occurs on Lys-85, Lys-95 and Lys-176 via 'Lys-11' and 'Lys-48' ubiquitin linkages. In the presence of PAR, Lys-131 and Lys-176 are ubiquitinated via 'Lys-6', 'Lys-33' and 'Lys-48' ubiquitin linkages. Autoubiquitination is enhanced upon PAR-binding.
  • Ubiquitination at Lys85, Lys95, Lys131, and Lys176
  • Modification sites at PhosphoSitePlus

Other Protein References for RNF146 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF146 Gene

Domains & Families for RNF146 Gene

Gene Families for RNF146 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for RNF146 Gene

InterPro:
Blocks:
  • Zn-finger, RING

Suggested Antigen Peptide Sequences for RNF146 Gene

GenScript: Design optimal peptide antigens:
  • RING finger protein 146 (RN146_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NTX7

UniProtKB/Swiss-Prot:

RN146_HUMAN :
  • The WWE domain mediates non-covalent PAR-binding.
Domain:
  • The WWE domain mediates non-covalent PAR-binding.
genes like me logo Genes that share domains with RNF146: view

Function for RNF146 Gene

Products:

  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for RNF146 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; EC=2.3.2.27;.

Enzyme Numbers (IUBMB) for RNF146 Gene

Phenotypes From GWAS Catalog for RNF146 Gene

Gene Ontology (GO) - Molecular Function for RNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA,IDA 21478859
GO:0005515 protein binding IPI 21478859
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RNF146: view
genes like me logo Genes that share phenotypes with RNF146: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF146

Clone products for research

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF146 Gene

Localization for RNF146 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RNF146 Gene

Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF146 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with RNF146: view

Pathways & Interactions for RNF146 Gene

genes like me logo Genes that share pathways with RNF146: view

Pathways by source for RNF146 Gene

UniProtKB/Swiss-Prot Q9NTX7-RN146_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for RNF146 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RNF146 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA,IMP 21478859
GO:0016055 Wnt signaling pathway IEA --
GO:0016567 protein ubiquitination IEA --
GO:0051865 protein autoubiquitination IDA 21478859
GO:0070936 protein K48-linked ubiquitination IMP 21478859
genes like me logo Genes that share ontologies with RNF146: view

Drugs & Compounds for RNF146 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for RNF146 Gene

Products:

  1. CRISPR products for research
  2. miRNA products for research
  3. Inhibitory RNAs for research
  4. Clone products for research

mRNA/cDNA for RNF146 Gene

10 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
15 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF146

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for RNF146 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - - -
SP6: - - - - - -
SP7: - - - -
SP8: - - - - - -
SP9: -
SP10: - - - - -
SP11: - - - - - - -
SP12: - -

Relevant External Links for RNF146 Gene

GeneLoc Exon Structure for
RNF146

Expression for RNF146 Gene

Products:

  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RNF146 Gene

mRNA expression in normal human tissues for RNF146 Gene
mRNA expression by BioGPS for RNF146 GenemRNA expression by GTEx for RNF146 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF146 Gene

This gene is overexpressed in NK cells (38.4), Testis (12.0), and Fetal Brain (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF146 Gene



Protein tissue co-expression partners for RNF146 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RNF146

SOURCE GeneReport for Unigene cluster for RNF146 Gene:

Hs.267120

mRNA Expression by UniProt/SwissProt for RNF146 Gene:

Q9NTX7-RN146_HUMAN
Tissue specificity: Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease.

Evidence on tissue expression from TISSUES for RNF146 Gene

  • Nervous system(4.8)
  • Eye(4.1)
  • Kidney(2.2)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with RNF146: view

Primer products for research

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF146 Gene

Orthologs for RNF146 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF146 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia RNF146 29 30
  • 100 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia RNF146 30
  • 97 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia RNF146A 30
  • 95 (a)
 OneToMany
RNF146B 29 30
  • 92.51 (n)
 OneToMany
Mouse
(Mus musculus)
 Mammalia Rnf146 29 16 30
  • 90.45 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia RNF146 29 30
  • 88.3 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Rnf146 29
  • 88.16 (n)
Platypus
(Ornithorhynchus anatinus)
 Mammalia RNF146 30
  • 80 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves RNF146 29 30
  • 80.48 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia RNF146 30
  • 82 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia rnf146 29
  • 68.5 (n)
Str.11229 29
African clawed frog
(Xenopus laevis)
 Amphibia Xl.14626 29
Zebrafish
(Danio rerio)
 Actinopterygii rnf146 29 30
  • 57.81 (n)
 OneToOne
wufi29e08 29
Fruit Fly
(Drosophila melanogaster)
 Insecta CG8786 30
  • 26 (a)
 OneToOne
Worm
(Caenorhabditis elegans)
 Secernentea C55A6.1 30
  • 28 (a)
 OneToMany
Y105E8A.14 30
  • 25 (a)
 OneToMany
C26B9.6 30
  • 17 (a)
 OneToMany
C02B8.6 30
  • 16 (a)
 OneToMany
Species where no ortholog for RNF146 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RNF146 Gene

ENSEMBL:
Gene Tree for RNF146 (if available)
TreeFam:
Gene Tree for RNF146 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RNF146: view image
Alliance of Genome Resources:
Additional Orthologs for RNF146

Paralogs for RNF146 Gene

No data available for Paralogs for RNF146 Gene

Variants for RNF146 Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RNF146 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs111808127 Benign: not provided 127,287,583(+) G/A
NM_001242849.1(RNF146):c.970G>A (p.Asp324Asn) 		MISSENSE
rs10081141 -- p.Cys25Arg

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RNF146 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RNF146 Gene

Variant ID Type Subtype PubMed ID
nsv7385 OTHER inversion 18451855

Variation tolerance for RNF146 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.58; 30.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RNF146 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF146
Leiden Open Variation Database (LOVD)
RNF146

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF146 Gene

Disorders for RNF146 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RNF146 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
cherubism
  • crbm
arthrogryposis, renal dysfunction, and cholestasis 1
  • arcs1
alcohol-related birth defect
  • arbd
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RN146_HUMAN
  • Note=Defects in RNF146 are a cause of susceptibility to breast cancer.

Additional Disease Information for RNF146

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RNF146: view

No data available for Genatlas for RNF146 Gene

Publications for RNF146 Gene

  1. The RNF146 and ECHDC1 genes as candidates for inherited breast and ovarian cancer in Jewish Ashkenazi women. (PMID: 19517271) Menachem TD … Friedman E (Familial cancer 2009) 3 4 40
  2. Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. (PMID: 18326623) Gold B … Offit K (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 40
  3. The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. (PMID: 15813938) von Rotz RC … Nitsch RM (The European journal of neuroscience 2005) 3 4 22
  4. Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination. (PMID: 22267412) Wang Z … Xu W (Genes & development 2012) 3 4
  5. RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling. (PMID: 21478859) Zhang Y … Cong F (Nature cell biology 2011) 3 4

ExternalLinks

View latest publications for RNF146 gene in Mastermind

Products for RNF146 Gene

Sources for RNF146 Gene