Aliases for RNF146 Gene
Aliases for RNF146 Gene
External Ids for RNF146 Gene
- HGNC: 21336
- Entrez Gene: 81847
- Ensembl: ENSG00000118518
- OMIM: 612137
- UniProtKB: Q9NTX7
Previous GeneCards Identifiers for RNF146 Gene
- GC06P127568
- GC06P127629
- GC06P125164
- GC06P127587
Summaries for RNF146 Gene
GeneCards Summary for RNF146 Gene
RNF146 (Ring Finger Protein 146) is a Protein Coding gene. Diseases associated with RNF146 include Norse. Among its related pathways are Signaling by Wnt and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity.
UniProtKB/Swiss-Prot for RNF146 Gene
-
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at Lys-48 and Lys-63, while AXIN1 is only ubiquitinated at Lys-48. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
Additional gene information for RNF146 Gene
- Monarch Initiative
- Search for RNF146 at DataMed
- Search for RNF146 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF146 Gene
Genomics for RNF146 Gene
GeneHancer (GH) Regulatory Elements for RNF146 Gene
Promoters and enhancers for RNF146 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH06J127265 | Promoter/Enhancer | 1.8 | Ensembl ENCODE dbSUPER | 650.7 | +1.4 | 1426 | 3.6 | PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 | RNF146 ECHDC1 CENPW LOC105377994 | |
| GH06J127419 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE | 2.4 | +154.4 | 154391 | 1.5 | FOXA2 ZNF143 ATF7 FOS RUNX3 JUNB REST NFIL3 MAFF NBN | ECHDC1 KIAA0408 RNF146 LOC100287856 RPL17P23 | |
| GH06J127102 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 2.5 | -163.9 | -163940 | 0.8 | JUN SIN3A BRCA1 RCOR1 FOSL2 FOS MAFK NFE2L2 CHD2 TCF7L2 | RNF146 RSPO3 LOC105377989 LOC105377991 | |
| GH06J127397 | Enhancer | 0.8 | FANTOM5 ENCODE | 2 | +131.7 | 131689 | 0.9 | STAT1 KLF1 RFX1 SOX6 ELF1 E4F1 FOSL1 OSR2 | ECHDC1 KIAA0408 RNF146 LOC100287856 GC06P127375 | |
| GH06J127115 | Enhancer | 0.4 | FANTOM5 ENCODE | 2.2 | -151.1 | -151059 | 0.2 | RNF146 RSPO3 LOC105377989 LOC105377991 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RNF146 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RNF146 Gene
Genomic Locations for RNF146 Gene
- chr6:127,266,340-127,288,567
- (GRCh38/hg38)
- Size:
- 22,228 bases
- Orientation:
- Plus strand
- chr6:127,587,755-127,609,712
- (GRCh37/hg19)
Genomic View for RNF146 Gene
Genes around RNF146 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q22.33 by Entrez Gene
- 6q22.33 by HGNC
- 6q22.33 by Ensembl
RNF146 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RNF146 Gene
Proteins for RNF146 Gene
-
Protein details for RNF146 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9NTX7-RN146_HUMAN
- Recommended name:
- E3 ubiquitin-protein ligase RNF146
- Protein Accession:
- Q9NTX7
- E1P572
- Q6FIB2
- Q7L8H4
- Q96K03
- Q96T06
- Q9NTX6
Protein attributes for RNF146 Gene
- Size:
- 359 amino acids
- Molecular mass:
- 38950 Da
- Quaternary structure:
-
- Can form homooligomers. Interacts with PARsylated AXIN1, AXIN2, BLZF1, CASC3, HIST1H1C, IPO7, LIG3, NCL, PARP1, XRCC1, XRCC5 and XRCC6. Interacts with DDB1, DHX15, IQGAP1, LRPPRC, PARP2, PRKDC, RUVBL2, TNKS1 and TNKS2. Binding often leads to interactor ubiquitination, in the presence of the appropriate E1 and E2 enzymes, and proteasomal degradation.
- Miscellaneous:
-
- Was named dactylidin after the Greek term daktylidi for ring, the thing around the finger (PubMed:15813938). Was named Iduna after the Norse goddess of protection and eternal youth (PubMed:21602803).
Protein Expression for RNF146 Gene
Post-translational modifications for RNF146 Gene
- Ubiquitinated; autoubiquitinated. Polyubiquitinated in the presence of UBE2D1, UBE2D2 and UBE2D3. Multimonoubiquitinated in the presence of UBE2E1. Not ubiquitinated in the presence of UBE2H, CDC34, UBE2L3, UBE2L6, nor UBE2C. In the absence of PAR, autoubiquitination occurs on Lys-85, Lys-95 and Lys-176 via Lys-11 and Lys-48 ubiquitin linkages. In the presence of PAR, Lys-131 and Lys-176 are ubiquitinated via Lys-6, Lys-33 and Lys-48 ubiquitin linkages. Autoubiquitination is enhanced upon PAR-binding.
- Ubiquitination at Lys176, Lys131, posLast=9595, and posLast=8585
- Modification sites at PhosphoSitePlus
Other Protein References for RNF146 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
-
- NP_001229775.1
- XP_024302332.1
- XP_016866829.1
- XP_016866827.1
- XP_016866830.1
- NP_112225.2
- NP_001229774.1
- XP_016866828.1
- NP_001229773.1
- XP_011534464.1
- NP_001229779.1
- XP_024302331.1
- XP_016866825.1
- XP_011534463.1
- XP_006715634.1
- NP_001229778.1
- NP_001229781.1
- XP_011534466.1
- XP_011534465.1
- NP_001229777.1
- XP_016866831.1
- XP_016866832.1
- NP_001229780.1
- NP_001229776.1
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RNF146
- Novus Biologicals Antibodies for RNF146
- Invitrogen Antibodies for RNF146
- GeneTex RNF146 Antibody for RNF146
-
Boster Bio Antibodies for RNF146
Protein Products
-
OriGene Purified Proteins for RNF146
- Search Origene for MassSpec and Protein Over-expression Lysates for RNF146
- Origene Custom Protein Services for RNF146
- Search GeneTex for Proteins for RNF146
Assay Products
No data available for DME Specific Peptides for RNF146 Gene
Domains & Families for RNF146 Gene
Gene Families for RNF146 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Potential drug targets
- Predicted intracellular proteins
- Predicted secreted proteins
Protein Domains for RNF146 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RNF146 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9NTX7- Domain:
-
- The WWE domain mediates non-covalent PAR-binding.
Function for RNF146 Gene
Molecular function for RNF146 Gene
- UniProtKB/Swiss-Prot Function:
- E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at Lys-48 and Lys-63, while AXIN1 is only ubiquitinated at Lys-48. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
- UniProtKB/Swiss-Prot CatalyticActivity:
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
Enzyme Numbers (IUBMB) for RNF146 Gene
Phenotypes From GWAS Catalog for RNF146 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein transferase activity | IDA | 21478859 |
| GO:0005515 | protein binding | IPI | 21478859 |
| GO:0008270 | zinc ion binding | IEA | -- |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for RNF146 Gene
- MGI mutant phenotypes for RNF146:
-
inferred from 1 alleles
- respiratory system phenotype
- limbs/digits/tail phenotype
- homeostasis/metabolism phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- craniofacial phenotype
- skeleton phenotype
- adipose tissue phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for RNF146:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RNF146
-
CRISPR Products
-
OriGene CRISPR knockouts for RNF146
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF146
- genomics-online: gRNA clones - Search results for 133 available RNF146 gene related products
- Overview of 133 available RNF146 gene related products
- Applied Biological Materials CRISPR for RNF146
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF146
- GenScript: Design CRISPR guide RNA sequences for RNF146
miRNA for RNF146 Gene
- miRTarBase miRNAs that target RNF146
-
- hsa-mir-17-5p (MIRT051033)
- hsa-mir-193a-3p (MIRT167719)
- hsa-mir-193b-3p (MIRT167723)
- hsa-mir-3133 (MIRT167732)
- hsa-mir-5687 (MIRT554706)
- hsa-mir-143-5p (MIRT554707)
- hsa-mir-92b-5p (MIRT554708)
- hsa-mir-16-1-3p (MIRT554709)
- hsa-mir-6754-5p (MIRT554710)
- hsa-mir-4270 (MIRT554711)
- hsa-mir-4441 (MIRT554712)
- hsa-mir-211-3p (MIRT554713)
- hsa-mir-4773 (MIRT554714)
- hsa-mir-4700-3p (MIRT554715)
- hsa-mir-186-5p (MIRT554716)
- hsa-mir-4735-3p (MIRT554717)
- hsa-mir-18b-5p (MIRT554718)
- hsa-mir-18a-5p (MIRT554719)
- hsa-mir-6844 (MIRT712217)
- hsa-mir-4685-3p (MIRT712218)
- hsa-mir-4287 (MIRT712219)
- hsa-mir-1248 (MIRT712220)
- hsa-mir-5088-3p (MIRT712221)
- hsa-mir-4267 (MIRT712222)
- hsa-mir-5690 (MIRT712223)
- hsa-mir-9-5p (MIRT712224)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF146
- Browse OriGene Inhibitory RNA Products For RNF146
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF146
- genomics-online: shRNA clones - Search results for 133 available RNF146 gene related products
- Overview of 133 available RNF146 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for RNF146 in any vector
- NM_030963.3
- XM_006715571.3
- XM_011536162.2
- XM_011536162.2
- XM_011536164.2
- XM_011536161.2
- XM_011536163.2
- XM_017011343.1
- XM_017011341.1
- NM_001242847.1
- NM_001242852.1
- XM_017011336.1
- NM_001242850.1
- XM_017011337.1
- NM_001242844.1
- NM_001242848.1
- NM_001242846.1
- XM_017011337.1
- NM_001242844.1
- NM_001242848.1
- NM_001242846.1
- XM_017011342.1
- XM_017011340.1
- NM_001242845.1
- XM_017011338.1
- XM_017011339.1
- NM_001242851.1
- Sino Biological Human cDNA Clone for RNF146
- VectorBuilder custom plasmid, inducible vectors for RNF146
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNF146
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF146
- Applied Biological Materials Clones for RNF146
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RNF146
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RNF146 Gene
Localization for RNF146 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RNF146 Gene
- Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (3)
- Plasma membrane (3)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005886 | plasma membrane | IDA | -- |
Pathways & Interactions for RNF146 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Deubiquitination |
.74
|
|
| 2 | Metabolism of proteins | ||
| 3 | Signaling by Wnt |
.71
|
|
| 4 | CDK-mediated phosphorylation and removal of Cdc6 | ||
| 5 | Signaling by GPCR | ||
Pathways by source for RNF146 Gene
8 Reactome pathways for RNF146 Gene
UniProtKB/Swiss-Prot Q9NTX7-RN146_HUMAN
- Pathway: Protein modification; protein ubiquitination.
Interacting Proteins for RNF146 Gene
Selected Interacting proteins:
Q9NTX7-RN146_HUMAN
ENSP00000357297
for RNF146 Gene via
IID
STRING
UniProtKB
GPS-Prot Interaction Network for RNF146
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process | IMP | 21478859 |
| GO:0016055 | Wnt signaling pathway | TAS | -- |
| GO:0016567 | protein ubiquitination | IEA | -- |
| GO:0016579 | protein deubiquitination | TAS | -- |
| GO:0051865 | protein autoubiquitination | IDA | 21478859 |
No data available for SIGNOR curated interactions for RNF146 Gene
Transcripts for RNF146 Gene
mRNA/cDNA for RNF146 Gene
- (185) Selected AceView cDNA sequences:
- (10) Additional mRNA sequences :
- (24) REFSEQ mRNAs :
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000309649 2624 bps (uc021zeu.2)
- ENST00000356799 2267 bps (uc063rek.1)
- ENST00000368314 2369 bps (uc003qav.4)
- ENST00000476956 884 bps (uc063rei.1)
- ENST00000477776 762 bps (uc063rem.1)
Unigene Clusters for RNF146 Gene
- Ring finger protein 146:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RNF146
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF146
- genomics-online: gRNA clones - Search results for 133 available RNF146 gene related products
- Overview of 133 available RNF146 gene related products
- Applied Biological Materials CRISPR for RNF146
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RNF146
- GenScript: Design CRISPR guide RNA sequences for RNF146
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF146
- Browse OriGene Inhibitory RNA Products For RNF146
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF146
- genomics-online: shRNA clones - Search results for 133 available RNF146 gene related products
- Overview of 133 available RNF146 gene related products
Clone Products
-
GenScript: Next-day shipping of latest version cDNA ORF clones for RNF146 in any vector
- NM_030963.3
- XM_006715571.3
- XM_011536162.2
- XM_011536162.2
- XM_011536164.2
- XM_011536161.2
- XM_011536163.2
- XM_017011343.1
- XM_017011341.1
- NM_001242847.1
- NM_001242852.1
- XM_017011336.1
- NM_001242850.1
- XM_017011337.1
- NM_001242844.1
- NM_001242848.1
- NM_001242846.1
- XM_017011337.1
- NM_001242844.1
- NM_001242848.1
- NM_001242846.1
- XM_017011342.1
- XM_017011340.1
- NM_001242845.1
- XM_017011338.1
- XM_017011339.1
- NM_001242851.1
- Sino Biological Human cDNA Clone for RNF146
- VectorBuilder custom plasmid, inducible vectors for RNF146
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNF146
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF146
- Applied Biological Materials Clones for RNF146
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP7: | - | - | - | - | |||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | - | |||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | ||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||
| SP12: | - | - |
Expression for RNF146 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Liver (Hepatobiliary System)
- Hepatocytes Liver Lobule
- Intestine (Gastrointestinal Tract)
- Ovary (Reproductive System)
This gene is overexpressed in NK cells (38.4), Testis (12.0), and Fetal Brain (8.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RNF146 Gene
NURSA nuclear receptor signaling pathways regulating expression of RNF146 Gene:
RNF146SOURCE GeneReport for Unigene cluster for RNF146 Gene:
Hs.267120mRNA Expression by UniProt/SwissProt for RNF146 Gene:
Q9NTX7-RN146_HUMAN
Tissue specificity:
Ubiquitously expressed. Up-regulated in brains from patients with Alzheimer disease.
Evidence on tissue expression from TISSUES for RNF146 Gene
- Nervous system(4.7)
- Eye(4.1)
Primer Products
-
OriGene qPCR primer pairs and template standards for RNF146
-
OriGene qPCR primer pairs for RNF146
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF146 Gene
Orthologs for RNF146 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RNF146 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | RNF146 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RNF146A 34 |
|
OneToMany | |
| RNF146B 34 33 |
|
OneToMany | |||
| mouse (Mus musculus) |
Mammalia | Rnf146 16 34 33 |
|
||
| dog (Canis familiaris) |
Mammalia | RNF146 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Rnf146 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RNF146 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RNF146 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RNF146 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rnf146 33 |
|
||
| Str.11229 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14626 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rnf146 34 33 |
|
OneToOne | |
| wufi29e08 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG8786 34 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | C55A6.1 34 |
|
OneToMany | |
| Y105E8A.14 34 |
|
OneToMany | |||
| C26B9.6 34 |
|
OneToMany | |||
| C02B8.6 34 |
|
OneToMany |
- Species where no ortholog for RNF146 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RNF146 Gene
- ENSEMBL:
- Gene Tree for RNF146 (if available)
- TreeFam:
- Gene Tree for RNF146 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RNF146: view image
Paralogs for RNF146 Gene
No data available for Paralogs for RNF146 Gene
Variants for RNF146 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000151823 | -- | 127,275,294(+) | T/C | intron_variant | |
| rs1000153927 | -- | 127,285,048(+) | A/G | 5_prime_UTR_variant, intron_variant | |
| rs1000214790 | -- | 127,285,348(+) | C/T | 5_prime_UTR_variant, intron_variant | |
| rs1000345693 | -- | 127,267,251(+) | C/T | intron_variant | |
| rs1000369053 | -- | 127,277,793(+) | A/G | intron_variant |
Residual Variation Intolerance Score:
49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.58;
30.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RNF146 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RNF146
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RNF146 Gene
Disorders for RNF146 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| norse |
|
|
Search RNF146 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RN146_HUMAN- Note=Defects in RNF146 are a cause of susceptibility to breast cancer.
Additional Disease Information for RNF146
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for RNF146 Gene
Publications for RNF146 Gene
- The RNF146 and ECHDC1 genes as candidates for inherited breast and ovarian cancer in Jewish Ashkenazi women. (PMID: 19517271) Menachem TD … Friedman E (Familial cancer 2009) 3 4 44 58
- Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. (PMID: 18326623) Gold B … Offit K (Proceedings of the National Academy of Sciences of the United States of America 2008) 3 4 44 58
- The novel cytosolic RING finger protein dactylidin is up-regulated in brains of patients with Alzheimer's disease. (PMID: 15813938) von Rotz RC … Nitsch RM (The European journal of neuroscience 2005) 3 4 22 58
- Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination. (PMID: 22267412) Wang Z … Xu W (Genes & development 2012) 3 4 58
- Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. (PMID: 21825151) Kang HC … Dawson TM (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 58
Products for RNF146 Gene
- Browse R&D Systems for Antibodies
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- Custom Antibody ServicesOriGene Antibodies for RNF146
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RNF146
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for RNF146
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- OriGene qPCR primer pairs for RNF146
- OriGene CRISPR knockouts for RNF146
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping of latest version cDNA ORF clones for RNF146 in any vector
- NM_030963.3
- XM_006715571.3
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- XM_011536161.2
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- XM_017011343.1
- XM_017011341.1
- NM_001242847.1
- NM_001242852.1
- XM_017011336.1
- NM_001242850.1
- XM_017011337.1
- NM_001242844.1
- NM_001242848.1
- NM_001242846.1
- XM_017011337.1
- NM_001242844.1
- NM_001242848.1
- NM_001242846.1
- XM_017011342.1
- XM_017011340.1
- NM_001242845.1
- XM_017011338.1
- XM_017011339.1
- NM_001242851.1
- GenScript Custom Purified and Recombinant Proteins Services for RNF146
- GenScript Custom Assay Services for RNF146
- GenScript Custom overexpressing Cell Line Services for RNF146
- GenScript: Design CRISPR guide RNA sequences for RNF146
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
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- Plasmid Preparation
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- Sino Biological Human cDNA Clone for RNF146
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- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for RNF146
- Novus Biologicals proteins and lysates for RNF146
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder custom plasmid, inducible vectors for RNF146
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RNF146
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 28 available RNF146 Antibodies ranked by validation data
- Compare Top RNF146 Antibodies
- antibodies-online: Search results for available RNF146 related products ranked by validation data
- antibodies-online: Search results for 11 available RNF146 Proteins ranked by validation data
- Compare Top RNF146 Proteins
- GeneTex RNF146 Antibody for RNF146
- Search GeneTex for Proteins for RNF146
- Horizon Cell Lines for RNF146
- genomics-online: cdna clones - Search results for 133 available RNF146 gene related products
- Overview of 133 available RNF146 gene related products
- orf clones - Search results for 133 available RNF146 gene related products
- Overview of 133 available RNF146 gene related products
- genomics-online: gRNA clones - Search results for 133 available RNF146 gene related products
- Overview of 133 available RNF146 gene related products
- genomics-online: primer clones - Search results for 133 available RNF146 gene related products
- Overview of 133 available RNF146 gene related products
- genomics-online: shRNA clones - Search results for 133 available RNF146 gene related products
- Overview of 133 available RNF146 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RNF146
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RNF146
- GeneCopoeia miRNA 3'UTR Target clone products for RNF146
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RNF146
- Boster Bio Antibodies for RNF146
- Browse Boster Bio ELISA Kits
Sources for RNF146 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio